Publications

1. Garmany A, Arrell DK, Yamada S, Jeon R, Behfar A, Park S, Terzic A. Decoded cardiopoietic cell secretome linkage to heart repair biosignature. Stem Cells Transl Med. 2024 Nov 12; 13 (11):1144-1159
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2. Livia C, Inglis S, Crespo-Diaz R, Rizzo S, Mahlberg R, Bagwell M, Hillestad M, Yamada S, Meenakshi Siddharthan DV, Singh RD, Li X, Arrell DK, Stalboerger P, Witt T, El Sabbagh A, Rihal M, Rihal C, Terzic A, Bartunek J, Behfar A. Infliximab Limits Injury in Myocardial Infarction. J Am Heart Assoc. 2024 May 7; 13 (9):e032172 Epub 2024 May 03
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3. Yamada S, Bartunek J, Povsic TJ, Cotter G, Davison BA, Edwards C, Behfar A, Metra M, Filippatos GS, Vanderheyden M, Wijns W, Terzic A. Cell Therapy Improves Quality-of-Life in Heart Failure: Outcomes From a Phase III Clinical Trial. Stem Cells Transl Med. 2024 Feb 14; 13 (2):116-124
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4. Arrell DK, Park S, Yamada S, Alekseev AE, Garmany A, Jeon R, Vuckovic I, Lindor JZ, Terzic A. K(ATP) channel dependent heart multiome atlas. Sci Rep. 2022 May 5; 12 (1):7314 Epub 2022 May 05
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5. Yamada S, Bartunek J, Behfar A, Terzic A. Mass Customized Outlook for Regenerative Heart Failure Care. Int J Mol Sci. 2021 Oct 22; 22 (21)
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6. Garmany A, Yamada S, Terzic A. Longevity leap: mind the healthspan gap. NPJ Regen Med. 2021 Sep 23; 6 (1):57 Epub 2021 Sept 23
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7. Arrell DK, Crespo-Diaz RJ, Yamada S, Jeon R, Garmany A, Park S, Adolf JP, Livia C, Hillestad ML, Bartunek J, Behfar A, Terzic A. Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome. Stem Cells Transl Med. 2021 Sep; 10 (9):1320-1328 Epub 2021 May 28
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8. Yamada S, Jeon R, Garmany A, Behfar A, Terzic A. Screening for regenerative therapy responders in heart failure. Biomark Med. 2021 Jun; 15 (10):775-783 Epub 2021 June 25
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9. Zhang S, Yamada S, Park S, Klepinin A, Kaambre T, Terzic A, Dzeja P. Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis. Biochem Biophys Res Commun. 2021 Mar 26; 546:59-64 Epub 2021 Feb 08
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10. Yamada S, Behfar A, Terzic A. Regenerative medicine clinical readiness. Regen Med. 2021 Mar; 16 (3):309-322 Epub 2021 Feb 24
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11. Li M, Yamada S, Shi A, Singh RD, Rolland TJ, Jeon R, Lopez N, Shelerud L, Terzic A, Behfar A. Brachyury engineers cardiac repair competent stem cells. Stem Cells Transl Med. 2021 Mar; 10 (3):385-397 Epub 2020 Oct 24
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12. Bansal A, Pandey MK, Yamada S, Goyal R, Schmit NR, Jeon R, Nesbitt JJ, Witt TA, Singh RD, Gunderson TM, Boroumand S, Li M, Crespo-Diaz RJ, Hillestad ML, Terzic A, Behfar A, DeGrado TR. [(89)Zr]Zr-DBN labeled cardiopoietic stem cells proficient for heart failure. Nucl Med Biol. 2020 Nov-Dec; 90-91:23-30 Epub 2020 Sept 09
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13. Ma H, Hayama T, Van Dyken C, Darby H, Koski A, Lee Y, Gutierrez NM, Yamada S, Li Y, Andrews M, Ahmed R, Liang D, Gonmanee T, Kang E, Nasser M, Kempton B, Brigande J, McGill TJ, Terzic A, Amato P, Mitalipov S. Deleterious mtDNA mutations are common in mature oocytes. Biol Reprod. 2020 Mar 13; 102 (3):607-619
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14. Yamada S, Arrell DK, Rosenow CS, Bartunek J, Behfar A, Terzic A. Ventricular remodeling in ischemic heart failure stratifies responders to stem cell therapy. Stem Cells Transl Med. 2020 Jan; 9 (1):74-79 Epub 2019 Aug 02
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15. Arrell DK, Rosenow CS, Yamada S, Behfar A, Terzic A. Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome. NPJ Regen Med. 2020; 5:5 Epub 2020 Mar 12
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16. Yamada S, Terzic A. Path Toward Proactive Therapy for Patent Ductus Arteriosus. Clin Pharmacol Ther. 2019 Dec; 106 (6):1187-1190 Epub 2019 Aug 21
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17. Singh RD, Hillestad ML, Livia C, Li M, Alekseev AE, Witt TA, Stalboerger PG, Yamada S, Terzic A, Behfar A. M(3)RNA Drives Targeted Gene Delivery in Acute Myocardial Infarction. Tissue Eng Part A. 2019 Jan; 25 (1-2):145-158 Epub 2018 Sept 21
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18. Nath KA, O'Brien DR, Croatt AJ, Grande JP, Ackerman AW, Nath MC, Yamada S, Terzic A, Tchkonia T, Kirkland JL, Katusic ZS. The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential. Am J Physiol Renal Physiol. 2018 Nov 1; 315 (5):F1493-F1499 Epub 2018 July 18
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19. Wang X, Yamada S, LaRiviere WB, Ye H, Bakeberg JL, Irazabal MV, Chebib FT, van Deursen J, Harris PC, Sussman CR, Behfar A, Ward CJ, Torres VE. Generation and phenotypic characterization of Pde1a mutant mice. PLoS One. 2017; 12 (7):e0181087 Epub 2017 July 27
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20. Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D. Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-alpha Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1alpha and Mitochondrial Homeostasis. Arterioscler Thromb Vasc Biol. 2015 Jun; 35 (6):1401-12 Epub 2015 Apr 16
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21. Yamada S, Arrell DK, Martinez-Fernandez A, Behfar A, Kane GC, Perez-Terzic CM, Crespo-Diaz RJ, McDonald RJ, Wyles SP, Zlatkovic-Lindor J, Nelson TJ, Terzic A. Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy. J Am Heart Assoc. 2015 May 11; 4 (5)
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22. Oommen S, Yamada S, Cantero Peral S, Campbell KA, Bruinsma ES, Terzic A, Nelson TJ. Human umbilical cord blood-derived mononuclear cells improve murine ventricular function upon intramyocardial delivery in right ventricular chronic pressure overload. Stem Cell Res Ther. 2015 Mar 26; 6:50
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23. Cantero Peral S, Burkhart HM, Oommen S, Yamada S, Nyberg SL, Li X, O'Leary PW, Terzic A, Cannon BC, Nelson TJ, Wanek Program Porcine Pipeline Group. Safety and feasibility for pediatric cardiac regeneration using epicardial delivery of autologous umbilical cord blood-derived mononuclear cells established in a porcine model system. Stem Cells Transl Med. 2015 Feb; 4(2):195-206. Epub 2015 Jan 05.
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24. Crespo-Diaz R, Yamada S, Bartunek J, Perez-Terzic C, de Waele P, Mauen S, Terzic A, Behfar A. Cardiopoietic index predicts heart repair fitness of patient-derived stem cells. Biomark Med. 2015; 9 (7):639-49 Epub 2015 May 27
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25. Wyles SP, Yamada S, Oommen S, Maleszewski JJ, Beraldi R, Martinez-Fernandez A, Terzic A, Nelson TJ. Inhibition of DNA topoisomerase II selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy. Stem Cells Dev. 2014 Oct 1; 23 (19):2274-82 Epub 2014 Aug 21
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26. Yamada S, Arrell DK, Kane GC, Nelson TJ, Perez-Terzic CM, Behfar A, Purushothaman S, Prinzen FW, Auricchio A, Terzic A. Mechanical dyssynchrony precedes QRS widening in ATP-sensitive K(+) channel-deficient dilated cardiomyopathy. J Am Heart Assoc. 2013 Dec 5; 2 (6):e000410 Epub 2013 Dec 05
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27. Yamada S, Nelson TJ, Kane GC, Martinez-Fernandez A, Crespo-Diaz RJ, Ikeda Y, Perez-Terzic C, Terzic A. Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction. J Physiol. 2013 Sep 1; 591 (17):4335-49 Epub 2013 Apr 08
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28. Folmes CD, Martinez-Fernandez A, Faustino RS, Yamada S, Perez-Terzic C, Nelson TJ, Terzic A. Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells. J Cardiovasc Transl Res. 2013 Feb; 6 (1):10-21 Epub 2012 Dec 18
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29. Kang L, Yamada S, Hernandez MC, Croatt AJ, Grande JP, Juncos JP, Vercellotti GM, Hebbel RP, Katusic ZS, Terzic A, Nath KA. Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula. Am J Physiol Renal Physiol. 2011 Oct; 301 (4):F845-51 Epub 2011 June 22
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30. Terzic A, Alekseev AE, Yamada S, Reyes S, Olson TM. Advances in cardiac ATP-sensitive K+ channelopathies from molecules to populations. Circ Arrhythm Electrophysiol. 2011 Aug; 4 (4):577-85
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31. Arrell DK, Zlatkovic Lindor J, Yamada S, Terzic A. K(ATP) channel-dependent metaboproteome decoded: systems approaches to heart failure prediction, diagnosis, and therapy. Cardiovasc Res. 2011 May 1; 90 (2):258-66 Epub 2011 Feb 14
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32. Thatava T, Nelson TJ, Edukulla R, Sakuma T, Ohmine S, Tonne JM, Yamada S, Kudva Y, Terzic A, Ikeda Y. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther. 2011 Mar; 18 (3):283-93 Epub 2010 Nov 04
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33. Behfar A, Yamada S, Crespo-Diaz R, Nesbitt JJ, Rowe LA, Perez-Terzic C, Gaussin V, Homsy C, Bartunek J, Terzic A. Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction. J Am Coll Cardiol. 2010 Aug 24; 56 (9):721-34
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34. Zlatkovic-Lindor J, Arrell DK, Yamada S, Nelson TJ, Terzic A. ATP-sensitive K(+) channel-deficient dilated cardiomyopathy proteome remodeled by embryonic stem cell therapy. Stem Cells. 2010 Aug; 28 (8):1355-67
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35. Alekseev AE, Reyes S, Yamada S, Hodgson-Zingman DM, Sattiraju S, Zhu Z, Sierra A, Gerbin M, Coetzee WA, Goldhamer DJ, Terzic A, Zingman LV. Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight. Cell Metab. 2010 Jan; 11 (1):58-69
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36. Nelson TJ, Martinez-Fernandez A, Yamada S, Ikeda Y, Perez-Terzic C, Terzic A. Induced pluripotent stem cells: advances to applications. Stem Cells Cloning. 2010 Jan 1; 3:29-37
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37. Arrell DK, Zlatkovic J, Kane GC, Yamada S, Terzic A. ATP-sensitive K+ channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility. J Proteome Res. 2009 Oct; 8 (10):4823-34
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38. Reyes S, Kane GC, Zingman LV, Yamada S, Terzic A. Targeted disruption of K(ATP) channels aggravates cardiac toxicity in cocaine abuse. Clin Transl Sci. 2009 Oct; 2 (5):361-5
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39. Martinez-Fernandez A, Nelson TJ, Yamada S, Reyes S, Alekseev AE, Perez-Terzic C, Ikeda Y, Terzic A. iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ Res. 2009 Sep 25; 105 (7):648-56 Epub 2009 Aug 20
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40. Nelson TJ, Martinez-Fernandez A, Yamada S, Perez-Terzic C, Ikeda Y, Terzic A. Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation. 2009 Aug 4; 120 (5):408-16 Epub 2009 July 20
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41. Yamada S, Nelson TJ, Behfar A, Crespo-Diaz RJ, Fraidenraich D, Terzic A. Stem cell transplant into preimplantation embryo yields myocardial infarction-resistant adult phenotype. Stem Cells. 2009 Jul; 27 (7):1697-705
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42. Nelson TJ, Behfar A, Yamada S, Martinez-Fernandez A, Terzic A. Stem cell platforms for regenerative medicine. Clin Transl Sci. 2009 Jun; 2 (3):222-7
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43. Nelson TJ, Martinez-Fernandez A, Yamada S, Mael AA, Terzic A, Ikeda Y. Induced pluripotent reprogramming from promiscuous human stemness related factors. Clin Transl Sci. 2009 Apr; 2 (2):118-26
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44. Yamada S, Nelson TJ, Crespo-Diaz RJ, Perez-Terzic C, Liu XK, Miki T, Seino S, Behfar A, Terzic A. Embryonic stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells. 2008 Oct; 26(10):2644-53. Epub 2008 Jul 31.
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45. Baker DJ, Perez-Terzic C, Jin F, Pitel KS, Niederlander NJ, Jeganathan K, Yamada S, Reyes S, Rowe L, Hiddinga HJ, Eberhardt NL, Terzic A, van Deursen JM. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol. 2008 Jul; 10 (7):825-36 Epub 2008 May 30
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46. Ohno S, Kubota T, Yoshida H, Tsuji K, Makiyama T, Yamada S, Kuga K, Yamaguchi I, Kita T, Horie M. A novel mutation associated with Jervell and Lange-Nielsen syndrome in a Japanese family. Circ J. 2008 May; 72 (5):687-93
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47. On K, Watanabe S, Yamada S, Takeyasu N, Nakagawa Y, Nishina H, Morimoto T, Aihara H, Kimura T, Sato Y, Tsukada K, Kandori A, Miyashita T, Ogata K, Suzuki D, Yamaguchi I, Aonuma K. Integral value of JT interval in magnetocardiography is sensitive to coronary stenosis and improves soon after coronary revascularization. Circ J. 2007 Oct; 71 (10):1586-92
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48. Taneja V, Behrens M, Cooper LT, Yamada S, Kita H, Redfield MM, Terzic A, David C. Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice. J Mol Cell Cardiol. 2007 Jun; 42 (6):1054-64 Epub 2007 Mar 27
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49. Behfar A, Perez-Terzic C, Faustino RS, Arrell DK, Hodgson DM, Yamada S, Puceat M, Niederlander N, Alekseev AE, Zingman LV, Terzic A. Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med. 2007 Feb 19; 204 (2):405-20 Epub 2007 Feb 05
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50. Yamada S, Kane GC, Behfar A, Liu XK, Dyer RB, Faustino RS, Miki T, Seino S, Terzic A. Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. J Physiol. 2006 Dec 15; 577(Pt 3):1053-65. Epub 2006 Oct 12.
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51. Kandori A, Miyashita T, Ogata K, Shimizu W, Yokokawa M, Kamakura S, Miyatake K, Tsukada K, Yamada S, Watanabe S, Yamaguchi I. Magnetocardiography study on ventricular depolarization-current pattern in patients with brugada syndrome and complete right-bundle branch blocks. Pacing Clin Electrophysiol. 2006 Dec; 29 (12):1359-67
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52. Ogata K, Kandori A, Miyashita T, Tsukada K, Nakatani S, Shimizu W, Kanzaki H, Miyatake K, Yamada S, Watanabe S, Yamaguchi I. Visualization of three-dimensional cardiac electrical excitation using standard heart model and anterior and posterior magnetocardiogram. Int J Cardiovasc Imaging. 2006 Jun-Aug; 22 (3-4):581-93 Epub 2006 Mar 07
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53. Kandori A, Miyashita T, Ogata K, Shimizu W, Yokokawa M, Kamakura S, Miyatake K, Tsukada K, Yamada S, Watanabe S, Yamaguchi I. Electrical space-time abnormalities of ventricular depolarization in patients with Brugada syndrome and patients with complete right-bundle branch blocks studied by magnetocardiography. Pacing Clin Electrophysiol. 2006 Jan; 29 (1):15-20
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54. Kane GC, Liu XK, Yamada S, Olson TM, Terzic A. Cardiac KATP channels in health and disease. J Mol Cell Cardiol. 2005 Jun; 38 (6):937-43 Epub 2005 Apr 25
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55. Behfar A, Hodgson DM, Zingman LV, Perez-Terzic C, Yamada S, Kane GC, Alekseev AE, Puceat M, Terzic A. Administration of allogenic stem cells dosed to secure cardiogenesis and sustained infarct repair. Ann N Y Acad Sci. 2005 May; 1049:189-98.
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56. Yamada S, Yamaguchi I. Magnetocardiograms in clinical medicine: unique information on cardiac ischemia, arrhythmias, and fetal diagnosis. Intern Med. 2005 Jan; 44 (1):1-19
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57. Kane GC, Behfar A, Yamada S, Perez-Terzic C, O'Cochlain F, Reyes S, Dzeja PP, Miki T, Seino S, Terzic A. ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits. Diabetes. 2004 Dec; 53 Suppl 3:S169-75
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58. Liu XK, Yamada S, Kane GC, Alekseev AE, Hodgson DM, O'Cochlain F, Jahangir A, Miki T, Seino S, Terzic A. Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. Diabetes. 2004 Dec; 53 Suppl 3:S165-8.
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59. Ono Y, Ishiyama A, Kasai N, Yamada S, On K, Watanabe S, Yamaguchi I, Miyashita T, Tsukada K. Bayesian classification of myocardial excitation abnormality using magnetocardiogram maps for mass screening. Neurol Clin Neurophysiol. 2004 Nov 30; 2004:43
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60. Yamada S, Tsukada K, Miyashita T, Kuga K, Yamaguchi I. Noninvasive, direct visualization of macro-reentrant circuits by using magnetocardiograms: initiation and persistence of atrial flutter. Europace. 2003 Oct; 5 (4):343-50
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61. Yamada S, Kuga K, On K, Yamaguchi I. Noninvasive recording of his potential using magnetocardiograms. Circ J. 2003 Jul; 67 (7):622-4
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62. Yamada S, Yamaguchi I. [Magnetocardiograms]. Nihon Rinsho. 2003 Apr; 61 Suppl 4:413-7
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63. Yamada S, Tsukada K, Miyashita T, Oyake Y, Kuga K, Yamaguchi I. Noninvasive diagnosis of partial atrial standstill using magnetocardiograms. Circ J. 2002 Dec; 66 (12):1178-80
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64. Eda K, Ohtsuka S, Seo Y, Yamada S, Ishiyama M, Miyamoto T, Horigome H, Yamaguchi I. Conservative treatment of hemolytic complication following coil embolization in two adult cases of patent ductus arteriosus. Jpn Circ J. 2001 Sep; 65 (9):834-6
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65. Yamada S, Tsukada K, Yamaguchi I. Noninvasive diagnosis of cardiac disease using magnetocardiograms. Jpn J Electrocardiol. 2001; 21(Suppl 2):55-68.
    
66. Yamada S, Kuga K, Yamaguchi I. Torsade de pointes induced by intravenous and long-term oral amiodarone therapy in a patient with dilated cardiomyopathy. Jpn Circ J. 2001 Mar; 65 (3):236-8
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67. Yamada S, Tsukada K, Miyashita T, Noguchi Y, Akamatsu K, Ebashi T, Kuga K, Yamaguchi I. Noninvasive diagnosis of arrhythmic foci by using magnetocardiograms, - Method and accuracy of magneto-anatomical mapping system -. J Arrhythmia. 2000; 16(5):580-6.
    
68. Tsukada K, Miyashita T, Kandori A, Mitsui T, Terada Y, Sato M, Shiono J, Horigome H, Yamada S, Yamaguchi I. An iso-integral mapping technique using magnetocardiogram, and its possible use for diagnosis of ischemic heart disease. Int J Card Imaging. 2000 Feb; 16 (1):55-66
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69. Terada Y, Mitsui T, Yamada S. Mitral regurgitation after pericardiectomy for constrictive pericarditis. Jpn J Thorac Cardiovasc Surg. 1999 Jan; 47 (1):27-30
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70. Tsukada K, Miyashita T, Kandori A, Sasabuti H, Suzuki H, Sato M, Yamada S, Shiono J, Terada Y, Horigome H, Yamaguchi I, Mitsui T. Noninvasive visualization of activated regions and current flow in the heart by analyzing vector components of a cardiac magnetic field. Computers in Cardiology. 1999; 26:403-6.
    
71. Yamada S, Yamaguchi I. Effect of relatively low dose amiodarone therapy on left ventricular function in patients with ventricular tachyarrhythmias. Jpn Circ J. 1998 Sep; 62 (9):707-9
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72. Hayashi M, Shimosawa T, Isaka M, Yamada S, Fujita R, Fujita T. Plasma adrenomedullin in diabetes. Lancet. 1997; 350(9089):1449-50.
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