Publications

  1. Garmany R, Dasari S, Bos JM, Kim ET, Gluscevic M, Martinez KA, Tester DJ, Dos Remedios C, Maleszewski JJ, Dearani JA, Ommen SR, Geske JB, Giudicessi JR, Ackerman MJ. A multi-omics atlas of sex-specific differences in obstructive hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2024 Nov; 196:26-34 Epub 2024 Sept 08
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  2. Kulkarni VK, Pinsky AM, Bos JM, Neves R, Bains S, Giudicessi JR, Allison TG, Ackerman MJ. Frequency and Genotype-Dependence of intrinsic chronotropic insufficiency among patients with congenital long QT syndrome. J Cardiovasc Electrophysiol. 2024 Oct 20 [Epub ahead of print]
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  3. Abbasi MA, Akiki E, El-Am EA, Geske JB, Bos JM, Ackerman MJ, Attia ZI, Friedman PA, Siontis KC, Newman DB. Artificial intelligence electrocardiography for the evaluation of cardiac involvement in Fabry disease. Curr Probl Cardiol. 2024 Oct 10; 50 (1):102877 [Epub ahead of print]
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  4. Neves R, Crotti L, Bains S, Bos JM, Dagradi F, Musu G, Garmany R, Giovenzana FLF, Cerea P, Giudicessi JR, Schwartz PJ, Ackerman MJ. Frequency of and outcomes associated with nonadherence to guideline-based recommendations for an implantable cardioverter-defibrillator in patients with congenital long QT syndrome. Heart Rhythm. 2024 Oct 2 Epub 2024 Oct 02
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  5. Castrichini M, Alsidawi S, Geske JB, Newman DB, Arruda-Olson AM, Bos JM, Ommen SR, Siontis KC, Ackerman MJ, Giudicessi JR. Incidence of newly recognized atrial fibrillation in patients with obstructive hypertrophic cardiomyopathy treated with Mavacamten. Heart Rhythm. 2024 Oct; 21 (10):2065-2067 Epub 2024 Apr 15
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  6. O'Neill MJ, Ng CA, Aizawa T, Sala L, Bains S, Winbo A, Ullah R, Shen Q, Tan CY, Kozek K, Vanags LR, Mitchell DW, Shen A, Wada Y, Kashiwa A, Crotti L, Dagradi F, Musu G, Spazzolini C, Neves R, Bos JM, Giudicessi JR, Bledsoe X, Gamazon ER, Lancaster MC, Glazer AM, Knollmann BC, Roden DM, Weile J, Roth F, Salem JE, Earle N, Stiles R, Agee T, Johnson CN, Horie M, Skinner J, Ackerman MJ, Schwartz PJ, Ohno S, Vandenberg JI, Kroncke BM. Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification. Circulation. 2024 Sep 24 Epub 2024 Sept 24
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  7. Lampert R, Day S, Ainsworth B, Burg M, Marino BS, Salberg L, Tome Esteban MT, Abrams DJ, Aziz PF, Barth C, Behr ER, Bell C, Berul CI, Bos JM, Bradley D, Cannom DS, Cannon BC, Concannon MA, Cerrone M, Czosek RJ, Dubin AM, Dziura J, Erickson CC, Estes NAM 3rd, Etheridge SP, Goldenberg I, Gray B, Haglund-Turnquist C, Harmon K, James CA, Johnsrude C, Kannankeril P, Lara A, Law IH, Li F, Link MS, Molossi SM, Olshansky B, Noseworthy PA, Saarel EV, Sanatani S, Shah M, Simone L, Skinner J, Tomaselli GF, Ware JS, Webster G, Zareba W, Zipes DP, Ackerman MJ. Vigorous Exercise in Patients With Congenital Long QT Syndrome: Results of the Prospective, Observational, Multinational LIVE-LQTS Study. Circulation. 2024 Aug 13; 150 (7):516-530 Epub 2024 July 25
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  8. Crotti L, Neves R, Dagradi F, Musu G, Giannetti F, Bos JM, Barbieri M, Cerea P, Giovenzana FLF, Torchio M, Mura M, Gnecchi M, Conte G, Auricchio A, Sala L, Odening KE, Ackerman MJ, Schwartz PJ. Therapeutic Efficacy of Mexiletine for Long QT Syndrome Type 2: Evidence From Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Transgenic Rabbits, and Patients. Circulation. 2024 Aug 13; 150 (7):531-543 Epub 2024 June 28
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  9. Kulkarni VK, Tobert KE, Bos JM, Cowl CT, Giudicessi JR, Ackerman MJ. Return to work for patients in high-risk professions diagnosed with a sudden cardiac death-predisposing genetic heart disease. Heart Rhythm. 2024 Jul 10 Epub 2024 July 10
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  10. Martinez KA, Bains S, Neves R, Giudicessi JR, Bos JM, Ackerman MJ. Sudden cardiac arrest occurring in temporal proximity to consumption of energy drinks. Heart Rhythm. 2024 Jul; 21 (7):1083-1088 Epub 2024 June 06
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  11. Rohatgi RK, Tseng AS, Sugrue AM, Lee AT, Scott CG, Wackel PL, Cannon BC, Bos JM, Ackerman MJ. Utilizing median and maximum QTc values improves prediction of breakthrough cardiac events in pediatric long QT syndrome. J Cardiovasc Electrophysiol. 2024 Jul; 35 (7):1370-1381 Epub 2024 May 09
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  12. Pinsky AM, Kulkarni VK, Bos JM, Neves R, Allison TG, Ackerman MJ. Proceed with caution: Standard protocol exercise stress tests fail to replicate the diagnostic utility of supine-stand tests for long QT syndrome. Pacing Clin Electrophysiol. 2024 Mar; 47 (3):455-461 Epub 2024 Feb 13
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  13. Bains S, Garmany R, Neves R, Giudicessi JR, Gao X, Tester DJ, Bos JM, Ackerman MJ. Temporal Association Between Vaping and Risk of Cardiac Events. Mayo Clin Proc. 2024 Feb; 99 (2):241-248
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  14. Giudicessi JR, Alsidawi S, Geske JB, Newman DB, Arruda-Olson AM, Bos JM, Ommen SR, Ackerman MJ. Genotype Influences Mavacamten Responsiveness in Obstructive Hypertrophic Cardiomyopathy. Mayo Clin Proc. 2024 Feb; 99 (2):341-343
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  15. Caraballo PJ, Bos JM, Qian R, Fischer KM, Johnsen PJ, Schreie DJ, Simon G, Ackerman MJ. Decision Support System Detecting Patients at Risk of Prolonged QT and Associated Mortality. Stud Health Technol Inform. 2024 Jan 25; 310:1378-1379
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  16. Neves R, Bains S, Bos JM, MacIntyre C, Giudicessi JR, Ackerman MJ. Precision therapy in congenital long QT syndrome. Trends Cardiovasc Med. 2024 Jan; 34 (1):39-47 Epub 2022 June 27
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  17. Bergeman AT, Lieve KVV, Kallas D, Bos JM, Roses I Noguer F, Denjoy I, Zorio E, Kammeraad JAE, Peltenburg PJ, Tobert K, Aiba T, Atallah J, Drago F, Batra AS, Brugada R, Borggrefe M, Clur SB, Cox MGPJ, Davis A, Dhillon S, Etheridge SP, Fischbach P, Franciosi S, Haugaa K, Horie M, Johnsrude C, Kane AM, Krause U, Kwok SY, LaPage MJ, Ohno S, Probst V, Roberts JD, Robyns T, Sacher F, Semsarian C, Skinner JR, Swan H, Tavacova T, Tisma-Dupanovic S, Tfelt-Hansen J, Yap SC, Kannankeril PJ, Leenhardt A, Till J, Sanatani S, Tanck MWT, Ackerman MJ, Wilde AAM, van der Werf C. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2023 Dec 19; 148 (25):2029-2037 Epub 2023 Oct 27
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  18. Crotti L, Spazzolini C, Nyegaard M, Overgaard MT, Kotta MC, Dagradi F, Sala L, Aiba T, Ayers MD, Baban A, Barc J, Beach CM, Behr ER, Bos JM, Cerrone M, Covi P, Cuneo B, Denjoy I, Donner B, Elbert A, Eliasson H, Etheridge SP, Fukuyama M, Girolami F, Hamilton R, Horie M, Iascone M, Jimenez-Jaimez J, Jensen HK, Kannankeril PJ, Kaski JP, Makita N, Munoz-Esparza C, Odland HH, Ohno S, Papagiannis J, Porretta AP, Prandstetter C, Probst V, Robyns T, Rosenthal E, Roses-Noguer F, Sekarski N, Singh A, Spentzou G, Stute F, Tfelt-Hansen J, Till J, Tobert KE, Vinocur JM, Webster G, Wilde AAM, Wolf CM, Ackerman MJ, Schwartz PJ. Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry. Eur Heart J. 2023 Sep 14; 44 (35):3357-3370
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  19. Garmany R, Bos JM, Dasari S, Johnson KL, Tester DJ, Giudicessi JR, Dos Remedios C, Maleszewski JJ, Ommen SR, Dearani JA, Ackerman MJ. Proteomic and phosphoproteomic analyses of myectomy tissue reveals difference between sarcomeric and genotype-negative hypertrophic cardiomyopathy. Sci Rep. 2023 Sep 1; 13 (1):14341 Epub 2023 Sept 01
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  20. Griffeth EM, Dearani JA, Schaff HV, Johnson JN, Ackerman MJ, Bos JM, Alzate-Aguirre M, Todd A, Cannon BC, Wackel PL, Stephens EH. Septal Myectomy Outcomes in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy. Ann Thorac Surg. 2023 Sep; 116 (3):499-507 Epub 2023 Apr 26
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  21. Martinez KA, Bos JM, Baggish AL, Phelan DM, Tobert KE, Newman DB, Scherer E, Petek BJ, Ackerman MJ, Martinez MW. Return-to-Play for Elite Athletes With Genetic Heart Diseases Predisposing to Sudden Cardiac Death. J Am Coll Cardiol. 2023 Aug 22; 82 (8):661-670
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  22. Neves R, Bains S, Bos JM, MacIntyre CJ, Giudicessi JR, Ackerman MJ. Fatal Cardiac Arrhythmias During Electronic Gaming in Patients With Genetically Mediated Heart Diseases. J Am Coll Cardiol. 2023 Aug 15; 82 (7):603-611
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  23. Younis A, Bos JM, Zareba W, Aktas MK, Wilde AAM, Tabaja C, Bodurian C, Tobert KE, McNitt S, Polonsky B, Shimizu W, Ackerman MJ, Goldenberg I. Association Between Syncope Trigger Type and Risk of Subsequent Life-Threatening Events in Patients With Long QT Syndrome. JAMA Cardiol. 2023 Aug 1; 8 (8):775-783
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  24. Tobert KE, Bos JM, Moir C, Polites SF, Ackerman MJ. Bilateral cardiac sympathetic denervation in patients with congenital long QT syndrome. Heart Rhythm. 2023 Jul; 20 (7):1033-1038 Epub 2023 Mar 17
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  25. Garmany R, Bos JM, Ommen SR, Ackerman MJ, Geske JB. Clinical course of patients with hypertrophic cardiomyopathy away from tertiary referral care. ESC Heart Fail. 2023 Jun; 10 (3):1919-1927 Epub 2023 Mar 28
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  26. Garmany R, Bos JM, Tester DJ, Giudicessi JR, Dos Remedios CG, Dasari S, Nagaraj NK, Nair AA, Johnson KL, Ryan ZC, Maleszewski JJ, Ommen SR, Dearani JA, Ackerman MJ. Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2023 Apr; 16(2):e003756. Epub 2023 Feb 20.
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  27. Peltenburg PJ, Pultoo SNJ, Tobert KE, Bos JM, Lieve KVV, Tanck M, Clur SB, Blom NA, Ackerman MJ, Wilde AAM, van der Werf C. Repeatability of ventricular arrhythmia characteristics on the exercise-stress test in RYR2-mediated catecholaminergic polymorphic ventricular tachycardia. Europace. 2023 Feb 16; 25 (2):619-626
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  28. Newman DB, Garmany R, Contreras AM, Bos JM, Johnson JN, Geske JB, Allison TG, Ommen SR, Ackerman MJ. Cardiopulmonary Exercise Testing in Athletes With Hypertrophic Cardiomyopathy. Am J Cardiol. 2023 Feb 15; 189:49-55 Epub 2022 Dec 09
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  29. Bains S, Neves R, Bos JM, Giudicessi JR, MacIntyre C, Ackerman MJ. Phenotypes of Overdiagnosed Long QT Syndrome. J Am Coll Cardiol. 2023 Feb 7; 81 (5):477-486
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  30. Tobert KE, Bos JM, Cannon BC, Ackerman MJ. Outcomes of Athletes With Genetic Heart Diseases and Implantable Cardioverter-Defibrillators Who Chose to Return to Play. Mayo Clin Proc. 2022 Nov; 97 (11):2028-2039 Epub 2022 Aug 16
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  31. Dewaswala N, Chen D, Bhopalwala H, Kaggal VC, Murphy SP, Bos JM, Geske JB, Gersh BJ, Ommen SR, Araoz PA, Ackerman MJ, Arruda-Olson AM. Natural language processing for identification of hypertrophic cardiomyopathy patients from cardiac magnetic resonance reports. BMC Med Inform Decis Mak. 2022 Oct 18; 22 (1):272
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  32. Martinez K, Bains S, Giudicessi JR, Bos JM, Neves R, Ackerman MJ. Spectrum and prevalence of side effects and complications with guideline-directed therapies for congenital long QT syndrome. Heart Rhythm. 2022 Oct; 19 (10):1666-1672 Epub 2022 June 13
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  33. De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y, Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Liu WR, Erbilgin A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Bos JM, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez V, Snyder M, Parikh VN, Ashley EA. Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy. Circ Genom Precis Med. 2022 Aug; 15 (4):e003563 Epub 2022 June 07
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  34. Perez Y, Tobert KE, Saunders MJ, Sorensen KB, Bos JM, Ackerman MJ. Diagnostic accuracy of the 12-lead electrocardiogram in the first 48 hours of life for newborns of a parent with congenital long QT syndrome. Heart Rhythm. 2022 Jun; 19 (6):969-974 Epub 2022 Feb 08
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  35. Chen D, Bhopalwala H, Dewaswala N, Arunachalam SP, Enayati M, Farahani NZ, Pasupathy K, Lokineni S, Bos JM, Noseworthy PA, Arsanjani R, Erickson BJ, Geske JB, Ackerman MJ, Araoz PA, Arruda-Olson AM. Deep Neural Network for Cardiac Magnetic Resonance Image Segmentation. J Imaging. 2022 May 23; 8 (5)
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  36. Enayati M, Zanjirani N, Scott C, Bos JM, Yao X, Ngufor C, Ackerman MJ, Arruda-Olson A. Unsupervised Clustering of Sparse Echo Data to Identify Patients for Implantation of Cardioverter-Defibrillator Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022 Article V001T01A008 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). American Society of Mechanical Engineers. https://doi.org/10.1115/DMD2022-1074. 2022.
  37. Bains S, Dotzler SM, Krijger C, Giudicessi JR, Ye D, Bikker H, Rohatgi RK, Tester DJ, Bos JM, Wilde AAM, Ackerman MJ. A phenotype-enhanced variant classification framework to decrease the burden of missense variants of uncertain significance in type 1 long QT syndrome. Heart Rhythm. 2022 Mar; 19 (3):435-442 Epub 2021 Nov 17
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  38. Peltenburg PJ, Kallas D, Bos JM, Lieve KVV, Franciosi S, Roston TM, Denjoy I, Sorensen KB, Ohno S, Roses-Noguer F, Aiba T, Maltret A, LaPage MJ, Atallah J, Giudicessi JR, Clur SB, Blom NA, Tanck M, Extramiana F, Kato K, Barc J, Borggrefe M, Behr ER, Sarquella-Brugada G, Tfelt-Hansen J, Zorio E, Swan H, Kammeraad JAE, Krahn AD, Davis A, Sacher F, Schwartz PJ, Roberts JD, Skinner JR, van den Berg MP, Kannankeril PJ, Drago F, Robyns T, Haugaa K, Tavacova T, Semsarian C, Till J, Probst V, Brugada R, Shimizu W, Horie M, Leenhardt A, Ackerman MJ, Sanatani S, van der Werf C, Wilde AAM. An International Multicenter Cohort Study on beta-Blockers for the Treatment of Symptomatic Children With Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2022 Feb; 145 (5):333-344 Epub 2021 Dec 07
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  39. Bains S, Lador A, Neves R, Bos JM, Giudicessi JR, Cannon BC, Ackerman MJ. Role of chronic continuous intravenous lidocaine in the clinical management of patients with malignant type 3 long QT syndrome. Heart Rhythm. 2022 Jan; 19 (1):81-87 Epub 2021 Sept 16
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  40. Kleiman R, Darpo B, Brown R, Rudo T, Chamoun S, Albert DE, Bos JM, Ackerman MJ. Comparison of electrocardiograms (ECG) waveforms and centralized ECG measurements between a simple 6-lead mobile ECG device and a standard 12-lead ECG. Ann Noninvasive Electrocardiol. 2021 Nov; 26 (6):e12872 Epub 2021 July 19
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  41. Siontis KC, Liu K, Bos JM, Attia ZI, Cohen-Shelly M, Arruda-Olson AM, Zanjirani Farahani N, Friedman PA, Noseworthy PA, Ackerman MJ. Detection of hypertrophic cardiomyopathy by an artificial intelligence electrocardiogram in children and adolescents. Int J Cardiol. 2021 Oct 1; 340:42-47 Epub 2021 Aug 19
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  42. Tobert KE, Bos JM, Garmany R, Ackerman MJ. Return-to-Play for Athletes With Long QT Syndrome or Genetic Heart Diseases Predisposing to Sudden Death. J Am Coll Cardiol. 2021 Aug 10; 78 (6):594-604
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  43. Goldenberg I, Bos JM, Yoruk A, Chen AY, Lopes C, Huang DT, Kutyifa V, Younis A, Aktas MK, Z Rosero S, McNitt S, Sotoodehnia N, Kudenchuk PJ, Rea TD, Arking DE, Scott CG, Briske KA, Sorensen K, J Ackerman M, Zareba W. Risk Prediction in Women With Congenital Long QT Syndrome. J Am Heart Assoc. 2021 Jul 20; 10 (14):e021088 Epub 2021 July 09
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  44. Cui H, Schaff HV, Lentz Carvalho J, Nishimura RA, Geske JB, Dearani JA, Lahr BD, Lee AT, Bos JM, Ackerman MJ, Ommen SR, Maleszewski JJ. Myocardial Histopathology in Patients With Obstructive Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 2021 May 4; 77 (17):2159-2170
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  45. Bos JM, Attia ZI, Albert DE, Noseworthy PA, Friedman PA, Ackerman MJ. Use of Artificial Intelligence and Deep Neural Networks in Evaluation of Patients With Electrocardiographically Concealed Long QT Syndrome From the Surface 12-Lead Electrocardiogram. JAMA Cardiol. 2021 May 1; 6 (5):532-538
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  46. Dotzler SM, Kim CSJ, Gendron WAC, Zhou W, Ye D, Bos JM, Tester DJ, Barry MA, Ackerman MJ. Suppression-Replacement KCNQ1 Gene Therapy for Type 1 Long QT Syndrome. Circulation. 2021 Apr 6; 143 (14):1411-1425 Epub 2021 Jan 28
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  47. Giudicessi JR, Schram M, Bos JM, Galloway CD, Shreibati JB, Johnson PW, Carter RE, Disrud LW, Kleiman R, Attia ZI, Noseworthy PA, Friedman PA, Albert DE, Ackerman MJ. Artificial Intelligence-Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device. Circulation. 2021 Mar 30; 143 (13):1274-1286 Epub 2021 Feb 01
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  48. Kowlgi GN, Giudicessi JR, Barake W, Bos JM, Ackerman MJ. Efficacy of intentional permanent atrial pacing in the long-term management of congenital long QT syndrome. J Cardiovasc Electrophysiol. 2021 Mar; 32 (3):782-789 Epub 2021 Feb 10
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  49. Niaz T, Saunders M, Bos JM, Campbell RM, Ackerman MJ. Prevalence of Suicide Among Patients With Sudden Death-Predisposing Genetic Heart Diseases. JACC Clin Electrophysiol 2021 Feb; 7 (2):253-255
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  50. Bhopalwala H, Dewaswala N, Liu S, Scott CG, Welper JM, Akinnusotu O, Bos JM, Ommen SR, Ackerman MJ, Pellikka PA, Geske JB, Noseworthy P, Arruda-Olson AM. Conversion of left atrial volume to diameter for automated estimation of sudden cardiac death risk in hypertrophic cardiomyopathy. Echocardiography. 2021 Feb; 38 (2):183-188 Epub 2020 Dec 16
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  51. Walsh R, Lahrouchi N, Tadros R, Kyndt F, Glinge C, Postema PG, Amin AS, Nannenberg EA, Ware JS, Whiffin N, Mazzarotto F, Skoric-Milosavljevic D, Krijger C, Arbelo E, Babuty D, Barajas-Martinez H, Beckmann BM, Bezieau S, Bos JM, Breckpot J, Campuzano O, Castelletti S, Celen C, Clauss S, Corveleyn A, Crotti L, Dagradi F, de Asmundis C, Denjoy I, Dittmann S, Ellinor PT, Ortuno CG, Giustetto C, Gourraud JB, Hazeki D, Horie M, Ishikawa T, Itoh H, Kaneko Y, Kanters JK, Kimoto H, Kotta MC, Krapels IPC, Kurabayashi M, Lazarte J, Leenhardt A, Loeys BL, Lundin C, Makiyama T, Mansourati J, Martins RP, Mazzanti A, Morner S, Napolitano C, Ohkubo K, Papadakis M, Rudic B, Molina MS, Sacher F, Sahin H, Sarquella-Brugada G, Sebastiano R, Sharma S, Sheppard MN, Shimamoto K, Shoemaker MB, Stallmeyer B, Steinfurt J, Tanaka Y, Tester DJ, Usuda K, van der Zwaag PA, Van Dooren S, Van Laer L, Winbo A, Winkel BG, Yamagata K, Zumhagen S, Volders PGA, Lubitz SA, Antzelevitch C, Platonov PG, Odening KE, Roden DM, Roberts JD, Skinner JR, Tfelt-Hansen J, van den Berg MP, Olesen MS, Lambiase PD, Borggrefe M, Hayashi K, Rydberg A, Nakajima T, Yoshinaga M, Saenen JB, Kaab S, Brugada P, Robyns T, Giachino DF, Ackerman MJ, Brugada R, Brugada J, Gimeno JR, Hasdemir C, Guicheney P, Priori SG, Schulze-Bahr E, Makita N, Schwartz PJ, Shimizu W, Aiba T, Schott JJ, Redon R, Ohno S, Probst V, Behr ER, Barc J, Bezzina CR, Nantes Referral Center for inherited cardiac arrhythmia. Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls. Genet Med. 2021 Jan; 23 (1):47-58 Epub 2020 Sept 07
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  52. Sugrue A, van Zyl M, Enger N, Mancl K, Eidem BW, Oh JK, Bos JM, Asirvatham SJ, Ackerman MJ. Echocardiography-Guided Risk Stratification for Long QT Syndrome. J Am Coll Cardiol. 2020 Dec 15; 76 (24):2834-2843
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  53. Niaz T, Bos JM, Sorensen KB, Moir C, Ackerman MJ. Left Cardiac Sympathetic Denervation Monotherapy in Patients With Congenital Long QT Syndrome. Circ Arrhythm Electrophysiol. 2020 Dec; 13 (12):e008830 Epub 2020 Nov 16
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  54. Wijeyeratne YD, Tanck MW, Mizusawa Y, Batchvarov V, Barc J, Crotti L, Bos JM, Tester DJ, Muir A, Veltmann C, Ohno S, Page SP, Galvin J, Tadros R, Muggenthaler M, Raju H, Denjoy I, Schott JJ, Gourraud JB, Skoric-Milosavljevic D, Nannenberg EA, Redon R, Papadakis M, Kyndt F, Dagradi F, Castelletti S, Torchio M, Meitinger T, Lichtner P, Ishikawa T, Wilde AAM, Takahashi K, Sharma S, Roden DM, Borggrefe MM, McKeown PP, Shimizu W, Horie M, Makita N, Aiba T, Ackerman MJ, Schwartz PJ, Probst V, Bezzina CR, Behr ER. SCN5A Mutation Type and a Genetic Risk Score Associate Variably With Brugada Syndrome Phenotype in SCN5A Families. Circ Genom Precis Med. 2020 Dec; 13 (6):e002911 Epub 2020 Nov 09
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  55. O'Hare BJ, Bos JM, Tester DJ, Ackerman MJ. Patients With Hypertrophic Cardiomyopathy Deemed Genotype Negative Based on Research Grade Genetic Analysis: Time for Repeat Diagnostic Testing With Next-Generation Sequencing. Circ Genom Precis Med 2020 Dec; 13 (6):e003013 Epub 2020 Nov 14
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  56. Moore JP, Gallotti RG, Shannon KM, Bos JM, Sadeghi E, Strasburger JF, Wakai RT, Horigome H, Clur SA, Hill AC, Shah MJ, Behere S, Sarquella-Brugada G, Czosek R, Etheridge SP, Fischbach P, Kannankeril PJ, Motonaga K, Landstrom AP, Williams M, Patel A, Dagradi F, Tan RB, Stephenson E, Krishna MR, Miyake CY, Lee ME, Sanatani S, Balaji S, Young ML, Siddiqui S, Schwartz PJ, Shivkumar K, Ackerman MJ. Genotype Predicts Outcomes in Fetuses and Neonates With Severe Congenital Long QT Syndrome. JACC Clin Electrophysiol. 2020 Nov; 6 (12):1561-1570 Epub 2020 Aug 26
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  57. Mattivi CL, Bos JM, Bagnall RD, Nowak N, Giudicessi JR, Ommen SR, Semsarian C, Ackerman MJ. Clinical Utility of a Phenotype-Enhanced MYH7-Specific Variant Classification Framework in Hypertrophic Cardiomyopathy Genetic Testing. Circ Genom Precis Med. 2020 Oct; 13 (5):453-459 Epub 2020 Sept 07
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  58. Ng K, Titus EW, Lieve KV, Roston TM, Mazzanti A, Deiter FH, Denjoy I, Ingles J, Till J, Robyns T, Connors SP, Steinberg C, Abrams DJ, Pang B, Scheinman MM, Bos JM, Duffett SA, van der Werf C, Maltret A, Green MS, Rutberg J, Balaji S, Cadrin-Tourigny J, Orland KM, Knight LM, Brateng C, Wu J, Tang AS, Skanes AC, Manlucu J, Healey JS, January CT, Krahn AD, Collins KK, Maginot KR, Fischbach P, Etheridge SP, Eckhardt LL, Hamilton RM, Ackerman MJ, Noguer FRI, Semsarian C, Jura N, Leenhardt A, Gollob MH, Priori SG, Sanatani S, Wilde AAM, Deo RC, Roberts JD. An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2020 Sep 8; 142 (10):932-947 Epub 2020 July 22
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  59. Chatterjee D, Pieroni M, Fatah M, Charpentier F, Cunningham KS, Spears DA, Chatterjee D, Suna G, Bos JM, Ackerman MJ, Schulze-Bahr E, Dittmann S, Notarstefano PG, Bolognese L, Duru F, Saguner AM, Hamilton RM. An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins. Eur Heart J. 2020 Aug 7; 41 (30):2878-2890
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  60. Turkowski KL, Dotzler SM, Tester DJ, Giudicessi JR, Bos JM, Speziale AD, Vollenweider JM, Ackerman MJ. Corrected QT Interval-Polygenic Risk Score and Its Contribution to Type 1, Type 2, and Type 3 Long-QT Syndrome in Probands and Genotype-Positive Family Members. Circ Genom Precis Med. 2020 Aug; 13 (4):e002922 Epub 2020 May 29
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  61. Lahrouchi N, Tadros R, Crotti L, Mizusawa Y, Postema PG, Beekman L, Walsh R, Hasegawa K, Barc J, Ernsting M, Turkowski KL, Mazzanti A, Beckmann BM, Shimamoto K, Diamant UB, Wijeyeratne YD, Kucho Y, Robyns T, Ishikawa T, Arbelo E, Christiansen M, Winbo A, Jabbari R, Lubitz SA, Steinfurt J, Rudic B, Loeys B, Shoemaker MB, Weeke PE, Pfeiffer R, Davies B, Andorin A, Hofman N, Dagradi F, Pedrazzini M, Tester DJ, Bos JM, Sarquella-Brugada G, Campuzano O, Platonov PG, Stallmeyer B, Zumhagen S, Nannenberg EA, Veldink JH, van den Berg LH, Al-Chalabi A, Shaw CE, Shaw PJ, Morrison KE, Andersen PM, Muller-Nurasyid M, Cusi D, Barlassina C, Galan P, Lathrop M, Munter M, Werge T, Ribases M, Aung T, Khor CC, Ozaki M, Lichtner P, Meitinger T, van Tintelen JP, Hoedemaekers Y, Denjoy I, Leenhardt A, Napolitano C, Shimizu W, Schott JJ, Gourraud JB, Makiyama T, Ohno S, Itoh H, Krahn AD, Antzelevitch C, Roden DM, Saenen J, Borggrefe M, Odening KE, Ellinor PT, Tfelt-Hansen J, Skinner JR, van den Berg MP, Olesen MS, Brugada J, Brugada R, Makita N, Breckpot J, Yoshinaga M, Behr ER, Rydberg A, Aiba T, Kaab S, Priori SG, Guicheney P, Tan HL, Newton-Cheh C, Ackerman MJ, Schwartz PJ, Schulze-Bahr E, Probst V, Horie M, Wilde AA, Tanck MWT, Bezzina CR. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome. Circulation. 2020 Jul 28; 142 (4):324-338 Epub 2020 May 20
    View PubMed
  62. MacIntyre CJ, Rohatgi RK, Sugrue AM, Bos JM, Ackerman MJ. Intentional nontherapy in long QT syndrome. Heart Rhythm. 2020 Jul; 17 (7):1147-1150 Epub 2020 Feb 24
    View PubMed
  63. Bos JM, Hebl VB, Oberg AL, Sun Z, Herman DS, Teekakirikul P, Seidman JG, Seidman CE, Dos Remedios CG, Maleszewski JJ, Schaff HV, Dearani JA, Noseworthy PA, Friedman PA, Ommen SR, Brozovich FV, Ackerman MJ. Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19. Mayo Clin Proc. 2020 Jul; 95 (7):1354-1368 Epub 2020 Apr 28
    View PubMed
  64. Bonura ED, Bos JM, Abdelsalam MA, Araoz PA, Ommen SR, Ackerman MJ, Geske JB. Cardiac Magnetic Resonance Imaging Features in Hypertrophic Cardiomyopathy Diagnosed at <21 Years of Age. Am J Cardiol. 2020 Apr 15; 125 (8):1249-1255 Epub 2020 Jan 28
    View PubMed
  65. Waddell-Smith KE, Skinner JR, Bos JM. Pre-Test Probability and Genes and Variants of Uncertain Significance in Familial Long QT Syndrome. Heart Lung Circ. 2020 Apr; 29 (4):512-519 Epub 2020 Jan 03
    View PubMed
  66. Lieve KVV, Dusi V, van der Werf C, Bos JM, Lane CM, Stokke MK, Roston TM, Djupsjobacka A, Wada Y, Denjoy I, Bundgaard H, Noguer FRI, Semsarian C, Robyns T, Hofman N, Tanck MW, van den Berg MP, Kammeraad JAE, Krahn AD, Clur SB, Sacher F, Till J, Skinner JR, Tfelt-Hansen J, Probst V, Leenhardt A, Horie M, Swan H, Roberts JD, Sanatani S, Haugaa KH, Schwartz PJ, Ackerman MJ, Wilde AAM. Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Arrhythm Electrophysiol. 2020 Mar; 13 (3):e007471 Epub 2020 Feb 16
    View PubMed
  67. Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ. An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition. Circulation. 2020 Feb 11; 141 (6):429-439 Epub 2020 Jan 16
    View PubMed
  68. Patel SI, Shamoun FE, Esser H, Parthasarathy S, Ackerman MJ, Geske JB, Ommen SR, Love WT, Somers VK, Chahal CA, Bos JM, Cha SS, Lester SJ. Sleep Disordered Breathing in Hypertrophic Cardiomyopathy Sleep and Vigilance. 2019; 4.1(4.1):3-9. Epub 2020 Jun 01.
  69. Higgins EM, Bos JM, Dotzler SM, John Kim CS, Ackerman MJ. MRAS Variants Cause Cardiomyocyte Hypertrophy in Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Additional Evidence for MRAS as a Definitive Noonan Syndrome-Susceptibility Gene. Circ Genom Precis Med. 2019 Nov; 12 (11):e002648 Epub 2019 Oct 22
    View PubMed
  70. Zhou W, Bos JM, Ye D, Tester DJ, Hrstka S, Maleszewski JJ, Ommen SR, Nishimura RA, Schaff HV, Kim CS, Ackerman MJ. Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations. J Cardiovasc Transl Res. 2019 Oct; 12 (5):394-403 Epub 2019 Feb 22
    View PubMed
  71. van der Werf C, Lieve KV, Bos JM, Lane CM, Denjoy I, Roses-Noguer F, Aiba T, Wada Y, Ingles J, Leren IS, Rudic B, Schwartz PJ, Maltret A, Sacher F, Skinner JR, Krahn AD, Roston TM, Tfelt-Hansen J, Swan H, Robyns T, Ohno S, Roberts JD, van den Berg MP, Kammeraad JA, Probst V, Kannankeril PJ, Blom NA, Behr ER, Borggrefe M, Haugaa KH, Semsarian C, Horie M, Shimizu W, Till JA, Leenhardt A, Ackerman MJ, Wilde AA. Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest. Eur Heart J. 2019 Sep 14; 40 (35):2953-2961
    View PubMed
  72. Nguyen A, Schaff HV, Nishimura RA, Geske JB, Ackerman MJ, Bos JM, Dearani JA, Ommen SR. Survival After Myectomy for Obstructive Hypertrophic Cardiomyopathy: What Causes Late Mortality? Ann Thorac Surg. 2019 Sep; 108 (3):723-729 Epub 2019 Apr 09
    View PubMed
  73. Anderson HN, Bos JM, Rohatgi RK, Ackerman MJ. The Effect of Left Cardiac Sympathetic Denervation on Exercise in Patients With Long QT Syndrome. JACC Clin Electrophysiol. 2019 Sep; 5 (9):1084-1090
    View PubMed
  74. Estes SI, Ye D, Zhou W, Dotzler SM, Tester DJ, Bos JM, Kim CSJ, Ackerman MJ. Characterization of the CACNA1C-R518C Missense Mutation in the Pathobiology of Long-QT Syndrome Using Human Induced Pluripotent Stem Cell Cardiomyocytes Shows Action Potential Prolongation and L-Type Calcium Channel Perturbation. Circ Genom Precis Med. 2019 Aug; 12 (8):e002534 Epub 2019 Aug 20
    View PubMed
  75. Bos JM, Crotti L, Rohatgi RK, Castelletti S, Dagradi F, Schwartz PJ, Ackerman MJ. Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome. Circ Arrhythm Electrophysiol. 2019 May; 12 (5):e007280
    View PubMed
  76. Alvarado FJ, Bos JM, Yuchi Z, Valdivia CR, Hernandez JJ, Zhao YT, Henderlong DS, Chen Y, Booher TR, Marcou CA, Van Petegem F, Ackerman MJ, Valdivia HH. Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2. JCI Insight. 2019 Mar 5; 5 Epub 2019 Mar 05
    View PubMed
  77. Clemens DJ, Tester DJ, Giudicessi JR, Bos JM, Rohatgi RK, Abrams DJ, Balaji S, Crotti L, Faure J, Napolitano C, Priori SG, Probst V, Rooryck-Thambo C, Roux-Buisson N, Sacher F, Schwartz PJ, Silka MJ, Walsh MA, Ackerman MJ. International Triadin Knockout Syndrome Registry. Circ Genom Precis Med. 2019 Feb; 12 (2):e002419
    View PubMed
  78. Lieve KVV, Verhagen JMA, Wei J, Bos JM, van der Werf C, Roses I Noguer F, Mancini GMS, Guo W, Wang R, van den Heuvel F, Frohn-Mulder IME, Shimizu W, Nogami A, Horigome H, Roberts JD, Leenhardt A, Crijns HJG, Blank AC, Aiba T, Wiesfeld ACP, Blom NA, Sumitomo N, Till J, Ackerman MJ, Chen SRW, van de Laar IMBH, Wilde AAM. Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2019 Feb; 16 (2):220-228 Epub 2018 Aug 28
    View PubMed
  79. Patel SI, Ackerman MJ, Shamoun FE, Geske JB, Ommen SR, Love WT, Cha SS, Bos JM, Lester SJ. QT prolongation and sudden cardiac death risk in hypertrophic cardiomyopathy. Acta Cardiol. 2019 Feb; 74 (1):53-58 Epub 2018 Mar 07
    View PubMed
  80. Giudicessi JR, Rohatgi RK, Bos JM, Ackerman MJ. Prevalence and clinical phenotype of concomitant long QT syndrome and arrhythmogenic bileaflet mitral valve prolapse. Int J Cardiol. 2019 Jan 1; 274:175-178 Epub 2018 Sept 11
    View PubMed
  81. Jansweijer JA, van Spaendonck-Zwarts KY, Tanck MWT, van Tintelen JP, Christiaans I, van der Smagt J, Vermeer A, Bos JM, Moss AJ, Swan H, Priori SG, Rydberg A, Tfelt-Hansen J, Ackerman MJ, Olivotto I, Charron P, Gimeno JR, van den Berg M, Wilde AAM, Pinto YM. Heritability in genetic heart disease: the role of genetic background. Open Heart. 2019; 6 (1):e000929 Epub 2019 May 28
    View PubMed
  82. Roston TM, Jones K, Hawkins NM, Bos JM, Schwartz PJ, Perry F, Ackerman MJ, Laksman ZWM, Kaul P, Lieve KVV, Atallah J, Krahn AD, Sanatani S. Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review. Heart Rhythm. 2018 Dec; 15 (12):1791-1799 Epub 2018 July 03
    View PubMed
  83. Chatterjee D, Fatah M, Akdis D, Spears DA, Koopmann TT, Mittal K, Rafiq MA, Cattanach BM, Zhao Q, Healey JS, Ackerman MJ, Bos JM, Sun Y, Maynes JT, Brunckhorst C, Medeiros-Domingo A, Duru F, Saguner AM, Hamilton RM. An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis. Eur Heart J. 2018 Nov 21; 39 (44):3932-3944
    View PubMed
  84. Owen HJ, Bos JM, Ackerman MJ. Wearable cardioverter defibrillators for patients with long QT syndrome. Int J Cardiol. 2018 Oct 1; 268:132-136
    View PubMed
  85. Lane CM, Bos JM, Rohatgi RK, Ackerman MJ. Beyond the length and look of repolarization: Defining the non-QTc electrocardiographic profiles of patients with congenital long QT syndrome. Heart Rhythm. 2018 Sep; 15 (9):1413-1419 Epub 2018 Apr 30
    View PubMed
  86. Baruteau AE, Kyndt F, Behr ER, Vink AS, Lachaud M, Joong A, Schott JJ, Horie M, Denjoy I, Crotti L, Shimizu W, Bos JM, Stephenson EA, Wong L, Abrams DJ, Davis AM, Winbo A, Dubin AM, Sanatani S, Liberman L, Kaski JP, Rudic B, Kwok SY, Rieubland C, Tfelt-Hansen J, Van Hare GF, Guyomarc'h-Delasalle B, Blom NA, Wijeyeratne YD, Gourraud JB, Le Marec H, Ozawa J, Fressart V, Lupoglazoff JM, Dagradi F, Spazzolini C, Aiba T, Tester DJ, Zahavich LA, Beausejour-Ladouceur V, Jadhav M, Skinner JR, Franciosi S, Krahn AD, Abdelsayed M, Ruben PC, Yung TC, Ackerman MJ, Wilde AA, Schwartz PJ, Probst V. SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups. Eur Heart J. 2018 Aug 14; 39 (31):2879-2887
    View PubMed
  87. Lane CM, Giudicessi JR, Ye D, Tester DJ, Rohatgi RK, Bos JM, Ackerman MJ. Long QT syndrome type 5-Lite: Defining the clinical phenotype associated with the potentially proarrhythmic p.Asp85Asn-KCNE1 common genetic variant. Heart Rhythm. 2018 Aug; 15 (8):1223-1230 Epub 2018 Apr 03
    View PubMed
  88. Dufendach KA, Timothy K, Ackerman MJ, Blevins B, Pflaumer A, Etheridge S, Perry J, Blom NA, Temple J, Chowdhury D, Skinner JR, Johnsrude C, Bratincsak A, Bos JM, Shah M. Clinical Outcomes and Modes of Death in Timothy Syndrome: A Multicenter International Study of a Rare Disorder. JACC Clin Electrophysiol. 2018 Apr; 4 (4):459-466 Epub 2017 Nov 06
    View PubMed
  89. Blackshear JL, Safford RE, Thomas CS, Bos JM, Ackerman MJ, Geske JB, Ommen SR, Shapiro BP, Johns GS. Platelet Function Analyzer 100 and Brain Natriuretic Peptide as Biomarkers in Obstructive Hypertrophic Cardiomyopathy. Am J Cardiol. 2018 Mar 15; 121 (6):768-774 Epub 2017 Dec 25
    View PubMed
  90. Anderson HN, Bos JM, Haugaa KH, Morlan BW, Tarrell RF, Caraballo PJ, Ackerman MJ. Prevalence and Outcome of High-Risk QT Prolongation Recorded in the Emergency Department from an Institution-Wide QT Alert System. J Emerg Med. 2018 Jan; 54 (1):8-15 Epub 2017 Oct 26
    View PubMed
  91. Sugrue A, Noseworthy PA, Kremen V, Bos JM, Qiang B, Rohatgi RK, Sapir Y, Attia ZI, Brady P, Caraballo PJ, Asirvatham SJ, Friedman PA, Ackerman MJ. Automated T-wave analysis can differentiate acquired QT prolongation from congenital long QT syndrome. Ann Noninvasive Electrocardiol. 2017 Nov; 22 (6) Epub 2017 Apr 21
    View PubMed
  92. Sugrue A, Rohatgi RK, Noseworthy PA, Kremen V, Bos JM, Qiang B, Sapir Y, Attia ZI, Scott CG, Brady P, Asirvatham SJ, Friedman PA, Ackerman MJ. Architectural T-Wave Analysis and Identification of On-Therapy Breakthrough Arrhythmic Risk in Type 1 and Type 2 Long-QT Syndrome. Circ Arrhythm Electrophysiol. 2017 Nov; 10 (11)
    View PubMed
  93. Warring SK, Anderson HN, Bos JM, Ackerman MJ. Inaccurate diagnosis of Brugada syndrome in a healthy woman based on SCN5A mutation classification. HeartRhythm Case Rep. 2017 Oct; 3 (10):450-454 Epub 2017 Aug 12
    View PubMed
  94. Anderson HN, Bos JM, Kapplinger JD, Meskill JM, Ye D, Ackerman MJ. Lidocaine attenuation testing: An in vivo investigation of putative LQT3-associated variants in the SCN5A-encoded sodium channel. Heart Rhythm. 2017 Aug; 14 (8):1173-1179 Epub 2017 Apr 13
    View PubMed
  95. Kelle AM, Bos JM, Etheridge SP, Cannon BC, Bryant RM, Johnson JN, Ackerman MJ. Cardiac transplantation in children and adolescents with long QT syndrome. Heart Rhythm. 2017 Aug; 14 (8):1182-1188 Epub 2017 Apr 14
    View PubMed
  96. Rohatgi RK, Sugrue A, Bos JM, Cannon BC, Asirvatham SJ, Moir C, Owen HJ, Bos KM, Kruisselbrink T, Ackerman MJ. Contemporary Outcomes in Patients With Long QT Syndrome. J Am Coll Cardiol. 2017 Jul 25; 70 (4):453-462
    View PubMed
  97. Cortez D, Bos JM, Ackerman MJ. Vectorcardiography identifies patients with electrocardiographically concealed long QT syndrome. Heart Rhythm. 2017 Jun; 14 (6):894-899 Epub 2017 Mar 06
    View PubMed
  98. Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ. Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. JCI Insight. 2017 Mar 9; 2 (5):e91225 Epub 2017 Mar 09
    View PubMed
  99. Cortez D, Schlegel TT, Ackerman MJ, Bos JM. ECG-derived spatial QRS-T angle is strongly associated with hypertrophic cardiomyopathy. J Electrocardiol. 2017 Mar - Apr; 50 (2):195-202 Epub 2016 Oct 14
    View PubMed
  100. Turkowski KL, Tester DJ, Bos JM, Haugaa KH, Ackerman MJ. Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy. Congenit Heart Dis. 2017 Mar; 12 (2):226-235 Epub 2017 Mar 21
    View PubMed
  101. Quick AP, Landstrom AP, Wang Q, Beavers DL, Reynolds JO, Barreto-Torres G, Tran V, Showell J, Philippen LE, Morris SA, Skapura D, Bos JM, Pedersen SE, Pautler RG, Ackerman MJ, Wehrens XH. Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. JACC Basic Transl Sci. 2017 Feb; 2 (1):56-67
    View PubMed
  102. McNamara JW, Li A, Lal S, Bos JM, Harris SP, van der Velden J, Ackerman MJ, Cooke R, Dos Remedios CG. MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. PLoS One. 2017; 12 (6):e0180064 Epub 2017 June 28
    View PubMed
  103. Ding Y, Long PA, Bos JM, Shih YH, Ma X, Sundsbak RS, Chen J, Jiang Y, Zhao L, Hu X, Wang J, Shi Y, Ackerman MJ, Lin X, Ekker SC, Redfield MM, Olson TM, Xu X. A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene. JCI Insight. 2016 Sep 8; 1 (14)
    View PubMed
  104. Schneider AE, Bos JM, Ackerman MJ. Effect of Left Cardiac Sympathetic Denervation on the Electromechanical Window in Patients with either Type 1 or Type 2 Long QT Syndrome: A Pilot Study. Congenit Heart Dis. 2016 Sep; 11 (5):437-443 Epub 2016 Feb 17
    View PubMed
  105. Sugrue A, Noseworthy PA, Kremen V, Bos JM, Qiang B, Rohatgi RK, Sapir Y, Attia ZI, Brady P, Asirvatham SJ, Friedman PA, Ackerman MJ. Identification of Concealed and Manifest Long QT Syndrome Using a Novel T Wave Analysis Program. Circ Arrhythm Electrophysiol. 2016 Jul; 9 (7)
    View PubMed
  106. Trivedi S, Schiltz B, Kanipakam R, Bos JM, Ackerman MJ, Ouellette Y. Effect of Ondansetron on QT Interval in Patients Cared for in the PICU. Pediatr Crit Care Med. 2016 Jul; 17 (7):e317-23
    View PubMed
  107. Ostby SA, Bos JM, Owen HJ, Wackel PL, Cannon BC, Ackerman MJ. Competitive Sports Participation in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia: A Single Center's Early Experience. JACC Clin Electrophysiol. 2016 Jun; 2(3):253-262. Epub 2016 Jun 20.
    View PubMed
  108. Murphy SL, Anderson JH, Kapplinger JD, Kruisselbrink TM, Gersh BJ, Ommen SR, Ackerman MJ, Bos JM. Evaluation of the Mayo Clinic Phenotype-Based Genotype Predictor Score in Patients with Clinically Diagnosed Hypertrophic Cardiomyopathy. J Cardiovasc Transl Res. 2016 Apr; 9 (2):153-61 Epub 2016 Feb 25
    View PubMed
  109. Gaba P, Bos JM, Cannon BC, Cha YM, Friedman PA, Asirvatham SJ, Ackerman MJ. Implantable cardioverter-defibrillator explantation for overdiagnosed or overtreated congenital long QT syndrome. Heart Rhythm. 2016 Apr; 13: (4)879-85.
    View PubMed
  110. Hebl VB, Miranda WR, Ong KC, Hodge DO, Bos JM, Gentile F, Klarich KW, Nishimura RA, Ackerman MJ, Gersh BJ, Ommen SR, Geske JB. The Natural History of Nonobstructive Hypertrophic Cardiomyopathy. Mayo Clin Proc. 2016 Mar; 91 (3):279-87
    View PubMed
  111. Antiel RM, Bos JM, Joyce DD, Owen HJ, Roskos PL, Moir C, Ackerman MJ. Quality of life after videoscopic left cardiac sympathetic denervation in patients with potentially life-threatening cardiac channelopathiescardiomyopathies. Heart Rhythm. 2016 Jan; 13: (1)62-9.
    View PubMed
  112. Warren CM, Karam CN, Wolska BM, Kobayashi T, de Tombe PP, Arteaga GM, Bos JM, Ackerman MJ, Solaro RJ. Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin I (K206I). Circ Cardiovasc Genet. 2015 Dec; 8 (6):765-73 Epub 2015 Nov 09
    View PubMed
  113. Kim SJ, Pundi KN, Bos JM, Ackerman MJ. Ventricular fibrillation after elective surgery in an adolescent with long QT syndrome. BMJ Case Rep. 2015 Nov 26; 2015
    View PubMed
  114. Joyce DD, Bos JM, Haugaa KH, Tarrell RF, Morlan BW, Caraballo PJ, Ackerman MJ. Frequency and cause of transient QT prolongation after surgery. Am J Cardiol. 2015 Nov 15; 116: (10)1605-9.
    View PubMed
  115. Loar RW, Bos JM, Will ML, Ommen SR, Ackerman MJ. Genotype-phenotype Correlations of Hypertrophic Cardiomyopathy When Diagnosed in Children, Adolescents, and Young Adults. Congenit Heart Dis. 2015 Nov-Dec; 10: (6)529-36.
    View PubMed
  116. Martins AS, Parvatiyar MS, Feng HZ, Bos JM, Gonzalez-Martinez D, Vukmirovic M, Turna RS, Sanchez-Gonzalez MA, Badger CD, Zorio DAR, Singh RK, Wang Y, Jin JP, Ackerman MJ, Pinto JR. In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene. Circ Cardiovasc Genet. 2015 Oct; 8 (5):653-664 Epub 2015 Aug 24
    View PubMed
  117. Boczek NJ, Ye D, Jin F, Tester DJ, Huseby A, Bos JM, Johnson AJ, Kanter R, Ackerman MJ. Identification and Functional Characterization of a Novel CACNA1C-Mediated Cardiac Disorder Characterized by Prolonged QT Intervals With Hypertrophic Cardiomyopathy, Congenital Heart Defects, and Sudden Cardiac Death. Circ Arrhythm Electrophysiol. 2015 Oct; 8 (5):1122-32 Epub 2015 Aug 07
    View PubMed
  118. Anderson HN, Bos JM, Haugaa KH, Morlan BW, Tarrell RF, Caraballo PJ, Ackerman MJ. Phenotype of Children with QT Prolongation Identified Using an Institution-Wide QT Alert System. Pediatr Cardiol. 2015 Oct; 36 (7):1350-6 Epub 2015 Apr 07
    View PubMed
  119. Rohatgi RK, Bos JM, Ackerman MJ. Stimulant therapy in children with attention-deficit/hyperactivity disorder and concomitant long QT syndrome: A safe combination? Heart Rhythm. 2015 Aug; 12 (8):1807-12 Epub 2015 May 05
    View PubMed
  120. Poterucha JT, Bos JM, Cannon BC, Ackerman MJ. Frequency and severity of hypoglycemia in children with beta-blocker-treated long QT syndrome. Heart Rhythm. 2015 Aug; 12 (8):1815-9 Epub 2015 Apr 27
    View PubMed
  121. Kebed KY, Bos JM, Anavekar NS, Mulvagh SL, Ackerman MJ, Ommen SR. Hypertrophic Cardiomyopathy, Athlete's Heart, or Both: A Case of Hypertrophic Cardiomyopathy Regression. Circ Cardiovasc Imaging. 2015 Jul; 8: (7)e003312.
    View PubMed
  122. Robinson JA, Bos JM, Etheridge SP, Ackerman MJ. Breath Holding Spells in Children with Long QT Syndrome. Congenit Heart Dis. 2015 Jul-Aug; 10 (4):354-61 Epub 2015 Apr 27
    View PubMed
  123. De Ferrari GM, Dusi V, Spazzolini C, Bos JM, Abrams DJ, Berul CI, Crotti L, Davis AM, Eldar M, Kharlap M, Khoury A, Krahn AD, Leenhardt A, Moir CR, Odero A, Olde Nordkamp L, Paul T, Roses I Noguer F, Shkolnikova M, Till J, Wilde AA, Ackerman MJ, Schwartz PJ. Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation. Circulation. 2015 Jun 23; 131: (25)2185-93.
    View PubMed
  124. Towe EC, Bos JM, Ommen SR, Gersh BJ, Ackerman MJ. Genotype-Phenotype Correlations in Apical Variant Hypertrophic Cardiomyopathy. Congenit Heart Dis. 2015 May-Jun; 10 (3):E139-45 Epub 2014 Dec 14
    View PubMed
  125. Sorita A, Bos JM, Morlan BW, Tarrell RF, Ackerman MJ, Caraballo PJ. Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes. J Am Med Inform Assoc. 2015 Apr; 22 (e1):e21-7 Epub 2014 Oct 16
    View PubMed
  126. Pundi KN, Bos JM, Cannon BC, Ackerman MJ. Automated external defibrillator rescues among children with diagnosed and treated long QT syndrome. Heart Rhythm. 2015 Apr; 12 (4):776-81 Epub 2015 Jan 07
    View PubMed
  127. Desimone CV, Bos JM, Bos KM, Liang JJ, Patel NA, Hodge DO, Noheria A, Asirvatham SJ, Ackerman MJ. Effects on repolarization using dynamic QT interval monitoring in long-QT patients following left cardiac sympathetic denervation. J Cardiovasc Electrophysiol. 2015 Apr; 26 (4):434-439 Epub 2015 Feb 08
    View PubMed
  128. Loar RW, Bos JM, Cannon BC, Ackerman MJ. Sudden cardiac arrest during sex in patients with either catecholaminergic polymorphic ventricular tachycardia or long-QT syndrome: a rare but shocking experience. J Cardiovasc Electrophysiol. 2015 Mar; 26 (3):300-4 Epub 2015 Jan 15
    View PubMed
  129. ter Bekke RM, Haugaa KH, van den Wijngaard A, Bos JM, Ackerman MJ, Edvardsen T, Volders PG. Electromechanical window negativity in genotyped long-QT syndrome patients: relation to arrhythmia risk. Eur Heart J. 2015 Jan 14; 36: (3)179-86.
    View PubMed
  130. Haugaa KH, Bos JM, Borkenhagen EJ, Tarrell RF, Morlan BW, Caraballo PJ, Ackerman MJ. Impact of left ventricular hypertrophy on QT prolongation and associated mortality. Heart Rhythm. 2014 Nov; 11: (11)1957-65.
    View PubMed
  131. Medford BA, Bos JM, Ackerman MJ. Epilepsy misdiagnosed as long QT syndrome: it can go both ways. Congenit Heart Dis. 2014 Jul-Aug; 9(4):E135-9. Epub 2013 Jun 10
    View PubMed
  132. Bos JM, Will ML, Gersh BJ, Kruisselbrink TM, Ommen SR, Ackerman MJ. Characterization of a phenotype-based genetic test prediction score for unrelated patients with hypertrophic cardiomyopathy. Mayo Clin Proc. 2014 Jun; 89 (6):727-37 Epub 2014 May 01
    View PubMed
  133. Kapplinger JD, Landstrom AP, Bos JM, Salisbury BA, Callis TE, Ackerman MJ. Distinguishing hypertrophic cardiomyopathy-associated mutations from background genetic noise. J Cardiovasc Transl Res. 2014 Apr; 7 (3):347-61 Epub 2014 Feb 08
    View PubMed
  134. Geske JB, Bos JM, Gersh BJ, Ommen SR, Eidem BW, Ackerman MJ. Deformation patterns in genotyped patients with hypertrophic cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2014 Apr; 15: (4)456-65.
    View PubMed
  135. Anderson JH, Bos JM, Cascino GD, Ackerman MJ. Prevalence and spectrum of electroencephalogram-identified epileptiform activity among patients with long QT syndrome. Heart Rhythm. 2014 Jan; 11: (1)53-7.
    View PubMed
  136. Bos JM, Bos KM, Johnson JN, Moir C, Ackerman MJ. Left cardiac sympathetic denervation in long QT syndrome: analysis of therapeutic nonresponders. Circ Arrhythm Electrophysiol. 2013 Aug; 6(4):705-11. Epub 2013 May 31.
    View PubMed
  137. Haugaa KH, Johnson JN, Bos JM, Phillips BL, Eidem BW, Ackerman MJ. Subclinical cardiomyopathy and long QT syndrome: an echocardiographic observation. Congenit Heart Dis. 2013 Jul-Aug; 8: (4)352-9.
    View PubMed
  138. Haugaa KH, Bos JM, Tarrell RF, Morlan BW, Caraballo PJ, Ackerman MJ. Institution-wide QT alert system identifies patients with a high risk of mortality. Mayo Clin Proc. 2013 Apr; 88 (4):315-25
    View PubMed
  139. Medlock MM, Tester DJ, Will ML, Bos JM, Ackerman MJ. Repeat long QT syndrome genetic testing of phenotype-positive cases: prevalence and etiology of detection misses. Heart Rhythm. 2012 Dec; 9 (12):1977-82 Epub 2012 Aug 08
    View PubMed
  140. Anderson JH, Bos JM, Meyer FB, Cascino GD, Ackerman MJ. Concealed long QT syndrome and intractable partial epilepsy: a case report. Mayo Clin Proc. 2012 Nov; 87 (11):1128-31 Epub 2012 Oct 08
    View PubMed
  141. Coleman MA, Bos JM, Johnson JN, Owen HJ, Deschamps C, Moir C, Ackerman MJ. Videoscopic left cardiac sympathetic denervation for patients with recurrent ventricular fibrillation/malignant ventricular arrhythmia syndromes besides congenital long-QT syndrome. Circ Arrhythm Electrophysiol. 2012 Aug 1; 5 (4):782-8 Epub 2012 July 11
    View PubMed
  142. Bos JM, Subramaniam M, Hawse JR, Christiaans I, Rajamannan NM, Maleszewski JJ, Edwards WD, Wilde AA, Spelsberg TC, Ackerman MJ. TGFbeta-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy. J Cell Biochem. 2012 Jun; 113 (6):1896-903
    View PubMed
  143. Johnson JN, Grifoni C, Bos JM, Saber-Ayad M, Ommen SR, Nistri S, Cecchi F, Olivotto I, Ackerman MJ. Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy. Eur Heart J. 2011 May; 32 (9):1114-20 Epub 2011 Feb 22
    View PubMed
  144. Landstrom AP, Adekola BA, Bos JM, Ommen SR, Ackerman MJ. PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing. Am Heart J. 2011 Jan; 161 (1):165-71
    View PubMed
  145. Rubinshtein R, Glockner JF, Ommen SR, Araoz PA, Ackerman MJ, Sorajja P, Bos JM, Tajik AJ, Valeti US, Nishimura RA, Gersh BJ. Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance imaging in patients with hypertrophic cardiomyopathy. Circ Heart Fail. 2010 Jan; 3 (1):51-8 Epub 2009 Oct 22
    View PubMed
  146. McLeod CJ, Bos JM, Theis JL, Edwards WD, Gersh BJ, Ommen SR, Ackerman MJ. Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations. Am Heart J. 2009 Nov; 158 (5):799-805 Epub 2009 Oct 03
    View PubMed
  147. Theis JL, Bos JM, Theis JD, Miller DV, Dearani JA, Schaff HV, Gersh BJ, Ommen SR, Moss RL, Ackerman MJ. Expression patterns of cardiac myofilament proteins: genomic and protein analysis of surgical myectomy tissue from patients with obstructive hypertrophic cardiomyopathy. Circ Heart Fail. 2009 Jul; 2 (4):325-33 Epub 2009 May 13
    View PubMed
  148. Landstrom AP, Parvatiyar MS, Pinto JR, Marquardt ML, Bos JM, Tester DJ, Ommen SR, Potter JD, Ackerman MJ. Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C. J Mol Cell Cardiol. 2008 Aug; 45 (2):281-8 Epub 2008 May 11
    View PubMed
  149. Bos JM, Theis JL, Tajik AJ, Gersh BJ, Ommen SR, Ackerman MJ. Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. Am Heart J. 2008 Jun; 155 (6):1128-34 Epub 2008 Feb 21
    View PubMed
  150. Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ. Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol. 2007 Jun; 42 (6):1026-35 Epub 2007 Apr 18
    View PubMed
  151. Theis JL, Bos JM, Bartleson VB, Will ML, Binder J, Vatta M, Towbin JA, Gersh BJ, Ommen SR, Ackerman MJ. Echocardiographic-determined septal morphology in Z-disc hypertrophic cardiomyopathy. Biochem Biophys Res Commun. 2006 Dec 29; 351: (4)896-902.
    View PubMed
  152. Bos JM, Hagler DJ, Silvilairat S, Cabalka A, O'Leary P, Daniels O, Miller FA, Abraham TP. Right ventricular function in asymptomatic individuals with a systemic right ventricle. J Am Soc Echocardiogr. 2006 Aug; 19: (8)1033-7.
    View PubMed
  153. Bos JM, Poley RN, Ny M, Tester DJ, Xu X, Vatta M, Towbin JA, Gersh BJ, Ommen SR, Ackerman MJ. Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin. Mol Genet Metab. 2006 May; 88 (1):78-85 Epub 2005 Dec 13
    View PubMed