Publications

  1. Jalan-Sakrikar N, Guicciardi ME, O'Hara SP, Azad A, LaRusso NF, Gores GJ, Huebert RC. Central role for cholangiocyte pathobiology in cholestatic liver diseases. Hepatology. 2024 Sep 9 Epub 2024 Sept 09
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  2. Victorelli S, Eppard M, Woo SH, Everts SPA, Martini H, Pirius N, Franco AC, Han Y, Saul D, Splinter PL, O'Hara SP, Valenzuela-Perez L, Lee HSK, Jurk D, LaRusso NF, Hirsova P, Passos JF. Mitochondrial RNA cytosolic leakage drives the SASP. Res Sq. 2024 Aug 27
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  3. Kang JH, Splinter PL, Trussoni CE, Pirius NE, Gores GJ, LaRusso NF, O'Hara SP. The epigenetic reader, bromodomain containing 2, mediates cholangiocyte senescence via interaction with ets proto-oncogene 1. Gastroenterology. 2023 Jul; 165 (1):228-43.e2
  4. Kang JH, Splinter PL, Trussoni CE, Pirius NE, Gores GJ, LaRusso NF, O'Hara SP. The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1. Gastroenterology. 2023 Jul; 165 (1):228-243.e2 Epub 2023 Apr 12
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  5. Trussoni CE, O'Hara SP, LaRusso NF. Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target. Semin Immunopathol. 2022 Jul; 44 (4):527-544 Epub 2022 Feb 17
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  6. Trussoni CE, O'Hara SP, LaRusso NF. Correction to: Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target. Semin Immunopathol. 2022 Jul; 44 (4):545-546
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  7. Bogert PS, O'Hara SP, LaRusso NF. Cellular senescence in the cholangiopathies. Curr Opin Gastroenterol. 2022 Mar 1; 38 (2):121-127
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  8. Jalan-Sakrikar N, De Assuncao TM, Navarro-Corcuera A, Hamdan FH, Loarca L, Kirkeby LA, Resch ZT, O'Hara SP, Juran BD, Lazaridis KN, Rosen CB, Heimbach JK, Taner T, Shah VH, LaRusso NF, Huebert RC. Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation. Hepatol Commun. 2022 Feb; 6 (2):345-360 Epub 2021 Aug 25
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  9. Alsuraih M, O'Hara SP, Woodrum JE, Pirius NE, LaRusso NF. Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2 (-/-) mouse. JHEP Rep. 2021 Jun; 3 (3):100250 Epub 2021 Jan 27
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  10. Al Suraih MS, Trussoni CE, Splinter PL, LaRusso NF, O'Hara SP. Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor. Liver Int. 2020 Oct; 40 (10):2455-2468 Epub 2020 July 07
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  11. O'Hara SP, Splinter PL, Trussoni CE, Guicciardi ME, Splinter NP, Al Suraih MS, Nasser-Ghodsi N, Stollenwerk D, Gores GJ, LaRusso NF. The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1. J Biol Chem. 2019 Dec 6; 294 (49):18698-18713 Epub 2019 Oct 28
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  12. Tietz-Bogert PS, Kim M, Cheung A, Tabibian JH, Heimbach JK, Rosen CB, Nandakumar M, Lazaridis KN, LaRusso NF, Sung J, O'Hara SP. Metabolomic Profiling of Portal Blood and Bile Reveals Metabolic Signatures of Primary Sclerosing Cholangitis. Int J Mol Sci. 2018 Oct 16; 19 (10)
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  13. Guicciardi ME, Trussoni CE, Krishnan A, Bronk SF, Lorenzo Pisarello MJ, O'Hara SP, Splinter PL, Gao Y, Vig P, Revzin A, LaRusso NF, Gores GJ. Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice. J Hepatol. 2018 Sep; 69 (3):676-686 Epub 2018 May 24
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  14. Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC. Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice. Hepatology. 2018 Jan; 67(1):247-259. Epub 2017 Nov 29.
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  15. O'Hara SP, Karlsen TH, LaRusso NF. Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link? Gut. 2017 Nov; 66 (11):1873-1877 Epub 2017 July 21
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  16. O'Hara SP, Splinter PL, Trussoni CE, Pisarello MJ, Loarca L, Splinter NS, Schutte BF, LaRusso NF. ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. J Biol Chem. 2017 Mar 24; 292 (12):4833-4846 Epub 2017 Feb 08
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  17. LaRusso NF, Tabibian JH, O'Hara SP. Role of the Intestinal Microbiome in Cholestatic Liver Disease. Dig Dis. 2017; 35 (3):166-168 Epub 2017 Mar 01
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  18. Tabibian JH, Varghese C, LaRusso NF, O'Hara SP. The enteric microbiome in hepatobiliary health and disease. Liver Int. 2016 Apr; 36 (4):480-7 Epub 2015 Dec 12
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  19. Tabibian JH, O'Hara SP, Trussoni CE, Tietz PS, Splinter PL, Mounajjed T, Hagey LR, LaRusso NF. Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis. Hepatology. 2016 Jan; 63 (1):185-96 Epub 2015 Aug 10
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  20. Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015 Aug; 14 (4):644-58 Epub 2015 Apr 22
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  21. De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC. Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes. Lab Invest. 2015 Jun; 95 (6):684-96 Epub 2015 Apr 13
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  22. Tabibian JH, Varghese C, O'Hara SP, LaRusso NF. Microbiome-Immune Interactions and Liver Disease. Clin Liver Dis (Hoboken). 2015 Apr; 5 (4):83-85 Epub 2015 May 07
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  23. Gradilone SA, O'Hara SP, Masyuk TV, Pisarello MJ, LaRusso NF. MicroRNAs and benign biliary tract diseases. Semin Liver Dis. 2015 Feb; 35 (1):26-35 Epub 2015 Jan 29
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  24. Trussoni CE, Tabibian JH, Splinter PL, O'Hara SP. Lipopolysaccharide (LPS)-Induced Biliary Epithelial Cell NRas Activation Requires Epidermal Growth Factor Receptor (EGFR). PLoS One. 2015; 10(4):e0125793. Epub 2015 Apr 27.
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  25. Tabibian JH, Trussoni CE, O'Hara SP, Splinter PL, Heimbach JK, LaRusso NF. Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis. Lab Invest. 2014 Oct; 94 (10):1126-33 Epub 2014 July 21
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  26. O'Hara SP, Gradilone SA, Masyuk TV, Tabibian JH, LaRusso NF. MicroRNAs in Cholangiopathies. Curr Pathobiol Rep. 2014 Sep 1; 2 (3):133-142
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  27. Tabibian JH, O'Hara SP, Lindor KD. Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies. Scand J Gastroenterol. 2014 Aug; 49 (8):901-8 Epub 2014 July 03
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  28. Tabibian JH, O'Hara SP, Splinter PL, Trussoni CE, LaRusso NF. Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis. Hepatology. 2014 Jun; 59 (6):2263-75 Epub 2014 Apr 25
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  29. Tabibian JH, Macura SI, O'Hara SP, Fidler JL, Glockner JF, Takahashi N, Lowe VJ, Kemp BJ, Mishra PK, Tietz PS, Splinter PL, Trussoni CE, LaRusso NF. Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography. Lab Invest. 2013 Jun; 93 (6):733-43 Epub 2013 Apr 15
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  30. O'Hara SP, Tabibian JH, Splinter PL, LaRusso NF. The dynamic biliary epithelia: molecules, pathways, and disease. J Hepatol. 2013 Mar; 58 (3):575-82 Epub 2012 Oct 17
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  31. Tabibian JH, Masyuk AI, Masyuk TV, O'Hara SP, LaRusso NF. Physiology of cholangiocytes. Compr Physiol. 2013 Jan; 3 (1):541-65
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  32. O'Hara SP, Bogert PS, Trussoni CE, Chen X, LaRusso NF. TLR4 promotes Cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis. J Parasitol. 2011 Oct; 97 (5):813-21 Epub 2011 Mar 23
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  33. O'Hara SP, Splinter PL, Trussoni CE, Gajdos GB, Lineswala PN, LaRusso NF. Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation. J Biol Chem. 2011 Sep 2; 286 (35):30352-30360 Epub 2011 July 13
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  34. Zhou R, O'Hara SP, Chen XM. MicroRNA regulation of innate immune responses in epithelial cells. Cell Mol Immunol. 2011 Sep; 8(5):371-9. Epub 2011 Jul 04.
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  35. O'Hara SP, Chen XM. The cell biology of cryptosporidium infection. Microbes Infect. 2011 Aug; 13 (8-9):721-30 Epub 2011 Mar 31
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  36. Ninlawan K, O'Hara SP, Splinter PL, Yongvanit P, Kaewkes S, Surapaitoon A, LaRusso NF, Sripa B. Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte. Parasitol Int. 2010 Dec; 59(4):616-21. Epub 2010 Sep 29.
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  37. Jagavelu K, Routray C, Shergill U, O'Hara SP, Faubion W, Shah VH. Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver. Hepatology. 2010 Aug; 52 (2):590-601
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  38. O'Hara SP, Gajdos GB, Trussoni CE, Splinter PL, LaRusso NF. Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization. Infect Immun. 2010 Jul; 78 (7):2927-36 Epub 2010 May 10
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  39. O'Hara SP, Splinter PL, Gajdos GB, Trussoni CE, Fernandez-Zapico ME, Chen XM, LaRusso NF. NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection. J Biol Chem. 2010 Jan 1; 285 (1):216-25 Epub 2009 Nov 10
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  40. O'Hara SP, Small AJ, Gajdos GB, Badley AD, Chen XM, Larusso NF. HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum. J Infect Dis. 2009 Apr 15; 199 (8):1195-204
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  41. Gong A, Zhou R, Hu G, Li X, Splinter PL, O'Hara SP, LaRusso NF, Soukup GA, Dong H, Chen XM. MicroRNA-513 regulates B7-H1 translation and is involved in interferon-gamma-induced B7-H1 expression in cholangiocytes. Journal of Immunology. 2009 Feb 1; 182(3):1325-33.
  42. O'Hara SP, Mott JL, Splinter PL, Gores GJ, LaRusso NF. MicroRNAs: key modulators of posttranscriptional gene expression. Gastroenterology. 2009 Jan; 136 (1):17-25 Epub 2008 Dec 03
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  43. Chen XM, O'Hara SP, LaRusso NF. The immunobiology of cholangiocytes. Immunol Cell Biol. 2008 Aug-Sep; 86(6):497-505. Epub 2008 May 27.
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  44. O'Hara SP, Small AJ, Chen XM, LaRusso NF. Host cell actin remodeling in response to Cryptosporidium. Subcell Biochem. 2008; 47:92-100
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  45. Chen XM, Splinter PL, O'Hara SP, LaRusso NF. A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem. 2007 Sep 28; 282 (39):28929-28938 Epub 2007 July 27
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  46. O'Hara SP, Small AJ, Nelson JB, Badley AD, Chen XM, Gores GJ, Larusso NF. The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism. Infect Immun. 2007 Feb; 75 (2):684-96 Epub 2006 Nov 21
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  47. Nelson JB, O'Hara SP, Small AJ, Tietz PS, Choudhury AK, Pagano RE, Chen XM, LaRusso NF. Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains. Cell Microbiol. 2006 Dec; 8 (12):1932-45 Epub 2006 July 18
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  48. O'Hara SP, Lin JJ. Accumulation of tropomyosin isoform 5 at the infection sites of host cells during Cryptosporidium invasion. Parasitol Res. 2006 Jun; 99(1):45-54. Epub 2006 Feb 15.
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  49. Chen XM, O'Hara SP, Nelson JB, Splinter PL, Small AJ, Tietz PS, Limper AH, LaRusso NF. Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB. J Immunol. 2005 Dec 1; 175 (11):7447-56
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  50. O'Hara SP, Huang BQ, Chen XM, Nelson J, LaRusso NF. Distribution of Cryptosporidium parvum sporozoite apical organelles during attachment to and internalization by cultured biliary epithelial cells. J Parasitol. 2005 Oct; 91(5):995-9.
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  51. Chen XM, O'Hara SP, Huang BQ, Splinter PL, Nelson JB, LaRusso NF. Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion. Proc Natl Acad Sci U S A. 2005 May 3; 102 (18):6338-43 Epub 2005 Apr 25
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  52. Chen XM, O'Hara SP, Huang BQ, Nelson JB, Lin JJ, Zhu G, Ward HD, LaRusso NF. Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion. Infect Immun. 2004 Dec; 72 (12):6806-16
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  53. O'Hara SP, Yu JR, Lin JJ. A novel Cryptosporidium parvum antigen, CP2, preferentially associates with membranous structures. Parasitol Res. 2004 Mar; 92(4):317-27. Epub 2004 Jan 16.
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  54. Yu JR, O'Hara SP, Lin JL, Dailey ME, Cain G, Lin JL. A common oocyst surface antigen of Cryptosporidium recognized by monoclonal antibodies. Parasitol Res. 2002 May; 88(5):412-20.