Publications

  1. Greenlund I, Bock J, Govindan N, Kantas D, Singh P, Covassin N, Somers V. Blood Pressure and Heart Rate Response to Orthostasis in Somali Americans. Res Sq. 2024 Oct 21
    View PubMed
  2. Singh P, Beyl RA, Stephens JM, Noland RC, Richard AJ, Boudreau A, Hebert RC, Ravussin E, Broussard JL, St-Onge MP, Marlatt KL. Effect of sleep restriction on insulin sensitivity and energy metabolism in postmenopausal women: A randomized crossover trial. Obesity (Silver Spring). 2023 May; 31 (5):1204-1215 Epub 2023 Mar 30
    View PubMed
  3. Munir SS, Sert Kuniyoshi FH, Singh P, Covassin N. Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review. Antioxidants (Basel). 2023 Apr 3; 12 (4) Epub 2023 Apr 03
    View PubMed
  4. Covassin N, Singh P, McCrady-Spitzer SK, St Louis EK, Calvin AD, Levine JA, Somers VK. Effects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity. J Am Coll Cardiol. 2022 Apr 05; 79(13):1254-1265.
    View PubMed
  5. Singh P, Covassin N, Marlatt K, Gadde KM, Heymsfield SB. Obesity, Body Composition, and Sex Hormones: Implications for Cardiovascular Risk. Compr Physiol. 2021 Dec 29; 12 (1):2949-2993
    View PubMed
  6. Singh P, Covassin N, Sert-Kuniyoshi FH, Marlatt KL, Romero-Corral A, Davison DE, Singh RJ, Jensen MD, Somers VK. Overfeeding-induced weight gain elicits decreases in sex hormone-binding globulin in healthy males-Implications for body fat distribution. Physiol Rep. 2021 Dec; 9 (23):e15127
    View PubMed
  7. Covassin N, Bukartyk J, Singh P, Calvin AD, St Louis EK, Somers VK. Effects of Experimental Sleep Restriction on Ambulatory and Sleep Blood Pressure in Healthy Young Adults: A Randomized Crossover Study. Hypertension. 2021 Sep; 78 (3):859-870 Epub 2021 July 12
    View PubMed
  8. Xie J, Covassin N, Fan Z, Singh P, Gao W, Li G, Kara T, Somers VK. Association Between Hypoxemia and Mortality in Patients With COVID-19. Mayo Clin Proc. 2020 Jun; 95 (6):1138-1147 Epub 2020 Apr 11
    View PubMed
  9. Polonis K, Becari C, Chahal CAA, Zhang Y, Allen AM, Kellogg TA, Somers VK, Singh P. Chronic Intermittent Hypoxia Triggers a Senescence-like Phenotype in Human White Preadipocytes. Sci Rep. 2020 Apr 22; 10 (1):6846
    View PubMed
  10. Polonis K, Sompalli S, Becari C, Xie J, Covassin N, Schulte PJ, Druliner BR, Johnson RA, Narkiewicz K, Boardman LA, Singh P, Somers VK. Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients. Cells. 2019 Apr 26; 8 (5)
    View PubMed
  11. Xie J, Covassin N, Chahal AA, Schulte PJ, Singh P, Somers VK, Caples SM. Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure. Am J Cardiol. 2019 Feb 15; 123 (4):632-637 Epub 2018 Nov 24
    View PubMed
  12. Sharma P, Dong Y, Somers VK, Peterson TE, Zhang Y, Wang S, Li G, Singh P. Intermittent hypoxia regulates vasoactive molecules and alters insulin-signaling in vascular endothelial cells. Sci Rep. 2018 Sep 20; 8(1):14110.
    View PubMed
  13. Covassin N, Greene EL, Singh P, Somers VK. Disparities in Hypertension Among African-Americans: Implications of Insufficient Sleep. Curr Hypertens Rep. 2018 Jun 8; 20 (7):57 Epub 2018 June 08
    View PubMed
  14. Covassin N, Sert-Kuniyoshi FH, Singh P, Romero-Corral A, Davison DE, Lopez-Jimenez F, Jensen MD, Somers VK. Experimental Weight Gain Increases Ambulatory Blood Pressure in Healthy Subjects: Implications of Visceral Fat Accumulation. Mayo Clin Proc. 2018 May; 93 (5):618-626
    View PubMed
  15. Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG, Olson LJ. Low leptin concentration may identify heart failure patients with central sleep apnea. J Sleep Res. 2018 Apr; 27 (2):240-243 Epub 2017 June 23
    View PubMed
  16. Xie J, Sert Kuniyoshi FH, Covassin N, Singh P, Gami AS, Chahal CAA, Somers VK. Excessive Daytime Sleepiness Independently Predicts Increased Cardiovascular Risk After Myocardial Infarction. J Am Heart Assoc. 2018 Jan 19; 7 (2)
    View PubMed
  17. Zhang Y, Somers KR, Becari C, Polonis K, Pfeifer MA, Allen AM, Kellogg TA, Covassin N, Singh P. Comparative Expression of Renin-Angiotensin Pathway Proteins in Visceral Versus Subcutaneous Fat. Front Physiol. 2018; 9:1370 Epub 2018 Oct 10
    View PubMed
  18. Singh P, Zhang Y, Sharma P, Covassin N, Soucek F, Friedman PA, Somers VK. Statins decrease leptin expression in human white adipocytes. Physiol Rep. 2018 Jan; 6(2).
    View PubMed
  19. Baheti S, Singh P, Zhang Y, Evans J, Jensen MD, Somers VK, Kocher JA, Sun Z, Chakkera HA. Adipose tissue DNA methylome changes in development of new-onset diabetes after kidney transplantation. Epigenomics. 2017 Nov; 9 (11):1423-1435 Epub 2017 Oct 02
    View PubMed
  20. Polonis K, Somers VK, Becari C, Covassin N, Schulte PJ, Druliner BR, Johnson RA, Narkiewicz K, Boardman LA, Singh P. Moderate-to-severe obstructive sleep apnea is associated with telomere lengthening. Am J Physiol Heart Circ Physiol. 2017 Nov 1; 313 (5):H1022-H1030 Epub 2017 Aug 19
    View PubMed
  21. Xie J, Chahal CAA, Covassin N, Schulte PJ, Singh P, Srivali N, Somers VK, Caples SM. Periodic limb movements of sleep are associated with an increased prevalence of atrial fibrillation in patients with mild sleep-disordered breathing. Int J Cardiol. 2017 Aug 15; 241:200-204 Epub 2017 Apr 22
    View PubMed
  22. Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG, Olson LJ. Sex differences in leptin modulate ventilation in heart failure. Heart Lung. 2017 May-Jun; 46 (3):187-191 Epub 2017 Feb 23
    View PubMed
  23. Tobaldini E, Covassin N, Calvin A, Singh P, Bukartyk J, Wang S, Montano N, Somers VK. Cardiac autonomic control and complexity during sleep are preserved after chronic sleep restriction in healthy subjects. Physiol Rep. 2017 Apr; 5 (7)
    View PubMed
  24. Hoffmann M, Wolf J, Szyndler A, Singh P, Somers VK, Narkiewicz K. Serum of obstructive sleep apnea patients impairs human coronary endothelial cell migration. Arch Med Sci. 2017 Feb 1; 13 (1):223-227 Epub 2015 Dec 16
    View PubMed
  25. Covassin N, Singh P, Somers VK. Keeping Up With the Clock: Circadian Disruption and Obesity Risk. Hypertension. 2016 Nov; 68 (5):1081-1090 Epub 2016 Sept 12
    View PubMed
  26. Pusalavidyasagar S, Sert Kuniyoshi FH, Shamsuzzaman AS, Singh P, Maharaj S, Leinveber P, Nykodym J, Somers VK. Comparison of Endothelial Function in Asian Indians Versus Caucasians. Metab Syndr Relat Disord. 2016 Sep; 14 (7):363-7 Epub 2016 May 12
    View PubMed
  27. Xie J, Sert Kuniyoshi FH, Covassin N, Singh P, Gami AS, Wang S, Chahal CA, Wei Y, Somers VK. Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an Independent Predictor of Poor Prognosis After Myocardial Infarction. J Am Heart Assoc. 2016 Jul 27; 5 (8) Epub 2016 July 27
    View PubMed
  28. Wolk R, Bertolet M, Singh P, Brooks MM, Pratley RE, Frye RL, Mooradian AD, Rutter MK, Calvin AD, Chaitman BR, Somers VK, BARI 2D Study Group. Prognostic Value of Adipokines in Predicting Cardiovascular Outcome: Explaining the Obesity Paradox. Mayo Clin Proc. 2016 Jul; 91 (7):858-66 Epub 2016 June 09
    View PubMed
  29. Covassin N, Singh P. Sleep Duration and Cardiovascular Disease Risk: Epidemiologic and Experimental Evidence. Sleep Med Clin. 2016 Mar; 11 (1):81-9 Epub 2016 Jan 09
    View PubMed
  30. Singh P, Sharma P, Sahakyan KR, Davison DE, Sert-Kuniyoshi FH, Romero-Corral A, Swain JM, Jensen MD, Lopez-Jimenez F, Kara T, Somers VK. Differential effects of leptin on adiponectin expression with weight gain versus obesity. Int J Obes (Lond). 2016 Feb; 40(2):266-74. Epub 2015 Sep 16.
    View PubMed
  31. Wolk R, Bertolet M, Brooks MM, Pratley RE, Sobel BE, Frye RL, Singh P, Calvin AD, Rutter MK, Mooradian AD, Somers VK, BARI 2D study group. Differential effects of insulin sensitization and insulin provision treatment strategies on concentrations of circulating adipokines in patients with diabetes and coronary artery disease in the BARI 2D trial. Eur J Prev Cardiol. 2016 Jan; 23 (1):50-8 Epub 2014 July 29
    View PubMed
  32. Sahakyan KR, Somers VK, Rodriguez-Escudero JP, Hodge DO, Carter RE, Sochor O, Coutinho T, Jensen MD, Roger VL, Singh P, Lopez-Jimenez F. Normal-Weight Central Obesity: Implications for Total and Cardiovascular Mortality. Ann Intern Med. 2015 Dec 01; 163(11):827-35. Epub 2015 Nov 10.
    View PubMed
  33. Soucek F, Covassin N, Singh P, Ruzek L, Kara T, Suleiman M, Lerman A, Koestler C, Friedman PA, Lopez-Jimenez F, Somers VK. Effects of Atorvastatin (80 mg) Therapy on Quantity of Epicardial Adipose Tissue in Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation. Am J Cardiol. 2015 Nov 1; 116 (9):1443-6 Epub 2015 Aug 14
    View PubMed
  34. Batsis JA, Sahakyan KR, Singh P, Bartels SJ, Somers VK, Lopez-Jimenez F. Leptin, adiposity, and mortality: results from the National Health and Nutrition Examination Survey III, 1988 to 1994. Mayo Clin Proc. 2015 Apr; 90(4):481-91.
    View PubMed
  35. Calvin AD, Covassin N, Kremers WK, Adachi T, Macedo P, Albuquerque FN, Bukartyk J, Davison DE, Levine JA, Singh P, Wang S, Somers VK. Experimental sleep restriction causes endothelial dysfunction in healthy humans. J Am Heart Assoc. 2014 Nov 25; 3 (6):e001143
    View PubMed
  36. Cundrle I, Somers VK, Singh P, Johnson BD, Scott CG, Olson LJ. The relationship between leptin and ventilatory control in heart failure. J Card Fail. 2014; 20(5):376.e9-14.
  37. Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG, van der Walt C, Olson LJ. Leptin deficiency promotes central sleep apnea in patients with heart failure. Chest. 2014 Jan; 145 (1):72-78
    View PubMed
  38. Hoffmann MS, Singh P, Wolk R, Narkiewicz K, Somers VK. Obstructive sleep apnea and intermittent hypoxia increase expression of dual specificity phosphatase 1. Atherosclerosis. 2013 Dec; 231 (2):378-83 Epub 2013 Oct 11
    View PubMed
  39. Diaz-Melean CM, Somers VK, Rodriguez-Escudero JP, Singh P, Sochor O, Llano EM, Lopez-Jimenez F. Mechanisms of adverse cardiometabolic consequences of obesity. Curr Atheroscler Rep. 2013 Nov; 15 (11):364
    View PubMed
  40. Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG, Olson LJ. The relationship between leptin and ventilatory control in heart failure. J Card Fail. 2013 Nov; 19 (11):756-61 Epub 2013 Oct 18
    View PubMed
  41. Singh P, Peterson TE, Sert-Kuniyoshi FH, Glenn JA, Davison DE, Romero-Corral A, Pusalavidyasagar S, Jensen MD, Somers VK. Leptin signaling in adipose tissue: role in lipid accumulation and weight gain. Circ Res. 2012 Aug 17; 111 (5):599-603 Epub 2012 June 22
    View PubMed
  42. Singh P, Somers VK, Romero-Corral A, Sert-Kuniyoshi FH, Pusalavidyasagar S, Davison DE, Jensen MD. Effects of weight gain and weight loss on regional fat distribution. Am J Clin Nutr. 2012 Aug; 96 (2):229-33 Epub 2012 July 03
    View PubMed
  43. Singh P, Peterson TE, Sert-Kuniyoshi FH, Jensen MD, Somers VK. Leptin upregulates caveolin-1 expression: implications for development of atherosclerosis. Atherosclerosis. 2011 Aug; 217 (2):499-502 Epub 2010 Oct 16
    View PubMed
  44. Sert Kuniyoshi FH, Singh P, Gami AS, Garcia-Touchard A, van der Walt C, Pusalavidyasagar S, Wright RS, Vasquez EC, Lopez-Jimenez F, Somers VK. Patients with obstructive sleep apnea exhibit impaired endothelial function after myocardial infarction. Chest. 2011 Jul; 140 (1):62-67 Epub 2011 Feb 24
    View PubMed
  45. Adachi T, Sert-Kuniyoshi FH, Calvin AD, Singh P, Romero-Corral A, van der Walt C, Davison DE, Bukartyk J, Konecny T, Pusalavidyasagar S, Sierra-Johnson J, Somers VK. Effect of weight gain on cardiac autonomic control during wakefulness and sleep. Hypertension. 2011 Apr; 57 (4):723-30 Epub 2011 Feb 28
    View PubMed
  46. Romero-Corral A, Sert-Kuniyoshi FH, Sierra-Johnson J, Orban M, Gami A, Davison D, Singh P, Pusalavidyasagar S, Huyber C, Votruba S, Lopez-Jimenez F, Jensen MD, Somers VK. Modest visceral fat gain causes endothelial dysfunction in healthy humans. J Am Coll Cardiol. 2010 Aug 17; 56 (8):662-6
    View PubMed
  47. Kuniyoshi FH, Pusalavidyasagar S, Singh P, Somers VK. Cardiovascular consequences of obstructive sleep apnoea. Indian J Med Res. 2010 Feb; 131:196-205.
    View PubMed
  48. Singh P, Peterson TE, Barber KR, Kuniyoshi FS, Jensen A, Hoffmann M, Shamsuzzaman AS, Somers VK. Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells. Biochem Biophys Res Commun. 2010 Jan 29; 392 (1):47-52 Epub 2010 Jan 05
    View PubMed
  49. Romero-Corral A, Sierra-Johnson J, Lopez-Jimenez F, Thomas RJ, Singh P, Hoffmann M, Okcay A, Korinek J, Wolk R, Somers VK. Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nat Clin Pract Cardiovasc Med. 2008 Jul; 5(7):418-25. Epub 2008 Apr 22.
    View PubMed
  50. Singh P, Hoffmann M, Wolk R, Shamsuzzaman AS, Somers VK. Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2007 Sep; 27 (9):e302-7 Epub 2007 July 05
    View PubMed
  51. Hoffmann MS, Singh P, Wolk R, Romero-Corral A, Raghavakaimal S, Somers VK. Microarray studies of genomic oxidative stress and cell cycle responses in obstructive sleep apnea. Antioxid Redox Signal. 2007 Jun; 9(6):661-9.
    View PubMed
  52. Deb DK, Dahiya P, Srivastava KK, Srivastava R, Srivastava BS. Selective identification of new therapeutic targets of Mycobacterium tuberculosis by IVIAT approach. Tuberculosis (Edinb). 2002; 82(4-5):175-82.
    View PubMed