Publications

1. Abou Jaoudeh RAR, Hartmann P, Olson O, Gupta O, Kumar S, Ibrahim SH, Fawaz R, Aqul A, Hassan S. Pharmacological management of pediatric metabolic dysfunction-associated steatotic liver disease. J Pediatr Gastroenterol Nutr. 2024 Nov 11 [Epub ahead of print]
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2. Habash NW, Jaoudeh RARA, Hentz RC, Sas DJ, Ibrahim SH, Hassan S. Primary hyperoxaluria: Long-term outcomes of isolated kidney versus simultaneous liver/kidney transplant. J Pediatr Gastroenterol Nutr. 2024 Oct; 79 (4):826-834 Epub 2024 July 15
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3. Kehar M, Ibrahim SH, Ramirez CM, Amin SA, Diamond T, Mohammad S. Utilization and perspectives of weight loss medications in pediatric metabolic dysfunction-associated steatotic liver disease. J Pediatr Gastroenterol Nutr. 2024 Sep; 79 (3):661-666 Epub 2024 May 02
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4. Gutierrez Sanchez LH, Ibrahim SH. Severe Acute Hepatitis of Unknown Etiology in Children: New Virus or Immune Dysregulation. Gastroenterology. 2024 Aug; 167 (3):432-435 Epub 2024 Apr 23
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5. Salama M, Pinto E Vairo F, Hentz R, Al Nofal A, Hassan S, Ibrahim SH, Lteif A, Creo A, Pittock S, Kumar S. Cardiometabolic Risk Markers in Children With Obesity and Variants in MC4R Pathway-related Genes. J Endocr Soc. 2024 Jul 26; 8 (9):bvae137 Epub 2024 July 25
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6. Khoury M, Guo Q, Furuta K, Correia C, Meroueh C, Kim Lee HS, Warasnhe K, Valenzuela-Perez L, Mazar AP, Kim I, Noh YK, Holmes H, Romero MF, Sussman CR, Pavelko KD, Islam S, Bamidele AO, Hirsova P, Li H, Ibrahim SH. Glycogen synthase kinase 3 activity enhances liver inflammation in MASH. JHEP Rep. 2024 Jun; 6 (6):101073 Epub 2024 Mar 26
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7. Federation of International Societies of Pediatric Hepatology, Gastroenterology and Nutrition (FISPGHAN). Paediatric steatotic liver disease has unique characteristics: A multisociety statement endorsing the new nomenclature. J Pediatr Gastroenterol Nutr. 2024 May; 78 (5):1190-1196 Epub 2024 Mar 26
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8. Meroueh C, Warasnhe K, Tizhoosh HR, Shah VH, Ibrahim SH. Digital pathology and spatial omics in steatohepatitis: Clinical applications and discovery potentials. Hepatology. 2024 Mar 22 [Epub ahead of print]
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9. McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. The evolving role of liver sinusoidal endothelial cells in liver health and disease. Hepatology. 2023 Aug 1; 78 (2):649-669 Epub 2023 Jan 03
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10. Parthasarathy G, Hirsova P, Kostallari E, Sidhu GS, Ibrahim SH, Malhi H. Extracellular Vesicles in Hepatobiliary Health and Disease. Compr Physiol. 2023 Jun 26; 13 (3):4631-4658 Epub 2023 June 26
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11. Dohnalkova E, Bayer RL, Guo Q, Bamidele AO, Kim Lee HS, Valenzuela-Pérez L, Krishnan A, Pavelko KD, Guisot NES, Bunyard P, Kim YB, Ibrahim SH, Gores GJ, Hirsova P. Rho-associated protein kinase 1 inhibition in hepatocytes attenuates nonalcoholic steatohepatitis. Hepatol Commun. 2023 Jun 01; 7(6). Epub 2023 Jun 02.
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12. Furuta K, Tang X, Islam S, Tapia A, Chen ZB, Ibrahim SH. Endotheliopathy in the metabolic syndrome: Mechanisms and clinical implications. Pharmacol Ther. 2023 Apr; 244:108372 Epub 2023 Mar 07
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13. Tahata S, Weckwerth J, Ligezka A, He M, Lee HE, Heimbach J, Ibrahim SH, Kozicz T, Furuya K, Morava E. Liver transplantation recovers hepatic N-glycosylation with persistent IgG glycosylation abnormalities: Three-year follow-up in a patient with phosphomannomutase-2-congenital disorder of glycosylation. Mol Genet Metab. 2023 Apr; 138(4):107559. Epub 2023 Mar 17.
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14. Thompson WS, Greenmyer JR, Lanpher BC, Brumbaugh JE, Bendel-Stenzel EM, Dimmock DP, Hobbs CA, Ibrahim SH, Hildreth AN. Ultra-rapid whole genome sequencing: A paradigm shift in the pre-transplant evaluation of neonatal acute liver failure. Liver Transpl. 2023 Jan 1; 29 (1):118-121 Epub 2022 Aug 21
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15. Greuter T, Yaqoob U, Gan C, Jalan-Sakrikar N, Kostallari E, Lu J, Gao J, Sun L, Liu M, Sehrawat TS, Ibrahim SH, Furuta K, Nozickova K, Huang BQ, Gao B, Simons M, Cao S, Shah VH. Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo. J Hepatol. 2022 Sep; 77 (3):723-734 Epub 2022 Apr 12
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16. Ibrahim SH, Kamath BM, Loomes KM, Karpen SJ. Cholestatic liver diseases of genetic etiology: Advances and controversies. Hepatology. 2022 Jun; 75 (6):1627-1646 Epub 2022 Mar 17
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17. Alexander E, O'Sullivan D, Aganga D, Hassan S, Ibrahim SH, Absah I. Clinical Implications for Children Developing Direct Hyperbilirubinemia on Extracorporeal Membrane Oxygenation. J Pediatr Gastroenterol Nutr. 2022 Mar 1; 74 (3):333-337
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18. Squires JE, Alonso EM, Ibrahim SH, Kasper V, Kehar M, Martinez M, Squires RH. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Diagnosis and Management of Pediatric Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2022 Jan 1; 74 (1):138-158
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19. Guo Q, Furuta K, Islam S, Caporarello N, Kostallari E, Dielis K, Tschumperlin DJ, Hirsova P, Ibrahim SH. Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis. Front Immunol. 2022; 13:983255 Epub 2022 Aug 25
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20. Guo Q, Furuta K, Aly A, Ibrahim SH. Isolation and Characterization of Mouse Primary Liver Sinusoidal Endothelial Cells. J Vis Exp. 2021 Dec 16; (178)
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21. Habash N, Wang Y, Morava E, Ibrahim SH. An Adolescent with Chanarin-Dorfman Syndrome Presenting with Ichthyosis and Hepatic Steatosis. JPGN Rep. 2021 Nov; 2 (4):e137 Epub 2021 Nov 08
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22. Ibrahim SH. Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications. Am J Physiol Gastrointest Liver Physiol. 2021 Jul 1; 321 (1):G67-G74 Epub 2021 May 26
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23. Furuta K, Guo Q, Pavelko KD, Lee JH, Robertson KD, Nakao Y, Melek J, Shah VH, Hirsova P, Ibrahim SH. Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis. J Clin Invest. 2021 Mar 15; 131 (6)
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24. Thalji L, Thalji NM, Heimbach JK, Ibrahim SH, Kamath PS, Hanson A, Schulte PJ, Haile DT, Kor DJ. Renal Function Parameters and Serum Sodium Enhance Prediction of Wait-List Outcomes in Pediatric Liver Transplantation. Hepatology. 2021 Mar; 73 (3):1117-1131
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25. Furuta K, Guo Q, Hirsova P, Ibrahim SH. Emerging Roles of Liver Sinusoidal Endothelial Cells in Nonalcoholic Steatohepatitis. Biology (Basel). 2020 Nov 12; 9 (11)
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26. Gao J, Wei B, de Assuncao TM, Liu Z, Hu X, Ibrahim S, Cooper SA, Cao S, Shah VH, Kostallari E. Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis. J Hepatol. 2020 Nov; 73 (5):1144-1154 Epub 2020 May 08
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27. Ibrahim SH, Hirsova P, Malhi H, Gores GJ. Nonalcoholic Steatohepatitis Promoting Kinases. Semin Liver Dis. 2020 Nov; 40 (4):346-357 Epub 2020 June 11
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28. Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H. IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology. 2020 Oct; 159 (4):1487-1503.e17 Epub 2020 June 20
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29. Mogul DB, Perito ER, Wood N, Mazariegos GV, VanDerwerken D, Ibrahim SH, Mohammad S, Valentino PL, Gentry S, Hsu E. Impact of Acuity Circles on Outcomes for Pediatric Liver Transplant Candidates. Transplantation. 2020 Aug; 104 (8):1627-1632
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30. Ibrahim SH, Jonas MM, Taylor SA, Gutierrez Sanchez LH, Wolf JL, Sundaram SS. Liver Diseases in the Perinatal Period: Interactions Between Mother and Infant. Hepatology. 2020 Apr; 71 (4):1474-1485 Epub 2020 Mar 18
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31. Elisofon SA, Magee JC, Ng VL, Horslen SP, Fioravanti V, Economides J, Erinjeri J, Anand R, Mazariegos GV, Society of Pediatric Liver Transplantation Research Group. Society of pediatric liver transplantation: Current registry status 2011-2018. Pediatr Transplant. 2020 Feb; 24(1):e13605. Epub 2019 Nov 03.
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32. Guo Q, Furuta K, Lucien F, Gutierrez Sanchez LH, Hirsova P, Krishnan A, Kabashima A, Pavelko KD, Madden B, Alhuwaish H, Gao Y, Revzin A, Ibrahim SH. Integrin beta(1)-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. J Hepatol. 2019 Dec; 71 (6):1193-1205 Epub 2019 Aug 06
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33. Gutierrez Sanchez LH, Tomita K, Guo Q, Furuta K, Alhuwaish H, Hirsova P, Baheti S, Alver B, Hlady R, Robertson KD, Ibrahim SH. Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis. Hepatol Commun. 2018 Dec; 2 (12):1493-1512 Epub 2018 Oct 01
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34. Ibrahim SH, Robertson KD. Use of the CRISPR/Cas9-based epigenetic gene activation system In Vivo: A new potential therapeutic modality. Hepatology 2018 Sep; 68 (3):1191-1193 Epub 2018 May 14
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35. Ibrahim SH, Hirsova P, Gores GJ. Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation. Gut. 2018 May; 67 (5):963-972 Epub 2018 Jan 24
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36. Tomita K, Niibe A, Kabashima A, Freeman BL, Bronk SF, Hirsova P, Ibrahim SH. Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity. J Cell Biochem. 2017 Oct; 118 (10):3249-3259 Epub 2017 May 15
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37. Hirsova P, Weng P, Salim W, Bronk SF, Griffith TS, Ibrahim SH, Gores GJ. TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity. Hepatol Commun. 2017 Sep; 1 (7):648-662 Epub 2017 July 20
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38. Tomita K, Kohli R, MacLaurin BL, Hirsova P, Guo Q, Sanchez LHG, Gelbard HA, Blaxall BC, Ibrahim SH. Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis. JCI Insight. 2017 Aug 3; 2 (15) Epub 2017 Aug 03
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39. Hirsova P, Ibrahim SH, Verma VK, Morton LA, Shah VH, LaRusso NF, Gores GJ, Malhi H. Extracellular vesicles in liver pathobiology: Small particles with big impact. Hepatology. 2016 Dec; 64 (6):2219-2233 Epub 2016 Oct 20
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40. Hirsova P, Ibrahim SH, Ibrabim SH, Gores GJ, Malhi H. Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. J Lipid Res. 2016 Oct; 57 (10):1758-1770 Epub 2016 Apr 05
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41. Hickey RD, Mao SA, Glorioso J, Elgilani F, Amiot B, Chen H, Rinaldo P, Marler R, Jiang H, DeGrado TR, Suksanpaisan L, O'Connor MK, Freeman BL, Ibrahim SH, Peng KW, Harding CO, Ho CS, Grompe M, Ikeda Y, Lillegard JB, Russell SJ, Nyberg SL. Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1. Sci Transl Med. 2016 Jul 27; 8 (349):349ra99
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42. Tomita K, Freeman BL, Bronk SF, LeBrasseur NK, White TA, Hirsova P, Ibrahim SH. CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis. Sci Rep. 2016 Jun 28; 6:28786 Epub 2016 June 28
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43. Ibrahim SH, Hirsova P, Malhi H, Gores GJ. Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame. Dig Dis Sci. 2016 May; 61 (5):1325-36 Epub 2015 Dec 01
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44. Hirsova P, Ibrahim SH, Krishnan A, Verma VK, Bronk SF, Werneburg NW, Charlton MR, Shah VH, Malhi H, Gores GJ. Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. Gastroenterology. 2016 Apr; 150 (4):956-67 Epub 2016 Jan 05
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45. Ibrahim SH, Hirsova P, Tomita K, Bronk SF, Werneburg NW, Harrison SA, Goodfellow VS, Malhi H, Gores GJ. Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. Hepatology. 2016 Mar; 63 (3):731-44 Epub 2015 Dec 11
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46. Ibrahim SH, Gores GJ, Hirsova P, Kirby M, Miles L, Jaeschke A, Kohli R. Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver Int. 2014 Mar; 34 (3):427-37 Epub 2013 Nov 20
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47. Kohli R, Setchell KD, Kirby M, Myronovych A, Ryan KK, Ibrahim SH, Berger J, Smith K, Toure M, Woods SC, Seeley RJ. A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. Endocrinology. 2013 Jul; 154(7):2341-51. Epub 2013 Apr 16.
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48. Hirsova P, Ibrahim SH, Bronk SF, Yagita H, Gores GJ. Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis. PLoS One. 2013; 8 (7):e70599 Epub 2013 July 22
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49. Hamouda NM, Grothe RM, Ibrahim SH. Multiple liver lesions in an immunosuppressed patient: is infection always the answer? Case Rep Gastroenterol. 2013; 7 (2):327-31 Epub 2013 Aug 16
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50. Ibrahim SH, Kohli R, Gores GJ. Mechanisms of lipotoxicity in NAFLD and clinical implications. J Pediatr Gastroenterol Nutr. 2011 Aug; 53 (2):131-40
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51. Ibrahim SH, Zhang L, Freese DK. A 3-year-old with immunoglobulin G4-associated cholangitis. J Pediatr Gastroenterol Nutr. 2011 Jul; 53(1):109-11.
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52. Ibrahim SH, Lindor KD. Current management of primary sclerosing cholangitis in pediatric patients. Paediatr Drugs. 2011 Apr 1; 13 (2):87-95
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53. Ibrahim SH, Akazawa Y, Cazanave SC, Bronk SF, Elmi NA, Werneburg NW, Billadeau DD, Gores GJ. Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. J Hepatol. 2011 Apr; 54(4):765-72. Epub 2010 Nov 23.
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54. Ibrahim SH, Voigt RG, Katusic SK, Weaver AL, Barbaresi WJ. Incidence of gastrointestinal symptoms in children with autism: a population-based study. Pediatrics. 2009 Aug; 124 (2):680-6 Epub 2009 July 27
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55. Ibrahim SH, Smyrk TC, Faubion WA. Treatment of isolated gastric Crohn's disease with inhaled corticosteroids. Case Rep Gastroenterol. 2008 Nov 5; 2 (3):363-8 Epub 2008 Nov 05
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