Publications

1. Bobori SN, Zhu Y, Saarinen A, Liuzzo AJ, Folmes CDL. Metabolic Remodeling during Early Cardiac Lineage Specification of Pluripotent Stem Cells. Metabolites. 2023 Oct 17; 13 (10)
   View PubMed
2. Minter Dykhouse K, Minter-Dykhouse K, Nelson TJ, Folmes CDL. Uncoupling of Proliferative Capacity from Developmental Stage During Directed Cardiac Differentiation of Pluripotent Stem Cells. Stem Cells Dev. 2022 Sep; 31 (17-18):521-528 Epub 2022 July 25
   View PubMed
3. Olesen K, Moruzzi N, Bulatovic I, Folmes C, Jeon R, Felldin U, Terzic A, Simonson OE, Le Blanc K, Osterholm C, Berggren PO, Schiffer T, Rodin S, Tilevik A, Grinnemo KH. Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells. Metabol Open. 2022 Mar; 13:100167 Epub 2022 Feb 03
   View PubMed
4. Tsogtbaatar E, Minter-Dykhouse K, Saarinen A, Folmes CDL. Extracellular Flux Analysis of Mitochondrial Function in Pluripotent Stem Cells. Methods Mol Biol. 2022; 2429:85-102
   View PubMed
5. Garcia-Cazorla A, Verdura E, Julia-Palacios N, Anderson EN, Goicoechea L, Planas-Serra L, Tsogtbaatar E, Dsouza NR, Schluter A, Urreizti R, Tarnowski JM, Gavrilova RH, Ruiz M, Rodriguez-Palmero A, Fourcade S, Cogne B, Besnard T, Vincent M, Bezieau S, Folmes CD, Zimmermann MT, Klee EW, Pandey UB, Artuch R, Cousin MA, Pujol A, SHMT2 Working Group. Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome. Acta Neuropathol. 2020 Dec; 140 (6):971-975 Epub 2020 Oct 05
   View PubMed
6. Kostenko S, Folmes C, Chang YH, Pannala R, El-Kurdi B, Khatua B, Rood C, Snozek C, Cartin-Ceba R, Singh VP, Lipotoxicity in COVID-19 Study Group. Mortality From Coronavirus Disease 2019 Increases With Unsaturated Fat and May Be Reduced by Early Calcium and Albumin Supplementation. Gastroenterology. 2020 Sep; 159 (3):1015-1018.e4 Epub 2020 May 27
   View PubMed
7. Tsogtbaatar E, Landin C, Minter-Dykhouse K, Folmes CDL. Energy Metabolism Regulates Stem Cell Pluripotency. Front Cell Dev Biol. 2020; 8:87 Epub 2020 Feb 28
   View PubMed
8. Wang F, Zhang S, Vuckovic I, Jeon R, Lerman A, Folmes CD, Dzeja PP, Herrmann J. Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation. Cell Metab. 2018 Sep 4; 28 (3):463-475.e4
   View PubMed
9. Wang F, Zhang S, Jeon R, Vuckovic I, Jiang X, Lerman A, Folmes CD, Dzeja PD, Herrmann J. Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity. EBioMedicine. 2018 Apr; 30:303-316 Epub 2018 Feb 13
   View PubMed
10. Franchi F, Peterson KM, Paulmurugan R, Folmes C, Lanza IR, Lerman A, Rodriguez-Porcel M. Noninvasive Monitoring of the Mitochondrial Function in Mesenchymal Stromal Cells. Mol Imaging Biol. 2016 Aug; 18 (4):510-8
    View PubMed
11. Folmes CD, Ma H, Mitalipov S, Terzic A. Mitochondria in pluripotent stem cells: stemness regulators and disease targets. Curr Opin Genet Dev. 2016 Jun; 38:1-7 Epub 2016 Mar 05
    View PubMed
12. Kang E, Wang X, Tippner-Hedges R, Ma H, Folmes CD, Gutierrez NM, Lee Y, Van Dyken C, Ahmed R, Li Y, Koski A, Hayama T, Luo S, Harding CO, Amato P, Jensen J, Battaglia D, Lee D, Wu D, Terzic A, Wolf DP, Huang T, Mitalipov S. Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs. Cell Stem Cell. 2016 May 5; 18 (5):625-36 Epub 2016 Apr 14
    View PubMed
13. Folmes CD, Terzic A. Energy metabolism in the acquisition and maintenance of stemness. Semin Cell Dev Biol. 2016 Apr; 52:68-75 Epub 2016 Feb 08
    View PubMed
14. Ryan ZC, Craig TA, Folmes CD, Wang X, Lanza IR, Schaible NS, Salisbury JL, Nair KS, Terzic A, Sieck GC, Kumar R. 1alpha,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells. J Biol Chem. 2016 Jan 15; 291 (3):1514-28 Epub 2015 Nov 24
    View PubMed
15. Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte JC, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015 Aug 13; 524 (7564):234-8 Epub 2015 July 15
    View PubMed
16. Folmes CD, Terzic A. Metabolic determinants of embryonic development and stem cell fate. Reprod Fertil Dev. 2014 Dec; 27 (1):82-8
    View PubMed
17. Perales-Clemente E, Folmes CD, Terzic A. Metabolic regulation of redox status in stem cells. Antioxid Redox Signal. 2014 Oct 10; 21 (11):1648-59 Epub 2014 Sept 04
    View PubMed
18. Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V. Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014; 2:24 Epub 2014 Nov 04
    View PubMed
19. Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V. Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014; 2:13 Epub 2014 Aug 18
    View PubMed
20. Faustino RS, Arrell DK, Folmes CD, Terzic A, Perez-Terzic C. Stem cell systems informatics for advanced clinical biodiagnostics: tracing molecular signatures from bench to bedside. Croat Med J. 2013 Aug; 54 (4):319-29
    View PubMed
21. Folmes CD, Arrell DK, Zlatkovic-Lindor J, Martinez-Fernandez A, Perez-Terzic C, Nelson TJ, Terzic A. Metabolome and metaboproteome remodeling in nuclear reprogramming. Cell Cycle. 2013 Aug 1; 12 (15):2355-65 Epub 2013 July 08
    View PubMed
22. Folmes CD, Martinez-Fernandez A, Perales-Clemente E, Li X, McDonald A, Oglesbee D, Hrstka SC, Perez-Terzic C, Terzic A, Nelson TJ. Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS. Stem Cells. 2013 Jul; 31 (7):1298-308
    View PubMed
23. Folmes CD, Martinez-Fernandez A, Faustino RS, Yamada S, Perez-Terzic C, Nelson TJ, Terzic A. Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells. J Cardiovasc Transl Res. 2013 Feb; 6 (1):10-21 Epub 2012 Dec 18
    View PubMed
24. Folmes CD, Dzeja PP, Nelson TJ, Terzic A. Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell. 2012 Nov 2; 11 (5):596-606
    View PubMed
25. Smith AJ, Nelson NG, Oommen S, Hartjes KA, Folmes CD, Terzic A, Nelson TJ. Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk. Stem Cells Transl Med. 2012 Oct; 1 (10):709-18 Epub 2012 Sept 27
    View PubMed
26. Folmes CDL, Nelson TJ, Dzeja PP, Terzic A. Energy metabolism plasticity enables stemness programs. Ann N Y Acad Sci. 2012 Apr; 1254:82-89
    View PubMed
27. Ussher JR, Folmes CD, Keung W, Fillmore N, Jaswal JS, Cadete VJ, Beker DL, Lam VH, Zhang L, Lopaschuk GD. Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. PLoS One. 2012; 7: (5)e37703.
    View PubMed
28. Folmes CD, Nelson TJ, Terzic A. Energy metabolism in nuclear reprogramming. Biomark Med. 2011 Dec; 5: (6)715-29.
    View PubMed
29. Folmes CD, Nelson TJ, Martinez-Fernandez A, Arrell DK, Lindor JZ, Dzeja PP, Ikeda Y, Perez-Terzic C, Terzic A. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab. 2011 Aug 3; 14 (2):264-71
    View PubMed
30. Jessen N, Koh HJ, Folmes CD, Wagg C, Fujii N, Lofgren B, Wolf CM, Berul CI, Hirshman MF, Lopaschuk GD, Goodyear LJ. Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function. Biochim Biophys Acta. 2010 Jul-Aug; 1802: (7-8)593-600.
    View PubMed
31. Folmes CD, Sawicki G, Cadete VJ, Masson G, Barr AJ, Lopaschuk GD. Novel O-palmitolylated beta-E1 subunit of pyruvate dehydrogenase is phosphorylated during ischemia/reperfusion injury. Proteome Sci. 2010; 8:38.
    View PubMed
32. Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiol Rev. 2010 Jan; 90: (1)207-58.
    View PubMed
33. Folmes CD, Wagg CS, Shen M, Clanachan AS, Tian R, Lopaschuk GD. Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts. Am J Physiol Heart Circ Physiol. 2009 Jul; 297: (1)H313-21.
    View PubMed
34. Folmes CD, Sowah D, Clanachan AS, Lopaschuk GD. High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency. J Mol Cell Cardiol. 2009 Jul; 47: (1)142-8.
    View PubMed
35. Folmes CD, Lopaschuk GD. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15; 73: (2)278-87.
    View PubMed
36. Folmes CD, Clanachan AS, Lopaschuk GD. Fatty acids attenuate insulin regulation of 5'-AMP-activated protein kinase and insulin cardioprotection after ischemia. Circ Res. 2006 Jul 7; 99 (1):61-8 Epub 2006 June 01
    View PubMed
37. Folmes CD, Clanachan AS, Lopaschuk GD. Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis. Curr Atheroscler Rep. 2005 Feb; 7: (1)63-70.
    View PubMed
38. Jilkina O, Kuzio B, Grover GJ, Folmes CD, Kong HJ, Kupriyanov VV. Sarcolemmal and mitochondrial effects of a KATP opener, P-1075, in "polarized" and "depolarized" Langendorff-perfused rat hearts. Biochim Biophys Acta. 2003 Dec 3; 1618: (1)39-50.
    View PubMed