Publications

1. Lok UW, Scott HM, Tang S, Santos J, Gong P, Huang C, Pone KA, Nienow MK, Ruka KL, Breutzman EN, Cheek-Norgan EH, Branda ME, Ruano R, Quintin RA, Schenone MH, Chen S, Enninga EAL. Ultrasound Microvessel Imaging of the Human Placenta Demonstrates Altered Vessel Densities in Fetal Growth Restriction With Vascular and Immune Pathologies: A Pilot Case-Control Study. J Ultrasound Med. 2024 Oct 18 [Epub ahead of print]
   View PubMed
2. Baumgarten SC, Wyatt MA, Ainsworth AJ, Fedyshyn B, Van Oort CC, Shenoy CC, Enninga EAL. Evaluation of the maternal systemic immune system during frozen euploid embryo transfer according to cycle outcome. J Reprod Immunol. 2024 Aug; 164:104261 Epub 2024 June 02
   View PubMed
3. Tekin B, Cubilla AL, Cheville JC, Smith CY, Jenkins SM, Dasari S, Enninga EAL, Norgan AP, Menon S, Whaley RD, Hernandez LH, Jimenez RE, Garcia JJ, Thompson RH, Leibovich BC, Karnes RJ, Boorjian SA, Pagliaro LC, Erickson LA, Guo R, Gupta S. High-risk human papilloma virus status & outcomes for penile squamous cell carcinoma: A single institution experience. Hum Pathol. 2024 Aug; 150:9-19 Epub 2024 June 21
   View PubMed
4. Teles Abrao Trad A, Ruano R, Zhang L, Rechberger J, Daniels DJ, Kolbe AB, Qureshi MY, Arendt KW, Segura L, Ibirogba ER, Andrews AG, Loudermilk A, Enninga EAL, Ahn ES, Schenone M. Ultrasound Guidance to Replicate Transuterine BioGlue Injection in the Fetal Hydrocephalus Sheep Model. Fetal Diagn Ther. 2024 Jul 27; 1-9. [Epub ahead of print]
   View PubMed
5. Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L, Doolittle ML, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. SenNet recommendations for detecting senescent cells in different tissues. Nat Rev Mol Cell Biol. 2024 Jun 3 Epub 2024 June 03
   View PubMed
6. Rose SJ, Nguyen EM, Branda ME, Melo V, Vega B, Kazemi-Butterfield N, Cheek-Norgan EH, Girard S, Norgan AP, Theiler RN, Enninga EAL. Maternal Factors and Placental Pathologies Associated with a Diagnosis of Chronic Villitis. Am J Perinatol. 2024 May; 41 (S 01):e3351-e3362 Epub 2023 Dec 06
   View PubMed
7. Mitra T, Gulati R, Ramachandran K, Rajiv R, Enninga EAL, Pierret CK, Kumari R S, Janardhanan R. Endocrine disrupting chemicals: gestational diabetes and beyond. Diabetol Metab Syndr. 2024 Apr 26; 16 (1):95
   View PubMed
8. Scott HM, Mehta R, Branda ME, Hughes J, Kane SV, Girard S, Norgan AP, Theiler RN, Enninga EAL. Effect of Anti-TNF Biologic Exposure During Pregnancy on Villitis of Unknown Etiology Diagnoses in Patients with Autoimmune Disease. Reprod Sci. 2024 Apr; 31 (4):997-1005 Epub 2023 Nov 16
   View PubMed
9. Monroe JM, Quach HQ, Punia S, Enninga EAL, Fedyshyn Y, Girsch JH, Fedyshyn B, Lemens M, Littlefield D, Behl S, Sintim-Aboagye E, Mejia Plazas MC, Yamaoka S, Ebihara H, Pandey A, Correia C, Ung CY, Li H, Vassallo R, Sun J, Johnson EL, Olson JE, Theel ES, Badley AD, Kennedy RB, Theiler RN, Chakraborty R. Vertical Transmission of SARS-CoV-2-Specific Antibodies and Cytokine Profiles in Pregnancy. J Infect Dis. 2024 Feb 14; 229 (2):473-484
   View PubMed
10. Enninga EAL, Quach HQ, Jang JS, de Araujo Correia MCM, Fedyshyn Y, Fedyshyn B, Lemens M, Littlefield D, Behl S, Sintim-Aboagye E, Mejia Plazas MC, Cardenas MC, Chakraborty S, Yamaoka S, Ebihara H, Pandey A, Li H, Badley AD, Johnson EL, Sun J, Norgan AP, Theiler RN, Chakraborty R. Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts. PLoS Pathog. 2024 Feb; 20(2):e1011990. Epub 2024 Feb 07.
    View PubMed
11. Lothert PK, Fedyshyn B, Girard S, Chakraborty R, Norgan AP, Enninga EAL. Spatial proteomics reveals phenotypic and functional differences in T cell and macrophage subsets during villitis of unknown etiology. Sci Rep. 2024 Jan 9; 14 (1):914 Epub 2024 Jan 09
    View PubMed
12. Gulati R, Mitra T, Rajiv R, Rajan EJE, Pierret C, Enninga EAL, Janardhanan R. Exosomal microRNAs in breast cancer: towards theranostic applications. Front Mol Biosci. 2024; 11:1330144. Epub 2024 Feb 22.
    View PubMed
13. Tekin B, Cheville JC, Herrera Hernandez L, Negron V, Smith CY, Jenkins SM, Dasari S, Enninga EAL, Norgan AP, Menon S, Cubilla AL, Whaley RD, Jimenez RE, Thompson RH, Leibovich BC, Karnes RJ, Boorjian SA, Pagliaro LC, Erickson LA, Guo R, Gupta S. Assessment of PD-L1, TROP2, and nectin-4 expression in penile squamous cell carcinoma. Hum Pathol. 2023 Dec; 142:42-50 Epub 2023 Nov 15
    View PubMed
14. Suvakov S, Kattah AG, Gojkovic T, Enninga EAL, Pruett J, Jayachandran M, Sousa C, Santos J, Abou Hassan C, Gonzales-Suarez M, Garovic VD. Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia. Compr Physiol. 2023 Sep 28; 13 (4):5077-5114 Epub 2023 Sept 28
    View PubMed
15. Brunton JS, Theiler RN, Mehta R, Branda ME, Enninga EAL, Torbenson VE. Efficacy of Rubella Vaccination after Co-Inoculation with Rhogam. Viruses. 2023 Aug 22; 15 (9)
    View PubMed
16. Liu X, Aneas I, Sakabe N, Anderson RL, Billstrand C, Paz C, Kaur H, Furner B, Choi S, Prichina AY, Enninga EAL, Dong H, Murtha A, Crawford GE, Kessler JA, Grobman W, Nobrega MA, Rana S, Ober C. Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1(+) non-immune cells in human spontaneous preterm labor. Sci Rep. 2023 May 16; 13 (1):7903
    View PubMed
17. Abrao Trad AT, Buddington R, Enninga E, Duncan J, Schenone CV, Mari G, Buddington K, Schenone M. Report of an Experiment With a Fetal Ex-Utero Support System in Piglets. Cureus. 2023 Apr; 15 (4):e38223 Epub 2023 Apr 27
    View PubMed
18. Enninga EAL, Garovic VD. Novel mechanism of increased preeclampsia risk after kidney donation. Kidney Int 2023 Apr; 103 (4):653-655
    View PubMed
19. Cardenas MC, Farnan S, Hamel BL, Mejia Plazas MC, Sintim-Aboagye E, Littlefield DR, Behl S, Punia S, Enninga EAL, Johnson E, Temesgen Z, Theiler R, Gray CM, Chakraborty R. Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far. Viruses. 2023 Mar 26; 15 (4)
    View PubMed
20. Couture C, Brien ME, Boufaied I, Duval C, Soglio DD, Enninga EAL, Cox B, Girard S. Proinflammatory changes in the maternal circulation, maternal-fetal interface, and placental transcriptome in preterm birth. Am J Obstet Gynecol. 2023 Mar; 228 (3):332.e1-332.e17 Epub 2022 Aug 24
    View PubMed
21. Cardenas MC, Cheek-Norgan EH, Branda ME, Norgan AP, Schenone MH, Lemens MA, Chakraborty R, Ruano R, Enninga EAL. Fetal surgery is not associated with increased inflammatory placental pathology. Prenat Diagn. 2023 Mar; 43 (3):382-392 Epub 2023 Jan 30
    View PubMed
22. Mejia MC, Cardenas MC, Narasimhan R, Littlefield D, Enninga EAL, Chakraborty R. A Systematic Review to Evaluate a Possible Association Between Congenital Toxoplasmosis and Preterm Labor. Pediatr Infect Dis J. 2022 Dec 1; 41 (12):e520-e524 Epub 2022 Oct 12
    View PubMed
23. Miller CM, L Enninga EA, Rizzo SA, Phillipps J, Guerrero-Cazares H, Destephano CC, Peterson TE, Stalboerger PG, Behfar A, Khan Z. Platelet-derived exosomes induce cell proliferation and wound healing in human endometrial cells. Regen Med. 2022 Nov; 17 (11):805-817 Epub 2022 Oct 04
    View PubMed
24. Girsch JH, Mejia Plazas MC, Olivier A, Farah M, Littlefield D, Behl S, Punia S, Sakemura R, Hemsath JR, Norgan A, Enninga EAL, Johnson EL, Chakraborty R. Host-Viral Interactions at the Maternal-Fetal Interface. What We Know and What We Need to Know. Frontiers (Boulder). 2022 Mar; 2. Epub 2022 Mar 24.
    View PubMed
25. Ikumi NM, Pillay K, Tilburgs T, Malaba TR, Dzanibe S, Enninga EAL, Chakraborty R, Lamorde M, Myer L, Khoo S, Jaspan HB, Gray CM. T-Cell Homeostatic Imbalance in Placentas From Women With Human Immunodeficiency Virus in the Absence of Vertical Transmission. J Infect Dis. 2021 Dec 8; 224 (12 Suppl 2):S670-S682
    View PubMed
26. Yeganeh Kazemi N, Fedyshyn B, Sutor S, Fedyshyn Y, Markovic S, Enninga EAL. Maternal Monocytes Respond to Cell-Free Fetal DNA and Initiate Key Processes of Human Parturition. J Immunol. 2021 Nov 15; 207 (10):2433-2444 Epub 2021 Oct 18
    View PubMed
27. Kazemi NY, Fedyshyn B, Yelsa I, Fedyshyn Y, Ruano R, Markovic SN, Chakraborty R, Enninga EAL. Increased cell-free fetal DNA release after apoptosis and sterile inflammation in human trophoblast cells. Am J Reprod Immunol. 2021 Nov; 86 (5):e13483 Epub 2021 July 20
    View PubMed
28. Wyatt MA, Baumgarten SC, Weaver AL, Van Oort CC, Fedyshyn B, Ruano R, Shenoy CC, Enninga EAL. Evaluating Markers of Immune Tolerance and Angiogenesis in Maternal Blood for an Association with Risk of Pregnancy Loss. J Clin Med. 2021 Aug 14; 10 (16)
    View PubMed
29. Johnson EL, Swieboda D, Olivier A, Enninga EAL, Chakraborty R. Robust innate immune responses at the placenta during early gestation may limit in utero HIV transmission. PLoS Pathog. 2021 Aug; 17 (8):e1009860 Epub 2021 Aug 25
    View PubMed
30. Narang K, Cheek EH, Enninga EAL, Theiler RN. Placental Immune Responses to Viruses: Molecular and Histo-Pathologic Perspectives. Int J Mol Sci. 2021 Mar 13; 22 (6)
    View PubMed
31. Enninga EAL, Jang JS, Hur B, Johnson EL, Wick MJ, Sung J, Chakraborty R. Maternal obesity is associated with phenotypic alterations in fetal immune cells by single-cell mass cytometry. Am J Reprod Immunol. 2021 Mar; 85 (3):e13358 Epub 2020 Nov 04
    View PubMed
32. Fogarty MJ, Enninga EAL, Ibirogba ER, Ruano R, Sieck GC. Impact of congenital diaphragmatic hernia on diaphragm muscle function in neonatal rats. J Appl Physiol (1985). 2021 Mar 1; 130 (3):801-812 Epub 2021 Jan 28
    View PubMed
33. Egan AM, Enninga EAL, Alrahmani L, Weaver AL, Sarras MP, Ruano R. Recurrent Gestational Diabetes Mellitus: A Narrative Review and Single-Center Experience. J Clin Med. 2021 Feb 3; 10 (4) Epub 2021 Feb 03
    View PubMed
34. Cardenas MC, Bustos SS, Enninga EAL, Mofenson L, Chakraborty R. Characterising and managing paediatric SARSCoV-2 infection: Learning about the virus in a global classroom. Acta Paediatr. 2021 Feb; 110(2):409-422. Epub 2020 Dec 25.
    View PubMed
35. Shahi M, Mamber Czeresnia R, Cheek EH, Quinton RA, Chakraborty R, Enninga EAL. Expression of Immune Checkpoint Receptors in Placentae With Infectious and Non-Infectious Chronic Villitis. Front Immunol. 2021; 12:705219 Epub 2021 July 30
    View PubMed
36. Hieken TJ, Glasgow AE, Enninga EAL, Kottschade LA, Dronca RS, Markovic SN, Block MS, Habermann EB. Sex-Based Differences in Melanoma Survival in a Contemporary Patient Cohort. J Womens Health (Larchmt). 2020 Sep; 29 (9):1160-1167 Epub 2020 Feb 27
    View PubMed
37. Kim T, Kim Y, Lucien F, Zhao Y, Enninga EAL. Decreased gremlin 1 expression in women with BMI >/=35 kg/m(2) is mediated by interleukin 10 and interleukin 1beta in the follicular fluid. F S Sci. 2020 Aug; 1 (1):16-26 Epub 2020 June 29
    View PubMed
38. Narang K, Enninga EAL, Gunaratne MDSK, Ibirogba ER, Trad ATA, Elrefaei A, Theiler RN, Ruano R, Szymanski LM, Chakraborty R, Garovic VD. SARS-CoV-2 Infection and COVID-19 During Pregnancy: A Multidisciplinary Review. Mayo Clin Proc. 2020 Aug; 95 (8):1750-1765 Epub 2020 May 30
    View PubMed
39. Orme JJ, Enninga EAL, Lucien-Matteoni F, Dale H, Burgstaler E, Harrington SM, Ball MK, Mansfield AS, Park SS, Block MS, Markovic SN, Yan Y, Dong H, Dronca RS, Winters JL. Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles. J Immunother Cancer. 2020 Aug; 8 (2)
    View PubMed
40. Jang JS, Juran BD, Cunningham KY, Gupta VK, Son YM, Yang JD, Ali AH, Enninga EAL, Sung J, Lazaridis KN. Single-cell mass cytometry on peripheral blood identifies immune cell subsets associated with primary biliary cholangitis. Sci Rep. 2020 Jul 28; 10 (1):12584 Epub 2020 July 28
    View PubMed
41. Enninga EAL, Raber P, Quinton RA, Ruano R, Ikumi N, Gray CM, Johnson EL, Chakraborty R, Kerr SE. Maternal T Cells in the Human Placental Villi Support an Allograft Response during Noninfectious Villitis. J Immunol. 2020 Jun 1; 204 (11):2931-2939 Epub 2020 Apr 22
    View PubMed
42. Lopes JL, Lopes GS, Enninga EAL, Kearney HM, Hoppman NL, Rowsey RA. Most noninvasive prenatal screens failing due to inadequate fetal cell free DNA are negative for trisomy when repeated. Prenat Diagn. 2020 Jun; 40 (7):831-837 Epub 2020 Apr 20
    View PubMed
43. Swieboda D, Johnson EL, Beaver J, Haddad L, Enninga EAL, Hathcock M, Cordes S, Jean V, Lane I, Skountzou I, Chakraborty R. Baby's First Macrophage: Temporal Regulation of Hofbauer Cell Phenotype Influences Ligand-Mediated Innate Immune Responses across Gestation. J Immunol. 2020 May 1; 204 (9):2380-2391 Epub 2020 Mar 25
    View PubMed
44. Enninga EAL, Leontovich AA, Fedyshyn B, Wakefield L, Gandhi M, Markovic SN, Ruano R, Kerr SE. Upregulation of HLA-Class I and II in Placentas Diagnosed with Villitis of Unknown Etiology. Reprod Sci. 2020 May; 27 (5):1129-1138 Epub 2020 Jan 06
    View PubMed
45. Duma N, Abdel-Ghani A, Yadav S, Hoversten KP, Reed CT, Sitek AN, Enninga EAL, Paludo J, Aguilera JV, Leventakos K, Lou Y, Kottschade LA, Dong H, Mansfield AS, Manochakian R, Adjei AA, Dronca RS. Sex Differences in Tolerability to Anti-Programmed Cell Death Protein 1 Therapy in Patients with Metastatic Melanoma and Non-Small Cell Lung Cancer: Are We All Equal? Oncologist. 2019 Nov; 24 (11):e1148-e1155 Epub 2019 Apr 29
    View PubMed
46. Roberson EC, Enninga EAL. The mystery of assisted reproductive technologies. Mol Reprod Dev. 2019 Feb; 86(2):121. Epub 2018 Dec 23.
    View PubMed
47. Enninga EAL, Theiler RN. Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta. J Immunol Res. 2019; 2019:7375217 Epub 2019 Feb 07
    View PubMed
48. Ruano R, Enninga EAL, Brana Rivera PE, Terzic A. Regenerative Prophylaxis In Utero. Clin Pharmacol Ther. 2019 Jan; 105 (1):39-41 Epub 2018 Nov 11
    View PubMed
49. Enninga EAL, Egan AM, Alrahmani L, Leontovich AA, Ruano R, Sarras MP Jr. Frequency of Gestational Diabetes Mellitus Reappearance or Absence during the Second Pregnancy of Women Treated at Mayo Clinic between 2013 and 2018. J Diabetes Res. 2019; 2019:9583927 Epub 2019 Nov 22
    View PubMed
50. Mihalas BP, Houston BJ, Green ES, Enninga EAL, Calderon EAR. The Primordial Journey. Mol Reprod Dev. 2018 Nov; 85 (11):809 Epub 2018 Oct 07
    View PubMed
51. Enninga EAL, Chatzopoulos K, Butterfield JT, Sutor SL, Leontovich AA, Nevala WK, Flotte TJ, Markovic SN. CD206-positive myeloid cells bind galectin-9 and promote a tumor-supportive microenvironment. J Pathol. 2018 Aug; 245 (4):468-477 Epub 2018 June 28
    View PubMed
52. Enninga EA, Ruano R. Fetal surgery for lower urinary tract obstruction: the importance of staging prior to intervention. Minerva Pediatr. 2018 Jun; 70 (3):263-269 Epub 2017 Nov 21
    View PubMed
53. Enninga EAL, Harrington SM, Creedon DJ, Ruano R, Markovic SN, Dong H, Dronca RS. Immune checkpoint molecules soluble program death ligand 1 and galectin-9 are increased in pregnancy. Am J Reprod Immunol. 2018 Feb; 79(2). Epub 2017 Dec 04.
    View PubMed
54. Enninga EAL, Moser JC, Weaver AL, Markovic SN, Brewer JD, Leontovich AA, Hieken TJ, Shuster L, Kottschade LA, Olariu A, Mansfield AS, Dronca RS. Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992-2011. Cancer Med. 2017 Oct; 6 (10):2203-2212 Epub 2017 Sept 06
    View PubMed
55. Vera Aguilera J, Enninga EAL, Markovic SN. Case report: colchicine in the treatment of dabrafenib and trametinib-associated pyrexia American Journal Of Hematology-oncology. 2017 Aug; 13 (8):19-23
    
56. Enninga EA, Nevala WK, Holtan SG, Leontovich AA, Markovic SN. Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma. Melanoma Res. 2016 Oct; 26 (5):429-41
    View PubMed
57. Grotz TE, Jakub JW, Mansfield AS, Goldenstein R, Enninga EA, Nevala WK, Leontovich AA, Markovic SN. Evidence of Th2 polarization of the sentinel lymph node (SLN) in melanoma. Oncoimmunology. 2015 Aug; 4 (8):e1026504 Epub 2015 June 01
    View PubMed
58. Enninga EA, Nevala WK, Enninga EA, Creedon DJ, Markovic SN, Holtan SG. Fetal sex-based differences in maternal hormones, angiogenic factors, and immune mediators during pregnancy and the postpartum period. Am J Reprod Immunol. 2015 Mar; 73 (3):251-62 Epub 2014 Aug 04
    View PubMed
59. Holtan SG, Chen Y, Kaimal R, Creedon DJ, Enninga EA, Nevala WK, Markovic SN. Growth modeling of the maternal cytokine milieu throughout normal pregnancy: macrophage-derived chemokine decreases as inflammation/counterregulation increases. J Immunol Res. 2015; 2015:952571 Epub 2015 Mar 17
    View PubMed
60. Enninga EA, Nevala WK, Holtan SG, Markovic SN. Immune Reactivation by Cell-Free Fetal DNA in Healthy Pregnancies Re-Purposed to Target Tumors: Novel Checkpoint Inhibition in Cancer Therapeutics. Front Immunol. 2015; 6:424 Epub 2015 Aug 26
    View PubMed
61. Dronca RS, Allred JB, Perez DG, Nevala WK, Lieser EA, Thompson M, Maples WJ, Creagan ET, Pockaj BA, Kaur JS, Moore TD, Marchello BT, Markovic SN. Phase II study of temozolomide (TMZ) and everolimus (RAD001) therapy for metastatic melanoma: a North Central Cancer Treatment Group study, N0675. Am J Clin Oncol. 2014 Aug; 37 (4):369-76
    View PubMed
62. Enninga EA, Holtan SG, Creedon DJ, Dronca RS, Nevala WK, Ognjanovic S, Markovic SN. Immunomodulatory effects of sex hormones: requirements for pregnancy and relevance in melanoma. Mayo Clin Proc. 2014 Apr; 89 (4):520-35
    View PubMed
63. Lieser EA, Lieser EA, Croghan GA, Nevala WK, Bradshaw MJ, Markovic SN, Mansfield AS. Up-regulation of pro-angiogenic factors and establishment of tolerance in malignant pleural effusions. Lung Cancer. 2013 Oct; 82 (1):63-8 Epub 2013 Aug 12
    View PubMed
64. Mansfield AS, Nevala WK, Lieser EA, Lieser EA, Leontovich AA, Markovic SN. The immunomodulatory effects of bevacizumab on systemic immunity in patients with metastatic melanoma. Oncoimmunology. 2013 May 1; 2 (5):e24436
    View PubMed