Publications

  1. Lehmann M, Krishnan R, Sucre J, Kulkarni HS, Pineda RH, Anderson C, Banovich NE, Behrsing HP, Dean CH, Haak A, Gosens R, Kaminski N, Zagorska A, Koziol-White C, Metcalf JP, Kim YH, Loebel C, Neptune E, Noel A, Raghu G, Sewald K, Sharma A, Suki B, Sperling A, Tatler A, Turner S, Rosas IO, van Ry P, Wille T, Randell SH, Pryhuber G, Rojas M, Bourke J, Konigshoff M. Precision Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research. An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2024 Nov 5 Epub 2024 Nov 05
    View PubMed
  2. Gao AY, Whaley MG, Saraf N, Bakri SJ, Haak AJ. Survey of Dopamine Receptor D2 Antagonists as Retinal Antifibrotics. J Ocul Pharmacol Ther. 2024 Oct; 40 (8):536-542 Epub 2024 Aug 29
    View PubMed
  3. Aravamudhan A, Dieffenbach PB, Choi KM, Link PA, Meridew JA, Haak AJ, Fredenburgh LE, Tschumperlin DJ. Non-canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells. Physiol Rep. 2024 Apr; 12 (7):e15999
    View PubMed
  4. Gao AY, Haak AJ, Bakri SJ. In vitro laboratory models of proliferative vitreoretinopathy. Surv Ophthalmol. 2023 Sep-Oct; 68 (5):861-874 Epub 2023 May 19
    View PubMed
  5. Gao AY, Diaz Espinosa AM, Nguyen BBN, Link PA, Meridew J, Jones DL, Gibbard DF, Tschumperlin DJ, Haak AJ. Dopamine Receptor D1 Is Exempt from Transforming Growth Factor beta-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts. J Pharmacol Exp Ther. 2023 Sep; 386 (3):277-287 Epub 2023 Apr 06
    View PubMed
  6. Betageri KR, Link PA, Haak AJ, Ligresti G, Tschumperlin DJ, Caporarello N. The matricellular protein CCN3 supports lung endothelial homeostasis and function. Am J Physiol Lung Cell Mol Physiol. 2023 Feb 1; 324 (2):L154-L168 Epub 2022 Dec 27
    View PubMed
  7. Gao AY, Diaz Espinosa AM, Nguyen BBN, Link PA, Meridew J, Jones DL, Gibbard DF, Tschumperlin DJ, Haak AJ. Dopamine receptor d1 is exempt from transforming growth factor beta-mediated antifibrotic g protein-coupled receptor landscape tampering in lung fibroblasts. Journal of Pharmacology and Experimental Therapeutics. 2023; 386 (3):277-87
  8. Gao AY, Diaz Espinosa AM, Giani F, Pham TX, Carver CM, Aravamudhan A, Bartman CM, Ligresti G, Caporarello N, Schafer MJ, Haak AJ. Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome. Am J Physiol Lung Cell Mol Physiol. 2022 Dec 1; 323 (6):L685-L697 Epub 2022 Oct 12
    View PubMed
  9. Gao AY, Link PA, Bakri SJ, Haak AJ. Dopamine receptor signaling regulates fibrotic activation of retinal pigmented epithelial cells. Am J Physiol Cell Physiol. 2022 Jul 1; 323 (1):C116-C124 Epub 2022 May 11
    View PubMed
  10. Zhang Q, Haak AJ, Sjogren B. Regulator of G protein signaling 2 inhibits Galphaq-dependent uveal melanoma cell growth. J Biol Chem. 2022 Jun; 298 (6):101955 Epub 2022 Apr 19
    View PubMed
  11. Buchl SC, Hanquier Z, Haak AJ, Thomason YM, Huebert RC, Shah VH, Maiers JL. Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice. Hepatol Commun. 2022 Mar; 6 (3):593-609 Epub 2021 Oct 22
    View PubMed
  12. Bale LK, Schafer MJ, Atkinson EJ, Le Brasseur NK, Haak AJ, Oxvig C, Conover CA. Pregnancy-associated plasma protein-A (PAPP-A) is a key component of an interactive cellular mechanism promoting pulmonary fibrosis. J Cell Physiol. 2022 Jan 30 [Epub ahead of print]
    View PubMed
  13. Link PA, Choi KM, Diaz Espinosa AM, Jones DL, Gao AY, Haak AJ, Tschumperlin DJ. Combined control of the fibroblast contractile program by YAP and TAZ. Am J Physiol Lung Cell Mol Physiol. 2022 Jan 1; 322 (1):L23-L32 Epub 2021 Nov 10
    View PubMed
  14. Choi KM, Haak AJ, Diaz Espinosa AM, Cummins KA, Link PA, Aravamudhan A, Wood DK, Tschumperlin DJ. GPCR-mediated YAP/TAZ inactivation in fibroblasts via EPAC1/2, RAP2C, and MAP4K7. J Cell Physiol. 2021 Nov; 236 (11):7759-7774 Epub 2021 May 28
    View PubMed
  15. Diaz-Espinosa AM, Link PA, Sicard D, Jorba I, Tschumperlin DJ, Haak AJ. Dopamine D1 receptor stimulates cathepsin K-dependent degradation and resorption of collagen I in lung fibroblasts. J Cell Sci. 2020 Dec 11; 133 (23)
    View PubMed
  16. Caporarello N, Meridew JA, Aravamudhan A, Jones DL, Austin SA, Pham TX, Haak AJ, Moo Choi K, Tan Q, Haresi A, Huang SK, Katusic ZS, Tschumperlin DJ, Ligresti G. Vascular dysfunction in aged mice contributes to persistent lung fibrosis. Aging Cell. 2020 Aug; 19 (8):e13196 Epub 2020 July 21
    View PubMed
  17. Mazzone A, Strege PR, Gibbons SJ, Alcaino C, Joshi V, Haak AJ, Tschumperlin DJ, Bernard CE, Cima RR, Larson DW, Chua HK, Graham RP, El Refaey M, Mohler PJ, Hayashi Y, Ordog T, Calder S, Du P, Farrugia G, Beyder A. microRNA overexpression in slow transit constipation leads to reduced Na(V)1.5 current and altered smooth muscle contractility. Gut. 2020 May; 69 (5):868-876 Epub 2019 Nov 22
    View PubMed
  18. Aravamudhan A, Haak AJ, Choi KM, Meridew JA, Caporarello N, Jones DL, Tan Q, Ligresti G, Tschumperlin DJ. TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation. Am J Physiol Lung Cell Mol Physiol. 2020 May 1; 318 (5):L852-L863 Epub 2020 Mar 11
    View PubMed
  19. Purdy MP, Ducharme M, Haak AJ, Ravix J, Tan Q, Sicard D, Prakash YS, Tschumperlin DJ, Stewart EA. YAP/TAZ are Activated by Mechanical and Hormonal Stimuli in Myometrium and Exhibit Increased Baseline Activation in Uterine Fibroids. Reprod Sci. 2020 Apr; 27 (4):1074-1085 Epub 2020 Feb 13
    View PubMed
  20. Haak AJ, Ducharme MT, Diaz Espinosa AM, Tschumperlin DJ. Targeting GPCR Signaling for Idiopathic Pulmonary Fibrosis Therapies. Trends Pharmacol Sci. 2020 Mar; 41 (3):172-182 Epub 2020 Jan 30
    View PubMed
  21. Diaz-Espinosa AM, Link PA, Sicard D, Jorba I, Tschumperlin DJ, Haak AJ. Dopamine D1 receptor stimulates cathepsin K-dependent degradation and resorption of collagen I in lung fibroblasts. J Cell Sci. 2020 Jan 1 Epub 2020 Jan 01
    View PubMed
  22. Tan Q, Ma XY, Liu W, Meridew JA, Jones DL, Haak AJ, Sicard D, Ligresti G, Tschumperlin DJ. Nascent Lung Organoids Reveal Epithelium- and Bone Morphogenetic Protein-mediated Suppression of Fibroblast Activation. Am J Respir Cell Mol Biol. 2019 Nov; 61 (5):607-619
    View PubMed
  23. Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD Jr, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Sci Transl Med. 2019 Oct 30; 11 (516)
    View PubMed
  24. Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G, Tschumperlin DJ. TGFbeta-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. J Cell Sci. 2019 Oct 18; 132 (20)
    View PubMed
  25. Caporarello N, Meridew JA, Jones DL, Tan Q, Haak AJ, Choi KM, Manlove LJ, Prakash YS, Tschumperlin DJ, Ligresti G. PGC1alpha repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state. Thorax. 2019 Aug; 74 (8):749-760 Epub 2019 June 10
    View PubMed
  26. Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ. CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. JCI Insight. 2019 May 16; 5
    View PubMed
  27. Haak AJ, Tan Q, Tschumperlin DJ. Matrix biomechanics and dynamics in pulmonary fibrosis. Matrix Biol. 2018 Nov; 73:64-76 Epub 2017 Dec 21
    View PubMed
  28. Sicard D, Haak AJ, Choi KM, Craig AR, Fredenburgh LE, Tschumperlin DJ. Aging and anatomical variations in lung tissue stiffness. Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1; 314 (6):L946-L955 Epub 2018 Feb 22
    View PubMed
  29. Oh RS, Haak AJ, Smith KMJ, Ligresti G, Choi KM, Xie T, Wang S, Walters PR, Thompson MA, Freeman MR, Manlove LJ, Chu VM, Feghali-Bostwick C, Roden AC, Schymeinsky J, Pabelick CM, Prakash YS, Vassallo R, Tschumperlin DJ. RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation. J Cell Sci. 2018 May 15; 131 (10)
    View PubMed
  30. Schafer MJ, Haak AJ, Tschumperlin DJ, LeBrasseur NK. Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations. Curr Rheumatol Rep. 2018 Jan 26; 20 (1):3
    View PubMed
  31. Haak AJ, Girtman MA, Ali MF, Carmona EM, Limper AH, Tschumperlin DJ. Phenylpyrrolidine structural mimics of pirfenidone lacking antifibrotic activity: A new tool for mechanism of action studies. Eur J Pharmacol. 2017 Sep 15; 811:87-92 Epub 2017 May 30
    View PubMed
  32. Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK. Cellular senescence mediates fibrotic pulmonary disease. Nat Commun. 2017 Feb 23; 8:14532
    View PubMed