Publications

1. Fayyaz AU, Eltony M, Prokop LJ, Koepp KE, Borlaug BA, Dasari S, Bois MC, Margulies KB, Maleszewski JJ, Wang Y, Redfield MM. Pathophysiological insights into HFpEF from studies of human cardiac tissue. Nat Rev Cardiol. 2024 Aug 28 [Epub ahead of print]
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2. Yang Y, Wang J, Wan J, Cheng Q, Cheng Z, Zhou X, Wang O, Shi K, Wang L, Wang B, Zhu X, Chen J, Feng D, Liu Y, Jahan-Mihan Y, Haddock AN, Edenfield BH, Peng G, Hohenstein JD, McCabe CE, O'Brien DR, Wang C, Ilyas SI, Jiang L, Torbenson MS, Wang H, Nakhleh RE, Shi X, Wang Y, Bi Y, Gores GJ, Patel T, Ji B. PTEN deficiency induces an extrahepatic cholangitis-cholangiocarcinoma continuum via aurora kinase A in mice. J Hepatol. 2024 Jul; 81 (1):120-134 Epub 2024 Feb 28
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3. Bhakuni T, Norden PR, Ujiie N, Tan C, Lee SK, Tedeschi T, Hsieh YW, Wang Y, Liu T, Fawzi AA, Kume T. FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation. Nat Commun. 2024 May 16; 15 (1):4097
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4. Zhu X, Yang Y, Feng D, Wang O, Chen J, Wang J, Wang B, Liu Y, Edenfield BH, Haddock AN, Wang Y, Patel T, Bi Y, Ji B. Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver. Am J Physiol Gastrointest Liver Physiol. 2024 May 1; 326 (5):G495-G503 Epub 2024 Mar 12
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5. Wang L, Wang J, Feng D, Wang B, Jahan-Mihan Y, Wang Y, Bi Y, Lim D, Ji B. A simple and effective genotyping workflow for rapid detection of CRISPR genome editing. Am J Physiol Gastrointest Liver Physiol. 2024 Apr 01; 326(4):G473-G481. Epub 2024 Feb 27.
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6. Wang Y, Wang E, Anany M, Fullsack S, Huo YH, Dutta S, Ji B, Hoeppner LH, Kilari S, Misra S, Caulfield T, Vander Kooi CW, Wajant H, Mukhopadhyay D. The crosstalk between neuropilin-1 and tumor necrosis factor-alpha in endothelial cells. Front Cell Dev Biol. 2024; 12:1210944 Epub 2024 June 27
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7. Singh Angom R, Wang Y, Wang E, Dutta SK, Mukhopadhyay D. Conditional, Tissue-Specific CRISPR/Cas9 Vector System in Zebrafish Reveals the Role of Nrp1b in Heart Regeneration. Arterioscler Thromb Vasc Biol. 2023 Oct; 43 (10):1921-1934 Epub 2023 Aug 31
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8. Ragavan VN, Nair PC, Jarzebska N, Angom RS, Ruta L, Bianconi E, Grottelli S, Tararova ND, Ryazanskiy D, Lentz SR, Tommasi S, Martens-Lobenhoffer J, Suzuki-Yamamoto T, Kimoto M, Rubets E, Chau S, Chen Y, Hu X, Bernhardt N, Spieth PM, Weiss N, Bornstein SR, Mukhopadhyay D, Bode-Boger SM, Maas R, Wang Y, Macchiarulo A, Mangoni AA, Cellini B, Rodionov RN. A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase. Nat Commun. 2023 Jun 9; 14 (1):3392 Epub 2023 June 09
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9. Fayyaz AU, Sabbah MS, Dasari S, Griffiths LG, DuBrock HM, Wang Y, Charlesworth MC, Borlaug BA, Jenkins SM, Edwards WD, Redfield MM. Histologic and proteomic remodeling of the pulmonary veins and arteries in a porcine model of chronic pulmonary venous hypertension. Cardiovasc Res. 2023 Mar 17; 119 (1):268-282
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10. Zhang Y, Ma Y, Wang Y, Mukhopadhyay D, Bi Y, Ji B. Aurora kinase a inhibitor MLN8237 suppresses pancreatic cancer growth. Pancreatology. 2022 Jun; 22 (5):619-625 Epub 2022 Apr 13
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11. Kilari S, Wang Y, Singh A, Graham RP, Iyer V, Thompson SM, Torbenson MS, Mukhopadhyay D, Misra S. Neuropilin-1 deficiency in vascular smooth muscle cells is associated with hereditary hemorrhagic telangiectasia arteriovenous malformations. JCI Insight. 2022 May 9; 7 (9) Epub 2022 May 09
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12. Wang J, Wang O, Bi Y, Wang Y, Crawford H, Ji B. Ptf1a Promoter-Driven Cre Expression During Spermatogenesis Causes Germline Recombination. Pancreas. 2022 Jan 1; 51 (1):90-93
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13. Wang Y, Angom RS, Kulkarni TA, Hoeppner LH, Pal K, Wang E, Tam A, Valiunas RA, Dutta SK, Ji B, Jarzebska N, Chen Y, Rodionov RN, Mukhopadhyay D. Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1. iScience. 2021 Oct 22; 24 (10):103189 Epub 2021 Sept 30
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14. Wan J, Wang J, Wagner LE 2nd, Wang OH, Gui F, Chen J, Zhu X, Haddock AN, Edenfield BH, Haight B, Mukhopadhyay D, Wang Y, Yule DI, Bi Y, Ji B. Pancreas-specific CHRM3 activation causes pancreatitis in mice. JCI Insight. 2021 Sep 8; 6 (17) Epub 2021 Sept 08
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15. Angom RS, Zhu J, Wu ATH, Sumitra MR, Pham V, Dutta S, Wang E, Madamsetty VS, Perez-Cordero GD, Huang HS, Mukhopadhyay D, Wang Y. LCC-09, a Novel Salicylanilide Derivative, Exerts Anti-Inflammatory Effect in Vascular Endothelial Cells. J Inflamm Res. 2021; 14:4551-4565 Epub 2021 Sept 08
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16. Wang Y, Singh AR, Zhao Y, Du T, Huang Y, Wan X, Mukhopadhyay D, Wang Y, Wang N, Zhang P. TRIM28 regulates sprouting angiogenesis through VEGFR-DLL4-Notch signaling circuit. FASEB J. 2020 Nov; 34 (11):14710-14724 Epub 2020 Sept 12
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17. Norden PR, Sabine A, Wang Y, Demir CS, Liu T, Petrova TV, Kume T. Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation. Elife. 2020 Jun 8; 9 Epub 2020 June 08
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18. Wang Y, Hao Y, Zhao Y, Huang Y, Lai D, Du T, Wan X, Zhu Y, Liu Z, Wang Y, Wang N, Zhang P. TRIM28 and TRIM27 are required for expressions of PDGFRbeta and contractile phenotypic genes by vascular smooth muscle cells. FASEB J. 2020 May; 34 (5):6271-6283 Epub 2020 Mar 11
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19. Gui F, Zhang Y, Wan J, Zhan X, Yao Y, Li Y, Haddock AN, Shi J, Guo J, Chen J, Zhu X, Edenfield BH, Zhuang L, Hu C, Wang Y, Mukhopadhyay D, Radisky ES, Zhang L, Lugea A, Pandol SJ, Bi Y, Ji B. Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H. J Clin Invest. 2020 Jan 2; 130 (1):189-202
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20. Wang Y, Hoeppner LH, Angom RS, Wang E, Dutta S, Doeppler HR, Wang F, Shen T, Scarisbrick IA, Guha S, Storz P, Bhattacharya R, Mukhopadhyay D. Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2beta. J Biol Chem. 2019 Oct 25; 294 (43):15759-15767 Epub 2019 Sept 06
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21. Wang Y, Wan X, Hao Y, Zhao Y, Du L, Huang Y, Liu Z, Wang Y, Wang N, Zhang P. NR6A1 regulates lipid metabolism through mammalian target of rapamycin complex 1 in HepG2 cells. Cell Commun Signal. 2019 Jul 17; 17 (1):77 Epub 2019 July 17
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22. Qiu S, Liu T, Piao C, Wang Y, Wang K, Zhou Y, Cai L, Zheng S, Lan F, Du J. AMPKalpha2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKalpha1 activation. J Cell Mol Med. 2019 Mar; 23 (3):1687-1697 Epub 2019 Jan 12
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23. Singh Angom R, Wang Y, Wang E, Pal K, Bhattacharya S, Watzlawik JO, Rosenberry TL, Das P, Mukhopadhyay D. VEGF receptor-1 modulates amyloid beta 1-42 oligomer-induced senescence in brain endothelial cells. FASEB J. 2019 Mar; 33 (3):4626-4637 Epub 2018 Dec 21
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24. Wang Y, Wang E, Zhang Y, Madamsetty VS, Ji B, Radisky DC, Grande JP, Misra S, Mukhopadhyay D. Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension. FASEB J. 2019 Jan; 33 (1):494-500 Epub 2018 Aug 17
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25. Wang Y, Huang Y, Liu Y, Li J, Hao Y, Yin P, Liu Z, Chen J, Wang Y, Wang N, Zhang P. Microtubule associated tumor suppressor 1 interacts with mitofusins to regulate mitochondrial morphology in endothelial cells. FASEB J. 2018 Aug; 32 (8):4504-4518 Epub 2018 Mar 20
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26. Wang Y, Li J, Huang Y, Dai X, Liu Y, Liu Z, Wang Y, Wang N, Zhang P. Tripartite motif-containing 28 bridges endothelial inflammation and angiogenic activity by retaining expression of TNFR-1 and -2 and VEGFR2 in endothelial cells. FASEB J. 2017 May; 31 (5):2026-2036 Epub 2017 Feb 03
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27. Wang Y, Cao Y, Mangalam AK, Guo Y, LaFrance-Corey RG, Gamez JD, Atanga PA, Clarkson BD, Zhang Y, Wang E, Angom RS, Dutta K, Ji B, Pirko I, Lucchinetti CF, Howe CL, Mukhopadhyay D. Neuropilin-1 modulates interferon-?-stimulated signaling in brain microvascular endothelial cells J Cell Sci. 2016; 129(20):3911-3921.
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28. Fatima A, Wang Y, Uchida Y, Norden P, Liu T, Culver A, Dietz WH, Culver F, Millay M, Mukouyama YS, Kume T. Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation. J Clin Invest. 2016 Jul 01; 126: (7)2437-51.
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29. Wang Y, Dai X, Liu Y, Li J, Liu Z, Yin P, Chen J, Wang Y, Wang N, Zhang P. MTUS1 silencing promotes E-selectin production through p38 MAPK-dependent CREB ubiquitination in endothelial cells Journal of Molecular and Cellular Cardiology. 2016; 101:1-10. Epub 1900 Jan 01.
    
30. Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D. RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. J Cell Sci. 2015 Oct 1; 128 (19):3556-68 Epub 2015 July 01
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31. Liu Y, Wang Y, Shi H, Jia L, Cheng J, Cui W, Li H, Li P, Du J. CARD9 mediates necrotic smooth muscle cell-induced inflammation in macrophages contributing to neointima formation of vein grafts. Cardiovasc Res. 2015 Oct 1; 108 (1):148-58 Epub 2015 Aug 04
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32. Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D. Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-alpha Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1alpha and Mitochondrial Homeostasis. Arterioscler Thromb Vasc Biol. 2015 Jun; 35 (6):1401-12 Epub 2015 Apr 16
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33. Hoeppner LH, Wang Y, Sharma A, Javeed N, Van Keulen VP, Wang E, Yang P, Roden AC, Peikert T, Molina JR, Mukhopadhyay D. Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells. Mol Oncol. 2015 Jan; 9 (1):270-81 Epub 2014 Aug 30
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34. Shi HT, Wang Y, Jia LX, Qin YW, Liu Y, Li HH, Qi YF, Du J. Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate vein graft neointimal hyperplasia. Cardiovasc Res. 2014 Mar 1; 101 (3):454-63 Epub 2013 Dec 06
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35. Zhang JM, Wang Y, Miao YJ, Zhang Y, Wu YN, Jia LX, Qi YF, Du J. Knockout of CD8 delays reendothelialization and accelerates neointima formation in injured arteries of mouse via TNF-alpha inhibiting the endothelial cells migration. PLoS One. 2013; 8 (5):e62001 Epub 2013 May 02
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36. Zhang Y, Wang Y, Liu Y, Wang N, Qi Y, Du J. Kruppel-like factor 4 transcriptionally regulates TGF-beta1 and contributes to cardiac myofibroblast differentiation. PLoS One. 2013; 8 (4):e63424 Epub 2013 Apr 30
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37. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J. Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arterioscler Thromb Vasc Biol. 2012 Jul; 32 (7):1675-86 Epub 2012 May 03
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38. Wang Y, Zhao B, Zhang Y, Tang Z, Shen Q, Zhang Y, Zhang W, Du J, Chien S, Wang N. Kruppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury. Br J Pharmacol. 2012 Apr; 165 (7):2378-88
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39. Cheng J, Wang Y, Ma Y, Chan BT, Yang M, Liang A, Zhang L, Li H, Du J. The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts. Circ Res. 2010 Nov 12; 107 (10):1265-74 Epub 2010 Sept 30
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40. Qin X, Wang X, Wang Y, Tang Z, Cui Q, Xi J, Li YS, Chien S, Wang N. MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A. 2010 Feb 16; 107 (7):3240-4 Epub 2010 Jan 27
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41. Tsai MC, Chen L, Zhou J, Tang Z, Hsu TF, Wang Y, Shih YT, Peng HH, Wang N, Guan Y, Chien S, Chiu JJ. Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells. Circ Res. 2009 Aug 28; 105 (5):471-80 Epub 2009 July 23
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42. Zhang P, Wang Y, Fan Y, Tang Z, Wang N. Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2008; 29(1):67-74.
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43. Tang Z, Wang Y, Fan Y, Zhu Y, Chien S, Wang N. Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries. Circulation. 2008 Aug 12; 118 (7):764-72 Epub 2008 July 28
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44. Fan Y, Wang Y, Tang Z, Zhang H, Qin X, Zhu Y, Guan Y, Wang X, Staels B, Chien S, Wang N. Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Feb; 28 (2):315-21 Epub 2007 Nov 29
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