Publications

Dashti P, Lewallen EA, Stein GS, van der Eerden BCJ, van Leeuwen JPTM, van Wijnen AJ. Dynamic strain and beta-catenin mediated suppression of interferon responsive genes in quiescent mesenchymal stromal/stem cells. Biochem Biophys Rep. 2024 Dec; 40:101847 Epub 2024 Oct 23
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Lewallen EA, Liu D, Karwoski J, Szeto WY, van Wijnen AJ, Laudanski K. Transcriptomic responses of peripheral blood leukocytes to cardiac surgery after acute inflammation, and three months recovery. Genomics. 2024 Sep; 116 (5):110878 Epub 2024 June 06
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Eirin A, Thaler R, Glasstetter LM, Xing L, Zhu XY, Osborne AC, Mondesir R, Bhagwate AV, Lerman A, van Wijnen AJ, Lerman LO. Obesity-driven mitochondrial dysfunction in human adipose tissue-derived mesenchymal stem/stromal cells involves epigenetic changes. Cell Death Dis. 2024 Jun 01; 15(6):387.
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Dashti P, Lewallen EA, Gordon JAR, Montecino MA, Davie JR, Stein GS, van Leeuwen JPTM, van der Eerden BCJ, van Wijnen AJ. Epigenetic regulators controlling osteogenic lineage commitment and bone formation. Bone. 2024 Apr; 181:117043 Epub 2024 Feb 09
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Struijk C, Lydon KL, Husen M, Verdonk P, Michielsen J, van Wijnen AJ, Krych AJ, Saris DBF. Cellular Enhancement of Frozen Meniscus Allograft Combining Native Meniscus and Mesenchymal Stromal Cell Injections. Cartilage. 2024 Feb 7; 19476035231224802 Epub 2024 Feb 07
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Dudakovic A, Limberg AK, Bothun CE, Dilger OB, Bayram B, Bettencourt JW, Salmons HI, Thaler R, Karczewski DC, Owen AR, Iyer VG, Payne AN, Carstens MF, van Wijnen AJ, Berry DJ, Sanchez-Sotelo J, Morrey ME, Abdel MP. AdipoRon reduces TGFbeta1-mediated collagen deposition in vitro and alleviates knee stiffness in vivo. J Cell Physiol. 2024 Feb; 239 (2):e31168 Epub 2023 Dec 27
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Singh G, O-Sullivan I, Natarajan Anbazhagan A, Ranjan K C C, Farooqui Z, Ma K, Wang J, Mwale F, Votta-Velis G, Bruce B, Ronald Kahn C, van Wijnen AJ, Im HJ. Loss of PKCdelta/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model. Gene. 2024 Jan 30; 893:147920 Epub 2023 Oct 25
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Cates WT, Denbeigh JM, Salvagno RT, Kakar S, van Wijnen AJ, Eaton C. Inflammatory Markers Involved in the Pathogenesis of Dupuytren's Contracture. Crit Rev Eukaryot Gene Expr. 2024; 34 (6):1-35
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Daneshian Y, Lewallen EA, Badreldin AA, Dietz AB, Stein GS, Cool SM, Ryoo HM, Cho YD, van Wijnen AJ. Fundamentals and Translational Applications of Stem Cells and Biomaterials in Dental, Oral and Craniofacial Regenerative Medicine. Crit Rev Eukaryot Gene Expr. 2024; 34 (6):37-60
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Taheri N, Choi EL, Nguyen VTT, Zhang Y, Huynh NM, Kellogg TA, van Wijnen AJ, Ordog T, Hayashi Y. Inhibition of EZH2 Reduces Aging-Related Decline in Interstitial Cells of Cajal of the Mouse Stomach. Cell Mol Gastroenterol Hepatol. 2024; 18 (4):101376 Epub 2024 July 03
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Dashti P, Lewallen EA, Gordon JAR, Montecino MA, van Leeuwen JPTM, Stein GS, van der Eerden BCJ, Davie JR, van Wijnen AJ. Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation. Bone Rep. 2023 Dec; 19:101704 Epub 2023 July 25
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Dashti P, Thaler R, Hawse JR, Galvan ML, van der Eerden BJ, van Wijnen AJ, Dudakovic A. G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals. Bone. 2023 Nov; 176:116866 Epub 2023 Aug 07
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Blouin S, Khani F, Messmer P, Roschger P, Hartmann MA, van Wijnen AJ, Thaler R, Misof BM. Vitamin C Deficiency Deteriorates Bone Microarchitecture and Mineralization in a Sex-Specific Manner in Adult Mice. J Bone Miner Res. 2023 Oct; 38 (10):1509-1520 Epub 2023 Aug 08
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Carrasco ME, Thaler R, Nardocci G, Dudakovic A, van Wijnen AJ. Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts. J Biol Chem. 2023 Sep; 299 (9):105155 Epub 2023 Aug 11
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van Wijnen AJ, Dashti P. Next-Generation Bone Stimulation: Doubling Down on Bone Anabolics: Commentary on an article by Monica Florio, PhD, et al.: "Dual Inhibition of the Wnt Inhibitors DKK1 and Sclerostin Promotes Fracture Healing and Increases the Density and Strength of Uninjured Bone. An Experimental Study in Nonhuman Primates". J Bone Joint Surg Am 2023 Aug 2; 105 (15):e38 Epub 2023 Aug 02
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Glasstetter LM, Oderinde TS, Mirchandani M, Rajagopalan KS, Barsom SH, Thaler R, Siddiqi S, Zhu XY, Tang H, Jordan KL, Saadiq IM, van Wijnen AJ, Eirin A, Lerman LO. Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells. Stem Cell Res Ther. 2023 May 25; 14 (1):143
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Grgic O, Prijatelj V, Dudakovic A, Vucic S, Dhamo B, Trajanoska K, Monnereau C, Zrimsek M, Gautvik KM, Reppe S, Shimizu E, Haworth S, Timpson NJ, Jaddoe VWV, Jarvelin MR, Evans D, Uitterlinden AG, Ongkosuwito EM, van Wijnen AJ, Medina-Gomez C, Rivadeneira F, Wolvius EB. Novel Genetic Determinants of Dental Maturation in Children. J Dent Res. 2023 Mar; 102 (3):349-356 Epub 2022 Nov 27
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Mumtaz N, Dudakovic A, Nair A, Koedam M, van Leeuwen JPTM, Koopmans MPG, Rockx B, van Wijnen AJ, van der Eerden BCJ. Zika virus alters osteogenic lineage progression of human mesenchymal stromal cells. J Cell Physiol. 2023 Feb; 238 (2):379-392 Epub 2022 Dec 20
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Dudakovic A, Bayram B, Bettencourt JW, Limberg AK, Galvan ML, Carrasco ME, Stans B, Thaler R, Morrey ME, Sanchez-Sotelo J, Berry DJ, van Wijnen AJ, Abdel MP. The epigenetic regulator BRD4 is required for myofibroblast differentiation of knee fibroblasts. J Cell Biochem. 2023 Feb; 124 (2):320-334 Epub 2023 Jan 17
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Bedar M, van Wijnen AJ, Shin AY. Safety of Allogeneic Mesenchymal Stem Cell Seeding of NeuraGen Nerve Guides in a Rabbit Model. Tissue Eng Part C Methods. 2023 Feb; 29 (2):43-53
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Farooqui N, Mohan A, Isik B, Goksu BB, Thaler R, Zhu XY, Krier JD, Saadiq IM, Ferguson CM, Jordan KL, Tang H, Textor SC, Hickson TJ, van Wijnen AJ, Eirin A, Lerman LO, Herrmann SM. Effect of Hypoxia Preconditioning on the Regenerative Capacity of Adipose Tissue Derived Mesenchymal Stem Cells in a Model of Renal Artery Stenosis. Stem Cells. 2023 Jan 30; 41(1):50-63.
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Dashti P, van de Peppel J, Thaler R, Paradise CR, Stein GS, Montecino MA, van Leeuwen JPTM, van der Eerden BJ, Dudakovic A, van Wijnen AJ. The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization. Gene. 2023 Jan 30; 851:146928 Epub 2022 Sept 30
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Dagneaux L, Limberg AK, Owen AR, Bettencourt JW, Dudakovic A, Bayram B, Gades NM, Sanchez-Sotelo J, Berry DJ, van Wijnen A, Morrey ME, Abdel MP. Knee immobilization reproduces key arthrofibrotic phenotypes in mice. Bone Joint Res. 2023 Jan; 12 (1):58-71
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Limberg AK, Salib CG, Tibbo ME, Vargas-Hernandez JS, Bettencourt JW, Bayram B, Berry CE, Dudakovic A, Bolon B, van Wijnen AJ, Morrey ME, Sanchez-Sotelo J, Berry DJ, Carter JM, Abdel MP. Immune cell populations differ in patients undergoing revision total knee arthroplasty for arthrofibrosis. Sci Rep. 2022 Dec 31; 12 (1):22627
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Thaler R, Khani F, Sturmlechner I, Dehghani SS, Denbeigh JM, Zhou X, Pichurin O, Dudakovic A, Jerez SS, Zhong J, Lee JH, Natarajan R, Kalajzic I, Jiang YH, Deyle DR, Paschalis EP, Misof BM, Ordog T, van Wijnen AJ. Vitamin C epigenetically controls osteogenesis and bone mineralization. Nat Commun. 2022 Oct 6; 13 (1):5883 Epub 2022 Oct 06
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Dudakovic A, Jerez S, Deosthale PJ, Denbeigh JM, Paradise CR, Gluscevic M, Zan P, Begun DL, Camilleri ET, Pichurin O, Khani F, Thaler R, Lian JB, Stein GS, Westendorf JJ, Plotkin LI, van Wijnen AJ. MicroRNA-101a enhances trabecular bone accrual in male mice. Sci Rep. 2022 Aug 3; 12 (1):13361 Epub 2022 Aug 03
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Bedar M, Jerez S, Pulos N, van Wijnen AJ, Shin AY. Dynamic seeding versus microinjection of mesenchymal stem cells for acellular nerve allograft: an in vitro comparison. J Plast Reconstr Aesthet Surg. 2022 Aug; 75 (8):2821-2830 Epub 2022 Apr 22
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Bayram B, Thaler R, Bettencourt JW, Limberg AK, Sheehan KP, Owen AR, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Dudakovic A, Abdel MP. Human outgrowth knee fibroblasts from patients undergoing total knee arthroplasty exhibit a unique gene expression profile and undergo myofibroblastogenesis upon TGFbeta1 stimulation. J Cell Biochem. 2022 May; 123 (5):878-892 Epub 2022 Feb 28
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Mathew SE, Xie Y, Bagheri L, Claton LE, Chu L, Badreldin A, Abdel MP, van Wijnen AJ, Haft GF, Milbrandt TA, Larson AN. Are Serum Ion Levels Elevated in Pediatric Patients With Metal Implants? J Pediatr Orthop. 2022 Mar 1; 42 (3):162-168
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Struijk C, Van Genechten W, Verdonk P, Krych AJ, Dietz AB, van Wijnen AJ, Saris DBF. Human meniscus allograft augmentation by allogeneic mesenchymal stromal/stem cell injections. J Orthop Res. 2022 Mar; 40 (3):712-726 Epub 2021 May 24
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Owen AR, Dagneaux L, Limberg AK, Bettencourt JW, Bayram B, Bolon B, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Abdel MP. Biomechanical, histological, and molecular characterization of a new posttraumatic model of arthrofibrosis in rats. J Orthop Res. 2022 Feb; 40 (2):323-337 Epub 2021 May 16
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Mohammadi M, Bagheri L, Badreldin A, Fatehi P, Pakzad L, Suntres Z, van Wijnen AJ. Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways. Chem Biol Interact. 2022 Jan 5; 351:109768 Epub 2021 Dec 03
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Trousdale WH, Limberg AK, Reina N, Salib CG, Thaler R, Dudakovic A, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen A, Abdel MP. Intra-articular celecoxib improves knee extension regardless of surgical release in a rabbit model of arthrofibrosis. Bone Joint Res. 2022 Jan; 11 (1):32-39
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Paradise CR, Galvan ML, Pichurin O, Jerez S, Kubrova E, Dehghani SS, Carrasco ME, Thaler R, Larson AN, van Wijnen AJ, Dudakovic A. Brd4 is required for chondrocyte differentiation and endochondral ossification. Bone. 2022 Jan; 154:116234 Epub 2021 Oct 23
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Rummukainen P, Tarkkonen K, Dudakovic A, Al-Majidi R, Nieminen-Pihala V, Valensisi C, Hawkins RD, van Wijnen AJ, Kiviranta R. Lysine-Specific Demethylase 1 (LSD1) epigenetically controls osteoblast differentiation. PLoS One. 2022; 17 (3):e0265027 Epub 2022 Mar 07
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Lewallen EA, Trousdale WH, Thaler R, Yao JJ, Xu W, Denbeigh JM, Nair A, Kocher JP, Dudakovic A, Berry DJ, Cohen RC, Abdel MP, Lewallen DG, van Wijnen AJ. Surface Roughness of Titanium Orthopedic Implants Alters the Biological Phenotype of Human Mesenchymal Stromal Cells. Tissue Eng Part A. 2021 Dec; 27 (23-24):1503-1516 Epub 2021 Aug 16
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Hevesi M, Denbeigh JM, Paggi CA, Galeano-Garces C, Bagheri L, Larson AN, Stuart MJ, Saris DBF, van Wijnen AJ, Krych AJ. Fresh Osteochondral Allograft Transplantation in the Knee: A Viability and Histologic Analysis for Optimizing Graft Viability and Expanding Existing Standard Processed Graft Resources Using a Living Donor Cartilage Program. Cartilage. 2021 Dec; 13 (1_suppl):948S-956S Epub 2019 Oct 16
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Nirala NK, Li Q, Ghule PN, Chen HJ, Li R, Zhu LJ, Wang R, Rice NP, Mao J, Stein JL, Stein GS, van Wijnen AJ, Ip YT. Hinfp is a guardian of the somatic genome by repressing transposable elements. Proc Natl Acad Sci U S A. 2021 Oct 12; 118 (41)
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Paradise CR, De La Vega RE, Galvan ML, Carrasco ME, Thaler R, van Wijnen AJ, Dudakovic A. Brd4 Inactivation Increases Adenoviral Delivery of BMP2 for Paracrine Stimulation of Osteogenic Differentiation as a Gene Therapeutic Concept to Enhance Bone Healing. JBMR Plus. 2021 Oct; 5 (10):e10520 Epub 2021 June 23
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Kilari S, Sharma A, Zhao C, Singh A, Cai C, Simeon M, van Wijnen AJ, Misra S. Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI. Transl Res. 2021 Sep; 235:32-47 Epub 2021 Mar 09
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Galvan ML, Paradise CR, Kubrova E, Jerez S, Khani F, Thaler R, Dudakovic A, van Wijnen AJ. Multiple pharmacological inhibitors targeting the epigenetic suppressor enhancer of zeste homolog 2 (Ezh2) accelerate osteoblast differentiation. Bone. 2021 Sep; 150:115993 Epub 2021 Apr 30
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Kobayashi Y, Quispe-Salcedo A, Bodas S, Matsumura S, Li E, Johnson R, Choudhury M, Fine DH, Nadimpalli S, Duncan HF, Dudakovic A, van Wijnen AJ, Shimizu E. Ezh2 knockout in mesenchymal cells causes enamel hyper-mineralization. Biochem Biophys Res Commun. 2021 Aug 27; 567:72-78 Epub 2021 June 16
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Lui H, Vaquette C, Denbeigh JM, Bindra R, Kakar S, van Wijnen AJ. Multiphasic scaffold for scapholunate interosseous ligament reconstruction: A study in the rabbit knee. J Orthop Res. 2021 Aug; 39(8):1811-1824. Epub 2020 Jul 07.
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Lui H, Samsonraj RM, Vaquette C, Denbeigh J, Kakar S, Cool SM, Dudakovic A, van Wijnen AJ. Combination of BMP2 and EZH2 Inhibition to Stimulate Osteogenesis in a 3D Bone Reconstruction Model. Tissue Eng Part A. 2021 Aug; 27 (15-16):1084-1098 Epub 2021 Jan 12
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Saffari TM, Mathot F, Thaler R, van Wijnen AJ, Bishop AT, Shin AY. Microcomputed analysis of nerve angioarchitecture after combined stem cell delivery and surgical angiogenesis to nerve allograft. J Plast Reconstr Aesthet Surg. 2021 Aug; 74 (8):1919-1930 Epub 2020 Dec 24
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Owen AR, Tibbo ME, van Wijnen AJ, Pagnano MW, Berry DJ, Abdel MP. Acquired Idiopathic Stiffness After Contemporary Total Knee Arthroplasty: Incidence, Risk Factors, and Results Over 25 Years. J Arthroplasty. 2021 Aug; 36 (8):2980-2985 Epub 2021 Apr 01
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Mathot F, Rbia N, Thaler R, Dietz AB, van Wijnen AJ, Bishop AT, Shin AY. Gene expression profiles of human adipose-derived mesenchymal stem cells dynamically seeded on clinically available processed nerve allografts and collagen nerve guides. Neural Regen Res. 2021 Aug; 16 (8):1613-1621
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van Wijnen AJ, Abdel MP. Toward a Genetic Crystal Ball for Patients with Rotator Cuff Disease: Commentary on an article by Elizabeth L. Yanik, PhD, ScM, et al.: "Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank". J Bone Joint Surg Am 2021 Jul 21; 103 (14):e55
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Beacon TH, Delcuve GP, Lopez C, Nardocci G, Kovalchuk I, van Wijnen AJ, Davie JR. The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes. Clin Epigenetics. 2021 Jul 8; 13 (1):138 Epub 2021 July 08
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Hickson LJ, Eirin A, Conley SM, Taner T, Bian X, Saad A, Herrmann SM, Mehta RA, McKenzie TJ, Kellogg TA, Kirkland JL, Tchkonia T, Saadiq IM, Tang H, Jordan KL, Zhu X, Griffin MD, Rule AD, van Wijnen AJ, Textor SC, Lerman LO. Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair. Diabetes. 2021 Jul; 70 (7):1561-1574 Epub 2021 Apr 15
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Lui H, Denbeigh J, Vaquette C, Tran HM, Dietz AB, Cool SM, Dudakovic A, Kakar S, van Wijnen AJ. Fibroblastic differentiation of mesenchymal stem/stromal cells (MSCs) is enhanced by hypoxia in 3D cultures treated with bone morphogenetic protein 6 (BMP6) and growth and differentiation factor 5 (GDF5). Gene. 2021 Jul 01; 788:145662. Epub 2021 Apr 20.
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Goelzer M, Dudakovic A, Olcum M, Sen B, Ozcivici E, Rubin J, van Wijnen AJ, Uzer G. Lamin A/C Is Dispensable to Mechanical Repression of Adipogenesis. Int J Mol Sci. 2021 Jun 19; 22 (12) Epub 2021 June 19
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Arora V, Singh G, O-Sullivan I, Ma K, Natarajan Anbazhagan A, Votta-Velis EG, Bruce B, Richard R, van Wijnen AJ, Im HJ. Gut-microbiota modulation: The impact of thegut-microbiotaon osteoarthritis. Gene. 2021 Jun 15; 785:145619 Epub 2021 Mar 27
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Pal D, Riester SM, Hasan B, Tufa SF, Dudakovic A, Keene DR, van Wijnen AJ, Schweitzer R. Ezh2 Is Essential for Patterning of Multiple Musculoskeletal Tissues but Dispensable for Tendon Differentiation. Stem Cells Dev. 2021 Jun 1; 30 (11):601-609 Epub 2021 Apr 27
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Bayram B, Owen AR, Dudakovic A, Bettencourt JW, Limberg AK, Morrey ME, Sanchez-Sotelo J, Berry DJ, Kocher JP, van Wijnen AJ, Abdel MP. Elevated Expression of Plasminogen Activator Inhibitor (PAI-1/SERPINE1) is Independent from rs1799889 Genotypes in Arthrofibrosis. Meta Gene. 2021 Jun; 28 Epub 2021 Mar 05
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Afarideh M, Thaler R, Khani F, Tang H, Jordan KL, Conley SM, Saadiq IM, Obeidat Y, Pawar AS, Eirin A, Zhu XY, Lerman A, van Wijnen AJ, Lerman LO. Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming. Epigenetics. 2021 Jun-Jul; 16 (7):705-717 Epub 2020 Sept 20
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Salib CG, Reina N, van Wijnen AJ, Hanssen AD, Berry DJ, Abdel MP. Absence of signature inflammatory markers in synovial fluid for total knee arthroplasties revised for arthrofibrosis. Orthop Traumatol Surg Res. 2021 May; 107 (3):102870 Epub 2021 Feb 24
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Isik B, Thaler R, Goksu BB, Conley SM, Al-Khafaji H, Mohan A, Afarideh M, Abumoawad AM, Zhu XY, Krier JD, Saadiq IM, Tang H, Eirin A, Hickson LJ, van Wijnen AJ, Textor SC, Lerman LO, Herrmann SM. Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis. Stem Cell Res Ther. 2021 Apr 14; 12(1):240.
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Krull AA, Setter DO, Gendron TF, Hrstka SCL, Polzin MJ, Hart J, Dudakovic A, Madigan NN, Dietz AB, Windebank AJ, van Wijnen AJ, Staff NP. Alterations of mesenchymal stromal cells in cerebrospinal fluid: insights from transcriptomics and an ALS clinical trial. Stem Cell Res Ther. 2021 Mar 18; 12 (1):187
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van de Peppel J, Schaaf GJ, Matos AA, Guo Y, Strini T, Verschoor W, Dudakovic A, van Wijnen AJ, van Leeuwen JPTM. Cell Surface Glycoprotein CD24 Marks Bone Marrow-Derived Human Mesenchymal Stem/Stromal Cells with Reduced Proliferative and Differentiation Capacity In Vitro. Stem Cells Dev. 2021 Mar; 30 (6):325-336
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Xie Z, McGrath C, Sankaran J, Styner M, Little-Letsinger S, Dudakovic A, van Wijnen AJ, Rubin J, Sen B. Low-Dose Tamoxifen Induces Significant Bone Formation in Mice. JBMR Plus. 2021 Mar; 5 (3):e10450 Epub 2021 Jan 20
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Farhat T, Dudakovic A, Chung JH, van Wijnen AJ, St-Arnaud R. Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses. J Cell Physiol. 2021 Feb; 236 (2):1195-1213 Epub 2020 July 19
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Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy CS, DeMambro V, Pettitt JA, Lary CW, Driscoll HE, McDonald MM, Kassem M, Rosen C, Andersen TL, van Wijnen AJ, Jafari A, Reagan MR. Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype. Cancer Res. 2021 Feb 1; 81 (3):634-647 Epub 2020 Nov 20
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van Wijnen AJ, Bagheri L, Badreldin AA, Larson AN, Dudakovic A, Thaler R, Paradise CR, Wu Z. Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development. Bone. 2021 Feb; 143:115659 Epub 2020 Sept 24
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Xu C, Ni S, Zhuang C, Li C, Zhao G, Jiang S, Wang L, Zhu R, van Wijnen AJ, Wang Y. Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway. Arthritis Res Ther. 2021 Jan 30; 23 (1):47
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Badreldin AA, Bagheri L, Zhang B, Larson AN, van Wijnen AJ. Relative mRNA and protein stability of epigenetic regulators in musculoskeletal cell culture models. Gene. 2021 Jan 15; 766:145032 Epub 2020 Aug 06
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Kubrova E, Su M, Galeano-Garces C, Galvan ML, Jerez S, Dietz AB, Smith J, Qu W, van Wijnen AJ. Differences in Cytotoxicity of Lidocaine, Ropivacaine, and Bupivacaine on the Viability and Metabolic Activity of Human Adipose-Derived Mesenchymal Stem Cells. Am J Phys Med Rehabil. 2021 Jan 1; 100 (1):82-91
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Houben RH, Thaler R, Friedrich PF, Shin AY, van Wijnen AJ, Bishop AT. Autogenous Arteriovenous Bundle Implantation Maintains Viability Without Increased Immune Response in Large Porcine Bone Allotransplants. Transplant Proc. 2021 Jan-Feb; 53 (1):417-426 Epub 2020 Sept 18
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Li Y, Meng Y, Zhu X, Van Wijnen A, Eirin A, Lerman LO. Metabolic Syndrome Is Associated With Altered mRNA and miRNA Content in Human Circulating Extracellular Vesicles. Front Endocrinol (Lausanne). 2021; 12:687586 Epub 2021 Aug 12
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Li Y, Meng Y, Liu Y, van Wijnen AJ, Eirin A, Lerman LO. Differentially Expressed Functional LncRNAs in Human Subjects With Metabolic Syndrome Reflect a Competing Endogenous RNA Network in Circulating Extracellular Vesicles. Front Mol Biosci. 2021; 8:667056 Epub 2021 Aug 17
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Davis JL, Thaler R, Cox L, Ricci B, Zannit HM, Wan F, Faccio R, Dudakovic A, van Wijnen AJ, Veis DJ. Constitutive activation of NF-kappaB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma. PLoS One. 2021; 16 (7):e0254426 Epub 2021 July 22
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Eirin A, Meng Y, Zhu XY, Li Y, Saadiq IM, Jordan KL, Tang H, Lerman A, van Wijnen AJ, Lerman LO. The Micro-RNA Cargo of Extracellular Vesicles Released by Human Adipose Tissue-Derived Mesenchymal Stem Cells Is Modified by Obesity. Front Cell Dev Biol. 2021; 9:660851 Epub 2021 May 20
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Fu Y, Paggi CA, Dudakovic A, van Wijnen AJ, Post JN, Karperien M. Engineering Cartilage Tissue by Co-culturing of Chondrocytes and Mesenchymal Stromal Cells. Methods Mol Biol. 2021; 2221:53-70
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Van Genechten W, Hevesi M, Olson N, Carstens M, Krych AJ, Verdonk P, van Wijnen AJ, Saris DBF. Anterior cruciate ligament graft healing by peptide-based vascular endothelial growth factor and bone morphogenetic protein recruitment. Journal of Cartilage and Joint Preservation. 2021; 1 (4):100030
Galea GL, Paradise CR, Meakin LB, Camilleri ET, Taipaleenmaki H, Stein GS, Lanyon LE, Price JS, van Wijnen AJ, Dudakovic A. Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2. Gene X. 2020 Dec; 5:100027 Epub 2020 Jan 16
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Galea GL, Paradise CR, Meakin LB, Camilleri ET, Taipaleenmaki H, Stein GS, Lanyon LE, Price JS, van Wijnen AJ, Dudakovic A. Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2. Gene. 2020 Dec; 763S:100027 Epub 2020 Jan 16
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Dudakovic A, Nam HK, Wijnen AJV, van Wijnen AJ, Hatch NE. Genetic background dependent modifiers of craniosynostosis severity. J Struct Biol. 2020 Dec 1; 212 (3):107629 Epub 2020 Sept 23
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Limberg AK, Tibbo ME, Salib CG, McLaury AR, Turner TW, Berry CE, Jay AG, Carter JM, Bolon B, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Abdel MP. Reduction of arthrofibrosis utilizing a collagen membrane drug-eluting scaffold with celecoxib and subcutaneous injections with ketotifen. J Orthop Res. 2020 Nov; 38 (11):2474-2483 Epub 2020 Mar 11
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Dagneaux L, Owen AR, Bettencourt JW, Barlow JD, Amadio PC, Kocher JP, Morrey ME, Sanchez-Sotelo J, Berry DJ, van Wijnen AJ, Abdel MP. Human Fibrosis: Is There Evidence for a Genetic Predisposition in Musculoskeletal Tissues? J Arthroplasty. 2020 Nov; 35 (11):3343-3352 Epub 2020 June 04
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Kubrova E, D'Souza RS, Hunt CL, Wang Q, van Wijnen AJ, Qu W. Injectable Biologics: What Is the Evidence? Am J Phys Med Rehabil. 2020 Oct; 99 (10):950-960
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Saffari TM, Badreldin A, Mathot F, Bagheri L, Bishop AT, van Wijnen AJ, Shin AY. Surgical angiogenesis modifies the cellular environment of nerve allografts in a rat sciatic nerve defect model. Gene. 2020 Aug 15; 751:144711 Epub 2020 Apr 27
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Bydon M, Moinuddin FM, Yolcu YU, Wahood W, Alvi MA, Goyal A, Elminawy M, Galeano-Garces C, Dudakovic A, Nassr A, Larson AN, van Wijnen AJ. Lumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis. Gene. 2020 Aug 5; 750:144634 Epub 2020 Mar 30
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Karau MJ, Zhang C, Mandrekar JN, Kohrs NJ, Puleo DA, van Wijnen AJ, Patel R, Boyce TG, Larson AN, Milbrandt TA. Topical vancomycin for treatment of methicillin-resistant Staphylococcus epidermidis infection in a rat spinal implant model. Spine Deform. 2020 Aug; 8 (4):553-559 Epub 2020 Feb 20
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Cai C, Kilari S, Zhao C, Simeon ML, Misra A, Li Y, van Wijnen AJ, Mukhopadhyay D, Misra S. Therapeutic Effect of Adipose Derived Mesenchymal Stem Cell Transplantation in Reducing Restenosis in a Murine Angioplasty Model. J Am Soc Nephrol. 2020 Aug; 31 (8):1781-1795 Epub 2020 June 25
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Mathot F, Rbia N, Thaler R, Bishop AT, van Wijnen AJ, Shin AY. Introducing human adipose-derived mesenchymal stem cells to Avance() nerve grafts and NeuraGen() nerve guides. J Plast Reconstr Aesthet Surg. 2020 Aug; 73 (8):1473-1481 Epub 2020 Apr 11
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Houben RH, Aleff RA, Friedrich PF, Shin AY, Wieben ED, van Wijnen AJ, Bishop AT. Transplant chimerism in porcine structural vascularized bone allotransplants. Gene. 2020 Jul 15; 747:144627 Epub 2020 Mar 26
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Bayram B, Limberg AK, Salib CG, Bettencourt JW, Trousdale WH, Lewallen EA, Reina N, Paradise CR, Thaler R, Morrey ME, Sanchez-Sotelo J, Berry DJ, van Wijnen AJ, Abdel MP. Molecular pathology of human knee arthrofibrosis defined by RNA sequencing. Genomics. 2020 Jul; 112 (4):2703-2712 Epub 2020 Mar 05
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Yao JJ, Lewallen EA, Thaler R, Dudakovic A, Wermers M, Day P, Eckdahl S, Jannetto P, Bornhorst JA, Larson AN, Abdel MP, Lewallen DG, van Wijnen AJ. Challenges in the Measurement and Interpretation of Serum Titanium Concentrations. Biol Trace Elem Res. 2020 Jul; 196 (1):20-26 Epub 2019 Nov 06
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Dudakovic A, Samsonraj RM, Paradise CR, Galeano-Garces C, Mol MO, Galeano-Garces D, Zan P, Galvan ML, Hevesi M, Pichurin O, Thaler R, Begun DL, Kloen P, Karperien M, Larson AN, Westendorf JJ, Cool SM, van Wijnen AJ. Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2. J Biol Chem. 2020 Jun 5; 295 (23):7877-7893 Epub 2020 Apr 24
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Bettencourt JW, McLaury AR, Limberg AK, Vargas-Hernandez JS, Bayram B, Owen AR, Berry DJ, Sanchez-Sotelo J, Morrey ME, van Wijnen AJ, Abdel MP. Total Protein Staining is Superior to Classical or Tissue-Specific Protein Staining for Standardization of Protein Biomarkers in Heterogeneous Tissue Samples. Gene Rep. 2020 Jun; 19 Epub 2020 Mar 06
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Paradise CR, Galvan ML, Kubrova E, Bowden S, Liu E, Carstens MF, Thaler R, Stein GS, van Wijnen AJ, Dudakovic A. The epigenetic reader Brd4 is required for osteoblast differentiation. J Cell Physiol. 2020 Jun; 235 (6):5293-5304 Epub 2019 Dec 23
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Qiu S, Shi C, Anbazhagan AN, Das V, Arora V, Kc R, Li X, O-Sullivan I, van Wijnen A, Chintharlapalli S, Gott-Velis G, Richard R, Mwale F, Shibuya M, Min S, Im HJ. Absence of VEGFR-1/Flt-1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model. J Cell Physiol. 2020 Jun; 235 (6):5305-5317 Epub 2019 Dec 25
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Sen B, Paradise CR, Xie Z, Sankaran J, Uzer G, Styner M, Meyer M, Dudakovic A, van Wijnen AJ, Rubin J. beta-Catenin Preserves the Stem State of Murine Bone Marrow Stromal Cells Through Activation of EZH2. J Bone Miner Res. 2020 Jun; 35 (6):1149-1162 Epub 2020 Feb 24
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Tibbo ME, Limberg AK, Salib CG, Turner TW, McLaury AR, Jay AG, Bettencourt JW, Carter JM, Bolon B, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Abdel MP. Anti-fibrotic effects of the antihistamine ketotifen in a rabbit model of arthrofibrosis. Bone Joint Res. 2020 Jun; 9 (6):302-310 Epub 2020 July 23
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Gluscevic M, Paradise CR, Dudakovic A, Karperien M, Dietz AB, van Wijnen AJ, Deyle DR. Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells. Gene. 2020 May 5; 737:144437 Epub 2020 Feb 04
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Jordan TL, Maar K, Redhage KR, Misra P, Blancas-Mejia LM, Dick CJ, Wall JS, Williams A, Dietz AB, van Wijnen AJ, Lin Y, Ramirez-Alvarado M. Light chain amyloidosis induced inflammatory changes in cardiomyocytes and adipose-derived mesenchymal stromal cells. Leukemia. 2020 May; 34 (5):1383-1393 Epub 2019 Dec 03
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Morhayim J, Ghebes CA, Erkeland SJ, Ter Borg MND, Hoogenboezem RM, Bindels EMJ, van Alphen FPJ, Kassem M, van Wijnen AJ, Cornelissen JJ, van Leeuwen JP, van der Eerden BCJ, Voermans C, van de Peppel J, Braakman E. Identification of osteolineage cell-derived extracellular vesicle cargo implicated in hematopoietic support. FASEB J. 2020 Apr; 34 (4):5435-5452 Epub 2020 Feb 21
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Schivo S, Khurana S, Govindaraj K, Scholma J, Kerkhofs J, Zhong L, Huang X, van de Pol J, Langerak R, van Wijnen AJ, Geris L, Karperien M, Post JN. ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease. Cell Signal. 2020 Apr; 68:109471 Epub 2019 Dec 11
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Taner T, Abrol N, Park WD, Hansen MJ, Gustafson MP, Lerman LO, van Wijnen AJ, Dietz AB, Gores GJ, Stegall MD. Phenotypic, Transcriptional, and Functional Analysis of Liver Mesenchymal Stromal Cells and Their Immunomodulatory Properties. Liver Transpl. 2020 Apr; 26 (4):549-563 Epub 2020 Mar 04
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Wyles CC, Paradise CR, Masters TL, Patel R, van Wijnen AJ, Abdel MP, Trousdale RT, Sierra RJ. Cobalt and Chromium Ion Release in Metal-on-Polyethylene and Ceramic-on-Polyethylene THA: A Simulator Study With Cellular and Microbiological Correlations. J Arthroplasty. 2020 Apr; 35 (4):1123-1129 Epub 2019 Nov 27
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Xu C, Jiang T, Ni S, Chen C, Li C, Zhuang C, Zhao G, Jiang S, Wang L, Zhu R, van Wijnen AJ, Wang Y. FSTL1 promotes nitric oxide-induced chondrocyte apoptosis via activating the SAPK/JNK/caspase3 signaling pathway. Gene. 2020 Mar 30; 732:144339 Epub 2020 Jan 09
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Houben RH, Thaler R, Kotsougiani D, Friedrich PF, Shin AY, van Wijnen AJ, Bishop AT. Neo-Angiogenesis, Transplant Viability, and Molecular Analyses of Vascularized Bone Allotransplantation Surgery in a Large Animal Model. J Orthop Res. 2020 Feb; 38 (2):288-296 Epub 2019 Oct 06
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Mathot F, Rbia N, Thaler R, Bishop AT, Van Wijnen AJ, Shin AY. Gene expression profiles of differentiated and undifferentiated adipose derived mesenchymal stem cells dynamically seeded onto a processed nerve allograft. Gene. 2020 Jan 15; 724:144151 Epub 2019 Oct 15
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Ling L, Ren X, Cao X, Hassan ABM, Mah S, Sathiyanathan P, Smith RAA, Tan CLL, Eio M, Samsonraj RM, van Wijnen AJ, Raghunath M, Nurcombe V, Hui JH, Cool SM. Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans. Stem Cell Reports. 2020 Jan 14; 14 (1):105-121 Epub 2020 Jan 02
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Kubrova E, Qu W, Galvan ML, Paradise CR, Yang J, Dietz AB, Dudakovic A, Smith J, van Wijnen AJ. Hypothermia and nutrient deprivation alter viability of human adipose-derived mesenchymal stem cells. Gene. 2020 Jan 5; 722:144058 Epub 2019 Sept 05
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Freeberg MAT, Easa A, Lillis JA, Benoit DSW, van Wijnen AJ, Awad HA. Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI-1/Serpine1) Null Mice. J Orthop Res. 2020 Jan; 38 (1):43-58 Epub 2019 Sept 01
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Mathot F, Rbia N, Bishop AT, Hovius SER, Van Wijnen AJ, Shin AY. Adhesion, distribution, and migration of differentiated and undifferentiated mesenchymal stem cells (MSCs) seeded on nerve allografts. J Plast Reconstr Aesthet Surg. 2020 Jan; 73 (1):81-89 Epub 2019 May 22
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Sankaran JS, Sen B, Dudakovic A, Paradise CR, Perdue T, Xie Z, McGrath C, Styner M, Newberg J, Uzer G, van Wijnen AJ, Rubin J. Knockdown of formin mDia2 alters lamin B1 levels and increases osteogenesis in stem cells. Stem Cells. 2020 Jan; 38 (1):102-117 Epub 2019 Nov 06
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Kubrova E, van Wijnen AJ, Qu W. Spine disorders and regenerative rehabilitation Current Physical Medicine and Rehabilitation Reports. 2020; 8(1):30-6. Epub 1900 Jan 01.
Venneker S, Kruisselbrink AB, Briaire-de Bruijn IH, de Jong Y, van Wijnen AJ, Danen EHJ, Bovee JVMG. Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status. Cancers (Basel). 2019 Dec 2; 11 (12) Epub 2019 Dec 02
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Salib CG, Lewallen EA, Paradise CR, Tibbo ME, Robin JX, Trousdale WH, Morrey LM, Xiao J, Turner TW, Limberg AK, Jay AG, Thaler R, Dudakovic A, Sanchez-Sotelo J, Morrey ME, Berry DJ, Lewallen DG, van Wijnen AJ, Abdel MP. Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq. Genomics. 2019 Dec; 111 (6):1404-1411 Epub 2018 Sept 21
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Salib CG, Reina N, Trousdale WH, Limberg AK, Tibbo ME, Jay AG, Robin JX, Turner TW, Jones CR, Paradise CR, Lewallen EA, Bolon B, Carter JM, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Abdel MP. Inhibition of COX-2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture. J Orthop Res. 2019 Dec; 37(12):2609-2620. Epub 2019 Aug 26.
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Soreide E, Denbeigh JM, Lewallen EA, Thaler R, Samsonraj RM, Jones DL, Xu W, Larson D, Nordsletten L, Kakar S, van Wijnen AJ. A multi-chamber tissue culture device for load-dependent parallel evaluation of tendon explants. BMC Musculoskelet Disord. 2019 Nov 18; 20 (1):549
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Nie H, Kubrova E, Wu T, Denbeigh JM, Hunt C, Dietz AB, Smith J, Qu W, van Wijnen AJ. Effect of Lidocaine on Viability and Gene Expression of Human Adipose-derived Mesenchymal Stem Cells: An in vitro Study. PM R. 2019 Nov; 11 (11):1218-1227 Epub 2019 May 30
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Sankaran J, Uzer G, van Wijnen AJ, Rubin J. Gene regulation through dynamic actin control of nuclear structure. Exp Biol Med (Maywood). 2019 Nov; 244 (15):1345-1353 Epub 2019 May 13
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Soreide E, Denbeigh JM, Lewallen EA, Thaler R, Xu W, Berglund L, Yao JJ, Martinez A, Nordsletten L, van Wijnen AJ, Kakar S. In vivo assessment of high-molecular-weight polyethylene core suture tape for intra-articular ligament reconstruction: an animal study. Bone Joint J. 2019 Oct; 101-B (10):1238-1247
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Liu X, Ni S, Li C, Xu N, Chen W, Wu M, van Wijnen AJ, Wang Y. Circulating microRNA-23b as a new biomarker for rheumatoid arthritis. Gene. 2019 Sep 5; 712:143911 Epub 2019 June 06
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Mathot F, Shin AY, Van Wijnen AJ. Targeted stimulation of MSCs in peripheral nerve repair. Gene. 2019 Aug 20; 710:17-23 Epub 2019 Mar 05
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Jerez S, Araya H, Hevia D, Irarrazaval CE, Thaler R, van Wijnen AJ, Galindo M. Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis. Gene. 2019 Aug 20; 710:246-257 Epub 2019 June 06
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Villanueva F, Araya H, Briceno P, Varela N, Stevenson A, Jerez S, Tempio F, Chnaiderman J, Perez C, Villarroel M, Concha E, Khani F, Thaler R, Salazar-Onfray F, Stein GS, van Wijnen AJ, Galindo M. The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis. J Cell Physiol. 2019 Aug; 234 (8):13659-13679 Epub 2019 Jan 13
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Law L, Hunt CL, van Wijnen AJ, Nassr A, Larson AN, Eldrige JS, Mauck WD, Pingree MJ, Yang J, Muir CW, Erwin PJ, Bydon M, Qu W. Office-Based Mesenchymal Stem Cell Therapy for the Treatment of Musculoskeletal Disease: A Systematic Review of Recent Human Studies. Pain Med. 2019 Aug 1; 20 (8):1570-1583
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Rbia N, Bulstra LF, Lewallen EA, Hovius SER, van Wijnen AJ, Shin AY. Seeding decellularized nerve allografts with adipose-derived mesenchymal stromal cells: An in vitro analysis of the gene expression and growth factors produced. J Plast Reconstr Aesthet Surg. 2019 Aug; 72 (8):1316-1325 Epub 2019 May 09
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Wyles CC, Paradise CR, Houdek MT, Slager SL, Terzic A, Behfar A, van Wijnen AJ, Sierra RJ. CORR(R) ORS Richard A. Brand Award: Disruption in Peroxisome Proliferator-Activated Receptor-gamma (PPARG) Increases Osteonecrosis Risk Through Genetic Variance and Pharmacologic Modulation. Clin Orthop Relat Res. 2019 Aug; 477 (8):1800-1812
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Tibbo ME, Limberg AK, Salib CG, Ahmed AT, van Wijnen AJ, Berry DJ, Abdel MP. Acquired Idiopathic Stiffness After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. J Bone Joint Surg Am. 2019 Jul 17; 101 (14):1320-1330
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Fritz AJ, Gillis NE, Gerrard DL, Rodriguez PD, Hong D, Rose JT, Ghule PN, Bolf EL, Gordon JA, Tye CE, Boyd JR, Tracy KM, Nickerson JA, van Wijnen AJ, Imbalzano AN, Heath JL, Frietze SE, Zaidi SK, Carr FE, Lian JB, Stein JL, Stein GS. Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer. Genes Chromosomes Cancer. 2019 Jul; 58 (7):484-499 Epub 2019 Mar 15
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van Wijnen AJ, Westendorf JJ. Epigenetics as a New Frontier in Orthopedic Regenerative Medicine and Oncology. J Orthop Res. 2019 Jul; 37 (7):1465-1474 Epub 2019 Apr 25
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Hong D, Fritz AJ, Gordon JA, Tye CE, Boyd JR, Tracy KM, Frietze SE, Carr FE, Nickerson JA, Van Wijnen AJ, Imbalzano AN, Zaidi SK, Lian JB, Stein JL, Stein GS. RUNX1-dependent mechanisms in biological control and dysregulation in cancer. J Cell Physiol. 2019 Jun; 234 (6):8597-8609 Epub 2018 Dec 04
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Aghajani Nargesi A, Zhu XY, Hickson LJ, Conley SM, van Wijnen AJ, Lerman LO, Eirin A. Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells. Stem Cell Rev Rep. 2019 Jun; 15 (3):427-438
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Rbia N, Bulstra LF, Thaler R, Hovius SER, van Wijnen AJ, Shin AY. In Vivo Survival of Mesenchymal Stromal Cell-Enhanced Decellularized Nerve Grafts for Segmental Peripheral Nerve Reconstruction. J Hand Surg Am. 2019 Jun; 44 (6):514.e1-514.e11 Epub 2018 Oct 06
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Kakar S, Greene RM, Denbeigh J, Van Wijnen A. Scapholunate Ligament Internal Brace 360 Tenodesis (SLITT) Procedure: A Biomechanical Study. J Wrist Surg. 2019 Jun; 8 (3):250-254 Epub 2018 Sept 18
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Shi C, Wu L, Lin W, Cai Y, Zhang Y, Hu B, Gao R, van Wijnen AJ, Yuan W, Ye X, Im HJ. Corrigendum to "Mir-202-3p regulates interleukin-1beta-induced expression of matrix metalloproteinase 1 in human nucleus pulposus" [Gene 687 (2019) 156-165]. Gene. 2019 May 15; 696:233 Epub 2019 Feb 13
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Pawar AS, Eirin A, Krier JD, Woollard JR, Zhu XY, Lerman A, van Wijnen AJ, Lerman LO. Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome. Stem Cell Res. 2019 May; 37:101423 Epub 2019 Mar 18
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Rojas A, Sepulveda H, Henriquez B, Aguilar R, Opazo T, Nardocci G, Bustos F, Lian JB, Stein JL, Stein GS, van Zundert B, van Wijnen AJ, Allende ML, Montecino M. Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts. J Cell Physiol. 2019 May; 234 (5):6244-6253 Epub 2018 Sept 07
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Hevesi M, Crispim JF, Paggi CA, Dudakovic A, van Genechten W, Hewett T, Kakar S, Krych AJ, van Wijnen AJ, Saris DBF. A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model. Tissue Eng Part C Methods. 2019 Apr; 25 (4):191-196
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Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, Jahn K, Long CL, Schluter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenmaki H, Hesse E. TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone. Nat Commun. 2019 Mar 22; 10 (1):1354
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Rojas A, Mardones R, Pritzker K, van Wijnen AJ, Galindo MA, Las Heras F. Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells. Gene. 2019 Mar 1; 687:228-237 Epub 2018 Nov 14
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Shi C, Wu L, Lin W, Cai Y, Zhang Y, Hu B, Gao R, Im HJ, Yuan W, Ye X, van Wijnen AJ. MiR-202-3p regulates interleukin-1beta-induced expression of matrix metalloproteinase 1 in human nucleus pulposus. Gene. 2019 Mar 1; 687:156-165 Epub 2018 Nov 17
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Das V, Kc R, Li X, Varma D, Qiu S, Kroin JS, Forsyth CB, Keshavarzian A, van Wijnen AJ, Park TJ, Stein GS, O-Sullivan I, Burris TP, Im HJ. Corrigendum to "Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain" [GENE 655 (2018) 1-12]. Gene. 2019 Jan 5; 680:105 Epub 2018 June 12
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Jang JS, Li Y, Mitra AK, Bi L, Abyzov A, van Wijnen AJ, Baughn LB, Van Ness B, Rajkumar V, Kumar S, Jen J. Molecular signatures of multiple myeloma progression through single cell RNA-Seq. Blood Cancer J. 2019 Jan 3; 9 (1):2 Epub 2019 Jan 03
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Aquino-Martinez R, Farr JN, Weivoda MM, Negley BA, Onken JL, Thicke BS, Fulcer MM, Fraser DG, van Wijnen AJ, Khosla S, Monroe DG. miR-219a-5p Regulates Rorß During Osteoblast Differentiation and in Age-related Bone Loss. J Bone Miner Res. 2019 Jan; 34(1):135-144. Epub 2018 Oct 15.
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Takai H, van Wijnen AJ, Ogata Y. Induction of chondrogenic or mesenchymal stem cells from human periodontal ligament cells through inhibition of Twist2 or Klf12. J Oral Sci. 2019; 61 (2):313-320
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Camilleri ET, Dudakovic A, Riester SM, Galeano-Garces C, Paradise CR, Bradley EW, McGee-Lawrence ME, Im HJ, Karperien M, Krych AJ, Westendorf JJ, Larson AN, van Wijnen AJ. Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development. J Biol Chem. 2018 Dec 7; 293 (49):19001-19011 Epub 2018 Oct 16
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Sanders T, Wenger DE, Ashraf A, McIntosh AL, Stans AA, Shaughnessy WJ, van Wijnen AJ, Larson AN. Treatment of Pediatric Osteoid Osteomas Not Amenable to Radiofrequency Ablation: A Retrospective Review of Surgical Outcomes. J Surg Orthop Adv. 2018 Winter; 27 (4):299-302
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Lewallen EA, van Wijnen AJ, Bonin CA, Lovejoy NR. Flyingfish (Exocoetidae) species diversity and habitats in the eastern tropical Pacific Ocean. Mar Biodivers. 2018 Dec; 48 (4):1755-1765 Epub 2017 Mar 09
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Das V, Kc R, Li X, Varma D, Qiu SJ, Kroin JS, Forsyth CB, Keshavarzian A, van Wijnen AJ, Park TJ, Stein GS, O-Sullivan I, Burris TP, Im HJ. Blockade of vascular endothelial growth factor receptor-1 (flt-1), reveals a novel analgesic for osteoarthritis-induced joint pain (vol 11, pg 94, 2018) Gene Reports. 2018 Dec; 13:234
Hong D, Fritz AJ, Zaidi SK, van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity. J Cell Physiol. 2018 Dec; 233 (12):9136-9144 Epub 2018 July 03
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Araya HF, Sepulveda H, Lizama CO, Vega OA, Jerez S, Briceno PF, Thaler R, Riester SM, Antonelli M, Salazar-Onfray F, Rodriguez JP, Moreno RD, Montecino M, Charbonneau M, Dubois CM, Stein GS, van Wijnen AJ, Galindo MA. Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2. J Cell Biochem. 2018 Nov; 119 (10):8204-8219 Epub 2018 June 19
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Arsoy D, Salib CG, Trousdale WH, Tibbo ME, Limberg AK, Viste A, Lewallen EA, Reina N, Yaszemski MJ, Berry DJ, van Wijnen AJ, Morrey ME, Sanchez-Sotelo J, Abdel MP. Joint contracture is reduced by intra-articular implantation of rosiglitazone-loaded hydrogels in a rabbit model of arthrofibrosis. J Orthop Res. 2018 Nov; 36 (11):2949-2955 Epub 2018 July 13
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Wagner ER, Parry J, Dadsetan M, Bravo D, Riester SM, Van Wijnen AJ, Yaszemski MJ, Kakar S. VEGF-mediated angiogenesis and vascularization of a fumarate-crosslinked polycaprolactone (PCLF) scaffold. Connect Tissue Res. 2018 Nov; 59 (6):542-549 Epub 2018 Mar 07
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Bravo D, Salduz A, Shogren KL, Okuno MN, Herrick JL, Okuno SH, Galindo M, van Wijnen AJ, Yaszemski MJ, Maran A. Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients. Gene. 2018 Oct 20; 674:1-7 Epub 2018 June 19
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Hevesi M, Hartigan DE, Wu IT, Wyles CC, Desai VS, van Wijnen AJ, Saris DBF, Levy BA, Krych AJ. The Rapidly Assessed Predictor of Intraoperative Damage (RAPID) Score: An In-Clinic Predictive Model for High-Grade Acetabular Chondrolabral Disruption. Orthop J Sports Med. 2018 Oct; 6 (10):2325967118799068 Epub 2018 Oct 03
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Meng Y, Eirin A, Zhu XY, Tang H, Hickson LJ, Lerman A, van Wijnen AJ, Lerman LO. Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway. Cell Transplant. 2018 Oct; 27 (10):1495-1503 Epub 2018 Sept 06
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Shi C, Das V, Li X, Kc R, Qiu S, O-Sullivan I, Ripper RL, Kroin JS, Mwale F, Wallace AA, Zhu B, Zhao L, van Wijnen AJ, Ji M, Lu J, Votta-Velis G, Yuan W, Im HJ. Development of an in vivo mouse model of discogenic low back pain. J Cell Physiol. 2018 Oct; 233 (10):6589-6602 Epub 2018 May 09
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Ghule PN, Seward DJ, Fritz AJ, Boyd JR, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Higher order genomic organization and regulatory compartmentalization for cell cycle control at the G1/S-phase transition. J Cell Physiol. 2018 Oct; 233 (10):6406-6413 Epub 2018 May 10
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Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. Nat Commun. 2018 Sep 7; 9 (1):3634 Epub 2018 Sept 07
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Soreide E, Murad MH, Denbeigh JM, Lewallen EA, Dudakovic A, Nordsletten L, van Wijnen AJ, Kakar S. Treatment of Dupuytren's contracture: a systematic review. Bone Joint J. 2018 Sep; 100-B (9):1138-1145
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Trousdale WH, Salib CG, Reina N, Lewallen EA, Viste A, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Abdel MP. A Drug Eluting Scaffold for the Treatment of Arthrofibrosis. Tissue Eng Part C Methods. 2018 Sep; 24 (9):514-523
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Lewallen EA, Salib CG, Trousdale WH, Berry CE, Hanssen GM, Robin JX, Tibbo ME, Viste A, Reina N, Morrey ME, Sanchez-Sotelo J, Hanssen AD, Berry DJ, van Wijnen AJ, Abdel MP. Molecular pathology of total knee arthroplasty instability defined by RNA-seq. Genomics. 2018 Sep; 110 (5):247-256 Epub 2017 Nov 22
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Paradise CR, Galeano-Garces C, Galeano-Garces D, Dudakovic A, Milbrandt TA, Saris DBF, Krych AJ, Karperien M, Ferguson GB, Evseenko D, Riester SM, van Wijnen AJ, Larson AN. Molecular characterization of physis tissue by RNA sequencing. Gene. 2018 Aug 20; 668:87-96 Epub 2018 May 25
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Dudakovic A, Camilleri ET, Paradise CR, Samsonraj RM, Gluscevic M, Paggi CA, Begun DL, Khani F, Pichurin O, Ahmed FS, Elsayed R, Elsalanty M, McGee-Lawrence ME, Karperien M, Riester SM, Thaler R, Westendorf JJ, van Wijnen AJ. Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice. J Biol Chem. 2018 Aug 17; 293 (33):12894-12907 Epub 2018 June 13
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Samsonraj RM, Paradise CR, Dudakovic A, Sen B, Nair AA, Dietz AB, Deyle DR, Cool SM, Rubin J, van Wijnen AJ. Validation of Osteogenic Properties of Cytochalasin D by High-Resolution RNA-Sequencing in Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissues. Stem Cells Dev. 2018 Aug 15; 27 (16):1136-1145 Epub 2018 July 23
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Rbia N, Bulstra LF, Bishop AT, van Wijnen AJ, Shin AY. A Simple Dynamic Strategy to Deliver Stem Cells to Decellularized Nerve Allografts. Plast Reconstr Surg. 2018 Aug; 142 (2):402-413
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Meng Y, Eirin A, Zhu XY, Tang H, Chanana P, Lerman A, van Wijnen AJ, Lerman LO. Obesity-induced mitochondrial dysfunction in porcine adipose tissue-derived mesenchymal stem cells. J Cell Physiol. 2018 Aug; 233 (8):5926-5936 Epub 2018 Feb 27
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Sterner RM, Kremer KN, Dudakovic A, Westendorf JJ, van Wijnen AJ, Hedin KE. Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis. J Immunol. 2018 Aug 1; 201 (3):1086-1096 Epub 2018 June 18
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Zaidi SK, Fritz AJ, Tracy KM, Gordon JA, Tye CE, Boyd J, Van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Nuclear organization mediates cancer-compromised genetic and epigenetic control. Adv Biol Regul. 2018 Aug; 69:1-10 Epub 2018 May 09
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Sahebi M, Hanafi MM, van Wijnen AJ, Rice D, Rafii MY, Azizi P, Osman M, Taheri S, Bakar MFA, Isa MNM, Noor YM. Contribution of transposable elements in the plant's genome. Gene. 2018 Jul 30; 665:155-166 Epub 2018 Apr 22
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Feigenson M, Shull LC, Taylor EL, Camilleri ET, Riester SM, van Wijnen AJ, Bradley EW, Westendorf JJ. Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development. J Bone Miner Res. 2017 Dec; 32 (12):2453-2465 Epub 2017 Sept 18
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van Wijnen AJ, Abdel MP. Vitamin-D Supplementation: A Low-Risk, High-Gain Therapy to Prevent PJI?: Commentary on an article by Vishal Hegde, MD, et al.: "Single-Dose, Preoperative Vitamin-D Supplementation Decreases Infection in a Mouse Model of Periprosthetic Joint Infection". J Bone Joint Surg Am 2017 Oct 18; 99 (20):e110
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Maradit Kremers H, Schleck CD, Lewallen EA, Larson DR, Van Wijnen AJ, Lewallen DG. Diabetes Mellitus and Hyperglycemia and the Risk of Aseptic Loosening in Total Joint Arthroplasty. J Arthroplasty. 2017 Sep; 32 (9S):S251-S253 Epub 2017 Mar 02
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Eirin A, Zhu XY, Puranik AS, Tang H, McGurren KA, van Wijnen AJ, Lerman A, Lerman LO. Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation. Kidney Int. 2017 Jul; 92 (1):114-124 Epub 2017 Feb 24
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Wagner ER, Parry J, Dadsetan M, Bravo D, Riester SM, van Wijnen AJ, Yaszemski MJ, Kakar S. Chondrocyte Attachment, Proliferation, and Differentiation on Three-Dimensional Polycaprolactone Fumarate Scaffolds. Tissue Eng Part A. 2017 Jul; 23 (13-14):622-629 Epub 2017 Mar 31
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Morrey ME, Abdel MP, Riester SM, Dudakovic A, van Wijnen AJ, Morrey BF, Sanchez-Sotelo J. Molecular landscape of arthrofibrosis: Microarray and bioinformatic analysis of the temporal expression of 380 genes during contracture genesis. Gene. 2017 Apr 30; 610:15-23 Epub 2017 Feb 03
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van de Peppel J, Strini T, Tilburg J, Westerhoff H, van Wijnen AJ, van Leeuwen JP. Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics. Stem Cell Reports. 2017 Apr 11; 8 (4):947-960 Epub 2017 Mar 23
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Parry JA, Olthof MG, Shogren KL, Dadsetan M, Van Wijnen A, Yaszemski M, Kakar S. Three-Dimension-Printed Porous Poly(Propylene Fumarate) Scaffolds with Delayed rhBMP-2 Release for Anterior Cruciate Ligament Graft Fixation. Tissue Eng Part A. 2017 Apr; 23 (7-8):359-365 Epub 2017 Feb 09
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Walker JA, Ewald TJ, Lewallen E, Van Wijnen A, Hanssen AD, Morrey BF, Morrey ME, Abdel MP, Sanchez-Sotelo J. Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints. Bone Joint Res. 2017 Mar; 6 (3):162-171
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Jerez S, Araya H, Thaler R, Charlesworth MC, Lopez-Solis R, Kalergis AM, Cespedes PF, Dudakovic A, Stein GS, van Wijnen AJ, Galindo M. Proteomic Analysis of Exosomes and Exosome-Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals Secretion of Proteins Related to Tumor Progression. J Cell Biochem. 2017 Feb; 118 (2):351-360 Epub 2016 Aug 15
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Maria S, Swanson MH, Enderby LT, D'Amico F, Enderby B, Samsonraj RM, Dudakovic A, van Wijnen AJ, Witt-Enderby PA. Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures. Aging (Albany NY). 2017 Jan 26; 9 (1):256-285
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Tai PWL, Wu H, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Genome-wide DNase hypersensitivity, and occupancy of RUNX2 and CTCF reveal a highly dynamic gene regulome during MC3T3 pre-osteoblast differentiation. PLoS One. 2017; 12 (11):e0188056 Epub 2017 Nov 27
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Bonin CA, Lewallen EA, Van Wijnen AJ, Cremer MJ. Habitat preference and behaviour of the Guiana dolphin (Sotalia guianensis) in a well-preserved estuary off Southern Brazil Pakistan Journal of Zoology. 2017; 49 (6):2235-42
Jo S, Lewallen EA, Morrey LB, Riester SM, Trousdale WH, Salib CG, Reina N, Yaszemski MJ, Sanchez-Sotelo J, Morrey ME, van Wijnen AJ, Abdel MP. Biopolymer-based intra-articular delivery of DKK1 into the contracted rabbit knee Gene Reports. 2017; 8:69-74. Epub 1900 Jan 01.
Eirin A, Zhu XY, Puranik AS, Woollard JR, Tang H, Dasari S, Lerman A, van Wijnen AJ, Lerman LO. Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells. PLoS One. 2017; 12 (3):e0174303 Epub 2017 Mar 23
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Zaidi SK, Lian JB, van Wijnen A, Stein JL, Stein GS. Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth. Adv Exp Med Biol. 2017; 962:95-102
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Lee JW, van Wijnen A, Bae SC. RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras? Adv Exp Med Biol. 2017; 962:321-332
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Kc R, Li X, Kroin JS, Liu Z, Chen D, Xiao G, Levine B, Li J, Hamilton JL, van Wijnen AJ, Piel M, Shelly DA, Brass D, Kolb E, Im HJ. PKCdelta null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth. Ann Rheum Dis. 2016 Dec; 75 (12):2133-2141 Epub 2016 Jan 18
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Taipaleenmaki H, Farina NH, van Wijnen AJ, Stein JL, Hesse E, Stein GS, Lian JB. Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells. Oncotarget. 2016 Nov 29; 7 (48):79032-79046
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Dudakovic A, Camilleri ET, Riester SM, Paradise CR, Gluscevic M, O'Toole TM, Thaler R, Evans JM, Yan H, Subramaniam M, Hawse JR, Stein GS, Montecino MA, McGee-Lawrence ME, Westendorf JJ, van Wijnen AJ. Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice. J Biol Chem. 2016 Nov 18; 291 (47):24594-24606 Epub 2016 Oct 10
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Ghule PN, Xie RL, Colby JL, Rivera-Perez JA, Jones SN, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos. Dev Biol. 2016 Nov 15; 419 (2):311-320 Epub 2016 Sept 05
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Barutcu AR, Hong D, Lajoie BR, McCord RP, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS. RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells. Biochim Biophys Acta. 2016 Nov; 1859 (11):1389-1397 Epub 2016 Aug 09
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Lin Y, Lewallen EA, Camilleri ET, Bonin CA, Jones DL, Dudakovic A, Galeano-Garces C, Wang W, Karperien MJ, Larson AN, Dahm DL, Stuart MJ, Levy BA, Smith J, Ryssman DB, Westendorf JJ, Im HJ, van Wijnen AJ, Riester SM, Krych AJ. RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes. J Orthop Res. 2016 Nov; 34 (11):1950-1959 Epub 2016 Mar 03
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Eirin A, Zhu XY, Puranik AS, Woollard JR, Tang H, Dasari S, Lerman A, van Wijnen AJ, Lerman LO. Comparative proteomic analysis of extracellular vesicles isolated from porcine adipose tissue-derived mesenchymal stem/stromal cells. Sci Rep. 2016 Oct 27; 6:36120
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Lewallen EA, Bonin CA, Li X, Smith J, Karperien M, Larson AN, Lewallen DG, Cool SM, Westendorf JJ, Krych AJ, Leontovich AA, Im HJ, van Wijnen AJ. The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes. Gene. 2016 Oct 15; 591 (2):456-64 Epub 2016 July 01
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Kroin JS, Kc R, Li X, Hamilton JL, Das V, van Wijnen AJ, Dall OM, Shelly DA, Kenworth T, Im HJ. Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model. Gene. 2016 Oct 10; 591 (1):1-5 Epub 2016 June 26
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Ewald TJ, Walker JA, Lewallen EA, Trousdale WH, Yaszemski MJ, Hanssen AD, Morrey BF, van Wijnen AJ, Sanchez-Sotelo J, Morrey ME, Abdel MP. Safety of Intra-Articular Implantation of Oligo[Poly(ethylene glycol) Fumarate] Scaffolds into the Rabbit Knee. Tissue Eng Part C Methods. 2016 Oct; 22 (10):991-998
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Saad A, Zhu XY, Herrmann S, Hickson L, Tang H, Dietz AB, van Wijnen AJ, Lerman L, Textor S. Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia. Stem Cell Res Ther. 2016 Sep 9; 7 (1):128 Epub 2016 Sept 09
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Morhayim J, van de Peppel J, Braakman E, Rombouts EW, Ter Borg MN, Dudakovic A, Chiba H, van der Eerden BC, Raaijmakers MH, van Wijnen AJ, Cornelissen JJ, van Leeuwen JP. Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells. Sci Rep. 2016 Sep 2; 6:32034 Epub 2016 Sept 02
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Onishi K, Jones DL, Riester SM, Lewallen EA, Lewallen DG, Sellon JL, Dietz AB, Qu W, van Wijnen AJ, Smith J. Human Adipose-Derived Mesenchymal Stromal/Stem Cells Remain Viable and Metabolically Active Following Needle Passage. PM R. 2016 Sep; 8 (9):844-54 Epub 2016 Jan 28
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Barutcu AR, Lajoie BR, Fritz AJ, McCord RP, Nickerson JA, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Stein GS, Imbalzano AN. SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells. Genome Res. 2016 Sep; 26 (9):1188-201 Epub 2016 July 19
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Kremers HM, Lewallen EA, van Wijnen AJ, Lewallen DG. Clinical Factors, Disease Parameters, and Molecular Therapies Affecting Osseointegration of Orthopedic Implants. Curr Mol Biol Rep. 2016 Sep; 2 (3):123-132 Epub 2016 June 29
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Camilleri ET, Gustafson MP, Dudakovic A, Riester SM, Garces CG, Paradise CR, Takai H, Karperien M, Cool S, Sampen HJ, Larson AN, Qu W, Smith J, Dietz AB, van Wijnen AJ. Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production. Stem Cell Res Ther. 2016 Aug 11; 7 (1):107
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Sahebi M, Hanafi MM, van Wijnen AJ, Azizi P, Abiri R, Ashkani S, Taheri S. Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins. Gene. 2016 Aug 10; 587: (2)107-19.
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Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ. Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling. Sci Signal. 2016 Aug 9; 9 (440):ra79 Epub 2016 Aug 09
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Aguilar R, Bustos FJ, Saez M, Rojas A, Allende ML, van Wijnen AJ, van Zundert B, Montecino M. Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus. Biochim Biophys Acta. 2016 Aug; 1859 (8):1043-55 Epub 2016 May 20
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Riester SM, Arsoy D, Camilleri ET, Dudakovic A, Paradise CR, Evans JM, Torres-Mora J, Rizzo M, Kloen P, Kruithof-de Julio M, van Wijnen AJ, Kakar S. Erratum to: RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren's disease. BMC Med Genomics. 2016 Jul 13; 9 (1):34 Epub 2016 July 13
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Wu Q, Madany P, Dobson JR, Schnabl JM, Sharma S, Smith TC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Muthuswami R, Imbalzano AN, Nickerson JA. The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation. Oncotarget. 2016 Jun 21; 7 (25):38270-38281
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Fang D, Gan H, Lee JH, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu RM, Westendorf JJ, Zhang Z. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016 Jun 10; 352 (6291):1344-8 Epub 2016 May 26
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Riester S, Ramaesch R, Wenger D, van Wijnen A, Kakar S. Predicting Fracture Risk for Enchondroma of the Hand. Hand (N Y). 2016 Jun; 11 (2):206-10 Epub 2016 Feb 02
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Lewallen EA, Jones DL, Dudakovic A, Thaler R, Paradise CR, Kremers HM, Abdel MP, Kakar S, Dietz AB, Cohen RC, Lewallen DG, van Wijnen AJ. Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene. 2016 May 1; 581 (2):95-106 Epub 2016 Jan 13
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Varela N, Aranguiz A, Lizama C, Sepulveda H, Antonelli M, Thaler R, Moreno RD, Montecino M, Stein GS, van Wijnen AJ, Galindo M. Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells. J Cell Physiol. 2016 May; 231 (5):1001-14 Epub 2015 Sept 18
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Barrett I, King AH, Riester S, van Wijnen A, Levy BA, Stuart MJ, Krych AJ. Internal Fixation of Unstable Osteochondritis Dissecans in the Skeletally Mature Knee with Metal Screws. Cartilage. 2016 Apr; 7 (2):157-62 Epub 2015 Dec 30
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Thaler R, Maurizi A, Roschger P, Sturmlechner I, Khani F, Spitzer S, Rumpler M, Zwerina J, Karlic H, Dudakovic A, Klaushofer K, Teti A, Rucci N, Varga F, van Wijnen AJ. Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate. J Biol Chem. 2016 Mar 25; 291(13):6754-71. Epub 2016 Jan 12.
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Grandy RA, Whitfield TW, Wu H, Fitzgerald MP, VanOudenhove JJ, Zaidi SK, Montecino MA, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation. Mol Cell Biol. 2016 Feb 15; 36 (4):615-27 Epub 2015 Dec 07
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Getzlaf MA, Lewallen EA, Kremers HM, Jones DL, Bonin CA, Dudakovic A, Thaler R, Cohen RC, Lewallen DG, van Wijnen AJ. Multi-disciplinary antimicrobial strategies for improving orthopaedic implants to prevent prosthetic joint infections in hip and knee. J Orthop Res. 2016 Feb; 34 (2):177-86 Epub 2015 Dec 29
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Ling L, Camilleri ET, Helledie T, Samsonraj RM, Titmarsh DM, Chua RJ, Dreesen O, Dombrowski C, Rider DA, Galindo M, Lee I, Hong W, Hui JH, Nurcombe V, van Wijnen AJ, Cool SM. Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells. Gene. 2016 Jan 15; 576 (1 Pt 2):292-303 Epub 2015 Oct 17
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Bonin CA, Lewallen EA, Baheti S, Bradley EW, Stuart MJ, Berry DJ, van Wijnen AJ, Westendorf JJ. Identification of differentially methylated regions in new genes associated with knee osteoarthritis. Gene. 2016 Jan 15; 576 (1 Pt 2):312-8 Epub 2015 Oct 17
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Lewallen EA, Bohonak AJ, Bonin CA, van Wijnen AJ, Pitman RL, Lovejoy NR. Population Genetic Structure of the Tropical Two-Wing Flyingfish (Exocoetus volitans). PLoS One. 2016; 11 (10):e0163198 Epub 2016 Oct 13
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Barlow JD, Morrey ME, Hartzler RU, Arsoy D, Riester S, van Wijnen AJ, Morrey BF, Sanchez-Sotelo J, Abdel MP. Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release: A biomechanical, histological, and genetic analysis. Bone Joint Res. 2016 Jan; 5 (1):11-7
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Fritz AJ, Barutcu AR, Martin-Buley L, van Wijnen AJ, Zaidi SK, Imbalzano AN, Lian JB, Stein JL, Stein GS. Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus. J Cell Biochem. 2016 Jan; 117 (1):9-19
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Ewald TJ, Walker JA, Lewallen EA, Trousdale WH, Yaszemski MJ, Hanssen AD, Morrey BF, Van Wijnen AJ, Sanchez-Sotelo J, Morrey ME, Abdel MP. Safety of intra-articular implantation of oligo[Poly(ethylene glycol) Fumarate] scaffolds into the rabbit knee Tissue Engineering - Part C: Methods. 2016; 22: (10)991-8.
Barutcu AR, Fritz AJ, Zaidi SK, van Wijnen AJ, Lian JB, Stein JL, Nickerson JA, Imbalzano AN, Stein GS. C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization. J Cell Physiol. 2016 Jan; 231 (1):31-5
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Kremer KN, Dudakovic A, Hess AD, Smith BD, Karp JE, Kaufmann SH, Westendorf JJ, van Wijnen AJ, Hedin KE. Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1alpha-TAZ Signaling Pathway in Osteoblasts. J Biol Chem. 2015 Dec 4; 290 (49):29478-92 Epub 2015 Oct 21
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Gordon JAR, Stein JL, Westendorf JJ, van Wijnen AJ. Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease. Bone. 2015 Dec; 81:739-745 Epub 2015 Mar 31
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Rojas A, Aguilar R, Henriquez B, Lian JB, Stein JL, Stein GS, van Wijnen AJ, van Zundert B, Allende ML, Montecino M. Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B. J Biol Chem. 2015 Nov 20; 290 (47):28329-28342 Epub 2015 Oct 09
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Dudakovic A, Camilleri ET, Xu F, Riester SM, McGee-Lawrence ME, Bradley EW, Paradise CR, Lewallen EA, Thaler R, Deyle DR, Larson AN, Lewallen DG, Dietz AB, Stein GS, Montecino MA, Westendorf JJ, van Wijnen AJ. Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2. J Biol Chem. 2015 Nov 13; 290 (46):27604-17 Epub 2015 Sept 30
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Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, Browne G, Colby JL, Winter GE, Bradner JE, Pratap J, Sluder G, Bhargava R, Chiosea SI, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Nickerson JA, Imbalzano AN. The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation. J Cell Physiol. 2015 Nov; 230 (11):2683-94
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Wagner ER, Bravo D, Dadsetan M, Riester SM, Chase S, Westendorf JJ, Dietz AB, van Wijnen AJ, Yaszemski MJ, Kakar S. Ligament Tissue Engineering Using a Novel Porous Polycaprolactone Fumarate Scaffold and Adipose Tissue-Derived Mesenchymal Stem Cells Grown in Platelet Lysate. Tissue Eng Part A. 2015 Nov; 21 (21-22):2703-13
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Kim JS, Ahmadinia K, Li X, Hamilton JL, Andrews S, Haralampus CA, Xiao G, Sohn HM, You JW, Seo YS, Stein GS, Van Wijnen AJ, Kim SG, Im HJ. Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis. J Cell Physiol. 2015 Nov; 230 (11):2837-47
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Riester SM, Arsoy D, Camilleri ET, Dudakovic A, Paradise CR, Evans JM, Torres-Mora J, Rizzo M, Kloen P, Julio MK, van Wijnen AJ, Kakar S. RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren's disease. BMC Med Genomics. 2015 Oct 7; 8:59 Epub 2015 Oct 07
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Bradley EW, Carpio LR, van Wijnen AJ, McGee-Lawrence ME, Westendorf JJ. Histone Deacetylases in Bone Development and Skeletal Disorders. Physiol Rev. 2015 Oct; 95 (4):1359-81
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Lenertz LY, Baughman CJ, Waldschmidt NV, Thaler R, van Wijnen AJ. Control of bone development by P2X and P2Y receptors expressed in mesenchymal and hematopoietic cells. Gene. 2015 Oct 1; 570 (1):1-7 Epub 2015 June 14
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Browne G, Taipaleenmaki H, Bishop NM, Madasu SC, Shaw LM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion. J Cell Physiol. 2015 Oct; 230 (10):2522-32
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Barutcu AR, Lajoie BR, McCord RP, Tye CE, Hong D, Messier TL, Browne G, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS. Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells. Genome Biol. 2015 Sep 28; 16:214 Epub 2015 Sept 28
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Kc R, Li X, Voigt RM, Ellman MB, Summa KC, Vitaterna MH, Keshavarizian A, Turek FW, Meng QJ, Stein GS, van Wijnen AJ, Chen D, Forsyth CB, Im HJ. Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint. J Cell Physiol. 2015 Sep; 230 (9):2174-2183
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Georgi N, Taipaleenmaki H, Raiss CC, Groen N, Portalska KJ, van Blitterswijk C, de Boer J, Post JN, van Wijnen AJ, Karperien M. MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors. Stem Cells Dev. 2015 Aug 15; 24 (16):1946-55 Epub 2015 June 17
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Ling L, Tan SK, Goh TH, Cheung E, Nurcombe V, van Wijnen AJ, Cool SM. Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy. Mol Cancer. 2015 Jul 23; 14:136 Epub 2015 July 23
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Wang Z, Perez-Terzic CM, Smith J, Mauck WD, Shelerud RA, Maus TP, Yang TH, Murad MH, Gou S, Terry MJ, Dauffenbach JP, Pingree MJ, Eldrige JS, Mohammed K, Benkhadra K, van Wijnen AJ, Qu W. Efficacy of intervertebral disc regeneration with stem cells - a systematic review and meta-analysis of animal controlled trials. Gene. 2015 Jun 10; 564 (1):1-8 Epub 2015 Mar 19
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Suijker J, Oosting J, Koornneef A, Struys EA, Salomons GS, Schaap FG, Waaijer CJ, Wijers-Koster PM, Briaire-de Bruijn IH, Haazen L, Riester SM, Dudakovic A, Danen E, Cleton-Jansen AM, van Wijnen AJ, Bovee JV. Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines. Oncotarget. 2015 May 20; 6 (14):12505-19
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Karkampouna S, Kloen P, Obdeijn MC, Riester SM, van Wijnen AJ, Kruithof-de Julio M. Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions. J Vis Exp. 2015 Apr 18; (98)
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Trombly DJ, Whitfield TW, Padmanabhan S, Gordon JA, Lian JB, van Wijnen AJ, Zaidi SK, Stein JL, Stein GS. Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells. BMC Genomics. 2015 Apr 17; 16:309
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Taipaleenmaki H, Browne G, Akech J, Zustin J, van Wijnen AJ, Stein JL, Hesse E, Stein GS, Lian JB. Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease. Cancer Res. 2015 Apr 1; 75 (7):1433-44 Epub 2015 Jan 29
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Thaler R, Sturmlechner I, Spitzer S, Riester SM, Rumpler M, Zwerina J, Klaushofer K, van Wijnen AJ, Varga F. Acute-phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis. FASEB J. 2015 Apr; 29(4):1344-59. Epub 2014 Dec 09.
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Lewallen EA, Riester SM, Bonin CA, Kremers HM, Dudakovic A, Kakar S, Cohen RC, Westendorf JJ, Lewallen DG, van Wijnen AJ. Biological strategies for improved osseointegration and osteoinduction of porous metal orthopedic implants. Tissue Eng Part B Rev. 2015 Apr; 21 (2):218-30 Epub 2014 Dec 18
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Yang S, Quaresma AJ, Nickerson JA, Green KM, Shaffer SA, Imbalzano AN, Martin-Buley LA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response. J Cell Sci. 2015 Feb 15; 128 (4):728-40 Epub 2015 Jan 20
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Gu SX, Li X, Hamilton JL, Chee A, Kc R, Chen D, An HS, Kim JS, Oh CD, Ma YZ, van Wijnen AJ, Im HJ. MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. Gene. 2015 Jan 25; 555 (2):80-7 Epub 2014 Oct 12
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Eirin A, Zhu XY, Ferguson CM, Riester SM, van Wijnen AJ, Lerman A, Lerman LO. Intra-renal delivery of mesenchymal stem cells attenuates myocardial injury after reversal of hypertension in porcine renovascular disease. Stem Cell Res Ther. 2015 Jan 19; 6:7
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Eirin A, Zhu XY, Ebrahimi B, Krier JD, Riester SM, van Wijnen AJ, Lerman A, Lerman LO. Intrarenal Delivery of Mesenchymal Stem Cells and Endothelial Progenitor Cells Attenuates Hypertensive Cardiomyopathy in Experimental Renovascular Hypertension. Cell Transplant. 2015; 24 (10):2041-53 Epub 2014 Nov 21
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Galea GL, Meakin LB, Savery D, Taipaleenmaki H, Delisser P, Stein GS, Copp AJ, Van Wijnen AJ, Lanyon LE, Price JS. Planar cell polarity aligns osteoblast division in response to substrate strain. J Bone Miner Res. 2015; 30(3):411-23.
Dudakovic A, Camilleri ET, Lewallen EA, McGee-Lawrence ME, Riester SM, Kakar S, Montecino M, Stein GS, Ryoo HM, Dietz AB, Westendorf JJ, van Wijnen AJ. Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells. J Cell Physiol. 2015 Jan; 230 (1):52-62
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Kapinas K, Kim H, Mandeville M, Martin-Buley LA, Croce CM, Lian JB, Van Wijnen AJ, Stein JL, Altieri DC, Stein GS. Microrna-mediated survivin control of pluripotency. J Cell Physiol. 2015 Jan; 230(1):63-70.
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Okolicsanyi RK, Camilleri ET, Oikari LE, Yu C, Cool SM, van Wijnen AJ, Griffiths LR, Haupt LM. Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion. PLoS One. 2015; 10 (9):e0137255 Epub 2015 Sept 10
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Hunt CL, Shen S, Nassr A, van Wijnen AJ, Larson AN, Eldrige JS, Mauck WD, Pingree MJ, Erwin PJ, Bydon M, Qu W. Current understanding of safety and efficacy of stem cell therapy for discogenic pain. A systematic review of human studies Techniques in Regional Anesthesia and Pain Management. 2015; 19(1-2):32-7. Epub 1900 Jan 01.
Yang XC, Sabath I, Kunduru L, van Wijnen AJ, Marzluff WF, Dominski Z. A conserved interaction that is essential for the biogenesis of histone locus bodies. J Biol Chem. 2014 Dec 5; 289 (49):33767-82 Epub 2014 Oct 22
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Bledsoe KL, McGee-Lawrence ME, Camilleri ET, Wang X, Riester SM, van Wijnen AJ, Oliveira AM, Westendorf JJ. RUNX3 facilitates growth of Ewing sarcoma cells. J Cell Physiol. 2014 Dec; 229 (12):2049-56
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Lopez-Camacho C, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Cbf beta and the leukemogenic fusion protein cbf beta-smmhc associate with mitotic chromosomes to epigenetically regulate ribosomal genes. J Cell Biochem. 2014 Dec; 15(12):2155-64.
Eirin A, Riester SM, Zhu XY, Tang H, Evans JM, O'Brien D, van Wijnen AJ, Lerman LO. MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells. Gene. 2014 Nov 1; 551 (1):55-64 Epub 2014 Aug 23
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Tai PW, Wu H, Gordon JA, Whitfield TW, Barutcu AR, van Wijnen AJ, Lian JB, Stein GS, Stein JL. Epigenetic landscape during osteoblastogenesis defines a differentiation-dependent Runx2 promoter region. Gene. 2014 Oct 15; 550 (1):1-9 Epub 2014 June 02
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Dudakovic A, Camilleri E, Riester SM, Lewallen EA, Kvasha S, Chen X, Radel DJ, Anderson JM, Nair AA, Evans JM, Krych AJ, Smith J, Deyle DR, Stein JL, Stein GS, Im HJ, Cool SM, Westendorf JJ, Kakar S, Dietz AB, van Wijnen AJ. High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells. J Cell Biochem. 2014 Oct; 115 (10):1816-28
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McGee-Lawrence ME, Carpio LR, Bradley EW, Dudakovic A, Lian JB, van Wijnen AJ, Kakar S, Hsu W, Westendorf JJ. Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice. Bone. 2014 Sep; 66:277-86 Epub 2014 June 25
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Cho YD, Yoon WJ, Kim WJ, Woo KM, Baek JH, Lee G, Ku Y, van Wijnen AJ, Ryoo HM. Epigenetic modifications and canonical wingless/int-1 class (WNT) signaling enable trans-differentiation of nonosteogenic cells into osteoblasts. J Biol Chem. 2014 Jul 18; 289 (29):20120-8 Epub 2014 May 27
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Kremer KN, Dudakovic A, McGee-Lawrence ME, Philips RL, Hess AD, Smith BD, van Wijnen AJ, Karp JE, Kaufmann SH, Westendorf JJ, Hedin KE. Osteoblasts protect aml cells from sdf-1-induced apoptosis. J Cell Biochem. 2014 Jun; 115(6):1128-37.
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Okolicsanyi RK, van Wijnen AJ, Cool SM, Stein GS, Griffiths LR, Haupt LM. Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity. J Cell Biochem. 2014 May; 115(5):967-76.
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Kim JH, Jang JW, Lee YS, Lee JW, Chi XZ, Li YH, Kim MK, Kim DM, Choi BS, Kim J, Kim HM, van Wijnen A, Park I, Bae SC. RUNX family members are covalently modified and regulated by PIAS1-mediated sumoylation. Oncogenesis. 2014 Apr 28; 3:e101
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Riester S, van Wijnen A, Rizzo M, Kakar S. Pathogenesis and Treatment of Dupuytren Disease. JBJS Rev. 2014 Apr 8; 2 (4)
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Piel MJ, Kroin JS, van Wijnen AJ, Kc R, Im HJ. Pain assessment in animal models of osteoarthritis. Gene. 2014 Mar 10; 537 (2):184-8 Epub 2013 Dec 10
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Zaidi SK, Grandy RA, Lopez-Camacho C, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes? Cancer Res. 2014 Jan 15; 74 (2):420-5 Epub 2014 Jan 09
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Barutcu AR, Tai PWL, Wu H, Gordon JAR, Whitfield TW, Dobson JR, Imbalzano AN, Lian JB, Van Wijnen AJ, Stein JL, Stein GS. The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter. Nucleic Acids Res. 2014; 42(16):10360-72.
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Dobson JR, Taipaleenmaki H, Hu YJ, Hong D, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Pratap J. hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3. Cancer Cell Int. 2014; 14:73 Epub 2014 Aug 02
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Ghule PN, Xie RL, Medina R, Colby JL, Jones SN, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Fidelity of histone gene regulation is obligatory for genome replication and stability. Mol Cell Biol. 2014; 34(14):2650-9.
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Lopez-Camacho C, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Core binding factor beta (CBF beta) is retained in the midbody during cytokinesis. J Cell Physiol. 2014; 229(10):1466-74.
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Aguilar R, Grandy R, Meza D, Sepulveda H, Pihan P, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. A functional N-terminal domain in C/EBP beta-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. J Cell Physiol. 2014; 229(10):1521-8.
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Martin JW, Chilton-MacNeill S, Koti M, van Wijnen AJ, Squire JA, Zielenska M. Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma. PLoS One. 2014; 9 (5):e95843 Epub 2014 May 16
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Leblanc KT, Walcott ME, Gaur T, O'Connell SL, Basil K, Tadiri CP, Mason-Savas A, Silva JA, van Wijnen AJ, Stein JL, Stein GS, Ayers DC, Lian JB, Fanning PJ. Runx1 activities in superficial zone chondrocytes, osteoarthritic chondrocyte clones and response to mechanical loading. J Cell Physiol. 2014; 230(2):440-8.
Tai PWL, Zaidi SK, Wu H, Grandy RA, Montecino M, Van Wijnen AJ, Lian JB, Stein GS, Stein JL. The dynamic architectural and epigenetic nuclear landscape: Developing the genomic almanac of biology and disease. J Cell Physiol. 2014; 229(6):711-27.
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Li X, Kroin JS, Kc R, Gibson G, Chen D, Corbett GT, Pahan K, Fayyaz S, Kim JS, van Wijnen AJ, Suh J, Kim SG, Im HJ. Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints. J Bone Miner Res. 2013 Dec; 28(12):2512-22.
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Yoon WJ, Islam R, Cho YD, Woo KM, Baek JH, Uchida T, Komori T, van Wijnen A, Stein JL, Lian JB, Stein GS, Choi JY, Bae SC, Ryoo HM. Pin1-mediated Runx2 modification is critical for skeletal development. J Cell Physiol. 2013 Dec; 228(12):2377-85.
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Dowdy CR, Frederick D, Zaidi SK, Colby JL, Lian JB, van Wijnen AJ, Gerstein RM, Stein JL, Stein GS. A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation. Exp Hematol. 2013 Nov; 41(11):980-991.e1. Epub 2013 Jun 30.
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Zaidi SK, Van Wijnen AJ, Lian JB, Stein JL, Stein GS. Targeting deregulated epigenetic control in cancer. J Cell Physiol. 2013 Nov; 228(11):2103-8.
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Dudakovic A, Evans JM, Li Y, Middha S, McGee-Lawrence ME, van Wijnen AJ, Westendorf JJ. Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces Akt phosphorylation. J Biol Chem. 2013 Oct 4; 288(40):28783-91. Epub 2013 Aug 12.
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Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ, Im HJ. A current review of molecular mechanisms regarding osteoarthritis and pain. Gene. 2013 Sep 25; 527(2):440-7. Epub 2013 Jul 02.
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Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Szabo G, Hoskin DW, Buechter DD, Van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep; 228(9):1884-96.
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Pande S, Browne G, Padmanabhan S, Zaidi SK, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells. J Cell Physiol. 2013 Aug; 228(8):1784-92.
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van der Deen M, Taipaleenmaki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ. MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. J Biol Chem. 2013 Jul 19; 288 (29):21307-21319 Epub 2013 May 29
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van Wijnen AJ, van de Peppel J, van Leeuwen JP, Lian JB, Stein GS, Westendorf JJ, Oursler MJ, Im HJ, Taipaleenmaki H, Hesse E, Riester S, Kakar S. MicroRNA functions in osteogenesis and dysfunctions in osteoporosis. Curr Osteoporos Rep. 2013 Jun; 11 (2):72-82
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Lucero CM, Vega OA, Osorio MM, Tapia JC, Antonelli M, Stein GS, van Wijnen AJ, Galindo MA. The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines. J Cell Physiol. 2013 Apr; 228(4):714-23.
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Galea GL, Meakin LB, Sugiyama T, Zebda N, Sunters A, Taipaleenmaki H, Stein GS, van Wijnen AJ, Lanyon LE, Price JS. Estrogen receptor alpha mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor beta. J Biol Chem. 2013 Mar 29; 288(13):9035-48. Epub 2013 Jan 29.
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Yan D, Chen D, Hawse JR, van Wijnen AJ, Im HJ. Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes. Gene. 2013 Mar 15; 517(1):12-8. Epub 2013 Jan 11.
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McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ. Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice. J Biol Chem. 2013 Feb 22; 288 (8):5291-302 Epub 2013 Jan 07
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Hovhannisyan H, Zhang Y, Hassan MQ, Wu H, Glackin C, Lian JB, Stein JL, Montecino M, Stein GS, van Wijnen AJ. Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene. J Cell Physiol. 2013 Feb; 228(2):313-21.
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Yan D, Chen D, Shen J, Xiao G, van Wijnen AJ, Im HJ. Bovine lactoferricin is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb; 228(2):447-56.
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Dombrowski C, Helledie T, Ling L, Grunert M, Canning CA, Jones CM, Hui JH, Nurcombe V, Van Wijnen AJ, Cool SM. FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21Waf1 and p27Kip1. Stem Cells. 2013; 31(12):2724-36.
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Kapinas K, Grandy R, Ghule P, Medina R, Becker K, Pardee A, Zaidi SK, Lian J, Stein J, van Wijnen A, Stein G. The abbreviated pluripotent cell cycle. J Cell Physiol. 2013 Jan; 228(1):9-20.
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Im HJ, Li X, Chen D, Yan D, Kim J, Ellman MB, Stein GS, Cole B, Kc R, Cs-Szabo G, van Wijnen AJ. Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells. J Cell Physiol. 2012 Oct; 227(10):3488-97.
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Bhakta G, Rai B, Lim ZX, Hui JH, Stein GS, van Wijnen AJ, Nurcombe V, Prestwich GD, Cool SM. Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2. Biomaterials. 2012 Sep; 33(26):6113-22. Epub 2012 Jun 09.
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Ellman MB, Kim JS, An HS, Chen D, Kc R, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 1; 505(2):283-90. Epub 2012 Jun 10.
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Helledie T, Dombrowski C, Rai B, Lim ZX, Hin IL, Rider DA, Stein GS, Hong W, van Wijnen AJ, Hui JH, Nurcombe V, Cool SM. Heparan sulfate enhances the self-renewal and therapeutic potential of mesenchymal stem cells from human adult bone marrow. Stem Cells Dev. 2012 Jul 20; 21(11):1897-910. Epub 2012 Jan 18.
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Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Ranjan KC, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul; 113(7):2532-42.
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Zhang Y, Xie RL, Gordon J, LeBlanc K, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem. 2012 Jun 22; 287(26):21926-35. Epub 2012 Apr 27.
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Ali SA, Dobson JR, Lian JB, Stein JL, van Wijnen AJ, Zaidi SK, Stein GS. A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation. J Cell Sci. 2012 Jun 1; 125(Pt 11):2732-9. Epub 2012 Mar 05.
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Bramono DS, Murali S, Rai B, Ling L, Poh WT, Lim ZX, Stein GS, Nurcombe V, van Wijnen AJ, Cool SM. Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2). Bone. 2012 Apr; 50(4):954-64. Epub 2011 Dec 28.
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Kim JS, Ellman MB, An HS, Yan D, van Wijnen AJ, Murphy G, Hoskin DW, Im HJ. Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc. J Cell Physiol. 2012 Apr; 227(4):1512-20.
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Lian JB, Stein GS, van Wijnen AJ, Stein JL, Hassan MQ, Gaur T, Zhang Y. MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol. 2012 Apr; 8(4):212-27. Epub 2012 Jan 31.
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van der Deen M, Akech J, Lapointe D, Gupta S, Young DW, Montecino MA, Galindo M, Lian JB, Stein JL, Stein GS, van Wijnen AJ. Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. J Biol Chem. 2012 Feb 10; 287(7):4503-17. Epub 2011 Dec 09.
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Min B, Kim MK, Zhang JW, Kim J, Chung KC, Oh BC, Stein GS, Lee YH, van Wijnen AJ, Bae SC. Identification of RUNX3 as a component of the MST/Hpo signaling pathway. J Cell Physiol. 2012 Feb; 227(2):839-49.
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Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JAR, Li Z, Croce CM, Van Wijnen AJ, Stein JL, Stein GS, Lian JB. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 2012; 287(50):42084-92.
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Choe CY, Kim H, Dong J, van Wijnen AJ, Law PY, Loh HH. The polypyrimidine/polypurine motif in the mouse mu opioid receptor gene promoter is a supercoiling-regulatory element. Gene. 2011 Nov 1; 487(1):52-61. Epub 2011 Jul 31.
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Abdollahi MR, Memari HR, van Wijnen AJ. Factor affecting the endogenous beta-glucuronidase activity in rapeseed haploid cells: how to avoid interference with the Gus transgene in transformation studies. Gene. 2011 Nov 1; 487(1):96-102. Epub 2011 Jul 22.
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Henriquez B, Hepp M, Merino P, Sepulveda H, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. C/EBPbeta binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells. J Cell Physiol. 2011 Nov; 226(11):3043-52.
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Li X, Kim JS, van Wijnen AJ, Im HJ. Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain. Mol Biol Rep. 2011 Nov; 38(8):5335-9. Epub 2011 Feb 16.
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Kim JS, Kroin JS, Buvanendran A, Li X, van Wijnen AJ, Tuman KJ, Im HJ. Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis. Arthritis Rheum. 2011 Oct; 63(10):2966-73.
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Liu LJ, Xie R, Hussain S, Lian JB, Rivera-Perez J, Jones SN, Stein JL, Stein GS, van Wijnen AJ. Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development. Gene. 2011 Sep 1; 483(1-2):1-10. Epub 2011 May 13.
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Liu JC, Lengner CJ, Gaur T, Lou Y, Hussain S, Jones MD, Borodic B, Colby JL, Steinman HA, van Wijnen AJ, Stein JL, Jones SN, Stein GS, Lian JB. Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation. J Biol Chem. 2011 Aug 26; 286(34):30057-70. Epub 2011 Jun 15.
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Li X, Gibson G, Kim JS, Kroin J, Xu S, van Wijnen AJ, Im HJ. MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene. 2011 Jul 1; 480(1-2):34-41. Epub 2011 Mar 21.
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Zhang Y, Xie RL, Croce CM, Stein JL, Lian JB, van Wijnen AJ, Stein GS. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9863-8. Epub 2011 May 31.
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Zaidi SK, Young DW, Montecino M, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Bookmarking the genome: maintenance of epigenetic information. J Biol Chem. 2011 May 27; 286(21):18355-61. Epub 2011 Mar 24.
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Ghule PN, Medina R, Lengner CJ, Mandeville M, Qiao M, Dominski Z, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Reprogramming the pluripotent cell cycle: restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells. J Cell Physiol. 2011 May; 226(5):1149-56.
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Pockwinse SM, Kota KP, Quaresma AJ, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Nickerson JA. Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression. J Cell Physiol. 2011 May; 226(5):1383-9.
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Emons J, Dutilh BE, Decker E, Pirzer H, Sticht C, Gretz N, Rappold G, Cameron ER, Neil JC, Stein GS, van Wijnen AJ, Wit JM, Post JN, Karperien M. Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation. J Endocrinol. 2011 May; 209(2):245-54. Epub 2011 Feb 09.
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Hawse JR, Cicek M, Grygo SB, Bruinsma ES, Rajamannan NM, van Wijnen AJ, Lian JB, Stein GS, Oursler MJ, Subramaniam M, Spelsberg TC. TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts. PLoS One. 2011 Apr 29; 6 (4):e19429
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Stein GS, Stein JL, van Wijnen AJ, Lian JB, Zaidi SK, Nickerson JA, Montecino MA, Young DW. An architectural genetic and epigenetic perspective. Integr Biol (Camb). 2011 Apr; 3(4):297-303. Epub 2010 Dec 24.
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Yan D, Chen D, Cool SM, van Wijnen AJ, Mikecz K, Murphy G, Im HJ. Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. Arthritis Res Ther. 2011; 13(4):R130. Epub 2011 Aug 11.
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Kim JS, Kroin JS, Li X, An HS, Buvanendran A, Yan D, Tuman KJ, van Wijnen AJ, Chen D, Im HJ. The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain. Arthritis Res Ther. 2011; 13(5):R165. Epub 2011 Oct 13.
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Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Cells Tissues Organs. 2011; 194(2-4):146-50. Epub 2011 May 19.
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Martin JW, Zielenska M, Stein GS, van Wijnen AJ, Squire JA. The Role of RUNX2 in Osteosarcoma Oncogenesis. Sarcoma. 2011; 2011:282745. Epub 2010 Dec 09.
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Pratap J, Akech J, Wixted JJ, Szabo G, Hussain S, McGee-Lawrence ME, Li X, Bedard K, Dhillon RJ, van Wijnen AJ, Stein JL, Stein GS, Westendorf JJ, Lian JB. The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss. Mol Cancer Ther. 2010 Dec; 9(12):3210-20.
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Kim JS, Ellman MB, An HS, van Wijnen AJ, Borgia JA, Im HJ. Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells. Arthritis Rheum. 2010 Dec; 62(12):3706-15.
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Hassan MQ, Gordon JA, Beloti MM, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):19879-84. Epub 2010 Oct 27.
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Bakshi R, Hassan MQ, Pratap J, Lian JB, Montecino MA, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS. The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes. J Cell Physiol. 2010 Nov; 225(2):569-76.
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Im HJ, Kim JS, Li X, Kotwal N, Sumner DR, van Wijnen AJ, Davis FJ, Yan D, Levine B, Henry JL, Desevre J, Kroin JS. Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model. Arthritis Rheum. 2010 Oct; 62(10):2995-3005.
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Zaidi SK, Young DW, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information. Mol Cell Biol. 2010 Oct; 30(20):4758-66. Epub 2010 Aug 09.
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Ling L, Dombrowski C, Foong KM, Haupt LM, Stein GS, Nurcombe V, van Wijnen AJ, Cool SM. Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway. J Biol Chem. 2010 Aug 20; 285(34):26233-44. Epub 2010 Jun 14.
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Zaidi SK, Young DW, Montecino MA, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet. 2010 Aug; 11(8):583-9. Epub 2010 Jul 13.
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Hassan MQ, Gordon JA, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Ribonucleoprotein immunoprecipitation (RNP-IP): a direct in vivo analysis of microRNA-targets. J Cell Biochem. 2010 Jul 1; 110(4):817-22.
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Gordon JA, Hassan MQ, Saini S, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Mol Cell Biol. 2010 Jul; 30(14):3531-41. Epub 2010 May 03.
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Han MS, Kim HJ, Wee HJ, Lim KE, Park NR, Bae SC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Choi JY. The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta. J Cell Biochem. 2010 May; 110(1):97-103.
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Jeong JH, Jung YK, Kim HJ, Jin JS, Kim HN, Kang SM, Kim SY, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Kato S, Choi JY. The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues. Mol Cell Biol. 2010 May; 30(10):2365-75. Epub 2010 Mar 15.
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Ling L, Murali S, Stein GS, van Wijnen AJ, Cool SM. Glycosaminoglycans modulate RANKL-induced osteoclastogenesis. J Cell Biochem. 2010 Apr 15; 109(6):1222-31.
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Gaur T, Hussain S, Mudhasani R, Parulkar I, Colby JL, Frederick D, Kream BE, van Wijnen AJ, Stein JL, Stein GS, Jones SN, Lian JB. Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse. Dev Biol. 2010 Apr 1; 340(1):10-21. Epub 2010 Jan 15.
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Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet. 2010 Mar 15; 19(6):1048-57. Epub 2009 Dec 24.
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Ali SA, Zaidi SK, Dobson JR, Shakoori AR, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4165-9. Epub 2010 Feb 16.
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van der Deen M, Akech J, Wang T, FitzGerald TJ, Altieri DC, Languino LR, Lian JB, van Wijnen AJ, Stein JL, Stein GS. The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells. J Cell Biochem. 2010 Mar 1; 109(4):828-37.
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Akech J, Wixted JJ, Bedard K, van der Deen M, Hussain S, Guise TA, van Wijnen AJ, Stein JL, Languino LR, Altieri DC, Pratap J, Keller E, Stein GS, Lian JB. Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene. 2010 Feb 11; 29(6):811-21. Epub 2009 Nov 16.
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Becker KA, Ghule PN, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells. J Cell Physiol. 2010 Feb; 222(2):456-64.
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Arriagada G, Paredes R, van Wijnen AJ, Lian JB, van Zundert B, Stein GS, Stein JL, Montecino M. 1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA. J Cell Physiol. 2010 Feb; 222(2):336-46.
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Leong DT, Lim J, Goh X, Pratap J, Pereira BP, Kwok HS, Nathan SS, Dobson JR, Lian JB, Ito Y, Voorhoeve PM, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ. Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Res. 2010; 12(5):R89. Epub 2010 Oct 28.
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Stein GS, Stein JL, Van Wijnen AJ, Lian JB, Montecino M, Croce CM, Choi JY, Ali SA, Pande S, Hassan MQ, Zaidi SK, Young DW. Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer. Adv Enzyme Regul. 2010; 50(1):160-7. Epub 2009 Nov 04.
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Stein GS, van Wijnen AJ, Imbalzano AN, Montecino M, Zaidi SK, Lian JB, Nickerson JA, Stein JL. Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments. Crit Rev Eukaryot Gene Expr. 2010; 20(2):149-55.
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Becker KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming. J Cell Physiol. 2010 Jan; 222(1):103-10.
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Zaidi SK, Medina RF, Pockwinse SM, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Subnuclear localization and intranuclear trafficking of transcription factors. Methods Mol Biol. 2010; 647:77-93.
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Pereira BP, Zhou Y, Gupta A, Leong DT, Aung KZ, Ling L, Pho RW, Galindo M, Salto-Tellez M, Stein GS, Cool SM, van Wijnen AJ, Nathan SS. Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1). J Cell Physiol. 2009 Dec; 221(3):778-88.
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San Martin IA, Varela N, Gaete M, Villegas K, Osorio M, Tapia JC, Antonelli M, Mancilla EE, Pereira BP, Nathan SS, Lian JB, Stein JL, Stein GS, van Wijnen AJ, Galindo M. Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells. J Cell Physiol. 2009 Dec; 221(3):560-71.
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Zaidi SK, Dowdy CR, van Wijnen AJ, Lian JB, Raza A, Stein JL, Croce CM, Stein GS. Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. Cancer Res. 2009 Nov 1; 69(21):8249-55. Epub 2009 Oct 13.
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Chi XZ, Kim J, Lee YH, Lee JW, Lee KS, Wee H, Kim WJ, Park WY, Oh BC, Stein GS, Ito Y, van Wijnen AJ, Bae SC. Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination. Cancer Res. 2009 Oct 15; 69(20):8111-9. Epub 2009 Oct 06.
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Zhang Y, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells. J Cell Biochem. 2009 Oct 15; 108(3):651-9.
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Pratap J, Imbalzano KM, Underwood JM, Cohet N, Gokul K, Akech J, van Wijnen AJ, Stein JL, Imbalzano AN, Nickerson JA, Lian JB, Stein GS. Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression. Cancer Res. 2009 Sep 1; 69(17):6807-14. Epub 2009 Aug 18.
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Das K, Leong DT, Gupta A, Shen L, Putti T, Stein GS, van Wijnen AJ, Salto-Tellez M. Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer. Eur J Cancer. 2009 Sep; 45(13):2239-48. Epub 2009 Jul 24.
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Haupt LM, Murali S, Mun FK, Teplyuk N, Mei LF, Stein GS, van Wijnen AJ, Nurcombe V, Cool SM. The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis. J Cell Physiol. 2009 Sep; 220(3):780-91.
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Filion TM, Qiao M, Ghule PN, Mandeville M, van Wijnen AJ, Stein JL, Lian JB, Altieri DC, Stein GS. Survival responses of human embryonic stem cells to DNA damage. J Cell Physiol. 2009 Sep; 220(3):586-92.
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Cruzat F, Henriquez B, Villagra A, Hepp M, Lian JB, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS, Montecino M. SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2. Biochemistry. 2009 Aug 4; 48(30):7287-95.
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Altieri DC, Languino LR, Lian JB, Stein JL, Leav I, van Wijnen AJ, Jiang Z, Stein GS. Prostate cancer regulatory networks. J Cell Biochem. 2009 Aug 1; 107(5):845-52.
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Xie R, Medina R, Zhang Y, Hussain S, Colby J, Ghule P, Sundararajan S, Keeler M, Liu LJ, van der Deen M, Mitra P, Lian JB, Rivera-Perez JA, Jones SN, Stein JL, van Wijnen AJ, Stein GS. The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12359-64. Epub 2009 Jul 09.
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Ghule PN, Dominski Z, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types. J Cell Physiol. 2009 Jul; 220(1):129-35.
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Li Z, Hassan MQ, Jafferji M, Aqeilan RI, Garzon R, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem. 2009 Jun 5; 284(23):15676-84. Epub 2009 Apr 02.
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Teplyuk NM, Zhang Y, Lou Y, Hawse JR, Hassan MQ, Teplyuk VI, Pratap J, Galindo M, Stein JL, Stein GS, Lian JB, van Wijnen AJ. The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts. Mol Endocrinol. 2009 Jun; 23(6):849-61. Epub 2009 Apr 02.
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Teplyuk NM, Haupt LM, Ling L, Dombrowski C, Mun FK, Nathan SS, Lian JB, Stein JL, Stein GS, Cool SM, van Wijnen AJ. The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts. J Cell Biochem. 2009 May 1; 107(1):144-54.
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Mitra P, Ghule PN, van der Deen M, Medina R, Xie RL, Holmes WF, Ye X, Nakayama KI, Harper JW, Stein JL, Stein GS, van Wijnen AJ. CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P. J Cell Physiol. 2009 May; 219(2):438-48.
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Pande S, Ali SA, Dowdy C, Zaidi SK, Ito K, Ito Y, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes. J Cell Physiol. 2009 Mar; 218(3):473-9.
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Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer. Ann N Y Acad Sci. 2009 Feb; 1155:4-14.
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Li X, Ellman M, Muddasani P, Wang JH, Cs-Szabo G, van Wijnen AJ, Im HJ. Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis. Arthritis Rheum. 2009 Feb; 60(2):513-23.
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Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. Transcription-factor-mediated epigenetic control of cell fate and lineage commitment. Biochem Cell Biol. 2009 Feb; 87(1):1-6.
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Lou Y, Javed A, Hussain S, Colby J, Frederick D, Pratap J, Xie R, Gaur T, van Wijnen AJ, Jones SN, Stein GS, Lian JB, Stein JL. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet. 2009 Feb 1; 18(3):556-68. Epub 2008 Nov 20.
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Zhang Y, Hassan MQ, Xie RL, Hawse JR, Spelsberg TC, Montecino M, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats). J Biol Chem. 2009 Jan 30; 284 (5):3125-3135 Epub 2008 Nov 18
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Javed A, Afzal F, Bae JS, Gutierrez S, Zaidi K, Pratap J, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation. Cells Tissues Organs. 2009; 189(1-4):133-7. Epub 2008 Aug 26.
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Hassan MQ, Saini S, Gordon JA, van Wijnen AJ, Montecino M, Stein JL, Stein GS, Lian JB. Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis. Cells Tissues Organs. 2009; 189(1-4):122-5. Epub 2008 Aug 14.
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Nathan SS, Pereira BP, Zhou YF, Gupta A, Dombrowski C, Soong R, Pho RW, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ. Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. Mol Biol Rep. 2009 Jan; 36(1):153-8. Epub 2008 Oct 18.
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Boucharaba A, Guillet B, Menaa F, Hneino M, van Wijnen AJ, Clezardin P, Peyruchaud O. Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms. Oncol Res. 2009; 18(4):173-84.
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Bakshi R, Zaidi SK, Pande S, Hassan MQ, Young DW, Montecino M, Lian JB, van Wijnen AJ, Stein JL, Stein GS. The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. J Cell Sci. 2008 Dec 1; 121(Pt 23):3981-90. Epub 2008 Nov 11.
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Medina R, Buck T, Zaidi SK, Miele-Chamberland A, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. Biochemistry. 2008 Nov 4; 47(44):11415-23. Epub 2008 Oct 14.
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Ghule PN, Dominski Z, Yang XC, Marzluff WF, Becker KA, Harper JW, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells. Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44):16964-9. Epub 2008 Oct 28.
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Jeong JH, Jin JS, Kim HN, Kang SM, Liu JC, Lengner CJ, Otto F, Mundlos S, Stein JL, van Wijnen AJ, Lian JB, Stein GS, Choi JY. Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain. J Cell Physiol. 2008 Nov; 217(2):511-7.
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Teplyuk NM, Galindo M, Teplyuk VI, Pratap J, Young DW, Lapointe D, Javed A, Stein JL, Lian JB, Stein GS, van Wijnen AJ. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008 Oct 10; 283(41):27585-97. Epub 2008 Jul 14.
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Pratap J, Wixted JJ, Gaur T, Zaidi SK, Dobson J, Gokul KD, Hussain S, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res. 2008 Oct 1; 68(19):7795-802.
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Zhang Y, Hassan MQ, Li ZY, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation. J Cell Biochem. 2008 Oct 1; 105(2):487-96.
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Li Z, Hassan MQ, Volinia S, van Wijnen AJ, Stein JL, Croce CM, Lian JB, Stein GS. A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13906-11. Epub 2008 Sep 10.
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Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer. J Cell Biochem. 2008 Aug 15; 104(6):2016-26.
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Ali SA, Zaidi SK, Dacwag CS, Salma N, Young DW, Shakoori AR, Montecino MA, Lian JB, van Wijnen AJ, Imbalzano AN, Stein GS, Stein JL. Phenotypic transcription factors epigenetically mediate cell growth control. Proc Natl Acad Sci U S A. 2008 May 6; 105(18):6632-7. Epub 2008 Apr 29.
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Medina R, Zaidi SK, Liu CG, Stein JL, van Wijnen AJ, Croce CM, Stein GS. MicroRNAs 221 and 222 bypass quiescence and compromise cell survival. Cancer Res. 2008 Apr 15; 68(8):2773-80.
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Jensen ED, Niu L, Caretti G, Nicol SM, Teplyuk N, Stein GS, Sartorelli V, van Wijnen AJ, Fuller-Pace FV, Westendorf JJ. p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation. J Cell Biochem. 2008 Apr 1; 103(5):1438-51.
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Javed A, Bae JS, Afzal F, Gutierrez S, Pratap J, Zaidi SK, Lou Y, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J Biol Chem. 2008 Mar 28; 283(13):8412-22. Epub 2008 Jan 18.
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Carvallo L, Henriquez B, Paredes R, Olate J, Onate S, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. 1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. J Cell Physiol. 2008 Mar; 214(3):740-9.
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Montecino M, Stein GS, Stein JL, Lian JB, van Wijnen AJ, Carvallo L, Marcellini S, Cruzat F, Arriagada G. Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery. Crit Rev Eukaryot Gene Expr. 2008; 18(2):163-72.
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Pockwinse SM, Zaidi SK, Medina RF, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. In situ nuclear organization of regulatory machinery. Methods Mol Biol. 2008; 455:239-59.
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van der Deen M, Hassan MQ, Pratap J, Teplyuk NM, Young DW, Javed A, Zaidi SK, Lian JB, Montecino M, Stein JL, Stein GS, van Wijnen AJ. Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells. Methods Mol Biol. 2008; 455:165-76.
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Zaidi SK, Pande S, Pratap J, Gaur T, Grigoriu S, Ali SA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19861-6. Epub 2007 Dec 05.
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Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS. The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. Cancer Res. 2007 Nov 1; 67(21):10334-42.
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Xie RL, Liu L, Mitra P, Stein JL, van Wijnen AJ, Stein GS. Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition. Gene. 2007 Nov 1; 402(1-2):94-102. Epub 2007 Aug 09.
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Muddasani P, Norman JC, Ellman M, van Wijnen AJ, Im HJ. Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. J Biol Chem. 2007 Oct 26; 282(43):31409-21. Epub 2007 Aug 27.
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Ghule PN, Becker KA, Harper JW, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells. J Cell Physiol. 2007 Oct; 213(1):9-17.
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Galindo M, Kahler RA, Teplyuk NM, Stein JL, Lian JB, Stein GS, Westendorf JJ, van Wijnen AJ. Cell cycle related modulations in Runx2 protein levels are independent of lymphocyte enhancer-binding factor 1 (Lef1) in proliferating osteoblasts. J Mol Histol. 2007 Oct; 38(5):501-6. Epub 2007 Sep 21.
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Miele A, Medina R, van Wijnen AJ, Stein GS, Stein JL. The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. J Cell Biochem. 2007 Sep 1; 102(1):136-48.
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Montecino M, Stein JL, Stein GS, Lian JB, van Wijnen AJ, Cruzat F, Gutierrez S, Olate J, Marcellini S, Gutierrez JL. Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence. Biochem Cell Biol. 2007 Aug; 85(4):419-25.
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Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A, Koff A. Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130. Mol Cell Biol. 2007 Jul; 27(14):5161-71. Epub 2007 May 14.
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Zaidi SK, Young DW, Javed A, Pratap J, Montecino M, van Wijnen A, Lian JB, Stein JL, Stein GS. Nuclear microenvironments in biological control and cancer. Nat Rev Cancer. 2007 Jun; 7(6):454-63.
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Mitra P, Xie R, Harper JW, Stein JL, Stein GS, van Wijnen AJ. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. J Cell Biochem. 2007 May 1; 101(1):181-91.
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Hassan MQ, Tare R, Lee SH, Mandeville M, Weiner B, Montecino M, van Wijnen AJ, Stein JL, Stein GS, Lian JB. HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Mol Cell Biol. 2007 May; 27(9):3337-52. Epub 2007 Feb 26.
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Montecino M, Stein GS, Cruzat F, Marcellini S, Stein JL, Lian JB, van Wijnen AJ, Arriagada G. An architectural perspective of vitamin D responsiveness. Arch Biochem Biophys. 2007 Apr 15; 460(2):293-9. Epub 2007 Jan 08.
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Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. J Cell Biochem. 2007 Apr 15; 100(6):1509-17.
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Im HJ, Muddasani P, Natarajan V, Schmid TM, Block JA, Davis F, van Wijnen AJ, Loeser RF. Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem. 2007 Apr 13; 282(15):11110-21. Epub 2007 Feb 20.
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Gutierrez J, Paredes R, Cruzat F, Hill DA, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Imbalzano AN, Montecino M. Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter. J Biol Chem. 2007 Mar 30; 282(13):9445-57. Epub 2007 Feb 01.
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Arriagada G, Paredes R, Olate J, van Wijnen A, Lian JB, Stein GS, Stein JL, Onate S, Montecino M. Phosphorylation at serine 208 of the 1alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):425-9.
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Carvallo L, Henriquez B, Olate J, van Wijnen AJ, Lian JB, Stein GS, Onate S, Stein JL, Montecino M. The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):420-4. Epub 2007 Jan 10.
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Young DW, Hassan MQ, Yang XQ, Galindo M, Javed A, Zaidi SK, Furcinitti P, Lapointe D, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3189-94. Epub 2007 Feb 20.
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Bae JS, Gutierrez S, Narla R, Pratap J, Devados R, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Javed A. Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. J Cell Biochem. 2007 Feb 1; 100(2):434-49.
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Becker KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells. J Cell Physiol. 2007 Feb; 210(2):517-26.
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Young DW, Hassan MQ, Pratap J, Galindo M, Zaidi SK, Lee SH, Yang X, Xie R, Javed A, Underwood JM, Furcinitti P, Imbalzano AN, Penman S, Nickerson JA, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 2007 Jan 25; 445(7126):442-6.
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van Wijnen AJ, Stein GS. The CBFB-MYH11 Butterfly Effect in Hematopoiesis. Blood. 2007; 109:3131-3132.
Stein GS, Lian JB, van Wijnen AJ, Stein JL, Javed A, Montecino M, Choi JY, Vradii D, Zaidi SK, Pratap J, Young D. Organization of transcriptional regulatory machinery in nuclear microenvironments: implications for biological control and cancer. Adv Enzyme Regul. 2007; 47:242-50. Epub 2007 Mar 23.
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Jackson RA, Murali S, van Wijnen AJ, Stein GS, Nurcombe V, Cool SM. Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2. J Cell Physiol. 2007 Jan; 210(1):38-50.
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Hassan MQ, Tare RS, Lee SH, Mandeville M, Morasso MI, Javed A, van Wijnen AJ, Stein JL, Stein GS, Lian JB. BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network. J Biol Chem. 2006 Dec 29; 281(52):40515-26. Epub 2006 Oct 23.
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Medina R, van Wijnen AJ, Stein GS, Stein JL. The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT. Biochemistry. 2006 Dec 26; 45(51):15915-20.
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Pratap J, Lian JB, Javed A, Barnes GL, van Wijnen AJ, Stein JL, Stein GS. Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone. Cancer Metastasis Rev. 2006 Dec; 25(4):589-600.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino M, Zaidi SK, Braastad C. An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition. J Cell Physiol. 2006 Dec; 209(3):706-10.
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Becker KA, Ghule PN, Therrien JA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase. J Cell Physiol. 2006 Dec; 209(3):883-93.
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Ling L, Murali S, Dombrowski C, Haupt LM, Stein GS, van Wijnen AJ, Nurcombe V, Cool SM. Sulfated glycosaminoglycans mediate the effects of FGF2 on the osteogenic potential of rat calvarial osteoprogenitor cells. J Cell Physiol. 2006 Dec; 209(3):811-25.
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Zaidi SK, Javed A, Pratap J, Schroeder TM, J Westendorf J, Lian JB, van Wijnen AJ, Stein GS, Stein JL. Alterations in intranuclear localization of Runx2 affect biological activity. J Cell Physiol. 2006 Dec; 209(3):935-42.
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Villagra A, Cruzat F, Carvallo L, Paredes R, Olate J, van Wijnen AJ, Stein GS, Lian JB, Stein JL, Imbalzano AN, Montecino M. Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity. J Biol Chem. 2006 Aug 11; 281(32):22695-706. Epub 2006 Jun 13.
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Lian JB, Stein GS, Javed A, van Wijnen AJ, Stein JL, Montecino M, Hassan MQ, Gaur T, Lengner CJ, Young DW. Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord. 2006 Jun; 7(1-2):1-16.
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Kim HJ, Nam SH, Kim HJ, Park HS, Ryoo HM, Kim SY, Cho TJ, Kim SG, Bae SC, Kim IS, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Choi JY. Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype. J Cell Physiol. 2006 Apr; 207 (1):114-22
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Kahler RA, Galindo M, Lian J, Stein GS, van Wijnen AJ, Westendorf JJ. Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts. J Cell Biochem. 2006 Apr 1; 97(5):969-83.
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Santos CR, Rodriguez-Pinilla M, Vega FM, Rodriguez-Peralto JL, Blanco S, Sevilla A, Valbuena A, Hernandez T, van Wijnen AJ, Li F, de Alava E, Sanchez-Cespedes M, Lazo PA. VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma. Mol Cancer Res. 2006 Mar; 4(3):177-85.
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Pockwinse SM, Rajgopal A, Young DW, Mujeeb KA, Nickerson J, Javed A, Redick S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Doxsey SJ. Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2. J Cell Physiol. 2006 Feb; 206(2):354-62.
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Kim YJ, Kim HN, Park EK, Lee BH, Ryoo HM, Kim SY, Kim IS, Stein JL, Lian JB, Stein GS, van Wijnen AJ, Choi JY. The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells. Gene. 2006 Jan 17; 366(1):145-51. Epub 2005 Nov 28.
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Vradii D, Wagner S, Doan DN, Nickerson JA, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Imbalzano AN, Stein GS. Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes. J Cell Physiol. 2006 Jan; 206(1):112-8.
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Holmes WF, Braastad CD, Mitra P, Hampe C, Doenecke D, Albig W, Stein JL, van Wijnen AJ, Stein GS. Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells. J Biol Chem. 2005 Nov 11; 280(45):37400-7. Epub 2005 Aug 29.
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Li X, Vradii D, Gutierrez S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Javed A. Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1. J Cell Biochem. 2005 Nov 1; 96(4):795-809.
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Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, Lian JB. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol. 2005 Oct; 25(19):8581-91.
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Gaur T, Lengner CJ, Hovhannisyan H, Bhat RA, Bodine PV, Komm BS, Javed A, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem. 2005 Sep 30; 280(39):33132-40. Epub 2005 Jul 25.
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Saltman LH, Javed A, Ribadeneyra J, Hussain S, Young DW, Osdoby P, Amcheslavsky A, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Bar-Shavit Z. Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1. J Cell Physiol. 2005 Sep; 204(3):871-80.
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Afzal F, Pratap J, Ito K, Ito Y, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Javed A. Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol. 2005 Jul; 204(1):63-72.
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Miele A, Braastad CD, Holmes WF, Mitra P, Medina R, Xie R, Zaidi SK, Ye X, Wei Y, Harper JW, van Wijnen AJ, Stein JL, Stein GS. HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition. Mol Cell Biol. 2005 Jul; 25(14):6140-53.
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Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY, Lian JB, Stein JL, Stein GS, van Wijnen AJ. The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem. 2005 May 27; 280(21):20274-85. Epub 2005 Mar 21.
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Vradii D, Zaidi SK, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7174-9. Epub 2005 May 03.
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Lengner CJ, Hassan MQ, Serra RW, Lepper C, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation. J Biol Chem. 2005 Apr 22; 280(16):15872-9. Epub 2005 Feb 08.
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Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005 Apr; 203(1):133-43.
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Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB. SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem. 2005 Mar 1; 94(4):720-30.
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Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, van Wijnen AJ, Lian JB, Stein GS. The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep. 2005 Feb; 6(2):128-33.
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Javed A, Barnes GL, Pratap J, Antkowiak T, Gerstenfeld LC, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1454-9. Epub 2005 Jan 21.
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Stein GS, Lian JB, Stein JL, van Wijnen AJ, Javed A, Montecino M, Zaidi SK, Young DW, Choi JY, Pratap J. Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer. Adv Enzyme Regul. 2005; 45:136-54. Epub 2005 Aug 30.
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Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS. Functional characterization of a human histone gene cluster duplication. Gene. 2004 Nov 10; 342(1):35-40.
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Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Intranuclear trafficking: organization and assembly of regulatory machinery for combinatorial biological control. J Biol Chem. 2004 Oct 15; 279(42):43363-6. Epub 2004 Jul 23.
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Young DW, Zaidi SK, Furcinitti PS, Javed A, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Quantitative signature for architectural organization of regulatory factors using intranuclear informatics. J Cell Sci. 2004 Oct 1; 117(Pt 21):4889-96. Epub 2004 Sep 14.
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Hassan MQ, Javed A, Morasso MI, Karlin J, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Mol Cell Biol. 2004 Oct; 24(20):9248-61.
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Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J, Zaidi K, van Wijnen A, Lian JB, Stein GS, Stein JL, Montecino M. Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol. 2004 Oct; 24(20):8847-61.
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Lengner CJ, Lepper C, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Primary mouse embryonic fibroblasts: a model of mesenchymal cartilage formation. J Cell Physiol. 2004 Sep; 200(3):327-33.
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Stein GS, Lian JB, van Wijnen AJ, Stein JL, Montecino M, Javed A, Zaidi SK, Young DW, Choi JY, Pockwinse SM. Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene. 2004 May 24; 23(24):4315-29.
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van Wijnen AJ, Stein GS, Gergen JP, Groner Y, Hiebert SW, Ito Y, Liu P, Neil JC, Ohki M, Speck N. Nomenclature for Runt-related (RUNX) proteins. Oncogene. 2004 May 24; 23(24):4209-10.
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Paredes R, Arriagada G, Cruzat F, Olate J, Van Wijnen A, Lian J, Stein G, Stein J, Montecino M. The Runx2 transcription factor plays a key role in the 1alpha,25-dihydroxy Vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):269-71.
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Zaidi SK, Sullivan AJ, Medina R, Ito Y, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J. 2004 Feb 25; 23(4):790-9. Epub 2004 Feb 12.
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Stein GS, Lian JB, van Wijnen AJ, Stein JL, Javed A, Montecino M, Zaidi SK, Young D, Choi JY, Gutierrez S, Pockwinse S. Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation. J Cell Biochem. 2004 Feb 1; 91(2):287-302.
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Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. In situ immunofluorescence analysis: analyzing RNA synthesis by 5-bromouridine-5'-triphosphate labeling. Methods Mol Biol. 2004; 285:29-31.
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Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. In situ immunofluorescence analysis: immunofluorescence microscopy. Methods Mol Biol. 2004; 285:23-8.
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Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, van Wijnen AJ, Stein JL, Stein GS. Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit Rev Eukaryot Gene Expr. 2004; 14(1-2):1-41.
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Stein GS, Stein JL, Lian JB, Van Wijnen AJ, Montecino M, Javed A, Zaidi SK, Young D, Choi JY, Pockwinse S. Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals. Eur J Histochem. 2004; 48(1):65-76.
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Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Protein-deoxyribonucleic acid interactions linked to gene expression: ligation-mediated polymerase chain reaction. Methods Mol Biol. 2004; 285:63-7.
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Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Protein-deoxyribonucleic acid interactions linked to gene expression: DNase I digestion. Methods Mol Biol. 2004; 285:57-62.
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Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Protein-deoxyribonucleic acid interactions linked to gene expression: electrophoretic mobility shift assay. Methods Mol Biol. 2004; 285:45-55.
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Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Chromatin immunoprecipitation. Methods Mol Biol. 2004; 285:41-4.
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Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Analysis of in vivo gene expression using epitope-tagged proteins. Methods Mol Biol. 2004; 285:37-40.
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Javed A, Zaidi SK, Gutierrez SE, Lengner CJ, Harrington KS, Hovhannisyan H, Cho BC, Pratap J, Pockwinse SM, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Immunofluorescence analysis using epitope-tagged proteins: in vitro system. Methods Mol Biol. 2004; 285:33-6.
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Zaidi SK, Young DW, Pockwinse SM, Javed A, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25):14852-7. Epub 2003 Dec 01.
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Kim JO, Kim HN, Hwang MH, Shin HI, Kim SY, Park RW, Park EY, Kim IS, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Choi JY. Differential gene expression analysis using paraffin-embedded tissues after laser microdissection. J Cell Biochem. 2003 Dec 1; 90(5):998-1006.
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Mitra P, Xie RL, Medina R, Hovhannisyan H, Zaidi SK, Wei Y, Harper JW, Stein JL, van Wijnen AJ, Stein GS. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mol Cell Biol. 2003 Nov; 23(22):8110-23.
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Stein GS, Zaidi SK, Braastad CD, Montecino M, van Wijnen AJ, Choi JY, Stein JL, Lian JB, Javed A. Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair. Trends Cell Biol. 2003 Nov; 13(11):584-92.
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Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN. Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem. 2003 Sep 12; 278(37):35325-36. Epub 2003 Jul 02.
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Pratap J, Galindo M, Zaidi SK, Vradii D, Bhat BM, Robinson JA, Choi JY, Komori T, Stein JL, Lian JB, Stein GS, van Wijnen AJ. Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts. Cancer Res. 2003 Sep 1; 63(17):5357-62.
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Gupta S, Luong MX, Bleuming SA, Miele A, Luong M, Young D, Knudsen ES, Van Wijnen AJ, Stein JL, Stein GS. Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription. J Cell Physiol. 2003 Sep; 196(3):541-56.
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Lian JB, Balint E, Javed A, Drissi H, Vitti R, Quinlan EJ, Zhang L, Van Wijnen AJ, Stein JL, Speck N, Stein GS. Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo. J Cell Physiol. 2003 Aug; 196(2):301-11.
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Xie RL, Gupta S, Miele A, Shiffman D, Stein JL, Stein GS, van Wijnen AJ. The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter. J Biol Chem. 2003 Jul 18; 278(29):26589-96. Epub 2003 May 05.
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Im HJ, Pacione C, Chubinskaya S, Van Wijnen AJ, Sun Y, Loeser RF. Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem. 2003 Jul 11; 278(28):25386-94. Epub 2003 May 06.
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Barnes GL, Javed A, Waller SM, Kamal MH, Hebert KE, Hassan MQ, Bellahcene A, Van Wijnen AJ, Young MF, Lian JB, Stein GS, Gerstenfeld LC. Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Cancer Res. 2003 May 15; 63(10):2631-7.
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Balint E, Lapointe D, Drissi H, van der Meijden C, Young DW, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J Cell Biochem. 2003 May 15; 89(2):401-26.
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Sierra J, Villagra A, Paredes R, Cruzat F, Gutierrez S, Javed A, Arriagada G, Olate J, Imschenetzky M, Van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol. 2003 May; 23(9):3339-51.
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Shen J, Hovhannisyan H, Lian JB, Montecino MA, Stein GS, Stein JL, Van Wijnen AJ. Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histones h3 and h4. Mol Endocrinol. 2003 Apr; 17(4):743-56. Epub 2003 Jan 09.
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Stein GS, Lian JB, Stein JL, van Wijnen AJ, Montecino M, Pratap J, Choi J, Zaidi SK, Javed A, Gutierrez S, Harrington K, Shen J, Young D. Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer. Blood Cells Mol Dis. 2003 Mar-Apr; 30(2):170-6.
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Hovhannisyan H, Cho B, Mitra P, Montecino M, Stein GS, Van Wijnen AJ, Stein JL. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. Mol Cell Biol. 2003 Feb; 23(4):1460-9.
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Stein GS, Lian JB, Montecino M, Stein JL, van Wijnen AJ, Javed A, Pratap J, Choi J, Zaidi SK, Gutierrez S, Harrington K, Shen J, Young D, Pockwinse S. Nuclear microenvironments support physiological control of gene expression. Chromosome Res. 2003; 11(5):527-36.
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Stein GS, Lian JB, Stein JL, van Wijnen AJ, Choi JY, Pratap J, Zaidi SK. Temporal and spatial parameters of skeletal gene expression: targeting RUNX factors and their coregulatory proteins to subnuclear domains. Connect Tissue Res. 2003; 44 Suppl 1:149-53.
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Lian JB, Stein JL, Stein GS, van Wijnen AJ, Montecino M, Javed A, Gutierrez S, Shen J, Zaidi SK, Drissi H. Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions. Connect Tissue Res. 2003; 44 Suppl 1:141-8.
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Stein GS, Lian JB, Stein JL, van Wijnen AJ, Montecino M, Javed A, Pratap J, Choi J, Zaidi SK, Gutierrez S, Harrington K, Shen J, Young D. Intranuclear trafficking of transcription factors: requirements for vitamin D-mediated biological control of gene expression (DeLuca mtg. Special issue). J Cell Biochem. 2003; 88:340-355.
Barseguian K, Lutterbach B, Hiebert SW, Nickerson J, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15434-9. Epub 2002 Nov 11.
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Harrington KS, Javed A, Drissi H, McNeil S, Lian JB, Stein JL, Van Wijnen AJ, Wang YL, Stein GS. Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains. J Cell Sci. 2002 Nov 1; 115(Pt 21):4167-76.
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Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, Yoshida M, Stein GS, Li X. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol. 2002 Nov; 22(22):7982-92.
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Zaidi SK, Sullivan AJ, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8048-53.
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Shen J, Montecino M, Lian JB, Stein GS, Van Wijnen AJ, Stein JL. Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription. J Biol Chem. 2002 Jun 7; 277(23):20284-92. Epub 2002 Mar 13.
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van der Meijden CM, Lapointe DS, Luong MX, Peric-Hupkes D, Cho B, Stein JL, van Wijnen AJ, Stein GS. Gene profiling of cell cycle progression through S-phase reveals sequential expression of genes required for DNA replication and nucleosome assembly. Cancer Res. 2002 Jun 1; 62(11):3233-43.
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Lengner CJ, Drissi H, Choi JY, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton. Mech Dev. 2002 Jun; 114(1-2):167-70.
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Paredes R, Gutierrez J, Gutierrez S, Allison L, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J, Montecino M. Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Biochem J. 2002 May 1; 363(Pt 3):667-76.
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Xie RL, van Wijnen AJ, van der Meijden CM, Stein JL, Stein GS. Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells. Cancer Res. 2002 May 1; 62(9):2510-5.
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van den Bemd GJ, Jhamai M, Staal A, van Wijnen AJ, Lian JB, Stein GS, Pols HA, van Leeuwen JP. A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands. J Biol Chem. 2002 Apr 26; 277(17):14539-46. Epub 2002 Feb 07.
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Drissi H, Pouliot A, Koolloos C, Stein JL, Lian JB, Stein GS, van Wijnen AJ. 1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter. Exp Cell Res. 2002 Apr 1; 274(2):323-33.
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Luong MX, van der Meijden CM, Xing D, Hesselton R, Monuki ES, Jones SN, Lian JB, Stein JL, Stein GS, Neufeld EJ, van Wijnen AJ. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol. 2002 Mar; 22(5):1424-37.
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Gilbert L, He X, Farmer P, Rubin J, Drissi H, van Wijnen AJ, Lian JB, Stein GS, Nanes MS. Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem. 2002 Jan 25; 277(4):2695-701. Epub 2001 Nov 26.
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Drissi H, Pouliot A, Stein JL, van Wijnen AJ, Stein GS, Lian JB. Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1. J Cell Biochem. 2002; 86(2):403-12.
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Villagra A, Gutierrez J, Paredes R, Sierra J, Puchi M, Imschenetzky M, Wijnen A, Lian J, Stein G, Stein J, Montecino M. Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts. J Cell Biochem. 2002; 85(1):112-22.
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Mitra P, Vaughan PS, Stein JL, Stein GS, van Wijnen AJ. Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. Biochemistry. 2001 Sep 4; 40(35):10693-9.
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Banerjee C, Javed A, Choi JY, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology. 2001 Sep; 142(9):4026-39.
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Zaidi SK, Javed A, Choi JY, van Wijnen AJ, Stein JL, Lian JB, Stein GS. A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene. J Cell Sci. 2001 Sep; 114(Pt 17):3093-102.
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Choi JY, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN, Stein GS. Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8650-5. Epub 2001 Jul 03.
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Xie R, van Wijnen AJ, van Der Meijden C, Luong MX, Stein JL, Stein GS. The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7. J Biol Chem. 2001 May 25; 276(21):18624-32. Epub 2001 Feb 13.
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Lian JB, Stein JL, Stein GS, Montecino M, van Wijnen AJ, Javed A, Gutierrez S. Contributions of nuclear architecture and chromatin to vitamin D-dependent transcriptional control of the rat osteocalcin gene. Steroids. 2001 Mar-May; 66(3-5):159-70.
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Gutierrez J, Sierra J, Medina R, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J, Montecino M. Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site. Biochemistry. 2000 Nov 7; 39(44):13565-74.
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Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. J Cell Physiol. 2000 Nov; 185(2):269-79.
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Lian JB, Stein GS, Stein JL, van Wijnen AJ. Marrow transplantation and targeted gene therapy to the skeleton. Clin Orthop Relat Res. 2000 Oct; (379 Suppl):S146-55.
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Hoffmann H, Green J, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Expression screening of factors binding to the osteocalcin bone-specific promoter element OC box I: isolation of a novel osteoblast differentiation-specific factor. J Cell Biochem. 2000 Sep 18; 80(1):156-68.
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Drissi H, Luc Q, Shakoori R, Chuva De Sousa Lopes S, Choi JY, Terry A, Hu M, Jones S, Neil JC, Lian JB, Stein JL, Van Wijnen AJ, Stein GS. Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. J Cell Physiol. 2000 Sep; 184(3):341-50.
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McNeil S, Javed A, Harrington KS, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Leukemia-associated AML1/ETO (8;21) chromosomal translocation protein increases the cellular representation of PML bodies. J Cell Biochem. 2000 Jul 19; 79(1):103-12.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino M, Choi J, Zaidi K, Javed A. Intranuclear trafficking of transcription factors: implications for biological control. J Cell Sci. 2000 Jul; 113 ( Pt 14):2527-33.
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Stein GS, Lian JB, Stein JL, van Wijnen AJ. Bone tissue specific transcriptional control: options for targeting gene therapy to the skeleton. Cancer. 2000 Jun 15; 88(12 Suppl):2899-902.
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Javed A, Guo B, Hiebert S, Choi JY, Green J, Zhao SC, Osborne MA, Stifani S, Stein JL, Lian JB, van Wijnen AJ, Stein GS. Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. J Cell Sci. 2000 Jun; 113 ( Pt 12):2221-31.
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Stein GS, Montecino M, van Wijnen AJ, Stein JL, Lian JB. Nuclear structure-gene expression interrelationships: implications for aberrant gene expression in cancer. Cancer Res. 2000 Apr 15; 60(8):2067-76.
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Gordon JA, Pockwinse SM, Stewart FM, Quesenberry PJ, Nakamura T, Croce CM, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Modified intranuclear organization of regulatory factors in human acute leukemias: reversal after treatment. J Cell Biochem. 2000 Feb; 77(1):30-43.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino M, Zaidi K, Javed A. Subnuclear organization and trafficking of regulatory proteins: implications for biological control and cancer. J Cell Biochem Suppl. 2000; Suppl 35:84-92.
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McNeil S, Zeng C, Harrington KS, Hiebert S, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14882-7.
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van Gurp MF, Pratap J, Luong M, Javed A, Hoffmann H, Giordano A, Stein JL, Neufeld EJ, Lian JB, Stein GS, van Wijnen AJ. The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A. Cancer Res. 1999 Dec 1; 59(23):5980-8.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, Javed A, McNeil S, Pockwinse SM. Insight into regulatory factor targeting to transcriptionally active subnuclear sites. Exp Cell Res. 1999 Nov 25; 253(1):110-6.
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Tang L, Guo B, Javed A, Choi JY, Hiebert S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Zhou GW. Crystal structure of the nuclear matrix targeting signal of the transcription factor acute myelogenous leukemia-1/polyoma enhancer-binding protein 2alphaB/core binding factor alpha2. J Biol Chem. 1999 Nov 19; 274(47):33580-6.
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Stein GS, Van Wijnen AJ, Montecino M, Stein JL, Lian JB. Nuclear structure/gene expression interrelationships. J Cell Physiol. 1999 Nov; 181(2):240-50.
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Javed A, Gutierrez S, Montecino M, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization. Mol Cell Biol. 1999 Nov; 19(11):7491-500.
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Bretzel G, Aziz M, Wendl-Richter U, Adatu F, Aisu T, van Wijnen A, Sticht-Groh V. Anti-tuberculosis drug resistance surveillance in Uganda 1996-1997. Int J Tuberc Lung Dis. 1999 Sep; 3(9):810-5.
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Drissi H, Hushka D, Aslam F, Nguyen Q, Buffone E, Koff A, van Wijnen A, Lian JB, Stein JL, Stein GS. The cell cycle regulator p27kip1 contributes to growth and differentiation of osteoblasts. Cancer Res. 1999 Aug 1; 59(15):3705-11.
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Last TJ, van Wijnen AJ, de Ridder MC, Stein GS, Stein JL. The homeodomain transcription factor CDP/cut interacts with the cell cycle regulatory element of histone H4 genes packaged into nucleosomes. Mol Biol Rep. 1999 Aug; 26(3):185-94.
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Hou Z, Nguyen Q, Frenkel B, Nilsson SK, Milne M, van Wijnen AJ, Stein JL, Quesenberry P, Lian JB, Stein GS. Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7294-9.
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Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Ryoo HM. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem. 1999 Apr 1; 73(1):114-25.
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Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Phosphorylation-mediated control of chromatin organization and transcriptional activity of the tissue-specific osteocalcin gene. J Cell Biochem. 1999 Mar 15; 72(4):586-94.
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Last TJ, van Wijnen AJ, Birnbaum MJ, Stein GS, Stein JL. Multiple interactions of the transcription factor YY1 with human histone H4 gene regulatory elements. J Cell Biochem. 1999 Mar 15; 72(4):507-16.
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Montecino M, Frenkel B, van Wijnen AJ, Lian JB, Stein GS, Stein JL. Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo. Biochemistry. 1999 Jan 26; 38(4):1338-45.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB. Interrelationships of transcriptional machinery with nuclear architecture. Crit Rev Eukaryot Gene Expr. 1999; 9(3-4):183-90.
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Aslam F, McCabe L, Frenkel B, van Wijnen AJ, Stein GS, Lian JB, Stein JL. AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation. Endocrinology. 1999 Jan; 140(1):63-70.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, Pockwinse SH, McNeil S. Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions. FASEB J. 1999; 13 Suppl:S157-66.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, McNeil S, Pockwinse SM. Transcriptional control within the three-dimensional context of nuclear architecture: requirements for boundaries and direction. J Cell Biochem. 1999; Suppl 32-33:24-31.
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Lian JB, Stein GS, Stein JL, van Wijnen AJ. Regulated expression of the bone-specific osteocalcin gene by vitamins and hormones. Vitam Horm. 1999; 55:443-509.
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Aziz F, van Wijnen AJ, Stein JL, Stein GS. HiNF-D (CDP-cut/CDC2/cyclin A/pRB-complex) influences the timing of IRF-2-dependent cell cycle activation of human histone H4 gene transcription at the G1/S phase transition. J Cell Physiol. 1998 Dec; 177(3):453-64.
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van der Meijden CM, Vaughan PS, Staal A, Albig W, Doenecke D, Stein JL, Stein GS, van Wijnen AJ. Selective expression of specific histone H4 genes reflects distinctions in transcription factor interactions with divergent H4 promoter elements. Biochim Biophys Acta. 1998 Oct 23; 1442(1):82-100.
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Last TJ, Birnbaum M, van Wijnen AJ, Stein GS, Stein JL. Repressor elements in the coding region of the human histone H4 gene interact with the transcription factor CDP/cut. Gene. 1998 Oct 23; 221(2):267-77.
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Choi JY, van Wijnen AJ, Aslam F, Leszyk JD, Stein JL, Stein GS, Lian JB, Penman S. Developmental association of the beta-galactoside-binding protein galectin-1 with the nuclear matrix of rat calvarial osteoblasts. J Cell Sci. 1998 Oct; 111 ( Pt 20):3035-43.
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Tang L, Guo B, van Wijnen AJ, Lian JB, Stein JL, Stein GS, Zhou GW. Preliminary crystallographic study of glutathione S-transferase fused with the nuclear matrix targeting signal of the transcription factor AML-1/CBF-alpha2. J Struct Biol. 1998 Sep; 123(1):83-5.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, Pockwinse S, McNeil S. Interrelationships of nuclear structure and transcriptional control: functional consequences of being in the right place at the right time. J Cell Biochem. 1998 Aug 1; 70(2):200-12.
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Lindenmuth D, van Wijnen AJ, Penman S, Stein JL, Stein GS, Lian JB. TGF-beta1 modifications in nuclear matrix proteins of osteoblasts during differentiation. J Cell Biochem. 1998 Jun 1; 69(3):291-303.
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Shalhoub V, Aslam F, Breen E, van Wijnen A, Bortell R, Stein GS, Stein JL, Lian JB. Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation: glucocorticoid regulation of basal and vitamin D stimulated gene expression. J Cell Biochem. 1998 May 1; 69(2):154-68.
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McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein GS. Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking. J Cell Biochem. 1998 Mar 15; 68(4):500-10.
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Zeng C, McNeil S, Pockwinse S, Nickerson J, Shopland L, Lawrence JB, Penman S, Hiebert S, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1585-9.
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Lian JB, Stein GS, Stein JL, van Wijnen AJ. Transcriptional control of osteoblast differentiation. Biochem Soc Trans. 1998 Feb; 26(1):14-21.
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Vaughan PS, van der Meijden CM, Aziz F, Harada H, Taniguchi T, van Wijnen AJ, Stein JL, Stein GS. Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2. J Biol Chem. 1998 Jan 2; 273(1):194-9.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB. Nuclear structure--skeletal gene expression interrelationships. Front Biosci. 1998; 3:d849-64. Epub 1998 Aug 01.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, Pockwinse SM, McNeil S. Linkages of nuclear architecture to biological and pathological control of gene expression. J Cell Biochem Suppl. 1998; 30-31:220-31.
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Lian JB, Stein GS, Stein JL, van Wijnen AJ. Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation. J Cell Biochem Suppl. 1998; 30-31:62-72.
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Bagchi M, Ansari SA, Lindenmuth DM, van Wijnen AJ, Lian J, Stein JL, Stein GS. Nuclear matrix associated DNA-binding proteins of ocular lens epithelial cells. Mol Biol Rep. 1998 Jan; 25(1):13-9.
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Aziz F, van Wijnen AJ, Vaughan PS, Wu S, Shakoori AR, Lian JB, Soprano KJ, Stein JL, Stein GS. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. Mol Biol Rep. 1998 Jan; 25(1):1-12.
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Guo B, Stein JL, van Wijnen AJ, Stein GS. ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element. Biochemistry. 1997 Nov 25; 36(47):14447-55.
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Ryoo HM, Hoffmann HM, Beumer T, Frenkel B, Towler DA, Stein GS, Stein JL, van Wijnen AJ, Lian JB. Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression. Mol Endocrinol. 1997 Oct; 11(11):1681-94.
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van Wijnen AJ, Cooper C, Odgren P, Aziz F, De Luca A, Shakoori RA, Giordano A, Quesenberry PJ, Lian JB, Stein GS, Stein JL. Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells. J Cell Biochem. 1997 Sep 15; 66(4):512-23.
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Birnbaum MJ, van Zundert B, Vaughan PS, Whitmarsh AJ, van Wijnen AJ, Davis RJ, Stein GS, Stein JL. Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo. J Cell Biochem. 1997 Aug 1; 66(2):175-83.
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Stein GS, Lian JB, van Wijnen AJ, Stein JL. The osteocalcin gene: a model for multiple parameters of skeletal-specific transcriptional control. Mol Biol Rep. 1997 Aug; 24(3):185-96.
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Lindenmuth DM, van Wijnen AJ, Hiebert S, Stein JL, Lian JB, Stein GS. Subcellular partitioning of transcription factors during osteoblast differentiation: developmental association of the AML/CBF alpha/PEBP2 alpha-related transcription factor-NMP-2 with the nuclear matrix. J Cell Biochem. 1997 Jul 1; 66(1):123-32.
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Zeng C, van Wijnen AJ, Stein JL, Meyers S, Sun W, Shopland L, Lawrence JB, Penman S, Lian JB, Stein GS, Hiebert SW. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6746-51.
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Vaughan PS, van Wijnen AJ, Stein JL, Stein GS. Interferon regulatory factors: growth control and histone gene regulation--it's not just interferon anymore. J Mol Med (Berl). 1997 May; 75(5):348-59.
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Pockwinse SM, Krockmalnic G, Doxsey SJ, Nickerson J, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Penman S. Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc Natl Acad Sci U S A. 1997 Apr 1; 94(7):3022-7.
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Guo B, Aslam F, van Wijnen AJ, Roberts SG, Frenkel B, Green MR, DeLuca H, Lian JB, Stein GS, Stein JL. YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene. Proc Natl Acad Sci U S A. 1997 Jan 7; 94(1):121-6.
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Ryoo HM, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Detection of a proliferation specific gene during development of the osteoblast phenotype by mRNA differential display. J Cell Biochem. 1997 Jan; 64(1):106-16.
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Ha H, van Wijnen AJ, Hecht NB. Tissue-specific protein-DNA interactions of the mouse protamine 2 gene promoter. J Cell Biochem. 1997 Jan; 64(1):94-105.
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Staal A, van Wijnen AJ, Birkenhager JC, Pols HA, Prahl J, DeLuca H, Gaub MP, Lian JB, Stein GS, van Leeuwen JP, Stein JL. Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. Mol Endocrinol. 1996 Nov; 10(11):1444-56.
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van Wijnen AJ, van Gurp MF, de Ridder MC, Tufarelli C, Last TJ, Birnbaum M, Vaughan PS, Giordano A, Krek W, Neufeld EJ, Stein JL, Stein GS. CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11516-21.
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Stein GS, Stein JL, Lian JB, van Wijnen AJ, Montecino M. Functional interrelationships between nuclear structure and transcriptional control: contributions to regulation of cell cycle- and tissue-specific gene expression. J Cell Biochem. 1996 Aug; 62(2):198-209.
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Staal A, Van Wijnen AJ, Desai RK, Pols HA, Birkenhager JC, Deluca HF, Denhardt DT, Stein JL, Van Leeuwen JP, Stein GS, Lian JB. Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements. Endocrinology. 1996 May; 137(5):2001-11.
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Banerjee C, Stein JL, Van Wijnen AJ, Frenkel B, Lian JB, Stein GS. Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site. Endocrinology. 1996 May; 137(5):1991-2000.
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Hoffmann HM, Beumer TL, Rahman S, McCabe LR, Banerjee C, Aslam F, Tiro JA, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Bone tissue-specific transcription of the osteocalcin gene: role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box. J Cell Biochem. 1996 May; 61(2):310-24.
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Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Montecino M. Transcriptional control of osteoblast growth and differentiation. Physiol Rev. 1996 Apr; 76(2):593-629.
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Stein JL, van Wijnen AJ, Lian JB, Stein GS. Control of cell cycle regulated histone genes during proliferation and differentiation. Int J Obes Relat Metab Disord. 1996 Mar; 20 Suppl 3:S84-90.
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Stein GS, Stein JL, Van Wijnen AJ, Lian JB. Transcriptional control of cell cycle progression: the histone gene is a paradigm for the G1/S phase and proliferation/differentiation transitions. Cell Biol Int. 1996 Jan; 20(1):41-9.
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Lian JB, Stein GS, Stein JL, Van Wijnen A, McCabe L, Banerjee C, Hoffmann H. The osteocalcin gene promoter provides a molecular blueprint for regulatory mechanisms controlling bone tissue formation: role of transcription factors involved in development. Connect Tissue Res. 1996; 35(1-4):15-21.
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Birnbaum MJ, van Wijnen AJ, Odgren PR, Last TJ, Suske G, Stein GS, Stein JL. Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3. Biochemistry. 1995 Dec 19; 34(50):16503-8.
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Desai RK, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine. Endocrinology. 1995 Dec; 136(12):5685-93.
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Guo B, Odgren PR, van Wijnen AJ, Last TJ, Nickerson J, Penman S, Lian JB, Stein JL, Stein GS. The nuclear matrix protein NMP-1 is the transcription factor YY1. Proc Natl Acad Sci U S A. 1995 Nov 7; 92(23):10526-30.
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Shakoori AR, van Wijnen AJ, Cooper C, Aziz F, Birnbaum M, Reddy GP, Grana X, De Luca A, Giordano A, Lian JB, et al. Cytokine induction of proliferation and expression of CDC2 and cyclin A in FDC-P1 myeloid hematopoietic progenitor cells: regulation of ubiquitous and cell cycle-dependent histone gene transcription factors. J Cell Biochem. 1995 Nov; 59(3):291-302.
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Merriman HL, van Wijnen AJ, Hiebert S, Bidwell JP, Fey E, Lian J, Stein J, Stein GS. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: interactions with the osteocalcin gene promoter. Biochemistry. 1995 Oct 10; 34(40):13125-32.
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Vaughan PS, Aziz F, van Wijnen AJ, Wu S, Harada H, Taniguchi T, Soprano KJ, Stein JL, Stein GS. Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2. Nature. 1995 Sep 28; 377(6547):362-5.
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Stein GS, Stein JL, van Wijnen A, Lian JB, Quesenberry PJ. Molecular mechanisms mediating control of cell cycle and cell growth. Exp Hematol. 1995 Sep; 23(10):1053-61.
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Wright KL, Birnbaum MJ, van Wijnen AJ, Stein GS, Stein JL. Bipartite structure of the proximal promoter of a human H4 histone gene. J Cell Biochem. 1995 Jul; 58(3):372-9.
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Birnbaum MJ, Wright KL, van Wijnen AJ, Ramsey-Ewing AL, Bourke MT, Last TJ, Aziz F, Frenkel B, Rao BR, Aronin N, et al. Functional role for Sp1 in the transcriptional amplification of a cell cycle regulated histone H4 gene. Biochemistry. 1995 Jun 13; 34(23):7648-58.
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Aslam F, Shalhoub V, van Wijnen AJ, Banerjee C, Bortell R, Shakoori AR, Litwack G, Stein JL, Stein GS, Lian JB. Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription. Mol Endocrinol. 1995 Jun; 9(6):679-90.
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Bagchi M, Van Wijnen A, Katar M, Merriman H, Lian J, Stein J, Stein G, Maisel H. Sequence-specific DNA binding activities of nuclear matrix proteins of mammalian lens epithelial cells. J Cell Biochem. 1995 May; 58(1):1-5.
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Kroeger PE, van Wijnen AJ, Pauli U, Wright KL, Stein GS, Stein JL. In vivo occupancy of histone gene proximal promoter elements reflects gene copy number-dependent titratable transactivation factors and cross-species compatibility of regulatory sequences. J Cell Biochem. 1995 Feb; 57(2):191-207.
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Stein GS, van Wijnen AJ, Stein J, Lian JB, Montecino M. Contributions of nuclear architecture to transcriptional control. Int Rev Cytol. 1995; 162A:251-78.
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Stein GS, Stein JL, van Wijnen AJ, Lian JB. The maturation of a cell. American Scientist. 1995; 84:28-37.
Breen EC, van Wijnen AJ, Lian JB, Stein GS, Stein JL. In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D-dependent transcriptional upregulation in intact cells. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12902-6.
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Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL. Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12887-91.
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van Wijnen AJ, Aziz F, Grana X, De Luca A, Desai RK, Jaarsveld K, Last TJ, Soprano K, Giordano A, Lian JB, et al. Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12882-6.
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Shakoori AR, van Wijnen AJ, Bortell R, Owen TA, Stein JL, Lian JB, Stein GS. Variations in vitamin D receptor transcription factor complexes associated with the osteocalcin gene vitamin D responsive element in osteoblasts and osteosarcoma cells. J Cell Biochem. 1994 Jun; 55(2):218-29.
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van den Ent FM, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Cell cycle controlled histone H1, H3, and H4 genes share unusual arrangements of recognition motifs for HiNF-D supporting a coordinate promoter binding mechanism. J Cell Physiol. 1994 Jun; 159(3):515-30.
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Ramsey-Ewing A, Van Wijnen AJ, Stein GS, Stein JL. Delineation of a human histone H4 cell cycle element in vivo: the master switch for H4 gene transcription. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4475-9.
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Stein GS, van Wijnen AJ, Stein JL, Lian JB, Bidwell JP, Montecino M. Nuclear architecture supports integration of physiological regulatory signals for transcription of cell growth and tissue-specific genes during osteoblast differentiation. J Cell Biochem. 1994 May; 55(1):4-15.
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Bidwell J, van Wijnen A, Banerjee C, Fey E, Merriman H, Penman S, Stein J, Lian J, Stein G. Parathyroid-responsive modifications in the nuclear matrix of ROS 17/2.8 rat osteosarcoma cells. Endocrinology. 1994 Apr; 134(4):1738-44.
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Bidwell JP, van Wijnen AJ, Fey EG, Merriman H, Penman S, Stein JL, Stein GS, Lian JB. Subnuclear distribution of the vitamin D receptor. J Cell Biochem. 1994 Apr; 54(4):494-500.
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Stein GS, Stein JL, van Wijnen AJ, Lian JB. Histone gene transcription: a model for responsiveness to an integrated series of regulatory signals mediating cell cycle control and proliferation/differentiation interrelationships. J Cell Biochem. 1994 Apr; 54(4):393-404.
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Bidwell JP, Fey EG, van Wijnen AJ, Penman S, Stein JL, Lian JB, Stein GS. Nuclear matrix proteins distinguish normal diploid osteoblasts from osteosarcoma cells. Cancer Res. 1994 Jan 1; 54(1):28-32.
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van Wijnen AJ, Bidwell JP, Fey EG, Penman S, Lian JB, Stein JL, Stein GS. Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C/EBP, OCT-1, and AP-1. Biochemistry. 1993 Aug 24; 32(33):8397-402.
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van den Ent FM, van Wijnen AJ, Last TJ, Bortell R, Stein JL, Lian JB, Stein GS. Concerted control of multiple histone promoter factors during cell density inhibition of proliferation in osteosarcoma cells: reciprocal regulation of cell cycle-controlled and bone-related genes. Cancer Res. 1993 May 15; 53(10 Suppl):2399-409.
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Bidwell JP, Van Wijnen AJ, Fey EG, Dworetzky S, Penman S, Stein JL, Lian JB, Stein GS. Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3162-6.
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Bortell R, van Wijnen AJ, Ramsey-Ewing AL, Stein GS, Stein JL. Differential regulation of H4 histone gene expression in 3T3-L1 pre-adipocytes during arrest of proliferation following contact inhibition or differentiation and its modulation by TGF beta 1. J Cell Biochem. 1992 Sep; 50(1):62-72.
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van Wijnen AJ, van den Ent FM, Lian JB, Stein JL, Stein GS. Overlapping and CpG methylation-sensitive protein-DNA interactions at the histone H4 transcriptional cell cycle domain: distinctions between two human H4 gene promoters. Mol Cell Biol. 1992 Jul; 12(7):3273-87.
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Bortell R, Owen TA, Bidwell JP, Gavazzo P, Breen E, van Wijnen AJ, DeLuca HF, Stein JL, Lian JB, Stein GS. Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):6119-23.
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Gerbaulet SP, van Wijnen AJ, Aronin N, Tassinari MS, Lian JB, Stein JL, Stein GS. Downregulation of histone H4 gene transcription during postnatal development in transgenic mice and at the onset of differentiation in transgenically derived calvarial osteoblast cultures. J Cell Biochem. 1992 Jun; 49(2):137-47.
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van der Houven van Oordt CW, van Wijnen AJ, Carter R, Soprano K, Lian JB, Stein GS, Stein JL. Protein-DNA interactions at the H4-site III upstream transcriptional element of a cell cycle regulated histone H4 gene: differences in normal versus tumor cells. J Cell Biochem. 1992 May; 49(1):93-110.
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Stein GS, Stein JL, van Wijnen AJ, Lian JB. Regulation of histone gene expression. Curr Opin Cell Biol. 1992 Apr; 4(2):166-73.
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Wright KL, Dell'Orco RT, van Wijnen AJ, Stein JL, Stein GS. Multiple mechanisms regulate the proliferation-specific histone gene transcription factor HiNF-D in normal human diploid fibroblasts. Biochemistry. 1992 Mar 17; 31(10):2812-8.
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van Wijnen AJ, Bidwell J, Lian JB, Stein JL, Stein GS. Stairway assays: rapid localization of multiple protein/DNA interaction sites in gene-regulatory 5' regions. Biotechniques. 1992 Mar; 12(3):400-7.
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van Wijnen AJ, Lian JB, Stein JL, Stein GS. Protein/DNA interactions involving ATF/AP1-, CCAAT-, and HiNF-D-related factors in the human H3-ST519 histone promoter: cross-competition with transcription regulatory sites in cell cycle controlled H4 and H1 histone genes. J Cell Biochem. 1991 Dec; 47(4):337-51.
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Stein GS, Lian JB, Dworetzky SI, Owen TA, Bortell R, Bidwell JP, van Wijnen AJ. Regulation of transcription-factor activity during growth and differentiation: involvement of the nuclear matrix in concentration and localization of promoter binding proteins. J Cell Biochem. 1991 Dec; 47(4):300-5.
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van Wijnen AJ, Owen TA, Holthuis J, Lian JB, Stein JL, Stein GS. Coordination of protein-DNA interactions in the promoters of human H4, H3, and H1 histone genes during the cell cycle, tumorigenesis, and development. J Cell Physiol. 1991 Jul; 148(1):174-89.
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van Wijnen AJ, Ramsey-Ewing AL, Bortell R, Owen TA, Lian JB, Stein JL, Stein GS. Transcriptional element H4-site II of cell cycle regulated human H4 histone genes is a multipartite protein/DNA interaction site for factors HiNF-D, HiNF-M, and HiNF-P: involvement of phosphorylation. J Cell Biochem. 1991 Jun; 46(2):174-89.
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van Wijnen AJ, Choi TK, Owen TA, Wright KL, Lian JB, Jaenisch R, Stein JL, Stein GS. Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2573-7.
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Owen TA, Bortell R, Yocum SA, Smock SL, Zhang M, Abate C, Shalhoub V, Aronin N, Wright KL, van Wijnen AJ, et al. Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9990-4.
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Owen TA, Holthuis J, Markose E, van Wijnen AJ, Wolfe SA, Grimes SR, Lian JB, Stein GS. Modifications of protein-DNA interactions in the proximal promoter of a cell-growth-regulated histone gene during onset and progression of osteoblast differentiation. Proc Natl Acad Sci U S A. 1990 Jul; 87(13):5129-33.
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Holthuis J, Owen TA, van Wijnen AJ, Wright KL, Ramsey-Ewing A, Kennedy MB, Carter R, Cosenza SC, Soprano KJ, Lian JB, et al. Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D. Science. 1990 Mar 23; 247(4949 Pt 1):1454-7.
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Stein GS, Stein JL, Lian JB, Van Wijnen AJ, Wright KL, Pauli U. Modifications in molecular mechanisms associated with control of cell cycle regulated human histone gene expression during differentiation. Cell Biophys. 1989 Dec; 15(3):201-23.
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van Wijnen AJ, Wright KL, Lian JB, Stein JL, Stein GS. Human H4 histone gene transcription requires the proliferation-specific nuclear factor HiNF-D. Auxiliary roles for HiNF-C (Sp1-like) and HiNF-A (high mobility group-like). J Biol Chem. 1989 Sep 5; 264(25):15034-42.
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Stein G, Lian J, Stein J, Briggs R, Shalhoub V, Wright K, Pauli U, van Wijnen A. Altered binding of human histone gene transcription factors during the shutdown of proliferation and onset of differentiation in HL-60 cells. Proc Natl Acad Sci U S A. 1989 Mar; 86(6):1865-9.
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Collar DG, Wright KL, van Wijnen AJ, Ramsey AL, Lian J, Stein JL, Stein GS. The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down-regulated during terminal differentiation in HL60 cells. J Biol Chem. 1988 Nov 5; 263(31):15860-3.
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van Wijnen AJ, Massung RF, Stein JL, Stein GS. Human H1 histone gene promoter CCAAT box binding protein HiNF-B is a mosaic factor. Biochemistry. 1988 Aug 23; 27(17):6534-41.
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van Wijnen AJ, Wright KL, Massung RF, Gerretsen M, Stein JL, Stein GS. Two target sites for protein binding in the promoter region of a cell cycle regulated human H1 histone gene. Nucleic Acids Res. 1988 Jan 25; 16(2):571-92.
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Helms SR, van Wijnen AJ, Kroeger P, Shiels A, Stewart C, Hirshman J, Stein JL, Stein GS. Identification of an enhancer-like element upstream from a cell cycle dependent human H4 histone gene. J Cell Physiol. 1987 Sep; 132(3):552-8.
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Kroeger P, Stewart C, Schaap T, van Wijnen A, Hirshman J, Helms S, Stein G, Stein J. Proximal and distal regulatory elements that influence in vivo expression of a cell cycle-dependent human H4 histone gene. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):3982-6.
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van Wijnen AJ, Stein JL, Stein GS. A nuclear protein with affinity for the 5' flanking region of a cell cycle dependent human H4 histone gene in vitro. Nucleic Acids Res. 1987 Feb 25; 15(4):1679-98.
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