Publications

1. Evans CH, Ghivizzani SC, Robbins PD. The 2024 OREF Clinical Research Award: Progress Toward a Gene Therapy for Arthritis. J Am Acad Orthop Surg. 2024 Dec 1; 32 (23):1052-1060 Epub 2024 Oct 17
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2. Atasoy-Zeybek A, Hawse GP, Nagelli CV, Lopez De Padilla CM, Abdel MP, Evans CH. Transcriptomic Changes During the Replicative Senescence of Human Articular Chondrocytes. Int J Mol Sci. 2024 Nov 12; 25 (22)
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3. Logli AL, Evans CH, Duryea J, Larson DR, Bakri K, Carlsen BT, Dennison DG, Karim KE, Pulos NA, Rhee PC, Rizzo M, Shin AY, Elhassan BT, Kakar S. Investigation Into the Effects of Intra-Articular Steroid on Post-Traumatic Osteoarthritis in Distal Radius Fractures: A Randomized Controlled Pilot Study. J Hand Surg Am. 2024 Aug; 49 (8):757-765 Epub 2024 Jan 04
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4. Atasoy-Zeybek A, Hawse GP, Nagelli CV, Lopez De Padilla C, Abdel MP, Evans CH. Transcriptomic changes during the replicative senescence of human articular chondrocytes. bioRxiv. 2023 Nov 7.
   
5. Panos JA, Coenen MJ, Nagelli CV, McGlinch EB, Atasoy-Zeybek A, Lopez De Padilla C, De la Vega RE, Evans CH. Segmental defect healing in the presence or absence of recombinant human BMP2: Novel insights from a rat model. J Orthop Res. 2023 Sep; 41 (9):1934-1944 Epub 2023 Feb 27
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6. Abdul TY, Hawse GP, Smith J, Sellon JL, Abdel MP, Wells JW, Coenen MJ, Evans CH, De La Vega RE. Prevalence of AAV2.5 neutralizing antibodies in synovial fluid and serum of patients with osteoarthritis. Gene Ther. 2023 Aug; 30 (7-8):587-591 Epub 2022 Mar 09
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7. Atasoy-Zeybek A, Coenen MJ, Hawse GP, Logeart-Avramoglou D, Evans CH, De La Vega RE. Efficient autocrine and paracrine signaling explain the osteogenic superiority of transgenic BMP-2 over rhBMP-2. Mol Ther Methods Clin Dev. 2023 Jun 8; 29:350-363 Epub 2023 Apr 03
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8. Peniche Silva CJ, De La Vega RE, Panos J, Joris V, Evans CH, Balmayor ER, van Griensven M. MiRNAs as Potential Regulators of Enthesis Healing: Findings in a Rodent Injury Model. Int J Mol Sci. 2023 May 10; 24 (10)
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9. Panos JA, Coenen MJ, Nagelli CV, McGlinch EB, Atasoy-Zeybek A, De Padilla CL, Coghlan RF, Johnstone B, Ferreira E, Porter RM, De la Vega RE, Evans CH. IL-1Ra gene transfer potentiates BMP2-mediated bone healing by redirecting osteogenesis toward endochondral ossification. Mol Ther. 2023 Feb 1; 31 (2):420-434 Epub 2022 Oct 17
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10. Iijima H, Gilmer G, Wang K, Bean AC, He Y, Lin H, Tang WY, Lamont D, Tai C, Ito A, Jones JJ, Evans C, Ambrosio F. Age-related matrix stiffening epigenetically regulates alpha-Klotho expression and compromises chondrocyte integrity. Nat Commun. 2023 Jan 10; 14 (1):18
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11. Nagelli CV, Evans CH, De la Vega RE. Gene Delivery to Chondrocytes. Adv Exp Med Biol. 2023; 1402:95-105.
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12. Nagelli CV, Evans CH, De la Vega RE. Electromechanobiology of Cartilage and Osteoarthritis. Advances in Experimental Medicine and Biology. 2023; 1402:95-105
    
13. Nagelli CV, Evans CH, De La Vega RE. Viral Gene Delivery in Chondrocytes. Methods Mol Biol. 2023; 2598:289-300
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14. Evans CH, Ghivizzani SC, Robbins PD. Osteoarthritis gene therapy in 2022. Curr Opin Rheumatol. 2023 Jan 1; 35 (1):37-43 Epub 2022 Nov 09
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15. Shi G, Long Z, De la Vega RE, Behfar A, Moran SL, Evans C, Zhao C. Purified exosome product enhances chondrocyte survival and regeneration by modulating inflammation and promoting chondrogenesis. Regen Med. 2023 Jan; 18 (1):55-71 Epub 2022 Oct 18
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16. Sherwin RE, McGlinch EB, Barry MA, Lopez De Padilla CM, Montonye DR, Evans CH, Atasoy-Zeybek A. AAV-mediated, in vivo gene delivery to the rotator cuff. European Cells and Materials. 2023; 46:154-70
    
17. Peniche Silva CJ, Muller SA, Quirk N, De la Vega RE, Coenen MJ, Evans CH, Balmayor ER, van Griensven M. Enthesis: not the same in each localisation - a molecular, histological and biomechanical study. Eur Cell Mater. 2022 Aug 17; 44:43-55
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18. Woloszyk A, Tuong ZK, Perez L, Aguilar L, Bankole AI, Evans CH, Glatt V. Fracture hematoma micro-architecture influences transcriptional profile and plays a crucial role in determining bone healing outcomes. Biomater Adv. 2022 Aug; 139:213027 Epub 2022 July 12
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19. Iijima H, Gilmer G, Wang K, Sivakumar S, Evans C, Matsui Y, Ambrosio F. Meta-analysis Integrated With Multi-omics Data Analysis to Elucidate Pathogenic Mechanisms of Age-Related Knee Osteoarthritis in Mice. J Gerontol A Biol Sci Med Sci. 2022 Jul 5; 77 (7):1321-1334
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20. Nagelli CV, De La Vega RE, Coenen M, De Padilla CL, Panos JA, Tovar A, Muller SA, Evans CH. Expedited gene delivery for osteochondral defect repair in a rabbit knee model: A one-year investigation. Osteoarthr Cartil Open. 2022 Jun; 4 (2) Epub 2022 Mar 26
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21. Peniche Silva CJ, Muller SA, Quirk N, Poh PSP, Mayer C, Motta A, Migliaresi C, Coenen MJ, Evans CH, Balmayor ER, van Griensven M. Enthesis Healing Is Dependent on Scaffold Interphase Morphology-Results from a Rodent Patellar Model. Cells. 2022 May 26; 11 (11)
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22. Nagelli CV, Hooke A, Quirk N, De Padilla CL, Hewett TE, van Griensven M, Coenen M, Berglund L, Evans CH, Muller SA. Mechanical and strain behaviour of human Achilles tendon during in vitro testing to failure. Eur Cell Mater. 2022 Apr 21; 43:153-161
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23. De La Vega RE, van Griensven M, Zhang W, Coenen MJ, Nagelli CV, Panos JA, Peniche Silva CJ, Geiger J, Plank C, Evans CH, Balmayor ER. Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2. Sci Adv. 2022 Feb 18; 8 (7):eabl6242 Epub 2022 Feb 16
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24. Watson-Levings RS, Palmer GD, Levings PP, Dacanay EA, Evans CH, Ghivizzani SC. Gene Therapy in Orthopaedics: Progress and Challenges in Pre-Clinical Development and Translation. Front Bioeng Biotechnol. 2022; 10:901317 Epub 2022 June 28
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25. Lopez De Padilla CM, Coenen MJ, Tovar A, De la Vega RE, Evans CH, Muller SA. Picrosirius Red Staining: Revisiting Its Application to the Qualitative and Quantitative Assessment of Collagen Type I and Type III in Tendon. J Histochem Cytochem. 2021 Oct; 69 (10):633-643 Epub 2021 Sept 22
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26. De la Vega RE, Atasoy-Zeybek A, Panos JA, VAN Griensven M, Evans CH, Balmayor ER. Gene therapy for bone healing: lessons learned and new approaches. Transl Res. 2021 Oct; 236:1-16 Epub 2021 May 05
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27. Evans CH, Ghivizzani SC, Robbins PD. Orthopaedic Gene Therapy: Twenty-Five Years On. JBJS Rev. 2021 Aug 26; 9 (8)
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28. Glatt V, Evans CH, Tetsworth K. Reverse dynamisation: a modern perspective on Stephan Perren's strain theory. Eur Cell Mater. 2021 Jun 10; 41:668-679 Epub 2021 June 10
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29. Liu TY, Bartnikowski M, Wu AC, Veitch M, Sokolowski KA, Millard SM, Pettit AR, Glatt V, Evans CH, Wells JW. Healing of sub-critical femoral osteotomies in mice is unaffected by tacrolimus and deletion of recombination activating gene 1. Eur Cell Mater. 2021 Mar 17; 41:345-354
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30. De la Vega RE, Coenen MJ, Muller SA, Nagelli CV, Quirk NP, Lopez de Padilla C, Evans CH. Effects of FK506 on the healing of diaphyseal, critical size defects in the rat femur. Eur Cell Mater. 2020 Oct 6; 40:160-171 Epub 2020 Oct 06
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31. Willett NJ, Boninger ML, Miller LJ, Alvarez L, Aoyama T, Bedoni M, Brix KA, Chisari C, Christ G, Dearth CL, Dyson-Hudson TA, Evans CH, Goldman SM, Gregory K, Gualerzi A, Hart J, Ito A, Kuroki H, Loghmani MT, Mack DL, Malanga GA, Noble-Haeusslein L, Pasquina P, Roche JA, Rose L, Stoddart MJ, Tajino J, Terzic C, Topp KS, Wagner WR, Warden SJ, Wolf SL, Xie H, Rando TA, Ambrosio F. Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field. Arch Phys Med Rehabil. 2020 May; 101 (5):917-923 Epub 2020 Feb 05
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32. Weissenberger M, Weissenberger MH, Gilbert F, Groll J, Evans CH, Steinert AF. Reduced hypertrophy in vitro after chondrogenic differentiation of adult human mesenchymal stem cells following adenoviral SOX9 gene delivery. BMC Musculoskelet Disord. 2020 Feb 17; 21 (1):109
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33. Weissenberger M, Weissenberger MH, Wagenbrenner M, Heinz T, Reboredo J, Holzapfel BM, Rudert M, Groll J, Evans CH, Steinert AF. Different types of cartilage neotissue fabricated from collagen hydrogels and mesenchymal stromal cells via SOX9, TGFB1 or BMP2 gene transfer. PLoS One. 2020; 15 (8):e0237479 Epub 2020 Aug 13
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34. Flores RR, Carbo L, Kim E, Van Meter M, De Padilla CML, Zhao J, Colangelo D, Yousefzadeh MJ, Angelini LA, Zhang L, Pola E, Vo N, Evans CH, Gambotto A, Niedernhofer LJ, Robbins PD. Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice. FASEB J. 2019 Aug; 33 (8):9505-9515 Epub 2019 June 06
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35. Atasoy-Zeybek A, Ivkovic A, Beyzadeoglu T, Onal A, Evans CH, Kose GT. Paracrine effects of living human bone particles on the osteogenic differentiation of mesenchymal stem cells. Eur Cell Mater. 2019 Jul 23; 38:14-22 Epub 2019 July 23
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36. Glatt V, Evans CH, Stoddart MJ. Regenerative rehabilitation: The role of mechanotransduction in orthopaedic regenerative medicine. J Orthop Res. 2019 Jun; 37 (6):1263-1269 Epub 2019 Jan 16
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37. De La Vega RE, Scheu M, Brown LA, Evans CH, Ferreira E, Porter RM. Specific, Sensitive, and Stable Reporting of Human Mesenchymal Stromal Cell Chondrogenesis. Tissue Eng Part C Methods. 2019 Mar; 25 (3):176-190
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38. Muller SA, Quirk NP, Muller-Lebschi JA, Heisterbach PE, Durselen L, Majewski M, Evans CH. Response of the Injured Tendon to Growth Factors in the Presence or Absence of the Paratenon. Am J Sports Med. 2019 Feb; 47 (2):462-467 Epub 2018 Dec 14
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39. Zhang W, De La Vega RE, Coenen MJ, Muller SA, Peniche Silva CJ, Aneja MK, Plank C, van Griensven M, Evans CH, Balmayor ER. An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis In Vitro and In Vivo. Tissue Eng Part A. 2019 Jan; 25 (1-2):131-144 Epub 2018 Oct 03
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40. Balmayor ER, Evans CH. RNA Therapeutics for Tissue Engineering. Tissue Eng Part A 2019 Jan; 25 (1-2):9-11
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41. Evans CH. Catering to chondrocytes. Sci Transl Med 2018 Nov 28; 10 (469)
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42. Quirk NP, Lopez De Padilla C, De La Vega RE, Coenen MJ, Tovar A, Evans CH, Muller SA. Effects of freeze-thaw on the biomechanical and structural properties of the rat Achilles tendon. J Biomech. 2018 Nov 16; 81:52-57 Epub 2018 Sept 15
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43. Graceffa V, Vinatier C, Guicheux J, Evans CH, Stoddart M, Alini M, Zeugolis DI. State of art and limitations in genetic engineering to induce stable chondrogenic phenotype. Biotechnol Adv. 2018 Nov 15; 36 (7):1855-1869 Epub 2018 July 21
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44. Duryea J, Evans C, Glatt V. Image Analysis Software as a Strategy to Improve the Radiographic Determination of Fracture Healing. J Orthop Trauma. 2018 Sep; 32 (9):e354-e358
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45. Evans CH, Ghivizzani SC, Robbins PD. Arthritis gene therapy is becoming a reality. Nat Rev Rheumatol. 2018 Jul; 14 (7):381-382
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46. Majewski M, Heisterbach P, Jaquiery C, Durselen L, Todorov A, Martin I, Evans CH, Muller SA. Improved tendon healing using bFGF, BMP-12 and TGFbeta1 in a rat model. Eur Cell Mater. 2018 Jun 13; 35:318-334 Epub 2018 June 13
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47. Watson Levings RS, Smith AD, Broome TA, Rice BL, Gibbs EP, Myara DA, Hyddmark EV, Nasri E, Zarezadeh A, Levings PP, Lu Y, White ME, Dacanay EA, Foremny GB, Evans CH, Morton AJ, Winter M, Dark MJ, Nickerson DM, Colahan PT, Ghivizzani SC. Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model. Hum Gene Ther Clin Dev. 2018 Jun; 29 (2):101-112
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48. Watson Levings RS, Broome TA, Smith AD, Rice BL, Gibbs EP, Myara DA, Hyddmark EV, Nasri E, Zarezadeh A, Levings PP, Lu Y, White ME, Dacanay EA, Foremny GB, Evans CH, Morton AJ, Winter M, Dark MJ, Nickerson DM, Colahan PT, Ghivizzani SC. Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model. Hum Gene Ther Clin Dev. 2018 Jun; 29 (2):90-100
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49. Muller SA, Evans CH, Heisterbach PE, Majewski M. The Role of the Paratenon in Achilles Tendon Healing: A Study in Rats. Am J Sports Med. 2018 Apr; 46 (5):1214-1219 Epub 2018 Mar 05
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50. Devine DM, Hoctor E, Hayes JS, Sheehan E, Evans CH. Extended release of proteins following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications. Mater Sci Eng C Mater Biol Appl. 2018 Mar 1; 84:281-289 Epub 2017 Nov 15
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51. Evans CH, Ghivizzani SC, Robbins PD. Arthritis Gene Therapy Approved in Korea. J Am Acad Orthop Surg 2018 Jan 15; 26 (2):e36-e38
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52. De La Vega RE, De Padilla CL, Trujillo M, Quirk N, Porter RM, Evans CH, Ferreira E. Contribution of Implanted, Genetically Modified Muscle Progenitor Cells Expressing BMP-2 to New Bone Formation in a Rat Osseous Defect. Mol Ther. 2018 Jan 3; 26 (1):208-218 Epub 2017 Oct 05
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53. Bougioukli S, Evans CH, Alluri RK, Ghivizzani SC, Lieberman JR. Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery. Curr Gene Ther. 2018; 18 (3):154-170
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54. Evans CH, Ghivizzani SC, Robbins PD. Gene Delivery to Joints by Intra-Articular Injection. Hum Gene Ther. 2018 Jan; 29 (1):2-14
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55. Wehling P, Evans C, Wehling J, Maixner W. Effectiveness of intra-articular therapies in osteoarthritis: a literature review. Ther Adv Musculoskelet Dis. 2017 Aug; 9 (8):183-196 Epub 2017 June 20
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56. Grodzinsky AJ, Wang Y, Kakar S, Vrahas MS, Evans CH. Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis. J Orthop Res. 2017 Mar; 35 (3):406-411 Epub 2017 Mar 02
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57. Liu F, Wells JW, Porter RM, Glatt V, Shen Z, Schinhan M, Ivkovic A, Vrahas MS, Evans CH, Ferreira E. Interaction between living bone particles and rhBMP-2 in large segmental defect healing in the rat femur. J Orthop Res. 2016 Dec; 34 (12):2137-2145 Epub 2016 Apr 25
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58. Evans CH, Chevalier X, Wehling P. Autologous Conditioned Serum. Phys Med Rehabil Clin N Am. 2016 Nov; 27 (4):893-908
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59. Muller SA, Durselen L, Heisterbach P, Evans C, Majewski M. Effect of a Simple Collagen Type I Sponge for Achilles Tendon Repair in a Rat Model. Am J Sports Med. 2016 Aug; 44 (8):1998-2004 Epub 2016 Apr 22
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60. Verrier S, Alini M, Alsberg E, Buchman SR, Kelly D, Laschke MW, Menger MD, Murphy WL, Stegemann JP, Schutz M, Miclau T, Stoddart MJ, Evans C. Tissue engineering and regenerative approaches to improving the healing of large bone defects. Eur Cell Mater. 2016 Jul 19; 32:87-110.
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61. Glatt V, Tepic S, Evans C. Reverse Dynamization: A Novel Approach to Bone Healing. J Am Acad Orthop Surg. 2016 Jul; 24 (7):e60-1
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62. Glatt V, Bartnikowski N, Quirk N, Schuetz M, Evans C. Reverse Dynamization: Influence of Fixator Stiffness on the Mode and Efficiency of Large-Bone-Defect Healing at Different Doses of rhBMP-2. J Bone Joint Surg Am. 2016 Apr 20; 98 (8):677-87
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63. Bara JJ, Herrmann M, Evans CH, Miclau T, Ratcliffe A, Richards RG. Improving translation success of cell-based therapies in orthopaedics. J Orthop Res. 2016 Jan; 34 (1):17-21 Epub 2015 Oct 06
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64. Glatt V, Evans CH, Tetsworth K. A Concert between Biology and Biomechanics: The Influence of the Mechanical Environment on Bone Healing. Front Physiol. 2016; 7:678 Epub 2017 Jan 24
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65. Wang G, Evans CH, Benson JM, Hutt JA, Seagrave J, Wilder JA, Grieger JC, Samulski RJ, Terse PS. Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model. Mol Ther Methods Clin Dev. 2016; 3:15052 Epub 2016 Jan 13
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66. Liu F, Ferreira E, Porter RM, Glatt V, Schinhan M, Shen Z, Randolph MA, Kirker-Head CA, Wehling C, Vrahas MS, Evans CH, Wells JW. Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle. Eur Cell Mater. 2015 Sep 21; 30:118-30; discussion 130-1 Epub 2015 Sept 21
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67. Evans CH, Huard J. Gene therapy approaches to regenerating the musculoskeletal system. Nat Rev Rheumatol. 2015 Apr; 11 (4):234-42 Epub 2015 Mar 17
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68. Docheva D, Muller SA, Majewski M, Evans CH. Biologics for tendon repair. Adv Drug Deliv Rev. 2015 Apr; 84:222-39 Epub 2014 Nov 21
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69. Evans CH. Native, living tissues as cell seeded scaffolds. Ann Biomed Eng. 2015 Mar; 43 (3):787-95 Epub 2014 Nov 06
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70. Pleticha J, Heilmann LF, Evans CH, Asokan A, Samulski RJ, Beutler AS. Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs. Mol Pain. 2014 Sep 2; 10:54 Epub 2014 Sept 02
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71. Evans C. Using genes to facilitate the endogenous repair and regeneration of orthopaedic tissues. Int Orthop. 2014 Sep; 38 (9):1761-9 Epub 2014 July 20
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72. Madry H, Alini M, Stoddart MJ, Evans C, Miclau T, Steiner S. Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols. Eur Cell Mater. 2014; 27s:17-21.
    
73. Sullivan CB, Porter RM, Evans CH, Ritter T, Shaw G, Barry F, Murphy JM. TNFalpha and IL-1beta influence the differentiation and migration of murine MSCs independently of the NF-kappaB pathway. Stem Cell Res Ther. 2014; 5(4):104. Epub 2014 Aug 27
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74. Evans CH, Setton LA, Kraus V. Progress in intra-articular therapy. Invited Article. Nat Rev Rheumatol.2014;10:11-22.
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75. Evans CH. Advances in regenerative orthopedics. Mayo Clin Proc. 2013 Nov; 88(11):1323-39.
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76. Ferreira E, Porter RM, Wehling N, O'Sullivan RP, Liu F, Boskey A, Estok DM, Harris MB, Vrahas MS, Evans CH, Wells JW. Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow. J Biol Chem. 2013 Oct 11; 288 (41):29494-505 Epub 2013 Aug 22
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77. Vo N, Niedernhofer LJ, Nasto LA, Jacobs L, Robbins PD, Kang J, Evans CH. An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. J Orthop Res. 2013 Jun; 31(6):831-7. Epub 2013 Mar 11
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78. Evans CH, Ghivizzani SC, Robbins PD. Arthritis gene therapy and its tortuous path into the clinic. Transl Res. 2013 Apr; 161(4):205-16. Epub 2013 Jan 29.
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79. Evans CH. Platelet-rich plasma à la carte J Bone Joint Surg Am.2013;e80:1-2.
    
80. Florine EM, Miller RE, Porter RM, Evans CH, Kurz B, Grodzinsky AJ. Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds. Cartilage. 2013 Jan 1; 4(1):63-74.
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81. Wells JW, Evans CH, Scott MC, Rutgen BC, O'Brien TD, Modiano JF, Cvetkovic G, Tepic S. Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation. PLoS One. 2013; 8 (1):e54464 Epub 2013 Jan 24
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82. Glatt V, Miller M, Ivkovic A, Liu F, Parry N, Griffin D, Vrahas M, Evans C. Improved healing of large segmental defects in the rat femur by reverse dynamization in the presence of bone morphogenetic protein-2. J Bone Joint Surg Am. 2012 Nov 21; 94 (22):2063-73
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83. Heisterbach PE, Todorov A, Fluckiger R, Evans CH, Majewski M. Effect of BMP-12, TGF-beta1 and autologous conditioned serum on growth factor expression in Achilles tendon healing. Knee Surg Sports Traumatol Arthrosc. 2012 Oct; 20(10):1907-14. Epub 2011 Nov 29.
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84. Evans CH, Liu F, Porter RM, O'Sullivan RP, Merghoub T, Lunsford EP, Robichaud K, Van Valen F, Lessnick SL, Gebhardt MC, Wells JW. EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors. Clin Cancer Res. 2012 Oct 1; 18(19):5341-51. Epub 2012 Aug 09.
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85. Evans CH. Gene delivery to bone. Adv Drug Deliv Rev. 2012 Sep; 64(12):1331-40. Epub 2012 Mar 26.
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86. Liu F, Porter RM, Wells J, Glatt V, Pilapil C, Evans CH. Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair. J Orthop Res. 2012 Jul; 30(7):1095-102. Epub 2011 Dec 28.
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87. Evans CH. Perspective. FDA arthritis advisory panel votes to continue anti-NGF clinical trials. Orthopedics Today. April 2012.
    
88. Evans CH, Ghivizzani SC, Robbins PD. Orthopedic gene therapy--lost in translation? J Cell Physiol. 2012 Feb; 227(2):416-20.
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89. Sullivan C, Murphy JM, Griffin MD, Porter RM, Evans CH, O'Flatharta C, Shaw G, Barry F. Genetic mismatch affects the immunosuppressive properties of mesenchymal stem cells in vitro and their ability to influence the course of collagen-induced arthritis. Arthritis Res Ther. 2012; 14(4):R167. Epub 2012 Jul 19.
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90. Majewski M, Porter RM, Betz OB, Betz VM, Clahsen H, Fluckiger R, Evans CH. Improvement of tendon repair using muscle grafts transduced with TGF-beta1 cDNA. Eur Cell Mater. 2012; 23:94-101; discussion 101-2. Epub 2012 Feb 16.
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91. Glatt V, Evans CH, Matthys R. Design, characterisation and in vivo testing of a new, adjustable stiffness, external fixator for the rat femur. Eur Cells Mater. 2012; 23:289 - 299.
    
92. Evans CH. Barriers to the clinical translation of orthopedic tissue engineering. Tissue Eng Part B Rev. 2011 Dec; 17(6):437-41. Epub 2011 Aug 08.
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93. Evans C. Gene therapy for the regeneration of bone. Injury. 2011 Jun; 42(6):599-604. Epub 2011 Apr 13.
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94. Steinert AF, Kunz M, Prager P, Barthel T, Jakob F, Noth U, Murray MM, Evans CH, Porter RM. Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A. 2011 May; 17(9-10):1375-88. Epub 2011 Mar 8
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95. Evans CH, Ghivizzani SC, Robbins PD. Getting arthritis gene therapy into the clinic. Nat Rev Rheumatol. 2011 Apr; 7(4):244-9. Epub 2010 Dec 07.
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96. Miller MA, Ivkovic A, Porter R, Harris MB, Estok DM 2nd, Smith RM, Evans CH, Vrahas MS. Autologous bone grafting on steroids: preliminary clinical results. A novel treatment for nonunions and segmental bone defects. Int Orthop. 2011 Apr; 35(4):599-605. Epub 2010 Apr 23.
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97. Ivkovic A, Marijanovic I, Hudetz D, Porter RM, Pecina M, Evans CH. Regenerative medicine and tissue engineering in orthopaedic surgery. Front Biosci. 2011; E3:923-944.
    
98. Lu YC, Evans CH, Grodzinsky AJ. Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines. Arthritis Res Ther. 2011; 13(5):R142. Epub 2011 Sep 02.
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99. Haddad-Weber M, Prager P, Kunz M, Seefried L, Jakob F, Murray MM, Evans CH, Noth U, Steinert AF. BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells. Cytotherapy. 2010 Jul; 12(4):505-13.
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100. Nazarian A, Pezzella L, Tseng A, Baldassarri S, Zurakowski D, Evans CH, Snyder BD. Application of structural rigidity analysis to assess fidelity of healed fractures in rat femurs with critical defects. Calcif Tissue Int. 2010 May; 86(5):397-403. Epub 2010 Mar 31.
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101. Evans CH. Arthritis gene therapy trials reach phase II. J Rheumatol. 2010; 37:683-5.
     
102. Evans CH. Gene therapy for bone healing. Expert Rev Mol Med. 2010; 12:e18. Epub 2010 Jun 23.
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103. Miller MA, Ivkovic A, Porter R, Harris MB, Estok DM, Smith RM, Evans CH, Vrahas MS. Autologous bone grafting on steroids: preliminary clinical results. A novel treatment for nonunions and segmental bone defects Internat Orthop. 2010. Epub 2010 Apr 23
     
104. Lefevre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, Korb A, Schnaker EM, Tarner IH, Robbins PD, Evans CH, Sturz H, Steinmeyer J, Gay S, Scholmerich J, Pap T, Muller-Ladner U, Neumann E. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med. 2009 Dec; 15(12):1414-20. Epub 2009 Nov 8
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105. Kay JD, Gouze E, Oligino TJ, Gouze JN, Watson RS, Levings PP, Bush ML, Dacanay A, Nickerson DM, Robbins PD, Evans CH, Ghivizzani SC. Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus. J Gene Med. 2009 Jul; 11(7):605-14.
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106. Kwong FN, Hoyland JA, Freemont AJ, Evans CH. Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion. J Orthop Res. 2009 Jun; 27(6):752-7.
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107. Steinert AF, Palmer GD, Pilapil C, Noth U, Evans CH, Ghivizzani SC. Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Eng Part A. 2009 May; 15(5):1127-39.
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108. Wehling N, Palmer GD, Pilapil C, Liu F, Wells JW, Muller PE, Evans CH, Porter RM. Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways. Arthritis Rheum. 2009 Mar; 60(3):801-12.
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109. Evans CH, Ghivizzani SC, Robbins PD. Orthopedic gene therapy in 2008. Mol Ther. 2009 Feb; 17(2):231-44. Epub 2008 Dec 09.
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110. Kwong FN, Hoyland JA, Evans CH, Freemont AJ. Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures. Int Orthop. 2009 Feb; 33(1):281-8. Epub 2008 Nov 21.
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111. Wehling P, Reinecke J, Baltzer AW, Granrath M, Schulitz KP, Schultz C, Krauspe R, Whiteside TW, Elder E, Ghivizzani SC, Robbins PD, Evans CH. Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis. Hum Gene Ther. 2009 Feb; 20(2):97-101.
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112. Evans CH, Ghivizzani SC, Robbins PD. Gene therapy of the rheumatic diseases: 1998 to 2008. Arthritis Res Ther. 2009; 11(1):209. Epub 2009 Jan 30.
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113. Evans CH, Ghivizzani SC, Robbins PD. Progress and Prospects: Genetic treatments for disorders of bones and joints. Gene Ther. 2009; 16:944-952.
     
114. Porter RM, Liu F, Pilapil C, Betz OB, Vrahas MS, Harris MB, Evans CH. Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty. J Orthop Res. 2009 Jan; 27(1):42-9.
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115. Glatt V, Kwong FN, Park K, Parry N, Griffin D, Vrahas M, Evans CH, Harris M. Ability of rhBMP-2 to enhance bone healing in the presence of tobramycin: evaluation in a rat segmental defect model. J Orthop Trauma. 2009; 23:693-701.
     
116. Majewski M, Ochsner PE, Liu F, Flückiger R, Evans CH. Accelerated healing of rat Achilles tendon in response to autologous conditioned serum. Am J Sports Med. 2009; 37:2117-2125.
     
117. Steinert AF, Proffen B, Kunz M, Hendrich C, Ghivizzani SC, Noth U, Rethwilm A, Eulert J, Evans CH. Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther. 2009; 11(5):R148. Epub 2009 Oct 02.
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118. Evans CH, Liu FJ, Glatt V, Hoyland JA, Kirker-Head C, Walsh A, Betz O, Wells JW, Betz V, Porter RM, Saad FA, Gerstenfeld LC, Einhorn TA, Harris MB, Vrahas MS. Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage. Eur Cell Mater. 2009; 18:96-111. Epub 2009 Dec 31.
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119. Ghivizzani SC, Gouze E, Gouze JN, Kay JD, Bush ML, Watson RS, Levings PP, Nickerson DM, Colahan PT, Robbins PD, Evans CH. Perspectives on the use of gene therapy for chronic joint diseases. Curr Gene Ther. 2008 Aug; 8(4):273-86.
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120. Betz VM, Betz OB, Harris MB, Vrahas MS, Evans CH. Bone tissue engineering and repair by gene therapy. Front Biosci. 2008; 13:833-841.
     
121. Steinert AF, Weber M, Kunz M, Palmer GD, Noth U, Evans CH, Murray MM. In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament. Biomaterials. 2008; 29:904-16.
     
122. Kisiday JD, Kopesky PW, Evans CH, Grodzinsky AJ, McIlwraith CW, Frisbie DD. Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures. J Orthop Res. 2008; 26:322-331.
     
123. Palmer GD, Stoddart MJ, Gouze E, Gouze JN, Ghivizzani SC, Porter RM, Evans CH. A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors. Gene Ther. 2008; 15:357-63.
     
124. Kwong FN, Richardson SM, Evans CH. Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells. Arthritis Res Ther. 2008; 10(3):R65. Epub 2008 Jun 04.
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125. Majewski M, Betz O, Ochsner PE, Liu F, Porter RM, Evans CH. Ex vivo adenoviral transfer of bone morphogenic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model. Gene Ther. 2008; 15:1139-1146.
     
126. Evans CH. Arthritis gene therapy trials and tribulations Bioethics Form Bioethicsforum.org. Dec 17, 2007.
     
127. Evans CH. John Hunter and the origins of modern orthopaedic research. J Orthop Res. 2007; 25:556-60.
     
128. Gouze JN, Evans CH, Ghivizzani SC, Gouze E. Application des techniques de therapie genique aux maladies osteo-articulaires. Med Sci (Paris). 2007; 23:303-310.
     
129. Evans CH, Palmer GD, Pascher A, Porter R, Kwong FN, Gouze E, Gouze JN, Liu F, Steinert A, Betz O, Betz V, Vrahas M, Ghivizzani SC. Facilitated endogenous repair: making tissue engineering simple, practical, and economical. Tissue Eng. 2007; 13:1987-93.
     
130. Steinert AF, Ghivizzani SC, Rethwilm A, Tuan RS, Evans CH, Noth U. Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res Ther. 2007; 9:213.
     
131. Betz OB, Betz VM, Nazarian A, Egermann M, Gerstenfeld LC, Einhorn TA, Vrahas MS, Bouxsein ML, Evans CH. Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther. 2007; 14:1039-44.
     
132. Gouze E, Gouze JN, Palmer GD, Pilapil C, Evans CH, Ghivizzani SC. Transgene persistence and cell turnover in the diathrodial joint: implications for gene therapy of chronic joint diseases. Mol Ther. 2007; 15:1114-20.
     
133. Goodrich LR, Hidaka C, Robbins PD, Evans CH, Nixon AJ. Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Jt Surg Br. 2007; 89:672-85.
     
134. Steinert AF, Palmer GD, Capito R, Hofstaetter JG, Pilapil C, Ghivizzani SC, Spector M, Evans CH. Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta1 complementary deoxyribonucleic acid. Tissue Eng. 2007; 13:2227-37.
     
135. Betz VM, Betz OB, Glatt V, Gerstenfeld LC, Einhorn TA, Bouxsein ML, Vrahas MS, Evans CH. Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose. Human Gene Ther. 2007; 18:907-15.
     
136. Evans CH, Gouze E, Gouze JN, Robbins PD, Ghivizzani SC. Gene therapeutic approaches-transfer in vivo. Adv Drug Deliv Rev. 2006; 58:243-58.
     
137. Evans CH, Ghivizzani SC, Wehling P, Robbins PD. Gene Therapy with the interleukin-1 receptor antagonist for the treatment of arthritis. Future Rheumatol. 2006; 1:173-178.
     
138. Evans CH. Potential biologic therapies for the intervertebral disc. J Bone Joint Surg Am. 2006; 88(Suppl 5-8):5-8.
     
139. Evans CH, Ghivizzani SC, Robbins PD. Gene therapy for arthritis: what next? Arthritis Rheum. 2006; 54:1714-29.
     
140. Gobezie R, Millett PJ, Sarracino DS, Evans C, Thornhill TS. Proteomics: applications to the study of rheumatoid arthritis and osteoarthritis. J Am Acad Orthop Surg. 2006; 14:325-32.
     
141. Evans CH, Ghivizzani SC, Robbins PD. Will arthritis gene therapy become a clinical reality? Nature Clin Pract Rheum. 2006; 2:344-345.
     
142. Meinel L, Hofmann S, Betz O, Fajardo R, Merkle HP, Langer R, Evans CH, Vunjak-Novakovic G, Kaplan DL. Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: comparison of adenovirus mediated gene transfer and protein delivery of BMP-2. Biomaterials. 2006; 27:4993-5002.
     
143. Betz OB, Betz VM, Nazarian A, Pilapil CG, Vrahas MS, Bouxsein ML, Gerstenfeld LC, Einhorn TA, Evans CH. Direct percutaneous gene delivery to enhance healing of segmental bone defects. J Bone Jt Surg Am. 2006; 88:355-65.
     
144. Egermann M, Baltzer AW, Adamaszek S, Evans C, Robbins P, Schneider E, Lill CA. Direct adenoviral transfer of Bone Morphogenetic Protein-2 cDNA enhances fracture healing in osteoporotic sheep. Hum Gene Ther. 2006; 17:507-517.
     
145. Egermann M, Lill CA, Griesbeck K, Evans CH, Robbins PD, Schneider E, Baltzer AW. Effect of BMP-2 gene transfer on bone healing in sheep. Gene Ther. 2006; 13:1290-9.
     
146. Goodrich LR, Brower-Toland BD, Warnick L, Robbins PD, Evans CH, Nixon AJ. Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations Gene Ther. 2006; 13:1253-62.
     
147. Evans CH. Gene therapy: what have we accomplished and where do we go from here? J Rheumatol Suppl. 2005; 72:17-20.
     
148. Evans CH, Ghivizzani SC, Gouze E, Rediske JJ, Schwarz EM, Robbins PD. The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics. Arthritis Res Ther. 2005; 7:273-8.
     
149. Egermann M, Schneider E, Evans CH, Baltzer AW. The potential of gene therapy for fracture healing in osteoporosis. Osteoporos Int 16 Suppl. 2005; 2:S120-8.
     
150. Evans CH. Latest developments in gene therapy. Asia Pacific Biotech News. 2005; 9:847-850.
     
151. Evans CH. Novel biological approaches to the intra-articular treatment of osteoarthritis. BioDrugs. 2005; 19:355-62.
     
152. Evans CH, Rosier RN. Molecular biology in orthopaedics: the advent of molecular orthopaedics. J Bone Jt Surg Am. 2005; 87:2550-64.
     
153. Evans CH, Ghivizzani SC, Herndon JH, Robbins PD. Gene therapy for the treatment of musculoskeletal diseases. J Am Acad Orthop Surg. 2005; 13:230-42.
     
154. Evans CH, Robbins PD, Ghivizzani SC, Wasko MC, Tomaino MM, Kang R, Muzzonigro TA, Vogt M, Elder EM, Whiteside TL, Watkins SC, Herndon JH. Gene transfer to human joints: Progress toward a gene therapy of arthritis. Proc Natl Acad Sci USA 102. 2005; 24:8698-8703.
     
155. Nixon AJ, Haupt JL, Frisbie DD, Morisset SS, McIlwraith CW, Robbins PD, Evans CH, Ghivizzani S. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther. 2005; 12:177-86.
     
156. Palmer GD, Steinert A, Pascher A, Gouze E, Gouze JN, Betz O, Johnstone B, Evans CH, Ghivizzani SC. Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro. Mol Ther. 2005; 12:219-28.
     
157. Haupt JL, Frisbie DD, McIlwraith CW, Robbins PD, Ghivizzani S, Evans CH, Nixon AJ. Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J Orthop Res. 2005; 23:118-26.
     
158. Evans CH. Gene therapies for osteoarthritis. Curr Rheumatol Rep. 2004; 6(1):31-40.
     
159. Evans CH. On the TRAIL of an arthritis cure. Gene Ther. 2004; 11(9):735-6.
     
160. Evans CH. Orthopaedics: gene therapy's dark horse. Gene Ther. 2004; 11(4):343.
     
161. Evans CH, Gouze JN, Gouze E, Robbins PD, Ghivizzani SC. Osteoarthritis gene therapy. Gene Ther. 2004; 11(4):379-89.
     
162. Evans CH, Ghivizzani SC, Robbins PD. The 2003 Nicolas Andry Award. Orthopaedic gene therapy. Clin Orthop Rel Res. 2004:316-29.
     
163. Gouze JN, Stoddart MJ, Gouze E, Palmer GD, Ghivizzani SC, Grodzinsky AJ, Evans CH. In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors. Methods Mol Med. 2004; 100:147-64.
     
164. Agarwal S, Deschner J, Long P, Verma A, Hofman C, Evans CH, Piesco N. Role of NF-kappaB transcription factors in anti-inflammatory and proinflammatory actions of mechanical signals. Arthritis Rheum. 2004; 50(11):3541-8.
     
165. Gouze JN, Gouze E, Palmer GD, Kaneto H, Ghivizzani SC, Grodzinsky AJ, Evans CH. Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes. Osteoarthritis Cartilage. 2004; 12(3):217-24.
     
166. Lattermann C, Baltzer AW, Zelle BA, Whalen JD, Niyibizi C, Robbins PD, Evans CH, Gruen GS. Feasibility of percutaneous gene transfer to an atrophic nonunion in a rabbit. Clin Orthop Rel Res. 2004; 425:237-43.
     
167. Lattermann C, Zelle BA, Whalen JD, Baltzer AW, Robbins PD, Niyibizi C, Evans CH, Fu FH. Gene transfer to the tendon-bone insertion site. Knee Surg Sports Traumatol Arthrosc. 2004; 12(5):510-5.
     
168. Pascher A, Palmer GD, Steinert A, Oligino T, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC. Gene delivery to cartilage defects using coagulated bone marrow aspirate. Gene Ther. 2004; 11(2):133-41.
     
169. Pascher A, Steiner A, Palmer GD, Betz O, Gouze JN, Gouze E, Pilapil C, Ghivizzani SC, Evans CH, Murray MM. Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. Mol Ther. 2004; 10(2):327-36.
     
170. Southwood LL, Frisbie DD, Kawcak CE, Ghivizzani SC, Evans CH, McIlwraith CW. Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model. J Orthop Res. 2004; 22(1):66-72.
     
171. Yang SY, Wu B, Mayton L, Mukherjee P, Robbins PD, Evans CH, Wooley PH. Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis. Gene Ther. 2004; 11(5):483-91.
     
172. Palmer GD, Gouze E, Gouze JN, Betz OB, Evans CH, Ghivizzani SC. Gene transfer to articular chondrocytes with recombinant adenovirus. Methods Mol Biol. 2003; 215:235-46.
     
173. Robbins PD, Evans CH, Chernajovsky Y. Gene therapy for arthritis. Gene Ther. 2003; 10(10):902-11.
     
174. Gouze E, Pawliuk R, Gouze JN, Pilapil C, Fleet C, Palmer GD, Evans CH, Leboulch P, Ghivizzani SC. Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther. 2003; 7(4):460-6.
     
175. Gouze JN, Gouze E, Palmer GD, Liew VS, Pacher A, Betz OB, Thornhill TS, Evans CH, Grodzinsky AJ, Ghivizzani SC. A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer. Arthritis Res Ther. 2003; 5(5):R301-9.
     
176. Mi Z, Ghivizzani SC, Lechman E, Glorioso JC, Evans CH, Robbins PD. Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther. 2003; 5(3):R132-9.
     
177. Yao Q, Wang S, Gambotto A, Glorioso JC, Evans CH, Robbins PD, Ghivizzani SC, Oligino TJ. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium. Gene Ther. 2003; 10(12):1055-60.
     
178. Maffulli N, Moller HD, Evans CH. Tendon healing: can it be optimised? Br J Sports Med. 2002; 36(5):315-6.
     
179. Palmer G, Pascher A, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC. Development of gene-based therapies for cartilage repair. Crit Rev Eukaryot Gene Expr. 2002; 12(4):259-73.
     
180. Lieberman JR, Ghivizzani SC, Evans CH. Gene transfer approaches to the healing of bone and cartilage. Mol Ther. 2002; 6(2):141-7.
     
181. Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH, McIlwraith CW. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther. 2002; 9(1):12-20.
     
182. Gouze E, Pawliuk R, Pilapil C, Gouze JN, Fleet C, Palmer GD, Evans CH, Leboulch P, Ghivizzani SC. In vivo gene delivery to synovium by lentiviral vectors. Mol Ther. 2002; 5(4):397-404.
     
183. Neumann E, Judex M, Kullmann F, Grifka J, Robbins PD, Pap T, Gay RE, Evans CH, Gay S, Scholmerich J, Muller-Ladner U. Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway. Gene Ther. 2002; 9(22):1508-19.
     
184. Samuel RE, Lee CR, Ghivizzani SC, Evans CH, Yannas IV, Olsen BR, Spector M. Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices. Hum Gene Ther. 2002; 13(7):791-802.
     
185. Yang S, Wu B, Mayton L, Evans CH, Robbins PD, Wooley PH. IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model. Inflamm Res. 2002; 51(7):342-50.
     
186. Evans CH, Ghivizzani SC, Oligino TA, Robbins PD. Future of adenoviruses in the gene therapy of arthritis. Arthritis Res. 2001; 3(3):142-6.
     
187. Ghivizzani SC, Oligino TJ, Glorioso JC, Robbins PD, Evans CH. Direct gene delivery strategies for the treatment of rheumatoid arthritis. Drug Discov Today. 2001; 6(5):259-267.
     
188. Gouze E, Ghivizzani SC, Palmer GD, Gouze JN, Robbins PD, Evans CH. Gene therapy for rheumatoid arthritis. Expert Opin Biol Ther. 2001; 1(6):971-8.
     
189. Gouze E, Ghivizzani SC, Robbins PD, Evans CH. Gene therapy for rheumatoid arthritis. Curr Rheumatol Rep. 2001; 3(1):79-85.
     
190. Gouze JN, Ghivizzani SC, Gouze E, Palmer GD, Betz OB, Robbins PD, Evans CH, Herndon JH. Gene therapy for rheumatoid arthritis. Hand Surg. 2001; 6(2):211-9.
     
191. Robbins PD, Jorgensen C, Evans CH. Gene therapy moves forward - The second international meeting on gene and cell therapies of arthritis and related disorders, 17-18 May 2001, Montpellier, France. Arthritis Res. 2001; 3:289-292.
     
192. Baltzer AW, Whalen JD, Wooley P, Latterman C, Truchan LM, Robbins PD, Evans CH. Gene therapy for osteoporosis: evaluation in a murine ovariectomy model. Gene Ther. 2001; 8(23):1770-6.
     
193. Brower-Toland BD, Saxer RA, Goodrich LR, Mi Z, Robbins PD, Evans CH, Nixon AJ. Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther. 2001; 12(2):117-29.
     
194. Del Vecchio MA, Georgescu HI, McCormack JE, Robbins PD, Evans CH. Approaches to enhancing the retroviral transduction of human synoviocytes. Arthritis Res. 2001; 3(4):259-63.
     
195. Saxer RA, Bent SJ, Brower-Toland BD, Mi Z, Robbins PD, Evans CH, Nixon AJ. Gene mediated insulin-like growth factor-I delivery to the synovium. J Orthop Res. 2001; 19(5):759-67.
     
196. Sud S, Yang SY, Evans CH, Robbins PD, Wooley PH. Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch. Inflammation. 2001; 25(6):361-72.
     
197. Whalen JD, Thomson AW, Lu L, Robbins PD, Evans CH. Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages. Mol Ther. 2001; 4(6):543-50.
     
198. Yao Q, Wang S, Glorioso JC, Evans CH, Robbins PD, Ghivizzani SC, Oligino TJ. Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation. Mol Ther. 2001; 3(6):901-10.
     
199. Kim SH, Kim S, Evans CH, Ghivizzani SC, Oligino T, Robbins PD. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol. 2001; 166(5):3499-505.
     
200. Ghivizzani SC, Oligino TJ, Robbins PD, Evans CH. Cartilage Injury and Repair. Phys Med Rehab Clin N Am. 2000; 11:289-307.
     
201. Kang R, Ghivizzani SC, Muzzonigro TS, Herndon JH, Robbins PD, Evans CH. The Marshall R. Urist Young Investigator Award. Orthopaedic applications of gene therapy. From concept to clinic Clin Orthop Relat Res. 2000:324-37.
     
202. Evans CH, Ghivizzani SC, Oligino TJ, Robbins PD. Gene therapy for autoimmune disorders. J Clin Immunol. 2000; 20:334-346.
     
203. Moller HD, Evans CH, Maffulli N. Current aspects of tendon healing. Orthopaede. 2000; 29:182-187.
     
204. Wehling P, Reinecke JA, Meijer H, Granrath M, Evans CH. Gene therapy of joint diseases—direct intervention in the underlying pathophysiology soon possible? (In German) Klinikarzt. 2000; 29:224-227.
     
205. Gassner R, Buckley MJ, Piesco N, Evans CH, Agarwal S. Zytokininduzierte Stickstoffmonoxidproduktion von Gelenkknorpelzellen unter kontinuierlicher passiver Bewegung. Mund Kiefer Gesichts Chir. 2000; 4(suppl 2):S479-S484.
     
206. Baltzer AW, Lattermann C, Whalen JD, Ghivizzani S, Wooley P, Krauspe R, Robbins PD, Evans CH. Potential role of direct adenoviral gene transfer in enhancing fracture repair. Clin Orthop Rel Res. 2000(379 Suppl):S120-5.
     
207. Evans CH, Ghivizzani SC, Herndon JH, Wasko MC, Reinecke J, Wehling P, Robbins PD. Clinical trials in the gene therapy of arthritis. Clin Orthop Rel Res. 2000(379 Suppl):S300-7.
     
208. Evans CH, Ghivizzani SC, Smith P, Shuler FD, Mi Z, Robbins PD. Using gene therapy to protect and restore cartilage. Clin Orthop Rel Res. 2000(379 Suppl):S214-9.
     
209. Evans CH, Robbins PD. Gene therapy in orthopaedics. Orthop Nurs. 2000; 19(1):16-22.
     
210. Ghivizzani SC, Evans CH. Gene therapy for rheumatoid arthritis. Clin Orthop Rel Res. 2000(379 Suppl):S308-10.
     
211. Hart DA, Evans CH. Orthopaedic gene therapy. Ligament and tendon Clin Orthop Rel Res. 2000(379 Suppl):S260-1.
     
212. Londino AV, Rothman D, Robbins PD, Evans CH. Gene therapy for juvenile rheumatoid arthritis? J Rheumatol Suppl. 2000; 58:53-5.
     
213. Nishida K, Gilbertson LG, Robbins PD, Evans CH, Kang JD. Potential applications of gene therapy to the treatment of intervertebral disc disorders. Clin Orthop Rel Res. 2000(379 Suppl):S234-41.
     
214. Niyibizi C, Smith P, Mi Z, Robbins PD, Evans CH. Potential of gene therapy for treating osteogenesis imperfecta. Clin Orthop Rel Res. 2000(379 Suppl):S126-33.
     
215. Nixon AJ, Brower-Toland BD, Bent SJ, Saxer RA, Wilke MJ, Robbins PD, Evans CH. Insulin-like growth factor-I gene therapy applications for cartilage repair. Clin Orthop Rel Res. 2000(379 Suppl):S201-13.
     
216. Nishida K, Gilbertson LG, Evans CH, Kang JD. Potential applications of gene therapy to the treatment of spinal disorders. Spine. 2000; 25:1308-1314.
     
217. Shuler FD, Georgescu HI, Niyibizi C, Studer RK, Mi Z, Johnstone B, Robbins RD, Evans CH. Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes. J Orthop Res. 2000; 18(4):585-92.
     
218. Smith P, Shuler FD, Georgescu HI, Ghivizzani SC, Johnstone B, Niyibizi C, Robbins PD, Evans CH. Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum. 2000; 43(5):1156-64.
     
219. Studer RK, Levicoff E, Georgescu H, Miller L, Jaffurs D, Evans CH. Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRbeta tyrosine phosphorylation. Am J Physiol Cell Physiol. 2000; 279(4):C961-9.
     
220. Xu Z, Buckley MJ, Evans CH, Agarwal S. Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes. J Immunol. 2000; 165(1):453-60.
     
221. Yao Q, Glorioso JC, Evans CH, Robbins PD, Kovesdi I, Oligino TJ, Ghivizzani SC. Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining. J Gene Med. 2000; 2(3):210-9.
     
222. Bosch P, Musgrave DS, Lee JK, Cummins J, Shuler F, Ghivizzani SC, Evans C, Robbins PD, Huard J. Osteoprogenitor cells within skeletal muscle. J Orthop Res. 2000; 18:933-933.
     
223. Baltzer AW, Lattermann C, Whalen JD, Wooley P, Weiss K, Grimm M, Ghivizzani SC, Robbins PD, Evans CH. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther. 2000; 7:734-9.
     
224. Cao M, Stefanovic-Racic M, Georgescu HI, Fu FH, Evans CH. Does nitric oxide help explain the differential healing capacity of the anterior cruciate, posterior cruciate, and medial collateral ligaments? Am J Sports Med ,. 2000; 28:176-82.
     
225. Gassner R, Buckley MJ, Piesco N, Evans C, Agarwal S. [Cytokine-induced nitric oxide production of joint cartilage cells in continuous passive movement. Anti-inflammatory effect of continuous passive movement on chondrocytes: in vitro study] Mund Kiefer Gesichtschir. 2000; 4 Suppl 2:S479-84,.
     
226. Gassner RJ, Buckley MJ, Studer RK, Evans CH, Agarwal S. Interaction of strain and interleukin-1 in articular cartilage: effects on proteoglycan synthesis in chondrocytes. Int J Oral Maxillofac Surg. 2000; 29:389-94.
     
227. Goto H, Shuler FD, Niyibizi C, Fu FH, Robbins PD, Evans CH. Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene. Osteoarthritis Cartilage. 2000; 8(4):266-71.
     
228. Kim SH, Evans CH, Kim S, Oligino T, Ghivizzani SC, Robbins PD. Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4. Arthritis Res. 2000; 2(4):293-302.
     
229. Mi Z, Ghivizzani S, Lechman ER, Jaffurs D, Glorioso JC, Evans CH, Robbins PD. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthritis Rheum. 2000; 43(11):2563-70.
     
230. Moller HD, Fu FH, Niyibizi C, Studer RK, Georgescu HJ, Robbins PD, Evans CH. [TGF-beta-1 gene transfer in joint cartilage cells. Stimulating effect in extracellular matrix synthesis] Orthopade. 2000; 29(2):75-9.
     
231. Moon SH, Gilbertson LG, Nishida K, Knaub M, Muzzonigro T, Robbins PD, Evans CH, Kang JD. Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders. Spine. 2000; 25(20):2573-9.
     
232. Sechriest VF, Miao YJ, Niyibizi C, Westerhausen-Larson A, Matthew HW, Evans CH, Fu FH, Suh JK. GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis. J Biomed Mater Res. 2000; 49(4):534-41.
     
233. Musgrave DS, Bosch P, Ghivizzani S, Robbins PD, Evans CH, Huard J. Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. Bone. 1999; 24:541-547.
     
234. Evans CH, Rediske JJ, Abramson SB, Robbins PD. Joint Efforts: Tackling arthritis using gene therapy. Mol Med Today. 1999; 5:148-151.
     
235. Evans CH, Robbins PD. Genetically augmented tissue engineering for the musculoskeletal system. Clin Orthop Rel Res. 1999; 367S:S410-S418.
     
236. Evans CH, Ghivizzani SC, Lechman E, Mi Z, Jaffurs D, Robbins PD. Lessons learned from gene transfer approaches. Arthritis Res. 1999; 1:21-24.
     
237. Studer R, Jaffurs D, Stefanovic-Racic M, Robbins PD, Evans CH. Nitric oxide in osteoarthritis. Osteoarthritis Cartilage. 1999; 7:377-379.
     
238. Robbins PD, Evans CH. Arthritis gene therapy. Drugs Today. 1999; 35:353-360.
     
239. Ghivizzani SC, Muzzonigro TS, Kang R, Evans CH, Robbins PD. Clinical gene therapy for arthritis. Drugs Today. 1999; 35:389-396.
     
240. Weiss KR, Georgescu HI, Gollin SM, Kang R, Evans CH. Trisomy 7 in synovial fibroblasts obtained from arthritic patients. Inflamm Res. 1999; 48 (Suppl 2):S132-S133.
     
241. Muzzonigro TS, Ghivizzani SC, Robbins PD, Evans CH. The role of gene therapy: fact or fiction? Clin Sports Med. 1999; 18:223-239.
     
242. Evans CH, Robbins PD. Gene therapy of arthritis. Intern Med. 1999; 38:233-239.
     
243. Evans CH, Robbins PD. Potential treatment of osteoarthritis by gene therapy. Rheum Dis Clin North America. 1999; 25:333-344.
     
244. Lechman ER, Mi Z, Ghivizzani SC, Evans CH, Robbins PD. Gene therapy for arthritis: Intra- articular transplantation of genetically modified synovial fibroblasts. Graft. 1999; 2:154-157.
     
245. Möller HD, Evans CH. Gen therapeutische Ansätze in der Arthrosebehandlung. Orthopäde. 1999; 28:76-81.
     
246. Evans CH. Cytokines and the role they play in the healing of ligaments and tendons. Sports Med. 1999; 28:71-76.
     
247. Evans CH, Ghivizzani SC, Kang R, Muzzonigro T, Wasko MC, Herndon JH, Robbins PD. Gene therapy for rheumatic diseases. Arthritis Rheum. 1999; 42:1-16.
     
248. Herndon JH, Robbins PD, Evans CH. Arthritis: Is the cure in your genes? J Bone Jt Surg. 1999; 81A:152-157.
     
249. Studer RK, Georgescu HI, Miller LA, Evans CH. Inhibition of chondrocyte TGF-* synthesis by nitric oxide: implications for matrix synthesis Arthritis Rheum. 1999; 42:248-257.
     
250. Hildebrand KA, Deie M, Allan CR, Smith DW, Georgescu HI, Robbins PD, Evans CH, Woo SL-Y. The expression of marker genes in the medial collateral and anterior cruciate ligaments. The use of different viral vectors and the effects of injury J Orthop Res. 1999; 17:37-42.
     
251. Suh JK, Baek GH, Aroen A, Malin CM, Niyibizi C, Evans CH, Westerhausen-Larson A. Intermittent negative hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism. Osteoarthritis Cartilage. 1999; 7:71-80.
     
252. Müller-Ladner U, Evans CH, Franklin BN, Roberts CR, Gay RE, Robbins PD, Gay S. Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model. Arthritis Rheum. 1999; 42:490-497.
     
253. Baltzer AWA, Lattermann C, Whalen JD, Braunstein S, Robbins PD, Evans CH. A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model Knee Surg Sports Traumatol Arthrosc. 1999; 7:197-202.
     
254. Goto H, Shuler FD, Lamsam C, Möller HD, Niyibizi C, Fu FH, Robbins PD, Evans CH. Lac Z marker gene transfer to the meniscus. J Bone Jt Surg. 1999; 81A:918-925.
     
255. Whalen JD, Lechman EL, Carlos CA, Weiss K, Kovesd I, Glorioso JC, Robbins PD, Evans CH. Adenoviral transfer of viral IL-10 gene peri-articularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. J Immunol. 1999; 162:3625-3632.
     
256. Oyama M, Tatlock A, Fukuta S, Kavalkovich K, Nishimura K, Johnstone B, Robbins PD, Evans CH, Niyibizi C. Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging. Gene Ther. 1999; 6:321-329.
     
257. Baltzer AWA, Whalen JD, Muzzonigro T, Georgescu HI, Robbins PD, Evans CH. In vitro transduction of human osteoblastic cells using retroviral vectors. Z Rheumatol. 1999; 58:88-94.
     
258. Oligino T, Ghivizzani SC, Wolfe D, Lechman E, Krisky D, Mi Z, Evans CH, Robbins PD, Glorioso JC. Herpes simplex viral vector-mediated delivery of the IL-1Ra gene to rabbit joints reduces the pathophysiology of IL-1 induced arthritis. Gene Ther. 1999; 6:1713-1720.
     
259. Lechman ER, Jaffurs D, Ghivizzani SC, Gambotto A, Kovesdi I, Mi Z, Evans CH, Robbins PD. Direct adenoviral gene transfer of vIL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral knees. J Immunol. 1999; 163:2202-2208.
     
260. Gassner R, Buckley MJ, Georgescu HI, Studer R, Stefanovic-Racic M, Xu Z, Piesco NP, Evans CH, Agarwal S. Cyclic tensile stress exerts anti-inflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase. J Immunol. 1999; 163:2187-2192.
     
261. Baltzer AWA, Whalen JD, Stefanovic-Racic M, Ziran B, Robbins PD, Evans CH. Adenoviral transduction of human osteoblastic cell cultures: a new perspective for gene therapy of bone diseases. Acta Orthop Scand. 1999; 70:419- 424.
     
262. Nishida K, Kang JD, Gilbertson LG, Moon SH, Suh JK, Vogt MT, Robbins PD, Evans CH. Modulation of the biological activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human TGF-*1 encoding gene. Spine. 1999; 24:2419-2425.
     
263. Rethinasamy P, Muthuchamy M, Hewett T, Boivin G, Wolska BM, Evans C, Solaro RJ, Wieczorek DF. Molecular and physiological effects of alpha-tropomyosin ablation in the mouse. Circ Res. 1998 Jan 9-23; 82(1):116-23.
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264. Niyibizi C, Baltzer A, Lattermann C, Oyama M, Whalen JD, Robbins PD, Evans CH. Potential role for gene therapy in the augmentation of fracture healing. Clin Orthop Rel Res. 1998; 355S:S148-S153.
     
265. Jaffurs D, Evans CH. Implications of the human genome project to musculoskeletal diseases. J Am Acad Orthop Surg. 1998; 6:1-14.
     
266. Evans CH, Ghivizzani SC, Whalen JD, Robbins PD. Gene therapy in autoimmune diseases. Ann Rheum Dis. 1998; 57:125-127.
     
267. Evans CH, Ghivizzani SC, Robbins PD. Blocking cytokines with genes. J Leuk Biol. 1998; 64:55-61.
     
268. Häuselmann HJ, Stefanovic-Racic M, Michel BA, Evans CH. Differences in nitric oxide production by superficial and deep human articular chondrocytes: implications for proteoglycan turnover in inflammatory joint diseases. J Immunol. 1998; 160:1444-1448.
     
269. Ghivizzani SC, Lechman ER, Kang R, Tio C, Kolls J, Evans CH, Robbins PD. Direct adenoviral-mediated gene transfer of IL-1 and TNF-* soluble receptors to rabbit knees with experimental arthritis has local and distal antiarthritic effects. Proc Natl Acad Sci USA,. 1998; 95:4613-4618.
     
270. Cao M, Stefanovic-Racic M, Georgescu HI, Miller LA, Evans CH. Generation of nitric oxide by lapine meniscal cells and its effect on matrix metabolism: stimulation of collagen production by arginine. J Orthop Res. 1998; 16:104-111.
     
271. Nishida K, Kang JD, Suh J-K, Robbins PD, Evans CH, Gilbertson LG. Adenovirus-mediated gene transfer to nucleus pulposus cells: implications for the treatment of intervertebral disc degeneration. Spine. 1998; 23:2437-2443.
     
272. Cao M, Westerhausen-Larson A, Niyibizi C, Kavalkovich K, Georgescu HI, Rizzo CF, Stefanovic-Racic M, Evans CH. Nitric oxide inhibits the synthesis of type II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target. Biochem J. 1997; 324:305-310.
     
273. Watkins SC, Macaulay W, Turner D, Kang R, Rubash HE, Evans CH. Identification of inducible nitric oxide synthase in human macrophages surrounding loosened hip prostheses. Am J Pathol. 1997; 150:1199-1206.
     
274. Kang R, Marui T, Ghivizzani SC, Nita IM, Georgescu HI, Suh J-K, Robbins PD, Evans CH. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study. Osteoarthritis Cartilage. 1997; 5:139-143.
     
275. Doughty LA, Patrene KD, Evans CH, Boggs SS, Robbins PD. Constitutive expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10. Gene Ther. 1997; 4:252-257.
     
276. Müller-Ladner U, Roberts CR, Franklin BN, Gay RE, Robbins PD, Evans CH, Gay S. Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective. J Immunol. 1997; 158:3492-3498.
     
277. Scherping SC, Schmidt CC, Georgescu HI, Kwoh CK, Evans CH, Woo SLY. Effect of growth factors on the proliferation of ligament fibroblasts from skeletally mature rabbits. Conn Tiss Res. 1997; 36:1-8.
     
278. Wehling P, Schulitz KP, Robbins PD, Evans CH, Reinecke, JA. Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy Spine. 1997; 22:1092-1097.
     
279. Kang JD, Stefanovic-Racic M, McIntyre LA, Georgescu HI, Evans CH. Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide interleukins, prostaglandin E2, and matrix metalloproteinases Spine. 1997; 22:1065-1073.
     
280. Pelletier JP, Caron JP, Evans CH, Robbins PD, Georgescu HI, Jovanovic D, Fernandes JC, Pelletier JM. In vivo suppression of early experimental osteoarthritis by IL-1Ra using gene therapy. Arthritis Rheum. 1997; 40:1012-1019.
     
281. Stefanovic-Racic M, Möllers MO, Miller LA, Evans CH. Nitric oxide and proteoglycan turnover in rabbit articular cartilage. J Orthop Res. 1997; 15:422-4.
     
282. Ghivizzani SC, Lechman ER, Tio C, Mulé KM, Chada S, McCormack JE, Evans CH, Robbins PD. Direct retroviral mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Ther. 1997; 4:977-982.
     
283. Balk M, Bray J, Day C, Epperly M, Greenberger J, Evans CH, Niyibizi C. Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from osteogenesis imperfecta mouse (oim). Bone. 1997; 21:7-15.
     
284. Ghivizzani SC, Kang R, Georgescu HI, Lechman ER, Jaffurs D, Engle JM, Watkins SC, Tindal MH, Suchanek MK, McKenzie LR, Evans CH, Robbins PD. Constitutive intraarticular expression of human IL-1* following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis. J Immunol. 1997; 159:3604-3612.
     
285. Cameron M, Buchgraber A, Passler H, Vogt M, Thonar E, Fu F, Evans CH. The natural history of the anterior cruciate ligament deficient knee: changes in synovial fluid cytokine and kertan sulfate concentrations. Am J Sports Med. 1997; 25:751-754.
     
286. Gerich T, Fu FH, Robbins PD, Evans CH. Prospects for gene therapy in sports medicine. Knee Surg Sports Traumatol Arthrosc. 1996; 4:180-187.
     
287. Robbins PD, Evans CH. Prospects for treating autoimmune and inflammatory diseases by gene therapy. Gene Ther. 1996; 3:187-189.
     
288. DeKosky ST, Styren SD, O’Malley ME, Goss JR, Kochanek P, Marion D, Evans CH, Robbins PD. Interleukin-1 receptor antagonist suppresses neutrophin response in injured rat brain. Ann Neurol. 1996; 39:123-127.
     
289. Stefanovic-Racic M, Morales TI, Taskiran D, McIntyre LA, Evans CH. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures. J Immunol. 1996; 156:1213-1220.
     
290. Nita I, Ghivizzani SC, Galea-Lauri J, Bandara G, Georgescu HI, Robbins PD, Evans CH. Direct gene delivery to synovium: an evaluation of potential vectors in vitro and in vivo. Arthritis Rheum. 1996; 39:820-828.
     
291. Lin CW, Robbins PD, Georgescu HI, Evans CH. Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts. Exp Cell Res. 1996; 223:117-126.
     
292. Otani K, Nita I, Macaulay W, Georgescu HI, Robbins PD, Evans CH. Suppression of antigen-induced arthritis by gene therapy. J Immunol. 1996; 156:3558-3562.
     
293. Wehling P, Cleveland SJ, Heininger K, Schulitz KP, Reineke J, Evans CH. Neurophysiological changes in lumbar nerve root inflammation in the rat after treatment with cytokine inhibitors: evidence for a role of interleukin-1. Spine. 1996; 21:931-935.
     
294. Kang JD, Georgescu HI, Larkin L, Stefanovic-Racic M, Donaldson WF, Evans CH. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and PGE2. Spine. 1996; 21:271-277.
     
295. Evans CH, Robbins PD, Ghivizzani SC, Herndon JH, Kang R, Bahnson AB, Barranger JA, Elders EM, Gay S, Tomaino MM, Wasko MC, Watkins SC, Whiteside TL, Glorioso JC, Lotze M, Wright TM. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther. 1996; 7:1261-1280.
     
296. Gerich TG, Kang R, Fu FH, Robbins PD, Evans CH. Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing. Gene Ther. 1996; 3:1089-1093.
     
297. Evans CH, Watkins SC, Stefanovic-Racic M. Nitric oxide and cartilage metabolism. Methods Enzymol. 1996; 269:75-88
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298. Evans CH, Stefanovic-Racic M, Lancaster JR. Nitric oxide and its role in orthopaedic disease. Clin Orthop Rel Res. 1995; 312:275-294.
     
299. Evans CH, Robbins PD. Possible orthopaedic applications of gene therapy. J Bone Jt Surg. 1995; 77A:1103-1114.
     
300. Evans CH, Robbins PD. Progress toward the treatment of arthritis by gene therapy. Ann Med. 1995; 27:543-546.
     
301. Kang JD, Georgescu HI, McIntyre-Larkin L, Stefanovic-Racic, Evans CH. Herniated cervical intervertebral discs spontaneously product matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine. 1995; 20:2373-2378.
     
302. Schmidt CC, Georgescu HI, Kwoh CK, Bloomstrom GL, Engle CP, Larkin LA, Evans CH, Woo SL-Y. The effect of growth factors on the proliferation of medial collateral and anterior cruciate ligament fibroblasts. J Orthop Res. 1995; 13:184-190.
     
303. Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH. Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis. J Rheumatol 199528. 1995; 22:1922-1928.
     
304. Boggs SS, Patrene KD, Mueller GM, Evans CH, Doughty LA, Robbins PD. Prolonged systemic expression of human IL-1 receptor antagonist protein in sera of lethally irradiated mice reconstituted with hematopoietic stem cells transduced with a retrovirus containing the IL-1ra gene. Gene Ther. 1995; 2:632-638.
     
305. Cameron ML, Fu FH, Paessler HH, Schneider M, Evans CH. Synovial fluid concentrations as ossible prognostic indicators in the ACL-deficient knee Knee Surg Sports Traumatol Arthrosc. 1994; 2:38-44.
     
306. Evans CH, Robbins PD. The interleukin-1 receptor antagonist and its delivery by gene transfer. Receptor. 1994; 4:9-15.
     
307. Evans CH, Robbins PD. Prospects for treating arthritis by gene therapy. J Rheumatol. 1994; 21:779-782.
     
308. Hung GL, Galea-Lauri J, Mueller GM, Georgescu HI, Larkin LA, Suchanek MK, Tindal MH, Robbins PD, Evans CH. Suppression of intraarticular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium. Gene Ther. 1994; 1:64-69.
     
309. Greis PE, Georgescu HI, Fu FH, Evans CH. The particle-induced synthesis of collagenase by synovial fibroblasts: an immunocytochemical study. J Orthop Res. 1994; 12:286-293.
     
310. Stefanovic-Racic M, Stadler J, Georgescu HI, Evans CH. Nitric oxide and energy production in articular chondrocytes. J Cellul Physiol. 1994; 159:274-280.
     
311. Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH. N-monomethylarginine an inhibitor of nitric oxide synthase, suppresses the onset of adjuvant arthritis in rats. Arthritis Rheum. 1994; 37:1062-1069.
     
312. Taskiran D, Stefanovic-Racic M, Georgescu HI, Evans CH. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun. 1994; 200:142-148.
     
313. Stefanovic-Racic M, Stadler J, Georgescu HI, Evans CH. Nitric oxide synthesis and its regulation by rabbit synoviocytes. J Rheumatol. 1994; 21:1892-1898.
     
314. Hauselmann HJ, Oppliger L, Michel BA, Stefanovic-Racic M, Evans CH. Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture. FEBS Lett. 1994; 352:361-364.
     
315. Stefanovic-Racic M, Stadler J, Evans CH. Nitric oxide and arthritis. Arthritis Rheum. 1993; 36:1036-1044.
     
316. Silvaggio VJ, Fu FH, Georgescu HI, Evans CH. The induction of IL-1 by freeze dried ethylene oxide treated bone-patellar tendon-bone allograft wear particles: an in vitro study. Arthroscopy. 1993; 9:82-86.
     
317. Galea-Lauri J, Wilkinson JM, Evans CH. Characterization of monoclonal antibodies against rabbit CD44: Evidence of a role for CD44 in modulating synoviocyte metabolism. Mol Immunol. 1993; 30:1383-1392.
     
318. Wehling P, Wirths J, Evans CH. The effect of cytokines on regeneration of compressed nerve roots and transsected peripheral nerves. Z Orthop. 1993; 131:83-93.
     
319. Bandara G, Mueller GM, Galea-Lauri J, Tindal MH, Georgescu HI, Suchanek MK, Hung GL, Glorioso JC, Robbins PD, Evans CH. Intraarticular expression of biologically active interleukin-1 receptor antagonist protein by ex vivo gene transfer. Proc Nat Acad Sci USA. 1993; 90:10764-10768.
     
320. Hulkower KI, Sagi-Eisenberg R, Traub LM, Georgescu HI, Evans CH. Synovial protein kinase C and its apparent insensitivity to interleukin-1. Eur J Biochem. 1992; 209:81-88.
     
321. Bandara G, Robbins PD, Georgescu HI, Mueller GM, Glorioso JC, Evans CH. Gene transfer to synoviocytes: prospects for gene treatment for arthritis. DNA Cell Biol. 1992; 11:227-231.
     
322. Bandara G, Lin CW, Georgescu HI, Evans CH. The synovial activation of chondrocytes: Evidence for complex cytokine interactions involving a possible novel factor. Biochim Biophys Acta. 1992; 1134:309-318.
     
323. Baratz M, Georgescu HI, Evans CH. Studies on the autocrine activation of a synovial cell line. J Orthop Res. 1991; 9:651-657.
     
324. Webster MW, McAuley CE, Steed DL, Miller DD, Evans CH. Collagen stability and collagenolytic activity in the normal and aneurysmal human abdominal aorta. Am J Surg. 1991; 161:635-638.
     
325. Evans CH, Georgescu HI, Lin CW, Mendelow D, Steed DL, Webster MW. Inducible synthesis of collagenase and other neutral metalloproteinases by cells of aortic origin. J Surg Res. 1991; 51:399-404.
     
326. Hulkower KI, Georgescu HI, Evans CH. Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C. Biochem J. 1991; 276:157-162.
     
327. Stadler J, Stefanovic-Racic M, Billiar, TR, Curran RD, McIntyre LA, Georgescu HI, Simmons RL, Evans CH. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol. 1991; 147:3915-3920.
     
328. Wehling P, Evans CH, Schulitz KP. Die interaktion zwischen synovialen zytokinen und peripherer nervenfunktion: ein mogliches element bei der entstehung radicularer syndrome. Z Orthop. 1990; 128:442-446.
     
329. Evans CH, Russell AP, Westcott VC. Approaches to paramagnetic separations in biology and medicine. Partic Sci Tech. 1989; 7:97-109.
     
330. Tsao M, Ferrarini M, Evans CH, Ambro A, Whiteside TL. Purification of a glycosaminoglycan stimulatory lymphokine from supernatants of in vitro activated human mononuclear cells. Clin Immunol Immunopathol. 1989; 50:122-131.
     
331. Watanabe S, Georgescu HI, Kuhns DB, Evans CH. Chondrocyte activation by a putative interleukin-1 derived from lapine polymorphonuclear leukocytes. Arch Biochem Biophys. 1989; 270:69-76.
     
332. Wehling P, Bandara G, Evans CH. Synovial cytokines impair the function of the sciatic nerve in rats: a possible element in the pathophysiology of radicular syndromes. Neuro-orthop. 1989; 7:55-59.
     
333. Yamage M, Evans CH. Suppression of mitogen- and antigen-induced lymphocyte proliferation by lanthanides. Experientia. 1989; 45:1129-1131.
     
334. Bandara G, Lin CW, Georgescu HI, Mendelow D, Evans CH. Chondrocyte activation by interleukin-1: analysis of the synergistic properties of fibroblast growth factor and phorbol myristate acetate. Arch Biochem Biophys. 1989; 274:539-547.
     
335. Hulkower KI, Georgescu HI, Evans CH. Altered patterns of protein phosphorylation in articular chondrocytes treated with interleukin-1 or synovial cytokines. FEBS Lett. 1989; 257:228-232.
     
336. Ferguson GM, Watanabe S, Georgescu HI, Evans CH. The synovial production of collagenase and chondrocyte activating factors in response to cobalt. J Orthop Res. 1988; 6:525-530.
     
337. Boniface RJ, Cain PR, Evans CH. Articular responses to purified cartilage proteoglycans. Arthritis Rheum. 1988; 31:258-266.
     
338. Wehling P, Pak MA, Molsberger A, Evans CH, Assheuer J. An experimental model for evaluating pathological changes in the spinal cord. Biomed Technik. 1988; 33:136-140.
     
339. Sung K, Mendelow D, Georgescu HI, Evans CH. Characterization of chondrocyte activation in response to cytokines synthesized by a synovial cell line. Biochim Biophys Acta. 1988; 971:148-156.
     
340. Lin CW, Phillips SL, Brinckerhoff CE, Georgescu HI, Bandara G, Evans CH. Induction of collagenase mRNA in lapine articular chondrocytes by synovial factors and interleukin-1. Arch Biochem Biophys. 1988; 261:351-354.
     
341. Olson EJ, Kang JD, Fu FH, Georgescu HI, Mason GC, Evans CH. The biochemical and histological effects of artificial ligament wear particles: In vitro and in vivo studies. Am J Sports Med. 1988; 16:558-570.
     
342. Georgescu HI, Mendelow D, Evans CH. HIG-82: An established cell line from rabbit periarticular soft tissue which retains the ‘activatable' phenotype. In Vitro. 1988; 24:1015-1022.
     
343. Russell AP, Evans CH, Westcott VC. Measurement of the susceptibility of paramagnetically-labeled cells with paramagnetic solutions. Anal Biochem. 1987; 164:181-189.
     
344. Evans CH, Mason GC. Studies on the stimulation of the bacterial, collagenolytic enzyme clostridiopeptidase A by cobalt (II) ions. Int J Biochem. 1986; 18:89-92.
     
345. Evans CH, Russell AP, Westcott VC. Demonstration of the principles of paramagnetic chromatography for resolving mixtures of particles. J Chromatog. 1986; 351:409-415.
     
346. Drouven BJ, Evans CH. Collagen fibrillogenesis in the presence of lanthanides. J Biol Chem. 1986; 261:11792-11797.
     
347. Watanabe S, Georgescu HI, Mendelow D, Evans CH. Chondrocyte activation in response to factor(s) produced by a continuous line of lapine synovial fibroblasts. Exp Cell Res. 1986; 67:218-226.
     
348. Evans CH. The lanthanide-enhanced affinity chromatography of clostridial collagenase. Biochem J. 1985; 225:553-556.
     
349. Evans CH, Ridella JD. Inhibition, by lanthanides, of neutral proteinases, secreted by human rheumatoid synovium. Eur J Biochem. 1985; 151:29-32.
     
350. Evans C. Empirical truth and progress in science. New Sci. 1984 Jan 26; 101 (1394):43-5
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351. Evans CH, Mazzocchi RA, Nelson DD, Rubash HE. Experimental arthritis induced by the intra-articular injection of allogenic cartilaginous particles into rabbit knees. Arthritis Rheum. 1984; 27:200-207.
     
352. Edwards RP, Georgescu HI, Evans CH. Enhanced endocytosis by ageing chondrocytes and fibroblasts. Exp Gerontol. 1984; 19:185-190.
     
353. Evans CH, Ridella JD. An evaluation of fluorometric proteinase assays which employ fluorescamine. Anal Biochem. 1984; 142:411-420.
     
354. Evans CH. An inverse correlation between mammalian lifespan and cartilage cellularity. Exp Gerontol. 1983; 18:137-138.
     
355. Evans CH. Application of ferrography to the study of wear and arthritis in human joints. Wear. 1983; 90:281-292.
     
356. Evans CH. Interesting and useful biochemical properties of the lanthanides. Trends Biochem Sci. 1983; 8:445-449.
     
357. Evans CH, Drouven BJ. The enhancement of the rate of collagen polymerization by calcium and lanthanide ions. Biochem J. 1983; 213:751-758.
     
358. Evans CH, Georgescu HI. Observations on the senescence of cells derived from articular cartilage. Mech Ageing Develop. 1983; 22:179-1.
     
359. Evans CH. The spectrophotometric determination of micromolar concentrations of Co2+ using o-phenanthroline. Anal Biochem. 1983; 135:335-339.
     
360. Evans CH, Mears DC, Stanitski CL. Ferrographic analysis of wear in human joints: evaluation by comparison with arthroscopic examination of symptomatic knee joints. J Bone Jt Surg. 1982; 64B:572-578.
     
361. Evans CH, Mears DC. The wear particles of synovial fluid: their ferrographic analysis and pathophysiological significance. Bull Prosth Res. 1981; 18:13-26.
     
362. Evans CH. Interactions tervalent lanthanide ions with bacterial collagenase (clostridiopeptidase A). Biochem J. 1981; 195:677-684.
     
363. Evans CH, Tew WP. Isolation of biological materials using erbium (III)-induced magnetic susceptibilities. Science. 1981; 213:653-654.
     
364. Evans CH, Mears DC, Cosgrove JL. Release of neutral proteinases from mononuclear phagocytes and synovial cells in response to cartilaginous wear particles in vitro. Biochim Biophys Acta. 1981; 677:287-294.
     
365. Evans CH, Mears DC, McKnight JL. A preliminary ferrographic survey of the wear particles in human synovial fluid. Arthritis Rheum. 1981; 24:912-918.
     
366. Evans CH, Bowen ER, Bowen J, Tew WP, Westcott VC. Synovial fluid analysis by ferrography. J Biochem Biophys Meth. 1980; 2:11-18.
     
367. Evans CH, Mears DC. Binding of the bone-seeking agent 99mTc-1-hydroxyethlidene-1 1-diphosphoric acid to cartilage and collagen in vitro and its stimulation by Er3+ and low pH. Calcif Tiss Internat. 1980; 32:91-94.
     
368. Evans CH. Is the A (Go) state time independent? J Theor Biol. 1979; 79:259-262.
     
369. Brown EG, Evans CH. Effects of benzimidazole on the purine, pyrimidine metabolism of yeast. Biochim Biophys Acta. 1979; 582:458-46.
     
370. Evans CH. Van Gansen P, Rasson I: Transcription in early and late passage embryonic mouse fibroblasts in primary culture: a correlated biochemical autoradiographical and ultrastructural study. Biol Cellul. 1978; 33:117-128.
     
371. Evans CH. Further evidence against the accumulation of altered enzymes in late passage embryonic mouse fibroblasts in vitro. Exp Gerontol. 1977; 12:169-171.
     
372. Evans CH. Thermosensitivity of nuclear RNA polymerase during the in vitro senescence of mouse fibroblasts. Differentiation. 1976; 5:101-105.