Publications

1. Wu Z, Xiao H, Kloeber JA, Ouyang Y, Yin P, Huang J, Chen B, Zhu S, Lu J, Han Y, Tu X, Dragojevic S, Luo K, Ting AT, Welliver M, Lou Z. Parkin deficiency promotes colorectal tumorigenesis and progression through RIPK3-dependent necroptotic inflammation. Cancer Commun (Lond). 2025 Jan 4 Epub 2025 Jan 04
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2. Zhou Q, Tu X, Hou X, Yu J, Zhao F, Huang J, Kloeber J, Olson A, Gao M, Luo K, Zhu S, Wu Z, Zhang Y, Sun C, Zeng X, Schoolmeester KJ, Weroha JS, Hu X, Jiang Y, Wang L, Mutter RW, Lou Z. Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy. Drug Resist Updat. 2024 May; 74:101085 Epub 2024 Apr 16
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3. Tu X, Lou Z, Mutter R. ATR promotes extracellular matrix stiffness mediated cytoskeleton remodeling and immunosuppression Cancer Research. 2024; 84(6_Supplement):5366.
   
4. Tu X, Mutter R, Lou Z, Dong H. A new pd-l1 antibody h1a causes pd-l1 degradation and sensitizes cancer cells for cytotoxic therapy. Journal of Immunology. 2023; 210(1 Suppl):230.06.
   
5. Huang J, Wu C, Kloeber JA, Gao H, Gao M, Zhu Q, Chang Y, Zhao F, Guo G, Luo K, Dai H, Liu S, Huang Q, Kim W, Zhou Q, Zhu S, Wu Z, Tu X, Yin P, Deng M, Wang L, Yuan J, Lou Z. SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology. Mol Cell. 2023 Apr 6; 83 (7):1043-1060.e10 Epub 2023 Feb 27
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6. Wu C, Luo K, Zhao F, Yin P, Song Y, Deng M, Huang J, Chen Y, Li L, Lee S, Kim J, Zhou Q, Tu X, Nowsheen S, Luo Q, Gao X, Lou Z, Liu Z, Yuan J. Correction to: USP20 positively regulates tumorigenesis and chemoresistance through beta-catenin stabilization. Cell Death Differ. 2023 Mar; 30 (3):857-858
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7. Zhu S, Hou J, Gao H, Hu Q, Kloeber JA, Huang J, Zhao F, Zhou Q, Luo K, Wu Z, Tu X, Yin P, Lou Z. SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses. Mol Cell. 2023 Feb 16; 83 (4):539-555.e7 Epub 2023 Jan 25
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8. Zhou Q, Huang J, Zhang C, Zhao F, Kim W, Tu X, Zhang Y, Nowsheen S, Zhu Q, Deng M, Chen Y, Qin B, Luo K, Liu B, Lou Z, Mutter RW, Yuan J. Author Correction: The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair. Nat Commun. 2022 Nov 23; 13 (1):7190
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9. Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J, Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J, Tao K, Lou Z. METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma. Nat Cancer. 2022 Sep; 3 (9):1088-1104 Epub 2022 Sept 22
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10. Sun L, Wang Y, Wang X, Navarro-Corcuera A, Ilyas S, Jalan-Sakrikar N, Gan C, Tu X, Shi Y, Tu K, Liu Q, Lou Z, Dong H, Sharpe AH, Shah VH, Kang N. PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-beta receptor I versus II. Cell Rep. 2022 Feb 8; 38 (6):110349
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11. Zhou Q, Huang J, Zhang C, Zhao F, Kim W, Tu X, Zhang Y, Nowsheen S, Zhu Q, Deng M, Chen Y, Qin B, Luo K, Liu B, Lou Z, Mutter RW, Yuan J. Author Correction: The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair (Nature Communications, (2020), 11, 1, (2639), 10.1038/s41467-020-16443-x). Nature Communications. 2022; 13 (1):7190
    
12. Zhu Q, Huang J, Huang H, Li H, Yi P, Kloeber JA, Yuan J, Chen Y, Deng M, Luo K, Gao M, Guo G, Tu X, Yin P, Zhang Y, Su J, Chen J, Lou Z. RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. Nat Commun. 2021 Nov 17; 12 (1):6653
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13. Zhang Y, Yang Q, Zeng X, Wang M, Dong S, Yang B, Tu X, Wei T, Xie W, Zhang C, Guo Q, Kloeber JA, Cao Y, Guo G, Zhou Q, Zhao F, Huang J, Liu L, Zhang K, Wang M, Yin P, Luo K, Deng M, Kim W, Hou J, Shi Y, Zhu Q, Chen L, Hu S, Yue J, Pi G, Lou Z. MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING. Cancer Discov. 2021 Nov; 11 (11):2726-2737 Epub 2021 June 07
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14. Zhao F, Kim W, Gao H, Liu C, Zhang Y, Chen Y, Deng M, Zhou Q, Huang J, Hu Q, Chen SH, Nowsheen S, Kloeber JA, Qin B, Yin P, Tu X, Guo G, Qin S, Zhang C, Gao M, Luo K, Liu Y, Lou Z, Yuan J. ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection. Nat Cell Biol. 2021 Aug; 23 (8):894-904 Epub 2021 Aug 05
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15. Zhou Q, Howard ME, Tu X, Zhu Q, Denbeigh JM, Remmes NB, Herman MG, Beltran CJ, Yuan J, Greipp PT, Boughey JC, Wang L, Johnson N, Goetz MP, Sarkaria JN, Lou Z, Mutter RW. Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining. Cancer Res. 2021 Jun 15; 81 (12):3333-3346 Epub 2021 Feb 17
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16. Guo G, Gao M, Gao X, Zhu B, Huang J, Tu X, Kim W, Zhao F, Zhou Q, Zhu S, Wu Z, Yan Y, Zhang Y, Zeng X, Zhu Q, Yin P, Luo K, Sun J, Deng M, Lou Z. Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling. Nat Commun. 2021 Apr 12; 12 (1):2187
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17. Gao M, Guo G, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M, Billadeau DD, Lou Z. DOCK7 protects against replication stress by promoting RPA stability on chromatin. Nucleic Acids Res. 2021 Apr 06; 49(6):3322-3337.
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18. Kim W, Zhao F, Gao H, Qin S, Hou J, Deng M, Kloeber JA, Huang J, Zhou Q, Guo G, Gao M, Zeng X, Zhu S, Tu X, Wu Z, Zhang Y, Yin P, Kaufmann SH, Luo K, Lou Z. USP13 regulates the replication stress response by deubiquitinating TopBP1. DNA Repair (Amst). 2021 Apr; 100:103063 Epub 2021 Feb 06
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19. Chen L, Hou J, Zeng X, Guo Q, Deng M, Kloeber JA, Tu X, Zhao F, Wu Z, Huang J, Luo K, Kim W, Lou Z. LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair. Clin Transl Med. 2021 Mar; 11 (3):e341
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20. Chen L, Hou J, You B, Song F, Tu X, Cheng X. An Analysis Regarding the Prognostic Significance of MAVS and Its Underlying Biological Mechanism in Ovarian Cancer. Front Cell Dev Biol. 2021; 9:728061 Epub 2021 Oct 14
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21. Gao M, Guo G, Huang J, Kloeber JA, Zhao F, Deng M, Tu X, Kim W, Zhou Q, Zhang C, Yin P, Luo K, Lou Z. USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP. Nat Commun. 2020 Oct 23; 11 (1):5362
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22. Huang J, Zhou Q, Gao M, Nowsheen S, Zhao F, Kim W, Zhu Q, Kojima Y, Yin P, Zhang Y, Guo G, Tu X, Deng M, Luo K, Qin B, Machida Y, Lou Z. Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Mol Cell. 2020 Sep 3; 79 (5):824-835.e5 Epub 2020 July 09
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23. Yu J, Qin B, Moyer AM, Nowsheen S, Tu X, Dong H, Boughey JC, Goetz MP, Weinshilboum R, Lou Z, Wang L. Author Correction: Regulation of sister chromatid cohesion by nuclear PD-L1. Cell Res. 2020 Sep; 30 (9):823
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24. Yu J, Qin B, Moyer AM, Nowsheen S, Tu X, Dong H, Boughey JC, Goetz MP, Weinshilboum R, Lou Z, Wang L. Regulation of sister chromatid cohesion by nuclear PD-L1. Cell Res. 2020 Jul; 30 (7):590-601 Epub 2020 Apr 29
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25. Zhou Q, Huang J, Zhang C, Zhao F, Kim W, Tu X, Zhang Y, Nowsheen S, Zhu Q, Deng M, Chen Y, Qin B, Luo K, Liu B, Lou Z, Mutter RW, Yuan J. The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair. Nat Commun. 2020 May 26; 11 (1):2639
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26. Chen Y, Wu J, Liang G, Geng G, Zhao F, Yin P, Nowsheen S, Wu C, Li Y, Li L, Kim W, Zhou Q, Huang J, Liu J, Zhang C, Guo G, Deng M, Tu X, Gao X, Liu Z, Chen Y, Lou Z, Luo K, Yuan J. CHK2-FOXK axis promotes transcriptional control of autophagy programs. Sci Adv. 2020 Jan; 6 (1):eaax5819 Epub 2020 Jan 01
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27. Qin G, Tu X, Li H, Cao P, Chen X, Song J, Han H, Li Y, Guo B, Yang L, Yan P, Li P, Gao C, Zhang J, Yang Y, Zheng J, Ju HQ, Lu L, Wang X, Yu C, Sun Y, Xing B, Ji H, Lin D, He F, Zhou G. Long Noncoding RNA p53-Stabilizing and Activating RNA Promotes p53 Signaling by Inhibiting Heterogeneous Nuclear Ribonucleoprotein K deSUMOylation and Suppresses Hepatocellular Carcinoma. Hepatology. 2020 Jan; 71 (1):112-129 Epub 2019 Aug 12
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28. Tu X, Qin B, Zhang Y, Zhang C, Kahila M, Nowsheen S, Yin P, Yuan J, Pei H, Li H, Yu J, Song Z, Zhou Q, Zhao F, Liu J, Zhang C, Dong H, Mutter RW, Lou Z. PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy. Mol Cell. 2019 Jun 20; 74 (6):1215-1226.e4 Epub 2019 Apr 30
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29. Song Z, Tu X, Zhou Q, Huang J, Chen Y, Liu J, Lee S, Kim W, Nowsheen S, Luo K, Yuan J, Lou Z. A novel UCHL(3) inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair. Cell Death Dis. 2019 May 21; 10 (6):398
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30. Wu J, Chen Y, Geng G, Li L, Yin P, Nowsheen S, Li Y, Wu C, Liu J, Zhao F, Kim W, Zhou Q, Huang J, Guo G, Zhang C, Tu X, Gao X, Lou Z, Luo K, Qiao H, Yuan J. USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2. Cancer Lett. 2019 May 1; 449:114-124 Epub 2019 Feb 13
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31. Qin B, Yu J, Nowsheen S, Wang M, Tu X, Liu T, Li H, Wang L, Lou Z. UFL1 promotes histone H4 ufmylation and ATM activation. Nat Commun. 2019 Mar 18; 10 (1):1242
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32. Tu X, Kahila MM, Zhou Q, Yu J, Kalari KR, Wang L, Harmsen WS, Yuan J, Boughey JC, Goetz MP, Sarkaria JN, Lou Z, Mutter RW. ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer. Mol Cancer Ther. 2018 Nov; 17 (11):2462-2472 Epub 2018 Aug 30
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33. Wu C, Luo K, Zhao F, Yin P, Song Y, Deng M, Huang J, Chen Y, Li L, Lee S, Kim J, Zhou Q, Tu X, Nowsheen S, Luo Q, Gao X, Lou Z, Liu Z, Yuan J. USP20 positively regulates tumorigenesis and chemoresistance through beta-catenin stabilization. Cell Death Differ. 2018 Nov; 25 (10):1855-1869 Epub 2018 June 04
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34. Li Y, Si L, Zhai Y, Hu Y, Hu Z, Bei JX, Xie B, Ren Q, Cao P, Yang F, Song Q, Bao Z, Zhang H, Han Y, Wang Z, Chen X, Xia X, Yan H, Wang R, Zhang Y, Gao C, Meng J, Tu X, Liang X, Cui Y, Liu Y, Wu X, Li Z, Wang H, Li Z, Hu B, He M, Gao Z, Xu X, Ji H, Yu C, Sun Y, Xing B, Yang X, Zhang H, Tan A, Wu C, Jia W, Li S, Zeng YX, Shen H, He F, Mo Z, Zhang H, Zhou G. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Nat Commun. 2016 May 31; 7:11664
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35. Tu X, Chong WP, Zhai Y, Zhang H, Zhang F, Wang S, Liu W, Wei M, Siu NH, Yang H, Yang W, Cao W, Lau YL, He F, Zhou G. Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection. J Infect. 2015 Jul; 71 (1):101-9 Epub 2015 Mar 27
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