Publications

1. Tocchetti CG, Farmakis D, Koop Y, Andres MS, Couch LS, Formisano L, Ciardiello F, Pane F, Au L, Emmerich M, Plummer C, Gulati G, Ramalingam S, Cardinale D, Brezden-Masley C, Iakobishvili Z, Thavendiranathan P, Santoro C, Bergler-Klein J, Keramida K, de Boer RA, Maack C, Lutgens E, Rassaf T, Fradley MG, Moslehi J, Yang EH, De Keulenaer G, Ameri P, Bax J, Neilan TG, Herrmann J, Mbakwem AC, Mirabel M, Skouri H, Hirsch E, Cohen-Solal A, Sverdlov AL, van der Meer P, Asteggiano R, Barac A, Ky B, Lenihan D, Dent S, Seferovic P, Coats AJS, Metra M, Rosano G, Suter T, Lopez-Fernandez T, Lyon AR. Cardiovascular toxicities of immune therapies for cancer - a scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio-Oncology. Eur J Heart Fail. 2024 Oct; 26 (10):2055-2076 Epub 2024 Aug 01
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2. Maier A, Teunissen AJP, Nauta SA, Lutgens E, Fayad ZA, van Leent MMT. Uncovering atherosclerotic cardiovascular disease by PET imaging. Nat Rev Cardiol. 2024 Sep; 21 (9):632-651 Epub 2024 Apr 04
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3. Strohm L, Daiber A, Ubbens H, Krishnankutty R, Oelze M, Kuntic M, Hahad O, Klein V, Hoefer IE, von Kriegsheim A, Kleinert H, Atzler D, Lurz P, Weber C, Wild PS, Munzel T, Knosalla C, Lutgens E, Daub S. Role of inflammatory signaling pathways involving the CD40-CD40L-TRAF cascade in diabetes and hypertension-insights from animal and human studies. Basic Res Cardiol. 2024 Aug; 119 (4):1-18 Epub 2024 Mar 30
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4. Porteiro B, Roscam Abbing RLP, In Het Panhuis W, de Waart DR, Duijst S, Bolt I, Vogels EW, Levels JHM, Bosmans LA, Vos WG, Oude Elferink RPJ, Lutgens E, van de Graaf SFJ. Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1(-/-)Ldlr(-/-) mice. J Lipid Res. 2024 Aug; 65 (8):100594 Epub 2024 July 14
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5. Kane J, Vos WG, Bosmans LA, van Os BW, den Toom M, Hoeksema-Hackmann S, Moen-de Wit D, Gijbels MJ, Beckers L, Grefhorst A, Levels JHM, Jakulj L, Vervloet MG, Lutgens E, Eringa EC. Peritoneal Dialysis Aggravates and Accelerates Atherosclerosis in Uremic ApoE(-/-) Mice. J Am Heart Assoc. 2024 Jul 16; 13 (14):e034066 Epub 2024 July 09
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6. Nitz K, Herrmann J, Lerman A, Lutgens E. Costimulatory and Coinhibitory Immune Checkpoints in Atherosclerosis: Therapeutic Targets in Atherosclerosis? JACC Basic Transl Sci. 2024 Jun; 9 (6):827-843 Epub 2024 Mar 13
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7. Di Venanzio L, Mahmoudi Hamidabad N, Lewis BR, Tiwari A, Rajai N, Copley EA, Rajotia A, Lutgens E, Lerman LO, Nardi V, Lerman A. Mortality risk in patients with carotid artery disease undergoing carotid endarterectomy compared to the general population European Heart Journal. 2024.
   
8. Zhu XY, Klomjit N, Pawar AS, Puranik AS, Yang ZZ, Lutgens E, Eirin A, Lerman A, Textor SC, Lerman LO. Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease. Am J Physiol Renal Physiol. 2024 Feb 1; 326 (2):F257-F264 Epub 2023 Nov 30
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9. Lutgens E, Osto E, Bochaton-Piallat ML. The European Society of Cardiology working group on atherosclerosis and vascular biology. Eur Heart J. 2024 Jan 7; 45 (2):84-86
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10. Vos WG, van Os BW, den Toom M, Beckers L, van Roomen CPAA, van Tiel CM, Mohapatra BC, Band H, Nitz K, Weber C, Atzler D, de Winther MPJ, Bosmans LA, Lutgens E, Seijkens TTP. T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation. Front Immunol. 2024; 15:1297893 Epub 2024 Mar 04
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11. van Os BW, Vos WG, Bosmans LA, van Tiel CM, Toom MD, Beckers L, Admiraal M, Hoeksema MA, de Winther MP, Lutgens E. CD40L modulates CD4(+) T-cell activation through receptor for activated C kinase 1. Eur J Immunol. 2023 Dec; 53 (12):e2350520 Epub 2023 Nov 20
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12. Roeters van Lennep JE, Tokgozoglu LS, Badimon L, Dumanski SM, Gulati M, Hess CN, Holven KB, Kavousi M, Kayikcioglu M, Lutgens E, Michos ED, Prescott E, Stock JK, Tybjaerg-Hansen A, Wermer MJH, Benn M. Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society. Eur Heart J. 2023 Oct 14; 44 (39):4157-4173
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13. Gigante B, Levy JH, van Gorp E, Bartoloni A, Bochaton-Piallat ML, Back M, Ten Cate H, Christersson C, Ferreiro JL, Geisler T, Lutgens E, Schulman S, Storey RF, Thachil J, Vilahur G, Liaw PC, Rocca B. Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis. Eur Heart J 2023 Aug 22; 44 (32):3040-3058
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14. Dib L, Koneva LA, Edsfeldt A, Zurke YX, Sun J, Nitulescu M, Attar M, Lutgens E, Schmidt S, Lindholm MW, Choudhury RP, Cassimjee I, Lee R, Handa A, Goncalves I, Sansom SN, Monaco C. Publisher Correction: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications. Nat Cardiovasc Res. 2023 Aug; 2 (8):794
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15. In Het Panhuis W, Schonke M, Modder M, Tom HE, Lalai RA, Pronk ACM, Streefland TCM, van Kerkhof LWM, Dolle MET, Depuydt MAC, Bot I, Vos WG, Bosmans LA, van Os BW, Lutgens E, Rensen PCN, Kooijman S. Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE *3-Leiden.CETP mice. EBioMedicine. 2023 Jul; 93:104680 Epub 2023 June 23
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16. Reiche ME, Poels K, Bosmans LA, Vos WG, Van Tiel CM, Gijbels MJJ, Aarts SABM, Den Toom M, Beckers L, Weber C, Atzler D, Rensen PCN, Kooijman S, Lutgens E. Adipocytes control hematopoiesis and inflammation through CD40 signaling. Haematologica. 2023 Jul 1; 108 (7):1873-1885 Epub 2023 July 01
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17. Dib L, Koneva LA, Edsfeldt A, Zurke YX, Sun J, Nitulescu M, Attar M, Lutgens E, Schmidt S, Lindholm MW, Choudhury RP, Cassimjee I, Lee R, Handa A, Goncalves I, Sansom SN, Monaco C. Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis increasing the risk of cerebrovascular complications. Nat Cardiovasc Res. 2023 Jun 26; 2 (7):656-672
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18. Sun J, Singh P, Shami A, Kluza E, Pan M, Djordjevic D, Michaelsen NB, Kennback C, van der Wel NN, Orho-Melander M, Nilsson J, Formentini I, Conde-Knape K, Lutgens E, Edsfeldt A, Goncalves I. Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture. J Am Coll Cardiol. 2023 Jun 13; 81 (23):2213-2227
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19. Bosmans LA, van Tiel CM, Aarts SABM, Willemsen L, Baardman J, van Os BW, Toom MD, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, den Bossche JV, de Winther MMPJ, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E. Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. Cardiovasc Res. 2023 May 22; 119 (5):1146-1160
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20. de Winther MPJ, Back M, Evans P, Gomez D, Goncalves I, Jorgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Yla-Herttuala S, Winkels H, Bochaton-Piallat ML, Monaco C. Translational opportunities of single-cell biology in atherosclerosis. Eur Heart J. 2023 Apr 7; 44 (14):1216-1230
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21. Lutgens E, Mulder WJM, CHECKPOINT ATHERO consortium. CHECKPOINT ATHERO: developing immune checkpoint-based therapeutics for atherosclerosis. Eur Heart J. 2023 Mar 21; 44 (12):1010-1012
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22. van Os BW, Vos WG, Bosmans LA, van Tiel CM, Lith SC, den Toom MS, Beckers L, Levels JHM, van Wouw SAE, Zelcer N, Zaal EA, Berkers CR, van der Lest CHA, Helms JB, Weber C, Atzler D, de Winther MPJ, Baardman J, Lutgens E. Hyperlipidaemia elicits an atypical, T helper 1-like CD4(+) T-cell response: a key role for very low-density lipoprotein. Eur Heart J Open. 2023 Mar; 3 (2):oead013 Epub 2023 Mar 03
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23. Pavlic A, Poelman H, Wasilewski G, Wichapong K, Lux P, Maassen C, Lutgens E, Schurgers LJ, Reutelingsperger CP, Nicolaes GAF. Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. Int J Mol Sci. 2023 Jan 19; 24 (3)
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24. van Os BW, Kusters PJH, den Toom M, Beckers L, van Tiel CM, Vos WG, de Jong E, Kieser A, van Roomen C, Binder CJ, Reiche ME, de Winther MP, Bosmans LA, Lutgens E. Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis. Front Cardiovasc Med. 2023; 10:1171764 Epub 2023 May 05
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25. Dib L, Koneva LA, Edsfeldt A, Zurke YX, Sun J, Nitulescu M, Attar M, Lutgens E, Schmidt S, Lindholm MW, Choudhury RP, Cassimjee I, Lee R, Handa A, Goncalves I, Sansom SN, Monaco C. Erratum: Author Correction: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications. Nat Cardiovasc Res. 2023; 2 (9):853 Epub 2023 Aug 07
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26. Nagy M, van der Meijden PEJ, Glunz J, Schurgers L, Lutgens E, Ten Cate H, Heitmeier S, Spronk HMH. Integrating Mechanisms in Thrombotic Peripheral Arterial Disease. Pharmaceuticals (Basel). 2022 Nov 18; 15 (11)
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27. Nitz K, Lacy M, Bianchini M, Wichapong K, Kucukgoze IA, Bonfiglio CA, Migheli R, Wu Y, Burger C, Li Y, Forne I, Ammar C, Janjic A, Mohanta S, Duchene J, Heemskerk JWM, Megens RTA, Schwedhelm E, Huveneers S, Lygate CA, Santovito D, Zimmer R, Imhof A, Weber C, Lutgens E, Atzler D. The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Circ Res. 2022 Sep 30; 131 (8):701-712 Epub 2022 Sept 14
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28. Vos WG, Lutgens E, Seijkens TTP. Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer?. Journal for Immunotherapy of Cancer. 2022 Sep; 10 (9):e005611
    
29. Nardi V, Franchi F, Prasad M, Fatica EM, Alexander MP, Bois MC, Lam J, Singh RJ, Meyer FB, Lanzino G, Xiong Y, Lutgens E, Lerman LO, Lerman A. Uric Acid Expression in Carotid Atherosclerotic Plaque and Serum Uric Acid Are Associated With Cerebrovascular Events. Hypertension. 2022 Aug; 79 (8):1814-1823 Epub 2022 June 03
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30. Kane J, Jansen M, Hendrix S, Bosmans LA, Beckers L, Tiel CV, Gijbels M, Zelcer N, Vries CJ, von Hundelshausen P, Vervloet M, Eringa E, Horrevoets AJ, Royen NV, Lutgens E. Anti-Galectin-2 Antibody Treatment Reduces Atherosclerotic Plaque Size and Alters Macrophage Polarity. Thromb Haemost. 2022 Jun; 122(6):1047-1057. Epub 2022 Feb 08.
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31. Christ A, Goossens PG, Wijnands E, Jin H, Legein B, Oth T, Isaacs A, Stoll M, Vanderlocht J, Lutgens E, Daemen MJAP, Zenke M, Biessen EAL. Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77. Biomedicines. 2022 May 17; 10 (5)
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32. Pattarabanjird T, Marshall M, Upadhye A, Srikakulapu P, Garmey JC, Haider A, Taylor AM, Lutgens E, McNamara CA. B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection. Circ Res. 2022 Apr; 130 (7):981-993 Epub 2022 Feb 25
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33. Carai P, Papageorgiou AP, Van Linthout S, Deckx S, Velthuis S, Lutgens E, Wijnands E, Tschope C, Schmuttermaier C, Kzhyshkowska J, Jones EAV, Heymans S. Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis. J Mol Cell Cardiol. 2022 Apr; 165:31-39 Epub 2021 Dec 28
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34. Poels K, Schreurs M, Jansen M, Vugts DJ, Seijkens TTP, van Dongen GAMS, Lutgens E, Beaino W. Immuno-PET Imaging of Atherosclerotic Plaques with [(89)Zr]Zr-Anti-CD40 mAb-Proof of Concept. Biology (Basel). 2022 Mar 6; 11 (3) Epub 2022 Mar 06
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35. Ouweneel AB, Reiche ME, Snip OSC, Wever R, van der Wel EJ, Schaftenaar FH, Kauerova S, Lutgens E, Van Eck M, Hoekstra M. Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis. J Cell Sci. 2022 Mar 1; 135 (5) Epub 2021 Nov 16
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36. Sauter M, Sauter RJ, Nording H, Lin C, Olbrich M, Autenrieth S, Gleissner C, Thunemann M, Otero N, Lutgens E, Aherrahrou Z, Wolf D, Zender L, Meuth S, Feil R, Langer HF. Apolipoprotein E derived from CD11c(+) cells ameliorates atherosclerosis. iScience. 2022 Jan 21; 25 (1):103677 Epub 2021 Dec 25
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37. van der Velden J, Asselbergs FW, Bakkers J, Batkai S, Bertrand L, Bezzina CR, Bot I, Brundel B, Carrier L, Chamuleau S, Ciccarelli M, Dawson D, Davidson SM, Dendorfer A, Duncker DJ, Eschenhagen T, Fabritz L, Falcao-Pires I, Ferdinandy P, Giacca M, Girao H, Gollmann-Tepekoylu C, Gyongyosi M, Guzik TJ, Hamdani N, Heymans S, Hilfiker A, Hilfiker-Kleiner D, Hoekstra AG, Hulot JS, Kuster DWD, van Laake LW, Lecour S, Leiner T, Linke WA, Lumens J, Lutgens E, Madonna R, Maegdefessel L, Mayr M, van der Meer P, Passier R, Perbellini F, Perrino C, Pesce M, Priori S, Remme CA, Rosenhahn B, Schotten U, Schulz R, Sipido K, Sluijter JPG, van Steenbeek F, Steffens S, Terracciano CM, Tocchetti CG, Vlasman P, Yeung KK, Zacchigna S, Zwaagman D, Thum T. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res. 2022 Jan 6 Epub 2022 Jan 06
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38. Kluza E, Beldman TJ, Shami A, Scholl ER, Malinova TS, Grootemaat AE, van der Wel NN, Goncalves I, Huveneers S, Mulder WJM, Lutgens E. Diverse ultrastructural landscape of atherosclerotic endothelium. Atherosclerosis. 2021 Dec; 339:35-45 Epub 2021 Nov 19
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39. Reilly NA, Lutgens E, Kuiper J, Heijmans BT, Wouter Jukema J. Effects of fatty acids on T cell function: role in atherosclerosis. Nat Rev Cardiol. 2021 Dec; 18 (12):824-837 Epub 2021 July 12
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40. Gissler MC, Scherrer P, Anto-Michel N, Pennig J, Hoppe N, Funer L, Hardtner C, Stachon P, Li X, Mitre LS, Marchini T, Madl J, Wadle C, Hilgendorf I, von Zur Muhlen C, Bode C, Weber C, Lutgens E, Wolf D, Gerdes N, Zirlik A, Willecke F. Deficiency of Endothelial CD40 Induces a Stable Plaque Phenotype and Limits Inflammatory Cell Recruitment to Atherosclerotic Lesions in Mice. Thromb Haemost. 2021 Nov; 121 (11):1530-1540 Epub 2021 May 13
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41. Lutgens E, Joffre J, van Os B, Ait-Oufella H. Targeting cytokines and immune checkpoints in atherosclerosis with monoclonal antibodies. Atherosclerosis. 2021 Oct; 335:98-109 Epub 2021 Sept 23
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42. Shami A, Edsfeldt A, Bengtsson E, Nilsson J, Shore AC, Natali A, Khan F, Lutgens E, Goncalves I. Soluble CD40 Levels in Plasma Are Associated with Cardiovascular Disease and in Carotid Plaques with a Vulnerable Phenotype. J Stroke. 2021 Sep; 23 (3):367-376 Epub 2021 Sept 30
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43. Bosmans LA, Shami A, Atzler D, Weber C, Goncalves I, Lutgens E. Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis. Vascul Pharmacol. 2021 Aug; 139:106884 Epub 2021 June 05
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44. Bonfiglio CA, Weber C, Atzler D, Lutgens E. Immunotherapy and cardiovascular diseases (CVD): novel avenues for immunotherapeutic approaches. QJM. 2021 Jul 22 Epub 2021 July 22
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45. Kassiteridi C, Cole JE, Griseri T, Falck-Hansen M, Goddard ME, Seneviratne AN, Green PA, Park I, Shami AG, Pattarabanjird T, Upadhye A, Taylor AM, Handa A, Channon KM, Lutgens E, McNamara CA, Williams RO, Monaco C. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circ Res. 2021 Jul 9; 129 (2):280-295 Epub 2021 May 12
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46. Lacy M, Bürger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, Heemskerk JWM, Goncalves I, Weber C, Gerdes N, Atzler D, Lutgens E. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun. 2021 Jun 18; 12(1):3754.
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47. Poels K, Neppelenbroek SIM, Kersten MJ, Antoni ML, Lutgens E, Seijkens TTP. Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem. J Immunother Cancer. 2021 Jun; 9 (6)
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48. van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Perez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R. Prosaposin mediates inflammation in atherosclerosis. Sci Transl Med. 2021 Mar 10; 13 (584)
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49. Bosmans LA, Bosch L, Kusters PJH, Lutgens E, Seijkens TTP. The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease. J Cardiovasc Transl Res. 2021 Feb; 14 (1):13-22 Epub 2020 Mar 28
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50. Baardman J, Verberk SGS, van der Velden S, Gijbels MJJ, van Roomen CPPA, Sluimer JC, Broos JY, Griffith GR, Prange KHM, van Weeghel M, Lakbir S, Molenaar D, Meinster E, Neele AE, Kooij G, de Vries HE, Lutgens E, Wellen KE, de Winther MPJ, Van den Bossche J. Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques. Nat Commun. 2020 Dec 8; 11 (1):6296 Epub 2020 Dec 08
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51. Daub S, Lutgens E, Munzel T, Daiber A. CD40/CD40L and Related Signaling Pathways in Cardiovascular Health and Disease-The Pros and Cons for Cardioprotection. Int J Mol Sci. 2020 Nov 12; 21 (22)
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52. Depuydt MAC, Prange KHM, Slenders L, Ord T, Elbersen D, Boltjes A, de Jager SCA, Asselbergs FW, de Borst GJ, Aavik E, Lonnberg T, Lutgens E, Glass CK, den Ruijter HM, Kaikkonen MU, Bot I, Slutter B, van der Laan SW, Yla-Herttuala S, Mokry M, Kuiper J, de Winther MPJ, Pasterkamp G. Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics. Circ Res. 2020 Nov 6; 127 (11):1437-1455 Epub 2020 Sept 28
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53. Genzel L, Adan R, Berns A, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, Eggen BJL, Elgersma Y, Erdogan I, Englitz B, Fentener van Vlissingen JM, la Fleur S, Fouchier R, Fitzsimons CP, Frieling W, Haagmans B, Heesters BA, Henckens MJAG, Herfst S, Hol E, van den Hove D, de Jonge MI, Jonkers J, Joosten LAB, Kalsbeek A, Kamermans M, Kampinga HH, Kas MJ, Keijer J, Kersten S, Kiliaan AJ, Kooij TWA, Kooijman S, Koopman WJH, Korosi A, Krugers HJ, Kuiken T, Kushner SA, Langermans JAM, Lesscher HMB, Lucassen PJ, Lutgens E, Netea MG, Noldus LPJJ, van der Meer JWM, Meye FJ, Mul JD, van Oers K, Olivier JDA, Pasterkamp RJ, Philippens IHCHM, Prickaerts J, Pollux BJA, Rensen PCN, van Rheenen J, van Rij RP, Ritsma L, Rockx BHG, Roozendaal B, van Schothorst EM, Stittelaar K, Stockhofe N, Swaab DF, de Swart RL, Vanderschuren LJMJ, de Vries TJ, de Vrij F, van Wezel R, Wierenga CJ, Wiesmann M, Willuhn I, de Zeeuw CI, Homberg JR. How the COVID-19 pandemic highlights the necessity of animal research. Curr Biol. 2020 Nov 2; 30 (21):4328
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54. Poels K, van Leent MMT, Boutros C, Tissot H, Roy S, Meerwaldt AE, Toner YCA, Reiche ME, Kusters PJH, Malinova T, Huveneers S, Kaufman AE, Mani V, Fayad ZA, de Winther MPJ, Marabelle A, Mulder WJM, Robert C, Seijkens TTP, Lutgens E. Immune Checkpoint Inhibitor Therapy Aggravates T Cell-Driven Plaque Inflammation in Atherosclerosis. JACC CardioOncol. 2020 Nov; 2 (4):599-610 Epub 2020 Oct 06
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55. Dweck MR, Maurovich-Horvat P, Leiner T, Cosyns B, Fayad ZA, Gijsen FJH, Van der Heiden K, Kooi ME, Maehara A, Muller JE, Newby DE, Narula J, Pontone G, Regar E, Serruys PW, van der Steen AFW, Stone PH, Waltenberger JL, Yuan C, Evans PC, Lutgens E, Wentzel JJ, Back M. Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2020 Oct 20; 21 (11):1177-1183
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56. Schnitzler JG, Poels K, Stiekema LCA, Yeang C, Tsimikas S, Kroon J, Stroes ESG, Lutgens E, Seijkens TTP. Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes. Int J Cardiol. 2020 Sep 15; 315:81-85 Epub 2020 May 07
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57. Poels K, van Leent MMT, Reiche ME, Kusters PJH, Huveneers S, de Winther MPJ, Mulder WJM, Lutgens E, Seijkens TTP. Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice. Cells. 2020 Aug 29; 9 (9)
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58. Shami A, Atzler D, Bosmans LA, Winkels H, Meiler S, Lacy M, van Tiel C, Ta Megens R, Nitz K, Baardman J, Kusters P, Seijkens T, Buerger C, Janjic A, Riccardi C, Edsfeldt A, Monaco C, Daemen M, de Winther MPJ, Nilsson J, Weber C, Gerdes N, Gonçalves I, Lutgens E. Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans. Eur Heart J. 2020 Aug 14; 41(31):2938-2948.
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59. Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Perez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020 Aug 1; 112 (2):413-426
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60. Baardman J, Lutgens E. Regulatory T Cell Metabolism in Atherosclerosis. Metabolites. 2020 Jul 8; 10 (7) Epub 2020 July 08
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61. Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourao A, Blanchet X, Wichapong K, Aslani M, Brunssen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchene J, Megens RTA, Sattler M, Weber C. Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Sci Transl Med. 2020 Jun 3; 12 (546)
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62. Legein B, Janssen EM, Theelen TL, Gijbels MJ, Walraven J, Klarquist JS, Hennies CM, Wouters K, Seijkens TTP, Wijnands E, Sluimer JC, Lutgens E, Zenke M, Hildner K, Biessen EAL, Temmerman L. Author Correction: Ablation of CD8alpha(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Sci Rep. 2020 May 26; 10 (1):8747
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