Publications

1. Zhuo D, Lei I, Li W, Liu L, Li L, Ni J, Liu Z, Fan G. The origin, progress, and application of cell-based cardiac regeneration therapy. J Cell Physiol. 2023 Aug; 238 (8):1732-1755 Epub 2023 June 19
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2. Duggal NM, Lei I, Wu X, Aaronson KD, Pagani FD, Lam HY, Tang PC, Michigan Congestive Heart Failure Investigators. Mitral regurgitation severity at left ventricular assist device implantation is associated with distinct myocardial transcriptomic signatures. J Thorac Cardiovasc Surg. 2023 Jul; 166 (1):141-152.e1 Epub 2021 Sept 14
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3. Chapman EA, Aballo TJ, Melby JA, Zhou T, Price SJ, Rossler KJ, Lei I, Tang PC, Ge Y. Defining the Sarcomeric Proteoform Landscape in Ischemic Cardiomyopathy by Top-Down Proteomics. J Proteome Res. 2023 Mar 3; 22 (3):931-941 Epub 2023 Feb 17
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4. Lei I, Huang W, Noly PE, Naik S, Ghali M, Liu L, Pagani FD, Abou El Ela A, Pober JS, Pitt B, Platt JL, Cascalho M, Wang Z, Chen YE, Mortensen RM, Tang PC. Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function. Sci Transl Med. 2023 Feb 8; 15 (682):eade3782 Epub 2023 Feb 08
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5. Noly PE, Naik S, Tang P, Lei I. Assessment of Ex Vivo Murine Biventricular Function in a Langendorff Model. J Vis Exp. 2022 Dec 23; (190)
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6. Tang PC, Haft JW, Lei I, Wang Z, Chen YE, Abou El Ela A, Wu X, Pitt B, Aaronson KD, Pagani FD. Impact of donor blood type on outcomes after prolonged allograft ischemic times. J Thorac Cardiovasc Surg. 2022 Sep; 164 (3):981-993.e8 Epub 2021 Jan 12
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7. Tang PC, Wu X, Zhang M, Likosky D, Haft JW, Lei I, Abou El Ela A, Si MS, Aaronson KD, Pagani FD. Determining optimal donor heart ischemic times in adult cardiac transplantation. J Card Surg. 2022 Jul; 37 (7):2042-2050 Epub 2022 Apr 30
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8. Noly PE, Duggal N, Jiang M, Nordsletten D, Bonini M, Lei I, Ela AAE, Haft JW, Pagani FD, Cascino TM, Tang PC. Role of the mitral valve in left ventricular assist device pathophysiology. Front Cardiovasc Med. 2022; 9:1018295 Epub 2022 Oct 28
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9. Lei I, Tian S, Gao W, Liu L, Guo Y, Tang P, Chen E, Wang Z. Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation. Elife. 2021 Dec 23; 10
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10. Cui H, Chen Y, Li K, Zhan R, Zhao M, Xu Y, Lin Z, Fu Y, He Q, Tang PC, Lei I, Zhang J, Li C, Sun Y, Zhang X, Horng T, Lu HS, Chen YE, Daugherty A, Wang D, Zheng L. Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection. Eur Heart J. 2021 Nov 7; 42 (42):4373-4385
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11. Lei I, Huang W, Ward PA, Pober JS, Tellides G, Ailawadi G, Pagani FD, Landstrom AP, Wang Z, Mortensen RM, Cascalho M, Platt J, Eugene Chen Y, Lam HYK, Tang PC. Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation. Physiol Rep. 2021 Sep; 9 (17):e15004
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12. Tang PC, Lei I, Chen YE, Wang Z, Ailawadi G, Romano MA, Salvi S, Aaronson KD, Si MS, Pagani FD, Haft JW. Risk factors for heart transplant survival with greater than 5 h of donor heart ischemic time. J Card Surg. 2021 Aug; 36 (8):2677-2684 Epub 2021 May 20
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13. Zhao C, Tian S, Liu Q, Xiu K, Lei I, Wang Z, Ma PX. Biodegradable nanofibrous temperature-responsive gelling microspheres for heart regeneration. Adv Funct Mater. 2020 May 20; 30 (21) Epub 2020 Mar 20
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14. Lei I, Wang Z, Chen YE, Ma PX, Huang W, Kim E, Lam HYK, Goldstein DR, Aaronson KD, Pagani FD, Tang PC. "The Secret Life of Human Donor Hearts": An Examination of Transcriptomic Events During Cold Storage. Circ Heart Fail. 2020 Apr; 13 (4):e006409 Epub 2020 Apr 08
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15. Mokbel M, Zamani H, Lei I, Chen YE, Romano MA, Aaronson KD, Haft JW, Pagani FD, Tang PC. Histidine-Tryptophan-Ketoglutarate Solution for Donor Heart Preservation Is Safe for Transplantation. Ann Thorac Surg. 2020 Mar; 109 (3):763-770 Epub 2019 Aug 27
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16. Han L, Madan V, Mayakonda A, Dakle P, Woon TW, Shyamsunder P, Nordin HBM, Cao Z, Sundaresan J, Lei I, Wang Z, Koeffler HP. Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice. Leukemia. 2019 Sep; 33 (9):2291-2305 Epub 2019 Mar 11
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17. Guo Y, Lei I, Tian S, Gao W, Hacer K, Li Y, Wang S, Liu L, Wang Z. Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming. J Biol Chem. 2019 Jun 7; 294 (23):9134-9146 Epub 2019 Apr 25
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18. Tian S, Lei I, Gao W, Liu L, Guo Y, Creech J, Herron TJ, Xian S, Ma PX, Eugene Chen Y, Li Y, Alam HB, Wang Z. HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction. EBioMedicine. 2019 Jan; 39:83-94 Epub 2018 Dec 11
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19. Lei I, Tian S, Chen V, Zhao Y, Wang Z. SWI/SNF Component BAF250a Coordinates OCT4 and WNT Signaling Pathway to Control Cardiac Lineage Differentiation. Front Cell Dev Biol. 2019; 7:358 Epub 2020 Jan 22
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20. Wang L, Meier EM, Tian S, Lei I, Liu L, Xian S, Lam MT, Wang Z. Transplantation of Isl1(+) cardiac progenitor cells in small intestinal submucosa improves infarcted heart function. Stem Cell Res Ther. 2017 Oct 16; 8 (1):230
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21. Li Y, Tian S, Lei I, Liu L, Ma P, Wang Z. Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice. Am J Transl Res. 2017; 9 (3):1530-1542 Epub 2017 Mar 15
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22. Liu L, Lei I, Wang Z. Improving cardiac reprogramming for heart regeneration. Curr Opin Organ Transplant. 2016 Dec; 21 (6):588-594
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23. Liu L, Lei I, Karatas H, Li Y, Wang L, Gnatovskiy L, Dou Y, Wang S, Qian L, Wang Z. Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts. Cell Discov. 2016; 2:16036 Epub 2016 Oct 11
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24. Liu Q, Tian S, Zhao C, Chen X, Lei I, Wang Z, Ma PX. Porous nanofibrous poly(L-lactic acid) scaffolds supporting cardiovascular progenitor cells for cardiac tissue engineering. Acta Biomater. 2015 Oct; 26:105-14 Epub 2015 Aug 14
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25. Lei I, West J, Yan Z, Gao X, Fang P, Dennis JH, Gnatovskiy L, Wang W, Kingston RE, Wang Z. BAF250a Protein Regulates Nucleosome Occupancy and Histone Modifications in Priming Embryonic Stem Cell Differentiation. J Biol Chem. 2015 Jul 31; 290 (31):19343-52 Epub 2015 June 12
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26. Takebayashi S, Lei I, Ryba T, Sasaki T, Dileep V, Battaglia D, Gao X, Fang P, Fan Y, Esteban MA, Tang J, Crabtree GR, Wang Z, Gilbert DM. Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains. Epigenetics Chromatin. 2013 Dec 13; 6 (1):42
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27. Lei I, Liu L, Sham MH, Wang Z. SWI/SNF in cardiac progenitor cell differentiation. J Cell Biochem. 2013 Nov; 114 (11):2437-45
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28. Lei I, Gao X, Sham MH, Wang Z. SWI/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development. J Biol Chem. 2012 Jul 13; 287 (29):24255-62 Epub 2012 May 23
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