A multi-omics research study for discovery and future clinical practice

Mayo Clinic is enrolling participants and collecting samples to study and better understand the impact of genes and environmental exposures on human disease.

Overview

What is the Tapestry 2.0 research study?

Tapestry 2.0 is a research study that aims to advance the study of genomics. It explores how interactions between people's genes and their environments affect human disease.

To do this, the study team is making a library of information and biological samples from thousands of people from diverse backgrounds and health statuses. This type of library is called a registry. Researchers at Mayo Clinic will use the information and test the biological samples to better understand why a disease or disorder occurs and how it develops over time.

Mayo Clinic's Center for Individualized Medicine is sponsoring the Tapestry 2.0 research study.

What information do I need to know before making a decision?

Please watch the Tapestry 2.0 introductory video before you decide whether to take part in the study.

Tapestry 2.0 Introduction

Tapestry 2.0: An Introductory Overview

Dr. Konstantinos Lazaridis, Center for Individualized Medicine, Mayo Clinic: Hello. My name is Dr. Konstantinos Lazaridis, and I'm serving as the Executive Director of Mayo Clinic's Center for Individualized Medicine. Today, I'm excited to tell you about a new research study we're launching called Tapestry 2.0. It represents a significant leap into a new era of medical exploration. We're diving deep into how your environmental exposures and unique biological makeup collectively interact to impact your health.

This study could transform the way we approach healthcare and disease prevention in the years to come. But to truly make a difference, we need participants from many different backgrounds to join us. Participating in Tapestry 2.0 means you're contributing to possible future discoveries that could someday prevent diseases before they start, diagnose conditions more accurately and treat illnesses with precision medicine approaches.

This study isn't about your personal healthcare, it's about working towards a healthier future for generations to come. Are you ready to be part of this study? Let's step into the future of medical research together. Please continue watching this video to learn more.

TAPESTRY 2.0:

Narrator: In the next 4 minutes, we will talk about what to expect, potential risks, and possible benefits.

We are inviting you to take part in this study because you have received care at Mayo Clinic and are at least 18 years old. Feel free to watch this video as many times as you want. It is important to us that you know the study's needs and the effort needed from you. Remember, this is a research study. It is your choice. You will not lose anything if you choose not to take part. Please know you can always talk to a member of our research team. They are available by e-mail or by phone to answer your questions.

WHAT TO EXPECT:

If you decide to join the Tapestry 2.0 study, your participation will be ongoing. We will ask you to give us four physical samples and complete an optional survey over one to two days. Three of these samples can be collected by you in your own home - saliva, urine, and stool. We will mail you everything you need to collect these samples and send them back to us. We will also ask for a sample of your blood. We will give you guidance for the location for blood collection.

If possible, we would like you to collect all the samples within two days between the first and last sample. It does not matter in what order you collect the samples. We will do research testing on all samples sent to us. This testing may include genetic testing. Genetic testing examines your DNA.

You may also have the choice to do surveys. These are not a requirement of this research study. Because this is a research study, we will not send you the results. However, if we see something that is concerning about your health, we will do our best to let you know if you so choose. It may take years to fully research the information you send us. In the future, we may ask you if you would send us more samples.

POTENTIAL RISKS:

As with any research study, there are potential risks that you should consider. Blood draws may lead to pain, lightheadedness, bruising, or rarely, infection at the site of the needle. Survey questions may make you feel uncomfortable. If this happens, you do not need to answer these questions. There is a chance that your medical information could be shared by mistake. We have safety measures in place to decrease this risk. Results from genetic tests may lead to strong feelings, issues with family and discrimination. Please know that there is a federal law that helps protect your job and health insurance from genetic discrimination.

GENETIC INFORMATION NONDISCRIMINATION ACT (GINA):

- Federal law that protects your job and health insurance from genetic discrimination

- GINA does not protect long term care, life, or disability insurance

- To learn more, please read the document 'GINA PATIENT RESOURCE' found on the website www.genome.gov

The name of this law is the Genetic Information Nondiscrimination Act. It is also known as GINA. GINA does not protect everyone. GINA does not protect long term care, life, or disability insurance. To learn more, please read the document 'GINA Patient Resource' found on the website www. genome.gov. Mayo Clinic takes your privacy very seriously. We will do our best to decrease information related risk.

This study will cost you nothing. There is no planned medical benefit for you for joining this research study. We will give you $10 for each type of physical sample you send to us. Blood, saliva, urine, and stool. The biggest benefit of joining this study is that you could be helping us to advance healthcare. This could make a difference to many people in the future.

Dr. Lazaridis: Please remember, it's up to you whether you wish to join this study. If you do join, you can stop at any time. As the Mayo brothers once said, the success of the clinic, past, present, and future, must be measured largely by its contributions to the general good of humanity. This is what we intend to do. Please contact us with any questions and thank you for your interest.

How do I get more information?

For more details about the Tapestry 2.0 research study — including eligibility, what to expect, results and costs — visit the Participation page and the Resources page. To ask the study team questions, visit the Contact page.

How do I enroll?

Please complete the interest and eligibility form linked in your invitation. If you cannot find your invitation, or if you deleted it, visit the Contact page to ask the study team for help.