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Cellular and Molecular Profile of Fat and Skin in Fat Grafting for Facial Lipoatrophy and Facial Reconstruction Surgical Outcomes

Overview

About this study

The purpose of this study is to characterize the cellular and molecular profile of adipose tissue collected for facial fat grafting and/or skin tissue (surgical waste) from facial reconstruction surgery, to elucidate the role of age-related hallmarks, such as cellular senescence, in patient outcomes. We will then explore the potential for using senotherapeutics to prime adipose tissue in the laboratory for improved patient results in facial fat grafting. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients that come for facial plastic/reconstructive surgery involving facial fat injection or other facial reconstruction surgery.

Exclusion Criteria:

  • Patients treated with immunotherapy.
  • Patients treated with chemotherapy/radiation therapy.
  • Smokers.
  • Patients with immuno-suppressed or compromised disease.
  • Patients with diabetes.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 6/7/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Saranya Wyles, M.D., Ph.D.

Open for enrollment

Contact information:

Ashlee Kirtz

(507) 284-1231

Kirtz.Ashlee@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20551772

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