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The research interests of Saranya P. Wyles, M.D., Ph.D., focus on the science of skin aging and wound healing through the lens of cellular aging (senescence) and regenerative medicine. She also pioneered the development of a novel regenerative medicine curriculum for medical and graduate students to better prepare the next generation of health care workers in regenerative clinical practice. The goal of Dr. Wyles' current work is to develop new regenerative therapies and clinical trials in dermatology to counteract the detrimental impact of senescent cells with aging and age-related skin diseases.
Dr. Wyles' program capitalizes on emerging regenerative technologies to transform therapeutic modalities in dermatology. In particular, the ability to target cellular senescence, the molecular root cause of age-associated chronic disease, through regenerative medicine can advance the dermatological therapeutic armamentarium. Specific contributions include the development of novel biotherapeutics to accelerate regenerative technologies to clinical readiness through the discovery-translation-application platform for patients with chronic age-related diseases including diabetes and associated skin complications, which account for the bulk of worldwide morbidity and mortality.
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