Saranya P. Wyles, M.D., Ph.D.

The purpose of thisstudy is to define the standard clinical features of atopic dermatitis, or eczema, a skin condition that affects many people.  

The purpose of this study is to characterize the cellular and molecular profile of adipose tissue collected for facial fat grafting and/or skin tissue (surgical waste) from facial reconstruction surgery, to elucidate the role of age-related hallmarks, such as cellular senescence, in patient outcomes. We will then explore the potential for using senotherapeutics to prime adipose tissue in the laboratory for improved patient results in facial fat grafting. 

The purpose of this trial is to evaluate the cosmetic role of novel anti-aging regenerative skin care product, human platelet extract (HPE), on skin rejuvenation. 

Skin aging is a natural part of human aging process caused by intrinsic and extrinsic factors, such as genetics, cellular metabolism, chronic light exposure and other toxins.  Cosmetological care for facial skin aging includes daily skin care, correct sun protection and aesthetic non-invasive procedures. 80 participants over the age of 40 years with moderate photoaging (dyschromic facial skin with fine lines and wrinkles) will be recruited from Mayo Clinic Center for Aesthetic Medicine and Surgery (CAMS) to participate in the study.  Subjects will be instructed to apply topical HPE to their entire face and decolletage twice daily, in the morning and at bedtime, for 12 weeks.  Subjects will also apply topical HPE versus marked-competitor (Skinceuticals CE Ferulic) to the dorsal hands in a non-randomized fashion.  Evaluations will include cosmetic questionnaires, standard photography and VISIA-CR 3D imaging.  Select subjects will also undergo skin biopsies, skin microbiome analysis and long-term evaluation at week 26 and week 52. This industry-sponsored, cosmetic study evaluates the role of topical HPE Skincare on overall skin appearance for aging skin.