Clinical Trials

The aim of this study is to assess quality of life in patients following esophageal resection for achalasia.

The purpose of this study is to assess symptoms and quality of life in patients following Heller’s cardiomyotomy for achalasia in the context of a sigmoid esophagus.

Based on the work of the Doctors at the Mayo Clinic Rochester, a new technique for a less invasive treatment for Achalasia has been developed.

The purpose of this study is to decide the role this less invasive treatment (Peroral Endoscopic Myotomy) has in the treatment of patient's with achalasia.

Would systemic steroids be an effective treatment in early variants of achalasia?

The purpose of this study is to evaluate the long-term (30 years) clinical effectiveness of endoscopic and surgical interventions for achalasia.

The objectives of this study are as follows: In patients with primary Type I or II Achalasia, following a single 5-mg dose of IW-1701, - To assess the safety and tolerability - To determine the effects on measures of esophageal function by high-resolution impedance manometry (HRIM) - To determine the pharmacokinetic (PK) parameters, Cmax, Tmax, and AUClast

Achalasia is a rare disorder of the esophagus characterized by absent peristalsis and impaired relaxation of the lower esophageal sphincter. This results in dysphagia, or the inability to swallow, and can lead to malnutrition and failure to thrive in severe disease. POEM has emerged as an effective, minimally invasive therapy for achalasia, enabling selective circular or full thickness myotomy through the distal esophagus, esophagogastric junction (EGJ) and cardia. POEM is a natural orifice transluminal endoscopic surgery (NOTES) alternative to Heller myotomy, and does not involve incisions to the chest or abdomen. This outpatient procedure involves same-day discharge or an overnight stay ...

The purpose of this study is to determine the prevalence of esophageal dysmotility among patients following bariatric surgery.

The purpose of this study is to evaluate the accuracy of balloon catheter based mucosal impedance for the diagnosis of GERD in patients who have undergone Peroral Endoscopic Myotomy (POEM).