Clinical Trials

Trudi will give us the data points to address residents and consultants skill level and areas of weakness during endoscopic sinus surgeries. (ESS)

The purpose of this study is to describe the proteome of mucus in patients without chronic rhinosinusitis (nCRS) with an emphasis on cytokines and bone morphogenic proteins present (BMPs), to describe the proteome of mucus in patients with chronic rhinosinusitis without polyps (CRSsNP) with an emphasis on cytokines and BMPs present, to describe the proteome of mucus in patients with allergic fungal sinusitis (AFRS) with an emphasis on cytokines and BMPs present, and to identify BMPs differentially elevated in patients with AFRS compared to patients with nCRS or CRS.

The purpose of this study is to describe the results of antibiotic resistant organisms after the use of topical antibiotics in the treatment of chronic rhinosinusitis.

The purpose of this study is to use pharmacy data to identify patient use patterns of prescribed topical medications for chronic rhinosinusitis, and then survey the patients who are not complying for the difficulties they feel prevent use. 

The purpose of this study is to find out what immune system processes cause the chronic inflammation that happens with chronic rhinosinusitis (CRS) and if there are different immune system pathways involved among CRS patients.

There are many subtypes of CRS. Different subtypes respond better to different types of treatments. The purpose of this study is to develop a standard way to classify the subtypes of CRS so that the patients can be treated with a more individualized approach.

The primary objective of this study is to investigate the contribution of group 2 innate lymphoid cells (ILC2s) to the immunologic mechanisms of chronic airway diseases.

The purpose of this study is to compare change in SNOT-22 score in patients who received medication therapy such as oral antibiotics, topical antibiotics, oral corticosteroids, topical corticosteroids, leukotriene receptor antagonist, and interleukin 5 receptor antagonist following endoscopic sinus surgery versus control in patient with chronic sinusitis with nasal polyps and a positive culture.

The purpose of this study is to identify differences in the sinus microbiota in patients with chronic rhinosinusitis (CRS) and determine potential immunological targets of CRS-associated pathogenic communities.  

This study is being done in order to gain a greater understanding of rhinitis and sinusitis conditions and to improve diagnostic and treatment options for these conditions.

This research study is being done for people who have asthma and chronic rhinosinusitis, hay fever, or you do not have any sinus disease, asthma or hay fever (control). The aim of the study is to investigate the functions of nasal epithelial cells.

The purpose of this study is to gather periodic quality of life data using the validated SNOT-22 protocol and/or other validated metrics using a free iPhone application for patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP).

The purpose of this study is to investigate the effect of benralizumab on the rate of asthma exacerbations, patient reported quality of life and lung function during 24-week treatment in patients with uncontrolled, severe asthma with eosinophilic inflammation. A subset of patients will be assessed for their ongoing chronic rhinosinusitis with nasal polyps.

The objectives of this study are to determine longitudinal effects of aspirin desensitization on circulating immune cells in Aspirin Exacerbated Respiratory Disease (AERD) subjects, and to compare effects of sinus surgery on circulating immune cells in patients with AERD compared to patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Immune cells in nasal polyp tissue removed at the time of endoscopic sinus surgery will also be compared to the profile of circulating immune cells before and after endoscopic sinus surgery and, for some subjects, after aspirin desensitization.

The purpose of this study is to investigate the mechanism through which aspirin works for the prevention of nasal polyp recurrence in AERD patients, while comparing two aspirin doses: 325 mg once-daily or 650 mg twice daily dose of aspirin.