Clinical Trials

The purpose of this study is to obtain more detailed information about bone structure in adults with repeat bone fractures.

The North American Scapula Consortium (NASCon) is a multi-center injury specific outcomes registry. There currently exists a paucity of outcomes data in the literature on this patient population. The NASCon registry will be a resource in which investigators can conduct adequately powered clinical outcomes research resulting in higher quality research with meaningful results, improved patient care, and evidence-based advancement for the treatment of scapula fractures. Registries can lead to significant discoveries in comparative effectiveness specifically in areas where randomized control studies are not possible. Collecting post-treatment (operative and non-operative) patient outcome data for similar injury patterns has been shown effective ...

In the United States, over 300,000 individuals over age 65 suffer from distal radius fractures (DRFs) each year. Despite the frequency of this injury and over 200 years of experience treating DRFs, management of elderly DRFs is still controversial. Close reduction and casting is a nonsurgical technique that is frequently used, but osteoporotic fractures, common in the elderly, often collapse and displace. The three currently applied surgical techniques are close reduction and percutaneous pinning, external fixation with or without percutaneous pinning, and internal fixation with volar locking plating. Preliminary evidence indicates that locking plate fixation can permit elderly patients to ...

The purpose of this study is to describe the complications that occur during a shoulder arthroplasty surgery and the outcomes after, due to the altered anatomy or damage from a previous surgery to fix a fracture.

This trial will study the effect of hematoma aspiration in patients with acute ankle fractures.

The purpose of this study is understanding changes in bone across a variety of conditions, including normal processes (such as skeletal changes that occur with aging), in pathologic conditions (such as in patients with diabetes), or in response to therapeutic interventions (such as in patients treated with teriparatide – a skeletal anabolic agent used clinically).

The purpose of this study is to assess the connection between patients with bone metabolism issues and fragility fractures, identifying risk factors for fragility fractures including vitamin D deficient populations.

The purpose of this study is to determine the incidence of swallowing disorders and the risk for aspiration in elderly patients who have cervical spine fractures.

The purpose of this study is to examine the ability of PCD-CT to (1) display subtle fractures of the wrist using the system’s increased spatial resolution compared to conventional wrist CT and MR; and (2)  evaluate the ability of PCD-CT with virtual non-calcium images to identify bone marrow edema at acute fracture sites.

The purpose of this study is to to determine whether or not prior living kidney donors have an increased risk of bone fractures. The study will also determine bone structure and health in prior living donors as compared to matched controls.  

We will determine if living kidney donors are at increased risk of bone disease and fractures following kidney donation. This information will be valuable in informing future kidney donors of the risks of donation and in devising treatments, such as administration of vitamin D analogs like calcitriol, to ...

The purpose of this study is to compare validated clinical and functional outcomes between patients who acutely present with 3- and 4-part Proximal Humerus Fractures (PHFs) treated nonoperatively or with rTSA. We hypothesize that in displaced 3- and 4-part proximal humerus fractures, rTSA will have better pain relief and functional outcomes than nonoperative treatment.

The primary objectives of this study are to obtain serological bone turnover markers and bone mineral density (BMD) measurements from hemophilia A and von Willebrand disease (VWD) patients aged  ≥ 6 to ≤ 25 years, to compare BMD measurements by HRpQCT and DXA with respect to severity of hemophilia A (mild, moderate, severe) and vWD, annualized bleeding rates, activity and joint scores, and to identify multivariate predictors (correlates) of BMD measurements, including serological bone turnover markers, biochemical and hormonal markers, chronological age, Tanner stage, gender, height, weight, BMI, type of bleeding disorder, severity of bleeding disorder, history of inhibitors, and ...

The aim of this protocol is to determine clinical, functional, radiographic, and survival outcomes in patients undergoing an uncemented reverse total shoulder arthroplasty for a proximal humerus fracture.

This purpose of this study is to answer if patients fair better with non-operative management or reverse total arthroplasty for treatment of 3- and 4-part proximal humerus fractures.

The purpose of this study is to identify an effective dose of bimagrumab that can increase lean muscle mass and improve physical function, then continue to assess the safety and effectiveness of bimagrumab in patients with muscle wasting after hip fracture surgery.

The purpose of this study is to evaluate the use of a single infusion of zoledronic acid-5 mg (ZA) vs. placebo for the prevention of fractures in men and women aged 65 years and older with Parkinson's Disease with 2 years of follow-up.

The purpose of this study is to to demonstrate the feasibility of performing ultrasound-guided erector spinae plane blocks in the Emergency Department (ED) and Intensive Care Unit (ICU).

The purpose of this study is to evaluate the effectiveness of vertebral fracture assessment (VFA) in evaluation of asymptomatic fracture in pre-liver transplant patients as compared to the current standard of care using spine x-ray
 

The purpose of this study is to assess key characteristics of bone quality, specifically material strength and porosity, in patients who have type 2 diabetes. These patients are at an unexplained increased risk for fractures and there is an urgent need to refine clinical assessment for this risk.

Displaced femoral neck fractures are one group of hip fracture patients that are commonly treated with cemented hemiarthroplasty (HA) or total hip arthroplasty (THA). In the elective hip arthroplasty population, the direct anterior approach (DAA) has shown to be effective in helping patients to quickly obtain high postoperative function. This approach has also been shown to be effective in arthroplasty for displaced femoral neck fractures in a few studies. However, the only studies that directly compare two approaches for hip arthroplasty for femoral neck fractures utilize the anterolateral approach (ALA) versus posterior approach (PA) or DAA versus PA. No studies ...

The purpose of this study is determine if posterior malleolar fractures involving less than 25% of the articular surface should undergo operative intervention to improve clinical outcomes.

The purpose of this study is to look at two different types of surgeries regularly used for treating cancer that has spread to and weakened the thigh bone (femur). Because it is not known which of these surgeries is best, the investigators will compare the results of the two procedures. They are looking to see if differences exist (after surgery) in function, quality of life, pain control, and possible complications.

The purposes of this study are to assess the accuracy of dual-energy CT (DECT) virtual non-calcium technique to detect subtle or occult pelvic or hip fractures in emergency room patients and to assess the impact on confidence of detection of pelvic or hip fractures utilizing the VNCa technique in radiology trainees with varying degrees of training.

The purpose of this study is to develop an evidenced-based guideline for pediatric opioid prescribing guideline from the emergency department for long bone fractures to more closely tailor pain management to abuse potential. 

The purpose of this study is to determine prevalence and incidence of osteopenia, osteoporosis, and fractures in patients with adenomas based on hormonal sub-type, and to determine the effect of abnormal steroid metabolome on bone density, bone metabolism, and fractures.

Preliminary indicates that there is a significant seasonal and regional variation in incidence and causative organisms for post traumatic wound infections after open fractures. This finding makes the current use of a generic antibiotic for prophylaxis suboptimal. In order to validate this original finding we need to conduct a large scale study to determine if the patterns of infection truly vary depending on the time of year and the region in which the fracture occurs, and if so to change the way prophylactic antibiotic use is administered.

The purpose of this study is to update rates of union after medial femoral condyle bone grafting for scaphoid nonunion, determine subjective patient outcomes after this procedure, determine radiographic results after this procedure.