Clinical Trials

The primary aim of this study is to retrospectively review the usage, describe the process and assess the outcomes of tobacco cessation e-consultation directed to the Nicotine Dependence Center of the Mayo Clinic (Rochester) from January 2016 to December 2016.

The purpose of this study is to develop and pilot test a culturally relevant, Facebook delivered intervention to promote smoking treatment uptake and cessation among Alaska Native (AN) smokers.

Learn more about this study.

The purpose of this study is to assess the effectiveness of high dose nicotine patch therapy to help the users of smokeless 'chewing' tobacco quit using long term or permanently. If found to be effective, chewers may use this treatment to help them quit and reduce their risk for negative health effects.

The purpose of this study is to propose a “quit for a bit” intervention to increase measurements of treatment engagement over the postoperative period (defined as the day of surgery to 30 days after surgery), and the willingness to continue treatment after this period, compared to the “quit for good” intervention. 

The purpose of this study is to determine if a brief educational intervention about the connections between smoking and chronic pain will promote the participation in a smoking abstinence therapy program among smokers seeking treatment for chronic pain.

This present effort is the first step of a larger study. We are limiting the scope this AAIRB application to only the first step. The goal of the overall research study is to examine the acceptability and feasibility of using NMR to inform selection of pharmacologic treatment to increase smoking abstinence among ANAI people.

The aim of this IRB application (Aim 1a) is to refine a metabolism-informed pharmacologic intervention to optimize design and participation of a future pilot.

We will use a community-based participatory research (CBPR) approach with ANAI customer-owners, providers, and leaders to refine ...

In the southwest region of Alaska where the project takes place, 79% of Alaska Native women smoke cigarettes or use smokeless tobacco (ST) during pregnancy. In addition, pregnancy appears to be a high risk period for initiation of tobacco use, primarily ST, among women reporting no use of tobacco 3 months before pregnancy. Intervention efforts targeting the entire community, not only pregnant women, to address social norms about tobacco use may be effective. Thus, the investigators will evaluate the efficacy of a novel, multi-component, theory-based intervention for reducing tobacco use during pregnancy, incorporating both individually targeted and community level components ...

The purpose of this study is to assess the effects of combining varenicline and bupropion SR for a potential additive benefit for helping patients stop smoking for longer periods (≥ 6 months smoking abstinence rates).

The aims of this study are 1) To assess the prevalence of tobacco use and cessation treatment preferences among YKHC employees, 2) To assess employee's current levels of perceived stress, engagement in physical activity, and feelings of resiliency to inform future tobacco cessation interventions, and to examine the relationship between these factors and tobacco use, and 3) To assess YKHC employees' perceptions and opinions of the hospital's current workplace tobacco policy and expansion of these regulations to all YKHC properties.

The goal of this pilot study is to better understand the health of the Somali community in the greater Phoenix area. Healthcare access and clinical service utilization will also be assessed in order to inform future reduction and cessations studies. Social networks will be examined in relation to accessing information about health and tobacco use. Long term objectives related to this study are the development of community-based interventions for tobacco use prevention, reduction, and cessation tailored to reduce disparities related tobacco use among the Somali community.

The purposes of this study are to determine the relationship between the use of e-cigarette and perceived social support in young adults, to characterize the pattern of co-use of nicotine and cannabis e-cigarette in young adults, and to identify if co-use of nicotine and cannabis e-cigarettes is a risk factor for use of combustible forms of tobacco and cannabis.

The purpose of this trial is to assess the impact of access to technology and/or coaching support on participation in and response to a behavioral health program for smoking cessation among rural Midwest Mayo Clinic patients.

The purpose of this study is to assess whether regular cigarette smokers who purchase an ENDS product from  Vape Shops that offer personalized coaching on product selection and use can result in regular cigarette smokers completely switching to an ENDS (i.e., discontinue cigarette smoking).

The purpose of this study is to to develop a Smokeless Tobacco (ST) reduction intervention among ST users not interested in quitting tobacco. The first step is to assess the effectiveness of the nicotine lozenges or tobacco-free snuff for reducing ST use or facilitating ST abstinence among ST users not interested in quitting.

The primary purpose of this study is to assess serum nicotine and cotinine concentrations at baseline and every 30 minutes during a 2-hour shisha smoking session among regular hookah users.

The purpose of this study is to see whether advice by clinicians to cigarette smokers who are parents of children undergoing elective surgery can reduce the exposure of these children to secondhand smoke in the time around surgery.    
 

This pilot study is being done to adapt an effective 1 session phone coaching intervention for nonsmoking support persons to a low income population. This study will also pilot new intervention components including text messaging and health incentives. The goal of the intervention is for support persons to prompt their smoker to use quitline services. To see if these methods are effective, smokers in this study will be asked to complete assessments about their quit attempts and smoking status. The study will also evaluate if the smokers use quitline services or not. The preliminary findings will be used to provide ...

 Nicotine patches and behavioral therapy may help reduce cigarette smoking and binge drinking in young adults.This randomized clinical trial studies nicotine patches with or without behavioral therapy in reducing cigarette smoking and binge drinking in young adults.

This randomized phase III trial studies how well smoking cessation intervention works in reducing surgical complications in patients with newly diagnosed lung cancer who smoke cigarettes. This study will use two smoking cessation interventions: Varenicline (a drug that reduces the craving and withdrawal symptoms that occur with abstinence from nicotine) with behavioral interventions (consisting of a brief clinician-delivered intervention and tobacco quitline [tobacco cessation service available through a toll-free telephone number] follow-up) with placebo (a pill with no active medication) along with the same behavioral interventions. It is not yet known whether smoking cessation intervention prior to surgery is effective ...