Clinical Trials

The purpose of this study is to evaluate if there is a decrease in blood flow to the incision following application of an ice pack.

This post-marketing investigation will evaluate the long term (up to 15 years) survivorship of the Attune Primary Knee Prosthesis in patients with non-inflammatory degenerative joint disease. Data from Subjects who receive one of four knee configurations will be pooled to establish a contemporary dataset.

This study will explore if there are any difference in functional outcomes between two different surgical procedures for total knee replacement: robot-assisted versus manually-executed total knee arthroplasty.

The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (the knee joint) is more effective at obtaining adequate tissue levels of the antibiotic than the current standard dose which is given intravenously (IV) through a wrist vein. The use of IORA vancomycin requires the use of a tourniquet for the duration of the procedure. Many surgeons prefer to perform the surgery with tourniquet use minimised or without a tourniquet at all. The aim of this study is to evaluate whether IORA vancomycin can achieve ...

The primary aim of the study is to compare the results of an established, successful procedure, which is total hip arthroplasty through a mini-posterior approach to a less studied - increasingly popular procedure, which is total hip replacement through the direct anterior approach utilizing the orthopedic table.

This study aims to assess pre- and postoperative serum mast cell tryptase levels in primary TKA patients to determine whether there is an association with the development of post-operative stiffness.

To assess the pain scores before and after saphenous nerve block placement in patients with degenerative joint disease of the ankle.

Study is designed to determine the maximum tolerated dose (MTD) of SNX-5422 when given in combination with everolimus.

The purpose of this study is to determine whether topical or intravenous administration of tranexamic acid during unilateral total knee replacement is more effective at reducing bleeding in the first 24 hours following surgery. Tranexamic acid is a synthetic drug that has been shown to reduce blood drain output and the need for blood transfusions in both its topical and intravenous forms and is commonly used in orthopedic surgery. We hypothesize that IV and topical administration of tranexamic acid will be equally good at reducing the loss of blood and the need for transfusion immediately following total knee replacement.

The purpose of this study is to determine the effectiveness and safety of using platelet rich plasma in the treatment of degenerative joint disease in the lumbar spine area.

The purpose of this study is to find out whether knee joint fluid (synovial fluid) contains substances which may interfere with laboratory tests not normally done on synovial fluid. 

A study to compare the safety of single ascending doses of SL-1002 to a placebo and the efficacy of a single treatment exposure of SL-1002 to relieve pain in patients suffering from knee osteoarthritis.

Corticosteroid injections are commonly used for the symptomatic treatment of knee osteoarthritis. Common practice is to inject the joint with a combination of corticosteroid and local anesthetic, with the rationale of providing longer duration pain relief with the corticosteroid and immediate, though short duration relief with the anesthetic. However, multiple in vitro and animal studies have shown that local anesthetic may be harmful to chondrocytes. Despite this data, use of intra-articular anesthetic remains widespread. Many clinicians believe incorporating the anesthetic is important because it can provide immediate pain relief and facilitate patient confidence in the treatment program. However, there is ...

The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee. The patient population is heterogeneous, involving different kinds of joint surface lesions: focal cartilage lesions, osteochondral defects and mild to moderate osteoarthritis, including multiple defects.

The primary aim of the study is to see if a single wrist injection (intra-articular) of dexamethasone at the time of treatment will reduce the incidence of early-onset of post traumatic osteoarthritis.

The purpose of the study is to identify a possibly novel mutation in an individual with early onset osteoarthritis.

The purpose of this study is to learn the effects of synovial fluid, a clear thick joint lubricant, on joint cartilage tissue and the development of osteoarthritis

The purpose of this study is to determine the safety and feasibility of autologous, adipose derived stromal vascular fraction injections in the treatment of knee osteoarthritis.

Will injection(s) of autologous culture-expanded AMSCs be safe and efficacious for treatment of painful Hip OA, and if so, which dosing regimen is most effective?

The purpose of this study is to determine the safety and practical treatment use of STEM cells collected from a patient's own fat tissue, expanded in laboratory culture, and injected to treat symptoms of mild to severe knee osteoarthritis.

The purpose of this study is to determine the safety of sc-rAAV2.5IL-1Ra, a gene therapy carried by a virus and delivered by injection into the knee joint of patients with moderate osteoarthritis of the knee.

The purpose of this study is to assess daily living activity levels of patients before and after total hip replacement, and to correlate these activities of daily living to those usually obtained with disease-specific questionnaires.

To determine the accuracy of unguided versus ultrasound (US) guided knee joint injections in obese patients with no clinically detectable effusion.

The purpose of this study is to evaluate the safety and feasibility of concentrated bone marrow aspirate administration after Comprehensive Arthroscopic Management (CAM) surgical procedure, and to determine pain relief, disease progression and range of motion in patients with osteoarthritis of the shoulder.

The purpose of this study is to assess and compare regenerative injection therapies such as bone marrow aspiration and concentration (BMAC) and platelet rich plasma (PRP) for osteoarthritis.

The purpose of this study is to determine if a treatment based on the combination of platelet rich plasma and HA obtained with the A-CP HA Kit is statistically superior to a saline placebo or HA alone in terms of Improvement of OA-related symptoms between baseline(D0) and Month 6, and reduction of pain at walking between baseline (D0) and Month 6.

The purpose of this study is to develop a research repository (a repository is a database of information) to collect data from patients being treated for hip disorders.

Aim #1: The aim of this research is to examine the results of periacetabular and femoroacetabular osteoplasty procedures in patients with symptomatic non-arthritic hip disease using clinical and radiographic evaluation.

The purpose of this study is to better understand the mechanisms that can cause knee osteoarthritis (OA) following anterior cruciate ligament (ACL) rupture and ACL reconstruction (ACLR). Those who suffer an ACL injury have a dramatically increased risk of developing early onset knee OA compared to those who do not injure their ACL. While research has established a causal link between ACL injury and OA, the mechanism behind it is still unclear.

The purpose of this study is to compare the postoperative pain levels both in the hospital setting as well as daily for two weeks following discharge between patients in the opioid treatment group and those in the non-opioid treatment group.

Aims, purpose, or objectives

Aim 1: To quantify passive stiffness modifications due to RSA in deltoid muscle.

Aim 2: To interpret these modifications in the light of postoperative clinical outcomes.

The purpose of this study is to investigate the correlation between a patient’s complete blood count with differential (CBC w/diff), platelet count, platelet-rich plasma (PRP) blood and platelet counts with a patient’s clinical outcome from a PRP injection for the treatment of knee osteoarthritis (OA).

The purpose of this study is to determine the extent to which duloxetine and the combined effects of painTrainer and duloxetine improve pain and function in participants with knee osteoarthritis (KOA). Also, among those interested in additional treatment, including those following conservative treatment and those inappropriate for conservative care, determine whether nonsurgical procedural interventions improve pain and function. Additionally, to identify clinical and psychosocial phenotypes that predict short- and longer-term outcomes.

The goals of this continuation of MeTeOR are to determine: a) whether the greater structural damage observed at five years in subjects treated with APM persists over 12 years; and b) whether structural changes observed in the first five years are associated with worse pain and function and greater TKR utilization at 12 years. We propose the following aims:

1. Conduct a 12-year follow-up visit of MeTeOR subjects to characterize the extent of cartilage damage over 12 years and identify factors associated with OA progression. MeTeOR participants will complete questionnaires and performance tests and undergo MRI and radiographs 12 years ...

The overall goal of this study is to develop regenerative cell therapy for use in patients with osteoarthritis (OA). The primary objective of this proposal is to conduct a pilot study that assesses the safety and feasibility of using concentrated bone marrow aspirate containing MSC to treat patients with painful knee OA.

The purpose of this study is to assess the accuracy of range of motion (ROM) measurements of the wrist and hand taken in person versus ROM taken during a telemedicine video interview.

This is a prospective, randomized, multicenter comparison study examining the outcomes of subjects with osteoarthritis and knee pain undergoing a procedure to create a radiofrequency lesion of the genicular nerves with the Cooled Radiofrequency Ablation (CRFA) system compared to subjects receiving Hyaluronic Acid (HA). Approximately 168 subjects will be enrolled into this study, with subjects undergoing either CRFA or HA injection in a 1:1 randomization scheme. Follow-up will be conducted for 12 months post-CRFA, with the primary endpoint being completed at month 6. Subjects randomized to the comparison (HA) group will have the option to cross-over to the neurotomy group ...

The purposes of this study is to isolate RNA from bone tissues from ONFH and osteoarthritis (OA) femoral heads and perform RNA sequencing to measure gene expression.

We will collect both non-invasive hemoglobin and conventional serum hemoglobin labs from patients postoperatively following outpatient total joint arthroplasty to determine how closely the values of these two studies correlate in the outpatient total joint arthroplasty patient population.

This study is designed to:
-analyze effects of surgical treatment
-improve surgical care and quality of life of patients with hip problems/diseases
-ID predictors of surgical outcomes to identify/improve future treatments
-Collect data, images, from patients undergoing surgical treatment of hip disorders (we will not be collecting social security numbers to send to Washington University).

This study aims to compare postoperative pain levels between three (3) treatment groups, using the Numerical Rating Scale (NRS).

The purpose of this study is to see if the inflammation in early stage arthritis can be cessated by changing synoviocyte-macrophage interactions in a way that macrophages do not get activated.

This study is being conducted to determine gene and protein expression profiles (i.e. which genes and proteins are turned off and on) of those with a possibility of developing osteolysis, infection, arthrofibrosis or metallosis of their THA/TKA.

This research trial will study the immune respone to COVID-19 vaccination in patients with rheumatic diseases.

The purpose of this study is to evaluate safety and efficacy and show non-inferiority of the investigational PERFORM Stemless Reverse device to the control PERFORM Stem Reverse device in subjects who are candidates for the treatment of noninflammatory degenerative joint disease (i.e., osteoarthritis), avascular necrosis, pseudoparalysis or anterior superior escape, rotator cuff tear arthropathy, correction of functional deformity, and post-traumatic arthritis.