Clinical Trials

The purpose of this study is to further the understanding of the natural history of recurrent pericarditis (RP), as well as document RP-related clinical, health-related quality of life (HRQoL), and economic burden and will assist the medical community to refine or develop data-driven recommendations for clinical management of RP patients to optimize clinical outcomes. It also aims to generate data in support of the impact of rilonacept on clinical outcomes in a real-world population.

The purpose of this study is to assess the effectiveness and safety of rilonacept treatment in subjects with recurrent pericarditis.

The study is comprised of 5 Parts:

1. Part 1 enrolls symptomatic subjects with recurrent idiopathic pericarditis (RIP) with an elevated marker of systemic inflammation (C-reactive protein [CRP] > 1mg/dL).
2. Part 2 enrolls symptomatic subjects with RIP with CRP ≤1 mg/dL which, in the opinion of the investigator, can be attributed to concomitant medications (e.g., corticosteroids) and with
3. pericardial inflammation present on cardiac magnetic resonance imaging (MRI) confirmed by the imaging core lab.
4. Part 3 enrolls subjects with corticosteroid-dependent RIP not experiencing symptoms which would meet the diagnostic criteria for a flare of pericarditis.
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The purpose of this study is to evaluate the effect of treatment with CardiolRxTM on recurrent pericarditis.

The purpose of this study is to learn more about identifying risk factors for progression from acute pericarditis to constrictive pericardial disease.

If serum sST2 predicts heart failure (HF) in several cardiovascular disorders, in myocarditis patients.

Until now, diagnosis of constriction was based on pressure changes of ventricle by conventional pressure-wide hemodynamic evaluation but not on ventricular volume change. This study will provide answers to persisting questions about volume changes during respiration in patients with constrictive pericarditis by directly measuring both right and left ventricular volume.

The purpose of this study is to learn whether Cardiac Magnetic Resonance Imaging (cMRI) and/or echocardiogram is useful to diagnose patients with unique heart conditions. This research study focuses on evaluating the use of cMRI or echocardiogram as a novel, non-invasive method for evaluating specific heart conditions.