Clinical Trials

Patients with active Axial Spondyloarthritis without x-ray evidence of Ankylosing Spondylitis and with signs of inflammation will be randomly assigned to receive certolizumab pegol (CZP) 200 mg every two weeks or placebo. The primary objective is to demonstrate the efficacy of CZP in these patients.

The objectives of this study are to use a questionnaire to detect Spondyloarthritis (SpA) manifestations will be administered to consecutive patients seen in participating IBD centers with a confirmed diagnosis of IBD, and perform a retrospective chart review to extract clinical data collected as routine standard of care during IBD office visits, including patient demographics, IBD phenotype, disease severity and activity, medication exposures, history of prior rheumatologic diagnoses, and other parameters related to axial and peripheral SpA.

The purpose of this study is to establish a comparator cohort of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and other spondyloarthropathies. We will collect demographic information, historical information about diagnosis and past treatment, and clinical, radiographic, and laboratory data on each patient using standardized data collection forms.  We will also collect blood and synovial tissue samples from each patient.  This will provide data and material for clinical and translational research to address questions related to the fundamental differences between the spondyloarthropathies and inflammatory arthritis relating to the response of bone to chronic inflammation.  We intend to enroll sequential ...