Hartzell V. Schaff, M.D.

The purpose of this study is to summarize the clinical, morphological, and pathological features of patients with hypertrophic cardiomyopathy (HCM) and end systolic cavity obliteration, to describe the surgical technique of enlarging the left ventricular (LV) cavity through the transapical approach to myectomy, to compare patients’ hemodynamic alterations before and after transapical septal myectomy, to assess patients’ functional recovery after apical myectomy, and to evaluate the survival rate of these targeted surgical patients.

The standard of care for obstructive hypertrophic cardiomyopathy (HCM) refractory to medical therapy is surgical septal myectomy. Percutaneous transluminal septal myocardial ablation, otherwise known today as alcohol septal ablation (ASA) has been growing as a favorable alternative to myectomy. There have been no randomized controlled trials conducted to evaluate ASA versus surgical myectomy. The purpose of this study is to compare overall survival between surgical septal myectomy and alcohol septal ablation. The study will also compare periprocedural and long-term complication rates for both myectomy and alcohol septal ablation. Furthermore, the study willl determine the rates of re-intervention for both myectomy and alcohol septal ablation and identify predictors of the need for re-intervention.

The purpose of this study is to evaluate and compare operative outcomes of the aortic valve-sparing (AVS) and aortic valve replacement (AVR) surgical interventions in different categories of patients with Marfan syndrome and estimate the predictors of the surgical outcomes.

The purpose of this study is to

• Establish the long term functional capacity of patients with hypertrophic cardiomyopathy and left ventricular outflow tract obstruction

• Establish patients who do not improve symptomatically on long term follow up

• In patients, who do not have long term symptomatic improvement, ascertain predictors of poor outcomes.

The purpose of this study is to compare ejection hemodynamics in patients with obstructive hypertrophic cardiomyopathy (HCM) before and after septal myectomy.

This study is aimed to describe the physiology that changes after operation for apical hypertrophic cardiomyopathy to explain symptom relief.

The purpose of this study is to collect long term follow up study data of the Trifecta valve in subjects who had the Trifecta valve implanted during the IDE study.

The purpose of this study is to evaluate the outcomes of surgical Aortic Valvotomy for congenital aortic stenosis.

The purpose of this study is:

• To ascertain the prevalence of major adverse cardiac events during pregnancy in patients with history of surgically corrected hypertrophic cardiomyopathy
• To determine the major adverse cardiac events (mortality, arrhythmias, hear failure, endocarditis, pulmonary embolism, myocardial infarction etc) in pregnant women after surgical correction of hypertrophic cardiomyopathy
   

The purpose of this study is to document trends of medication usage in patients with isolated coronary artery bypass graft in Mayo Clinic Rochester 10, 5 or 1 years ago who were discharged on a full medication regime and compare how many of these patients still receive full secondary prevention drugs, which patients are on partial regimens and reasons for such difference.

The purpose of this study is to determine how many patients suffer from sexual function problems and ascertain if they are improved or modified by cardiac surgical intervention.

The purpose of this study is to:

1. Determine the structural accuracy of virtual three dimensional models of heart in patients with hypertrophic cardiomyopathy (HCM).

2. To explore the utility of virtual three dimensional modeling of heart in pre-operative planning of myectomy in patients with hypertrophic cardiomyopathy (HCM).

The goal of ths study is to determine the effectiveness of adding topical tranexamic acid (TXA) to our standard practice of care for patients undergoing redo or complex cardiac procedures. The study will use a control group for comparision.

The objective of this study is to evaluate the safety and performance of the Trifecta™ GT (Glide Technology) valve through 5 year follow-up in a prospective, multi-center, real-world setting. This study is intended to satisfy post-market clinical follow-up requirements of CE Mark in Europe.