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  • IKZF1 and UBR4 mutations in autoimmune disease Rochester, Minn.

    The purpose of this study is to identify immune mechanism how IKZF1 and UBR4 mutations cause disease. Understanding of the functional implications of these gene mutations will allow the development of a better disease model that could also be relevant for non-familial disease and allow more targeted treatment.
  • Immune Aging (IA) Rochester, Minn.

    The objective of this study is to identify immune defects that compromise the immune response with age.  As humans age, vaccinations become less effective. Vaccines are only partially protective or not protective at all in older populations. Preventing or compensating these defects may improve immune responses in the elderly.

     

     

     
  • T-cell Clonality in Rheumatoid Arthritis (SMRA) Rochester, Minn.

    The purpose of the study is to determine whether somatic mutations in T cells contribute to the pathogenesis of rheumatoid arthritis (RA).
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