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An International Phase 3 Randomized Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma (ADAPT) (ADAPT)
Rochester, Minn.
This is a trial of AGS-003, which is being studied as a possible treatment for Advanced Renal Cell Carcinoma. The purpose of this study is to determine whether there is an overall survival (OS) benefit between subjects treated with AGS-003 in combination with standard treatment versus subjects treated with standard treatment alone.
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Analysis of Tumor and Immune Cells Isolated from Tissue and Urine of Bladder Cancer Patients
Rochester, Minn.
The purpose of this study is to optimize methods in order to analyze immune cell profile in tissue and urine of bladder cancer patients.
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Automated Renal Characterization, Tumor Identification and Classification (ARCTIC) on Abdominal CT Scan (ARCTIC)
Rochester, Minn.
The purpose of this study is to evaluate the accuracy and application of an AI tool to abdominal CT images obtained during routine clinical care for patients with kidney tumors.
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CMN-001-1, A Phase 2b Randomized Trial of Autologous Dendritic Cell Immunotherapy (CMN-001) Plus Standard Treatment of Advanced Renal Cell Carcinoma (CMN-001-1)
Rochester, Minn.
The purpose of this study is to evaluate CMN-001 in a randomized trial between standard-of-care (SOC) (first line ipilimumab+nivolumab followed by second line lenvatinib+everolimus) with or without CMN-001.
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Neoadjuvant Intravesical NIS Measles Virus (MV-NIS) in Patients Undergoing Cystectomy for Urothelial Carcinoma But Ineligible for Neoadjuvant Cisplatin-based Chemotherapy
Rochester, Minn.,
Jacksonville, Fla.
This is a Phase 1 study designed to test the tolerability and feasibility of intravesical therapy with an attenuated Measles virus (MV-NIS) in patients with urothelial carcinoma who are undergoing radical cystectomy but are ineligible or do not desire neoadjuvant chemotherapy.
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Prospective Study of Contribution of 3D Models in Resection of Renal Cell Cancer
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.
The purpose of this study is to evaluate the impact on surgical planning and patient acceptance and understanding of 3D kidney tumor models prior to surgery.
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WO39210 A Phase III, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of Atezolizumab (Anti−PD-L1 Antibody) as Adjuvant Therapy in Patients With Renal Cell Carcinoma at High Risk of Developing Metastasis Following Nephrectomy (IMmotion010)
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.
This is a Phase III, multicenter, randomized, placebo-controlled, double-blind study to evaluate the efficacy and safety of atezolizumab versus placebo in participants with RCC who are at high risk of disease recurrence following nephrectomy.
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