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Clinical Studies
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Heart Failure (HF) Clinic Biobank
Rochester, Minn.
The objectives of this study are to collect and store samples and information from participants’ health records for future research about heart failure.
Closed for Enrollment
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Define in Hospitalized Decompensated CHF Patients With Renal Dysfunction, the Renal Actions of Low Dose Intravenous Infusion of BNP in the Presence and Absence of Acute PDE V Inhibition in Improving Renal Function (Aim 3 BNP/PDEV)
Rochester, Minn.
The purpose of the study is to determine if low doses of BNP can improve renal function in people with chronic heart failure with renal dysfunction, also to determine whether Sildenafil assists with improvement. This study will enroll only hospitalized patients with heart failure.
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Define in Humans With Compensated CHF and Renal Dysfunction, the Modulating Action of Chronic AT1 Receptor Blockade in Addition to ACE Inhibition on Cardiorenal and Humoral Function
Rochester, Minn.
To advance our understanding of the mechanisms of human cardiorenal syndrome with emphasis upon the interaction of diuretic therapy and the renal-angiotensin-aldosterone -system and cGMP pathway.
The belief is that the chronic AT1 receptor blockade in subjects with compensated CHF and renal dysfunction will improve renal function with increased sodium excretion, glomerular filtration rate and effective renal plasma flow and renal function reserve as compared to the response of placebo-treated subjects.
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Effects of Neprilysin Inhibition with Arni (LCZ 696) On the Cardiorenal and Humoral Response to Acute Saline Volume Expansion in DM with and without PDD
Rochester, Minn.
The purpose of this study is to learn more about if the medication, Entresto, could help the function of the heart and kidneys.
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To Define the Effects of Decreasing the Furosemide Dose on Cardiorenal and Humoral Function in Humans with Compensated Chronic Heart Failure (CHF) with and without Renal Dysfunction (Aim1)
Rochester, Minn.
The purpose of this study is to define the effects of decreasing the furosemide (lasix) dose on heart, kidney and biochemical balance, in people with compensated heart failure and kidney dysfunction and also in people with compensated heart failure without kidney dysfunction.
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