Gregory A. Worrell, M.D., Ph.D.

The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.

The purpose if this study  to combine state of the art cerebral signal processing techniques and localization methods with intracranial electrode recordings to investigate the interaction of local hippocampal and neocortical networks with distributed brain activity.

The purpose of this study is to demonstrate the safety and feasibility of chronic mesial temporal lobe epilepsy (MTLE) network recordings with 4 implanted depth electrodes targeting: anterior nucleus of the thalamus (ANT), entorhinal cortex (ERC), piriform cortex (PiC), dippocampal fornix (HCF).

The purpose of this study is to track neuropsychiatric symptoms in patients with epilepsy.

This study will use powerful 7T MRI scanning to find very small brain lesions that cause partial epileptic seizures.These small lesions can be missed by current MRI scanners. When a  neurosurgeon can find and remove the small area where the seizure starts, it is often possible to cure the epilepsy.

The primary objectives of this study are (1) to identify biomarkers of successfulmemory encoding and retrieval, and (2) to identify brain regions that can bestimulated to enhance memory performance. The secondary objective is to identifybiomarkers that can be used to predict cognitive impairment following resectionsurgery.

The purpose of this study is to investigate the feasibility and safety of thalamic CL stimulation in restoring consciousness in epilepsy patients.

The main purpose of the study is to demonstrate the performance and safety of the 24/7 EEG™ SubQ system as a reliable ultra long-term recorder of epileptic electrographic seizures. First, by comparison to simultaneously recorded video-EEG in the epilepsy monitoring unit (gold standard). Second, by comparison to self-reported seizure log books throughout 12-52 weeks of outpatient EEG monitoring.

The purpose of this study is to track seizure occurrence, seizure probability, behavioral state, cognition, and mood using an implantable brain sensing and stimulation device (Medtronic RC+S Summit) coupled to an external, handheld, patient assistant device (PAD) with capability for patient interaction (patient data input). The system (RC+S & PAD) provides intracranial EEG (iEEG) sensing, electrical brain stimulation, and machine learning algorithms running on the RC+S and PAD that will be coupled with electrical brain stimulation (EBS) to prevent seizures and improve quality of life in patients with epilepsy

The purpose of this study is to investigate if blood and/or MRI markers of inflammation and immune system activation may show changes in relation to when you have a seizure, and to noninvasively detect seizure related structural and functional alterations in acute seizure by MRI.

The aim of this study is to develop and validate a novel source imaging approach based on deep learning and artificial intelligence for noninvasive localization and imaging of EZ in patients with focal epilepsy, from scalp recorded EEG and MEG.

The purpose of this MRI calibration study is to determine usability and optimize functionality of the MRI acquisition and post-processing techniques for white matter null imaging.

The aim of this feasibility study is to investigate whether we can improve sleep quality in patients who have DBS devices implanted for existing neurological indications by delivering targeted stimulation patterns during specific stages of sleep using their existing DBS device. We will only use electrical stimulation frequencies that have been proven to be safe for patients. We will perform these studies in patients admitted to the hospital in order to examine the structure and quality of sleep as well as how alert patients are when they wake up, while also monitoring physiological markers such as brainwave activity, heart rate and blood pressure.  Upon awakening, we will ask the patients to provide their subjective opinion of their sleep and complete some simple tests to see how alert they are compared to a night of no electrical stimulation.

We hope that our study will open new ways of optimizing sleep in patients with neurological disease who are implanted with DBS device.  We also believe tha tour findings will broaden the understanding of how the activity of deep brain areas influences sleep and alertness.

The purpose of this study is to search for necessary changes in programming or assessment structure in order to reliably capture behavioral assessments from patients during their stay in the epilepsy monitoring unit. Behavioral assessments will be collected during period of time without seizure activity, during seizure activity, and immediately after a seizure event.