Erin K. O'Brien, M.D.

Closed for Enrollment

• Bleeding and Coagulation Function in Patients with AERD (Aspirin Exacerbated Respiratory Disease) Rochester, Minn.

  The purpose of this study is to learn more about aspirin exacerbated respiratory disease (AERD) by collecting blood samples from affected patients to study bleeding and clotting function.

• Follow-on Study of Coagulation Function in Patients with AERD (Aspirin Exacerbated Respiratory Disease) Rochester, Minn.

  The purpose of this study is to better characterize the extent the pathways involved in AERD (leukotriene, prostaglandin, and thromboxane) impact coagulation pathways. 

• Immune Changes in Chronic Rhinosinusitis with Nasal Polyps and Aspirin Sensitivity After Aspirin Desensitization Rochester, Minn.

  The objectives of this study are to determine longitudinal effects of aspirin desensitization on circulating immune cells in Aspirin Exacerbated Respiratory Disease (AERD) subjects, and to compare effects of sinus surgery on circulating immune cells in patients with AERD compared to patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Immune cells in nasal polyp tissue removed at the time of endoscopic sinus surgery will also be compared to the profile of circulating immune cells before and after endoscopic sinus surgery and, for some subjects, after aspirin desensitization.

   

   

• Metabolomic Analysis of Nasal Swab Mucus Rochester, Minn.

  The purpose of this study is determine if the metabolomic profile of nasal secretions can be used to reliably diagnose the presence or absence of sinusitis.