Faculty

Ian R. Lanza, Ph.D.

Clinical Studies

Exercise Response in Humans with Obesity Rochester, Minn.
Fat tissue was once believed to be only important for storing energy, but we are now learning that fat tissue released a large number of molecules that can affect other tissues. Muscles may be affected by fat that accumulates in the abdominal area and around the muscles themselves. This project seeks to understand how fat tissue may influence important functions o muscles.
Mechanisms of Anabolic Resistance in Older Humans Rochester, Minn.
The purpose of this study is to determine how adipose tissue influences skeletal muscle function and anabolic response to exercise in older adults.

Continued efforts are needed to identify new ways to extend healthspan in older adults. Toward this goal, skeletal muscle is critical because of its role in mobility, metabolic health, and overall well-being. The loss of muscle mass and function (sarcopenia) is a common feature of aging that is associated with poor outcomes. Sarcopenia is often accompanied by mitochondrial impairments, oxidative stress, and insulin resistance, which can lead to further deterioration of muscle health and metabolic disease. These phenotypes, along with the key role of skeletal muscle in macronutrient metabolism, have motivated initiatives to target skeletal muscle to improve health in older adults.

Chronic Inflammation and Exercise Responsiveness Rochester, Minn.
The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans.
Dietary Omega-3 Fatty Acids as a Therapeutic Strategy in Insulin Resistant Humans Rochester, Minn.
This study is being done to understand the effects of dietary omega-3 fats on insulin sensitivity in adult men and women.
Enhancing Adaptations to Exercise Rochester, Minn.
Researchers are trying to understand how chronic inflammation affects muscle function and responses to exercise.They are also trying to determine if suppressing chronic inflammation using omega-3 fatty acids (n3-PUFA) restores skeletal muscle function and exercise responsiveness in older adults.
Omega-3 Fatty Acids to Combat Sarcopenia Rochester, Minn.
The purpose of this study is to determine how omega-3 fatty acids influence muscle protein metabolism and mitochondrial physiology in the context of human aging.
Pharmacokinetic profile of rosemary extract supplement Rochester, Minn.
The purpose of this study is to improve muscle health and metabolism in humans, a food product for humans that contains ursolic acid (CJ dietary supplement).