Jacob C. Jentzer, M.D.

Closed for Enrollment

• A Pilot Randomized Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography for Post-Cardiac Arrest Patients Without ECG ST Segment Elevation (PEARL) Rochester, Minn.

  This study is a pilot, multi-centered, randomized, clinical trial to evaluate the safety and efficacy of performing early Coronary Angiography (CAG) versus no early CAG in post-cardiac arrest patients without ST segment elevation. Safety will be assessed by evaluating the association of major adverse events (re-arrest, bleeding, pulmonary edema, hypotension, acute renal insufficiency, and pneumonia) with early coronary angiogram. Efficacy will be assessed by a composite endpoint of improved left ventricular regional and global function (both regional wall motion analysis and left ventricular ejection fraction) as measured by echocardiography prior to hospital discharge and favourable neurological function (Cerebral Performance Categories 1 or 2) at discharge.

• Artificial Intelligence enhanced detection of dyskalemia in the hospital setting Rochester, Minn.

  The purpose of this study is to prospectively demonstrate that implementation of AI-ECG directed monitoring for the effective treatment of dyskalemia (both hyper- and hypokalemia) in acutely ill, hospitalized patients will serve the following purposes:

• Hemodynamic Assessment of Patients with Cardiac Pacemakers Rochester, Minn.

  The purpose of this study is to determine how changes in pacemaker rate affect systemic hemodynamics, including blood pressure and cardiac output, in acutely ill patients with cardiac pacemakers.

• Response to Dobutamine Stress Echocardiography after Resuscitation from Out-of-Hospital Cardiac Arrest Rochester, Minn.

  This purpose of this study is to evaluate the feasibility and safety of dobutamine stress echocardiography in patients who suffered an OHCA, as a way to predict recovery of heart function.