William Tatum, D.O.

The purpose of the study is to assess the success of a single administration of Staccato alprazolam compared with placebo both in rapidly terminating a seizure episode within 90 seconds and with no recurrence of seizure(s) up to 2 hours after investigational medicinal product (IMP) administration.

The purpose of the study is to evaluate the long-term safety and tolerability of Staccato alprazolam.

This is a multi-center study with an overall aim of evaluating the accuracy to which neurologists can discriminate seizures from other epileptic, nonepileptic or physiologic seizures by home video recordings, with the overall goal of determining whether this is a feasible diagnostic method in settings where video electroencephalogram monitoring  (VEM) may be limited.  

This will be achieved by obtaining smartphone video recordings from consecutive adult patients with the intent of admission to the epilepsy monitoring unit to capture the seizure. Adults included will have a confirmed electroclinical diagnosis by video-EEG monitoring of the event of concern, classified as either epileptic or non- epileptic seizure, or physiologic event.  The videos will be reviewed, and qualitative analysis determined as definite seizure, probable or unable to indeterminate epileptic, non epileptic or physiologic seizure. The answer will also include a quantitative scale rating the certainty of diagnosis. Classifications will be compared to electroclinical diagnosis for assessment of accuracy.  

The videos will be reviewed, and qualitative analysis determined as definite seizure, probable or unable to indeterminate epileptic, non epileptic or physiologic seizure. The answer will also include a quantitative scale rating the certainty of diagnosis. Classifications will be compared to electroclinical diagnosis for assessment of accuracy.

This is a multi-center, double-blind, randomized, parallel group, dose-ranging study to investigate the efficacy and clinical usability of STAP-001 in adult (18 years of age and older) subjects with epilepsy with a predictable seizure pattern. These subjects have an established diagnosis of focal or generalized epilepsy with a documented history of predictable seizure episodes. This is an in-patient study. The subjects will be admitted to a Clinical Research Unit (CRU) or Epilepsy Monitoring Unit (EMU) for study participation. The duration of the stay in the in-patient unit will be 2-8 days. One seizure event per subject will be treated with study medication. The duration and timing of the seizure event and occurrence of subsequent seizures will be assessed by the Staff Caregiver(s)1 through clinical observation and confirmed with video electroencephalogram (EEG).

The purpose of this study is to establish the effectiveness and safety of IV ganaxolone for the treatment of Status Epilepticus (SE) after failure of first-line benzodiazepines and two second-line IV antiepileptic drugs (AEDs)

The purpose of this study is to evaluate the effectiveness of Perampanel on seizure frequency in adult patients with brain-tumor with and without seizures associated with glioma.

The seizure detection and warning system is an ambulatory system designed to monitor and analyze EMG data to detect the onset of GTC seizures and to provide a warning signal to alert caregivers that a seizure is occurring.

The purpose of this study is to evaluate the clinical effectiveness, safety and tolerability of XEN1101 administered as adjunctive treatment in adult patients diagnosed with focal epilepsy, followed by an optional open-label extension (OLE).

The purpose of this study is to assess the effectiveness, safety, and tolerability profile of CVL-865 as adjunctive treatment in participants with drug-resistant focal onset seizures.

The purpose of this study is to collect preliminary data related to the clinical utility of the SPEAC System in patients with a history of motor seizures.

Altered mental status (AMS) is one of the most common reasons for inpatient neurology consultation. Non-convulsive status epilepticus (NCSE) is frequently on the differential diagnosis of the patient with AMS. NCSE becomes more refractory to treatment after one hour of seizure activity, making rapid identification and treatment of NCSE of great clinical importance. Currently, an electroencephalogram (EEG) technologist must be called in from home during non-workday hours in order to obtain a stat EEG. The investigators propose the time required for diagnosis of NCSE at Mayo Clinic can be significantly decreased with rapid placement of an EEG cap by the onsite neurology residents.

The purpose of this study is to characterize the use of the Monteris NeuroBlate System for the performance of brain laser interstitial thermal therapy (LITT) ablation treatment of medial temporal lobe epilepsy that is resistant to medical tharapy.

The purpose of this study is to evaluate the initial safety and effectiveness of Microburst VNS stimulation in subjects with refractory epilepsy.

The purpose of this study is to find out if home-recorded Smartphone videos can be used to accurately diagnose epilepsy in patients seeking evaluation for seizures. The idea is to compare the home-recorded video to video-EEG monitoring, which is the current gold-standard for diagnosis.

The primary aim of this study is to compare the pre- and post-single photon emission computed tomography (SPECT) seizure frequency following an IV benzodiazepine protocol versus reinstitution of maintenance antiseizure drugs (ASDS).