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Clinical Studies
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Development and Delivery of a Novel Hypnotherapy Protocol for Treatment of Symptomatic Bloating
Rochester, Minn.
The purpose of this study is to assess the effectiveness in self-administered hypnotherapy protocol in decreasing the sensation of bloating, as assessed by validated patient reported outcomes, can be developed and validated using telehealth-based research, and digitally delivered.
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Investigation of Mannitol-Based Solutions in the Quantification of Visceral Hypersensitivity
Rochester, Minn.
The purpose of this study is to assess the degree of GI dysfunction after (pain, nausea, diarrhea) utilizing visual analogue scales in patients undergoing CTEs for other causes vs. patients with known small bowel ulcerations/strictures (Crohn’s disease) with pain to develop normative and known abnormal values. Compare the degree of GI dysfunction in patients with DGBIs (Functional dyspepsia, irritable bowel syndrome, chronic abdominal pain) to patients undergoing CTEs for other causes and those with documented small bowel damage.
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Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias (GAVE)
Rochester, Minn.
The purpose of this study is to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding. It can also cause symptoms such as abdominal pain and nausea. By participating in this study, you will help us learn how often these symptoms occur and how they relate to stomach functioning.
Closed for Enrollment
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An Integrated Assessment of Gastric Functions
Rochester, Minn.
The purposes of this study are to assess gastric motility and emptying with scintigraphy in patients with upper gastrointestinal symptoms, to evaluate the relationship between daily symptoms and GE, motility, and symptoms during a GE study, to assess fasting and postprandial gastric volumes and motility with MRI in patients with upper gastrointestinal symptoms, and to compare gastric motility measured with scintigraphy and MRI.
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Pharmacodynamics, Pharmacogenetics, Clinical Efficacy and Safety of Tradipitant for Functional Dyspepsia
Rochester, Minn.
The purpose of this study is to analyze the effects of the NK1 receptor antagonist, tradipitant, on gastric function and symptom improvement in patients with functional dyspepsia. We will utilize and further validate simultaneous measurements of gastric emptying and gastric accommodation utilizing a solid meal and nuclear medicine scanning technique to better understand the pathophysiology of functional dyspepsia as well as the mechanism of action of tradipitant. Further understanding of the underlying gastric physiologic changes will provide groundwork for future diagnostic and therapeutic advances in functional dyspepsia.
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The Integrated Assessment of Gastric Functions
Rochester, Minn.
The purpose of this study is to investigate, in a cohort of healthy people and patients who are experiencing upper gastrointestinal symptoms, whether gastric emptying scintigraphy can be modified to evaluate both gastric emptying, gastric antral motility and the symptomatic response to feeding, in a single non-invasive test.
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