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  • An Integrated Assessment of Gastric Functions Rochester, Minn.

    The purposes of this study are to assess gastric motility and emptying with scintigraphy in patients with upper gastrointestinal symptoms, to evaluate the relationship between daily symptoms and GE, motility, and symptoms during a GE study, to assess fasting and postprandial gastric volumes and motility with MRI in patients with upper gastrointestinal symptoms, and to compare gastric motility measured with scintigraphy and MRI.

     

  • Pharmacodynamics, Pharmacogenetics, Clinical Efficacy and Safety of Tradipitant for Functional Dyspepsia Rochester, Minn.

    The purpose of this study is to analyze the effects of the NK1 receptor antagonist, tradipitant, on gastric function and symptom improvement in patients with functional dyspepsia. We will utilize and further validate simultaneous measurements of gastric emptying and gastric accommodation utilizing a solid meal and nuclear medicine scanning technique to better understand the pathophysiology of functional dyspepsia as well as the mechanism of action of tradipitant. Further understanding of the underlying gastric physiologic changes will provide groundwork for future diagnostic and therapeutic advances in functional dyspepsia.

  • The Integrated Assessment of Gastric Functions Rochester, Minn.

    The purpose of this study is to investigate, in a cohort of healthy people and patients who are experiencing upper gastrointestinal symptoms, whether gastric emptying scintigraphy can be modified to evaluate both gastric emptying, gastric antral motility and the symptomatic response to feeding, in a single non-invasive test.

     

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