Lauren A. Dalvin, M.D.

The purpose of this study is to test neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma.

The purpose of this study is to determine if a relay lens and right angle mirror can be used in conjunction with an FDA-approved optical coherence tomography (OCT) unit to allow imaging in supine patients.

The purpose of this study is to use clinical, imaging, molecular, and epidemiological investigation toward the goal of providing new knowledge about ocular tumors that will be useful in understanding, diagnosing, monitoring, and suggesting new avenues of treatment. This study does not involve experimental treatment of any ocular tumor, but rather observation of tumor natural history or outcomes following standard of care therapy, associated systemic and ocular conditions, and basic research investigations to better understand tumor biomarkers and pathophysiology.

The purpose of this study is to evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following treatment of choroidal melanoma with iodine-125 plaque brachytherapy.

The Ptosis after Plaque Radiotherapy (PtaP) study involves investigation of the effect of plaque radiotherapy surgery on upper eyelid position. The study investigates clinical and imaging data prior to and 4 months following plaque radiotherapy and examines the frequency and degree of upper eyelid blepharoptosis. Comparison will be made to filtering glaucoma surgery, which involves similar operative time and manipulation of extraocular muscles and Tenon’s fascia. The fellow eye will be used as a no treatment control. This study will provide new data to improve the understanding of blepharoptosis as a side effect of plaque radiotherapy. This study involves a simple ruler measurement of eyelid position prior to and 4 months after surgery that is performed by the treating physician as part of the patient’s standard of care office visit. This study does not involve any experimental tests and does not require any additional office visits or cost for the patient or the practice.

The purpose of this study is to systematically and prospectively record accurate and complete data regarding the clinical presentation, treatment, and outcomes of patients diagnosed with RB; collect, bank, preserve, and analyze biomaterials from patients with RB, and to correlate phenotypic data with findings from human biomaterials.

The purpose of this study is to characterize ultrasound vibro-elastography features of ocular tumors.

The purpose of this study is to validate MYD88 testing in fluid specimens.

The purpose of this study is to analyze patient satisfaction with the Virtual Follow-up Pathway of Eye Freckles within the Mayo Clinic Rochester Department of Ophthalmology.

The purpose of this study is to determine the efficacy and safety of bel-sar compared to sham control for the treatment of primary indeterminate lesions and small choroidal melanoma (IL/CM).