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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 191-200 of 833 for cardiovascular

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  1. A Study of the Delivery of Yamani-15/5 Chemical Solution for Peripheral Artery Disease

    Jacksonville, FL

  2. A Study to Evaluate the Effectiveness and Safety of Etripamil for the Termination of Spontaneous Paroxysmal Supraventricular Tachycardia (PSVT)

    Rochester, MN

  3. Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI)

  4. Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement

    Rochester, MN

  5. The PRONTO Study, a Global Phase 2b Study of NEOD001 in Previously Treated Subjects With Light Chain (AL) Amyloidosis

    Jacksonville, FL, Rochester, MN

  6. Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure

    La Crosse, WI, Jacksonville, FL

  7. Grit as a Predictor of Outcomes in Transcatheter Valvular Therapeutic Candidates

  8. Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim 2)

    Rochester, MN

  9. The PARTNER 3 - AVIV Trial

    Rochester, MN

  10. A Study to Evaluate Dapagliflozin to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure

    Rochester, MN

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