Clinical Trials

The purpose of this study is to develop and implement advanced risk models based on preoperative and real-time streaming high-resolution intraoperative data.

The purpose of this study is to assess factors affecting opioid prescribing variability among surgical and primary care providers, utilizing a qualitative approach, and to identify factors influencing the transition (i.e., “handoff”) of opioid prescribing from surgical providers to primary care providers in the postoperative period for a subset of patients receiving prolonged postoperative opioid use, utilizing qualitative assessment.

Surgeons use the absence of post-operative complications and a short hospital stay as a proxy for successful surgery and recovery. Patients define recovery as ‘return to normal’, which encompasses their overall quality of life (QOL), physical and mental well-being, social functioning, and the absence of pain or fatigue, also known as patient reported outcomes (PROs). The Patient Reported Outcomes Measurement Information System (PROMIS) and the 10 point Linear Analogue Self- Assessment Questionnaire (LASA) tools are both candidates for effective, easily accessible measures of patient recovery after surgery. The purpose of this study is to define which PROMIS sub-scores and individual ...

The purpose of this study is to determine the incidence of postoperative residual weakness (a train-of-four ratio < 0.9)="" in="" patients="" getting="" ‘fast="" track="" anesthesia’="" following="" liver="" transplantation. ="" our="" clinical="" practice="" routinely="" utilizes="" sugammadex="" in="" this="" patient="" population="" and="" we="" have="" anecdotally="" observed="" excellent="" outcomes.="" we="" hypothesize="" that="" the="" incidence="" of="" postoperative="" residual="" weakness="" with="" sugammadex="" and="" quantitative="" monitoring="" is="" low=""><5%) and that patients receiving fast track anesthesia have shorter hospital length of stays than the national average (12).  additionally, postoperative pulmonary complications (ppc) can occur from residual weakness.  we will utilize previous definitions of ppcs  (13).  ... and="" that="" patients="" receiving="" fast="" track="" anesthesia="" have="" shorter="" hospital="" length="" of="" stays="" than="" the="" national="" average="" (12). ="" additionally,="" postoperative="" pulmonary="" complications="" (ppc)="" can="" occur="" from="" residual="" weakness. ="" we="" will="" utilize="" previous="" definitions="" of="" ppcs ="" (13). ="" ...="">

The primary objective of this study is to evaluate sternal bone healing following a full median sternotomy versus standard of care for sternal closure with wire cerclage. Additional outcomes on post-operative pain and analgesic usage, patient function and quality of life, and complications will also be collected. A health economics study will also be conducted, in which cost and billing data will be collected from sites participating in this clinical study.

This randomized pilot phase II trial studies how well serum bovine immunoglobulin protein isolate works in improving quality of life and post-operative recovery in patients with gynecological cancer after undergoing surgery. Serum bovine immunoglobulin supplementation may improve the quality of life of patients with gynecological cancer.

The purpose of this study is to compare a ventilation strategy using higher levels of positive end expiratory pressure and recruitment maneuvers to one using lower levels of positive end expiratory pressure without recruitment maneuvers in obese patients at an intermediate-to-high risk for post surgery respiratory complications.

The purpose of this study is to observe changes in bowel pattern based on gum-chewing, examine bowel function after anterior lumbar interbody fusion, measure length of time to return of bowel function after anterior lumbar interbody fusion, compare return of bowel function in patients who chew gum and patients standardized to usual post-operative care, measure the hospital length of stay amongst study groups, and measure post-operative pain amongst study groups.

This randomized clinical trial studies the intensity of adjuvant ("helper") therapy required in p16 positive oropharynx cancer patients, who have had all known disease removed surgically by a minimally invasive approach, and who have extracapsular spread in their lymph nodes. After the surgery, patients are randomized to receive either radiation alone, or radiation and weekly cis-platinum during therapy. Patients are then followed for cancer, functional and quality of life outcomes.

The purposes of this study are to prospectively evaluate the effects of a structured, modified Mediterranean diet on post-liver transplant weight gain and development of PTMS, to prospectively evaluate the effects of a structured, modified Mediterranean diet on cardiovascular outcomes post-liver transplantation, and to prospectively evaluate the effects of a structured, modified Mediterranean diet on development or recurrence or de novo NAFLD/NASH in liver-transplant patients.

The purpose of this study is to to determine the impact of anesthesia (liposomal bupivacaine) on diaphragm muscle forces using a non-invasive ultrasonographic shear wave elastography (SWE) method.  

The purpose of this study is to evaluate safety and efficacy outcomes in renal transplant recipients in whom post-transplant care is managed using AlloSure®. AlloSure® is a non-invasive test to measure donor-derived cell-free DNA (dd-cfDNA). The AlloSure test is intended to assess the probability of allograft rejection in kidney transplant recipients with clinical suspicion of rejection and to inform clinical decision-making regarding the necessity of renal biopsy in such patients at least 2 weeks post-transplant in conjunction with standard clinical assessment. Amendment 1 (A1): Is an observational study to develop and validate the clinical use of KidneyCare®.

The purpose of this study is to evaluate the effect of a pre-ICU admission simulation session on post-operative delirium in the elective cardiothoracic surgical population while in the intensive care unit.

The purpose of this study is to assess perioperative and postoperative outcomes to date in patients treated with surgery (Periacetabular Osteotomy or PAO) for Developmental Dysplasia of the Hip (DDH) receiving formal postoperative physical therapy versus those patients who did not receive formal postoperative physical therapy.

The purpose of this study is to assess the reliability of a single question with a yes or no answer, as a measure of outcome following recovery from total hip or knee replacement.

The purpose of this study is to analyze the difference between the Blood Flow Restriction (BFR) and SHAM-BFR groups in change in muscle diameter (hypertrophy) from 2 weeks pre-operative to 8-10 days post-operative.

The purposes of this study are to validate noninvasive hemoglobin monitoring in postoperative orthopedic pediatric patients, to evaluate patient, parent, and provider preference of noninvasive hemoglobin monitoring compared to invasive blood draw, and to evaluate cost effectiveness of noninvasive monitoring in comparison to invasive blood draws.

A feasibility study on the provision of acupuncture treatment in the hospital to 20 patients who have undergone open heart surgery procedures. The acupuncture treatments may begin as early as postoperative Day 2.

The purpose of this study is to assess operative and postoperative outcomes after aortic valve surgery, evaluate for changes in ascending aorta diameter by comparing pre-operative CT imaging to measurements on follow-up imaging, and examine late outcomes and functional status during the follow-up period with specific focus on mortality, need for re-operation and incidence of aortic dissection.

The primary purpose of this study is to determine bariatric patients’ preference of telemedicine or in-person assessment for post-operative care.

The purpose of this study is to evaluate whether proton radiation therapy (proton RT) reduces acute gastrointestinal toxicities at the end of treatment compared to intensity modulated radiation therapy (IMRT).

The purpose of this study is to explore the effectiveness of massage therapy combined with acupuncture in breast cancer patients recovering from autologous tissue reconstruction with the hope that the combination will augment the benefit obtained by massage therapy alone.

The Researchers overall goal is to evaluate the benefit and utility of preemptive genotypic data to guide post-operative nausea and vomiting treatment in the bariatric surgical population. The hypothesis is that using genotypic variation in CYP2D6 to select the appropriate 5HT3 serotonin receptor antagonist to treat PONV will decrease rates of PONV in the bariatric surgical population.

In the light of the pandemic, institutions have had to take greater precautions and instigate procedures to aim to improve safety and reduce risk for patients undergoing surgery. One intiative was designed to implement a same day discharge for patients undergoing mastectomy with or without alloplastic reconstruction. This study aims to evaluate the outcomes and patient satisfaction with same day mastectomy with or without alloplastic reconstruction following COVID-19 and compare satisfaction and outcomes (e.g complications) with patients pre-COVID 19. This is part of a quality improvement project.