Overview

The Stem Cell and Organoid Core currently provides researchers with access to high-quality human induced-pluripotent stem cell (iPSC) production, expansion, validation and quality control services. Services under development include production of iPSC-derived organoids and microphysiological systems, as well as scalable provision of healthy control and genetically modified iPSC lines for research and test development. In the near future, the core also will support the production of adult tissue-derived stem cells and organoids.

Diagram showing how fibroblasts are isolated from a skin punch biopsy and reprogrammed into induced pluripotent stem cells (iPSCs). Human-induced pluripotent stem cells for research and test development

Fibroblasts isolated from a skin punch biopsy are reprogrammed into induced pluripotent stem cells (iPSCs). Then the iPSCs are used to generate numerous human cell types using directed differentiation, an application that produces a potentially unlimited source of cells and tissues that can be manipulated. These human cells can be combined to form 3D "organoids" that resemble the structure and function of a patient's own tissue. Organoids and other microphysiological systems can be used for drug development and screening. They also can form the basis for transplant and cell replacement therapies.