Infectious Diseases Research

Below are current clinical trials.

273 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. Evaluation of the Effects of Caffeine, Via the ACE2 Receptor, on Clinical Severity of COVID-19 Disease

   Jacksonville, Fla.

   The purpose of this study is to assess levels of caffeine intake among patients who tested positive for COVID-19 infection and compare that to disease severity.

2. T Cell Response to COVID19 Vaccinated Individuals

   Rochester, Minn., Jacksonville, Fla.

   The first aim of this study is to verify that the TCR beta sequencing and curation platforms we will be using are able to identify patients with severe COVID-19 based on the TCR repertoires. This may be accomplished by testing and analyzing results between two cohorts: patients presenting acutely to MCF with mild COVID-19 and patients presenting with severe COVID-19. This will be accomplished by utilizing the the immunoSEQ Human T-cell Receptor Beta (hsTCB) Assay (Adaptive Biothechnologies) and the publicly available ImmuneCODE Open Access Database to confirm previously published data (PMID: 34253751). Both procedures will be performed by the company that created both platforms, Adaptive Biothechnologies.

   The second aim of this study is to sequence the TCR receptors of participating patients and identify TCR motifs that may indicate a predisposition to (or protection from) severe SARS-CoV-2, leading to possible risk stratification of such patients, and whether or not age, gender or ethnicity has any contribution to said risk. This may require that we examine all three cohorts listed in the Subject Information section.

   The third aim is to measure SARS-CoV-2 anti-spike and anti-nucleocapsid antibodies to distinguish patients that have not been exposed to SARS-CoV-2 to those that have been exposed.

3. A Study of Bacteria Present on the Skin and within the Gastrointestinal Tract and the Connection to Postoperative Infectious Complications

   Rochester, Minn.

   The purpose of this study is to better understand why patients get infectious complications after colon or rectal surgery by identifying the bacteria present on the skin and within the gastrointestinal tract in both healthy volunteers undergoing a colonoscopy, and in patients undergoing colon and rectal surgery. By comparing the bacteria within these two groups, we will better understand the causes of postoperative infectious complications.

4. A Study to Evaluate the Effectiveness and Safety of an Amikacin Liposome Inhalation Suspension-based Regimen in Adults with Nontuberculous Mycobacterial Lung Infection

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to evaluate the effectiveness of ALIS + azithromycin (AZI) + ethambutol (ETH) compared to the empty liposome control (ELC) + AZI + ETH on patient reported respiratory symptoms at Month 13.

5. A Study of the Effect of Ixazomib on the Reservoir of T Cells Infected with HIV DNA

   Rochester, Minn.

   The purpose of this study is to determine the safety and tolerability of ixazomib in HIV infected patients who are on a stable regimen of ART that suppresses HIV replication, and to determine the effectiveness of ixazomib on reservoir T cells that are infected with HIV DNA.

6. Anti-Influenza Hyperimmune Intravenous Immunoglobulin Pilot Study (INSIGHT 005: Flu-IVIG Pilot)

   Rochester, Minn.

   The purpose of this randomized, double-blind, placebo-controlled trial of intravenous hyperimmune immunoglobulin (Flu-IVIG) in individuals with influenza A or B is to determine the pharmacokinetic (PK) profile of Flu-IVIG and assess whether antibody levels observed following Flu-IVIG transfusion are similar to those predicted. This pilot study will inform a larger study that will be powered to compare Flu-IVIG with placebo for efficacy.

7. A Study to Evaluate a Real-Time Diagnostic Platform for the Detection of Influenza Strains in Saliva

   Rochester, Minn.

   The purpose of this study is to develop a colorimetric test for influenza virus detection in a chemically engineered cup/tube. When sample fluid (saliva) is in the tube, the fluid color turning blue indicates a positive result. We are in the process of developing this test, and will test on saliva samples from flu patients.

8. A Study to Improve Treatment of Clostridium Difficile Infection and using Information Technology to Improve the Care of Patients with Severe Clostridium Difficile Infection

   Rochester, Minn.

   The purpose of the study is to ascertain the efficacy of implementation of standard treatment guidelines for the treatment of C. difficile infection based on disease severity and number of instances of this infection.

9. A Study to Evaluate the Effectiveness of Merimepodib in Adult Patients with Advanced COVID-1

   Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   This study will evaluate the efficacy of merimepodib (MMPD) administered orally every eight hours (q8h) for 10 days in adult patients with advanced COVID-19.

10. A Study to Evaluate the Role of Mucosal Microbiome in the Development, Clearance and Recurrence of Clostridium Difficile Infection

    Rochester, Minn.

    The purpose of this study is to characterize mucosal and luminal microbiome in patients diagnosed with Clostridium difficile infection (CDI), at the time of diagnosis and after treatment, to determine the effect of mucosa associated microbiome on outcome of CDI and the effect of antibiotic treatment on mucosa associated microbiome