Overview

The laboratory of Elina Jerschow, M.D., M.S., at Mayo Clinic is dedicated to unraveling the complexities of aspirin-exacerbated respiratory disease (AERD) and related conditions. Our research focuses on understanding the intricate interplay between the immune system, cellular mechanisms and the microbiome in shaping disease outcomes.

Our research is centered on the role of cellular immune responses — particularly the contributions of CD4+ T cells and other immune subsets — in driving inflammation and tissue remodeling in AERD. We explore how these cells interact with environmental factors and the microbiome to influence disease severity and progression.

Our lab employs cutting-edge techniques in immunology, genomics and microbiome analysis to uncover new therapeutic targets and strategies to improve patient outcomes. By integrating approaches from multiple fields, we aim to bridge the gap between basic science and clinical applications, fostering a deeper understanding of AERD and advancing personalized medicine.

We are committed to collaboration and innovation, and we invite researchers, clinicians and students to join us in our mission to transform the care of patients with AERD.

Affiliations

We work closely with these Mayo Clinic researchers and laboratories:

• Connie B. Chang, Ph.D.
• Early Life Immune Responses: Kathryn A. Knoop
• Lung Development and Regeneration: Douglas G. Brownfield