Selected Publications

Recent publications from the laboratory include:

• Khoury M, Guo Q, Furuta K, Correia C, Meroueh C, Kim Lee HS, Warasnhe K, Valenzuela-Perez L, Mazar AP, Kim I, Noh YK, Holmes H, Romero MF, Sussman CR, Pavelko KD, Islam S, Bamidele AO, Hirsova P, Li H, Ibrahim SH. Glycogen synthase kinase 3 activity enhances liver inflammation in MASH. JHEP Reports. 2024; doi:10.1016/j.jhepr.2024.101073.
• Meroueh C, Warasnhe K, Tizhoosh HR, Shah VH, Ibrahim SH. Digital pathology and spatial omics in steatohepatitis: Clinical applications and discovery potentials. Hepatology. 2024; doi:10.1097/HEP.0000000000000866.
• McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. The evolving role of liver sinusoidal endothelial cells in liver health and disease. Hepatology. 2023; doi:10.1097/HEP.0000000000000207.
• Parthasarathy G, Hirsova P, Kostallari E, Sidhu GS, Ibrahim SH, Malhi H. Extracellular vesicles in hepatobiliary health and disease. Comprehensive Physiology. 2023; doi:10.1002/cphy.c210046.
• Dohnalkova E, Bayer RL, Guo Q, Bamidele AO, Kim Lee HS, Valenzuela-Pérez L, Krishnan A, Pavelko KD, Guisot NES, Bunyard P, Kim YB, Ibrahim SH, Gores GJ, Hirsova P. Rho-associated protein kinase 1 inhibition in hepatocytes attenuates nonalcoholic steatohepatitis. Hepatology Communications. 2023; doi:10.1097/HC9.0000000000000171.
• Furuta K, Tang X, Islam S, Tapia A, Chen ZB, Ibrahim SH. Endotheliopathy in the metabolic syndrome: Mechanisms and clinical implications. Pharmacology & Therapeutics. 2023; doi:10.1016/j.pharmthera.2023.108372.
• Greuter T, Yaqoob U, Gan C, Jalan-Sakrikar N, Kostallari E, Lu J, Gao J, Sun L, Liu M, Sehrawat TS, Ibrahim SH, Furuta K, Nozickova K, Huang BQ, Gao B, Simons M, Cao S, Shah VH. Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo. Journal of Hepatology. 2022; doi:10.1016/j.jhep.2022.03.029.
• Guo Q, Furuta K, Islam S, Caporarello N, Kostallari E, Dielis K, Tschumperlin DJ, Hirsova P, Ibrahim SH. Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis. Frontiers in Immunology. 2022; doi:10.3389/fimmu.2022.983255.
• Guo Q, Furuta K, Aly A, Ibrahim SH. Isolation and characterization of mouse primary liver sinusoidal endothelial cells. Journal of Visualized Experiments. 2021; doi:10.3791/63062.
• Ibrahim SH. Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: Therapeutic implications. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2021; doi:10.1152/ajpgi.00009.2021.
• Furuta K, Guo Q, Pavelko KD, Lee JH, Robertson KD, Nakao Y, Melek J, Shah VH, Hirsova P, Ibrahim SH. Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis. Journal of Clinical Investigation. 2021; doi:10.1172/JCI143690.
• Furuta K, Guo Q, Hirsova P, Ibrahim SH. Emerging roles of liver sinusoidal endothelial cells in nonalcoholic steatohepatitis. Biology (Basel). 2020; doi:10.3390/biology9110395.
• Gao J, Wei B, de Assuncao TM, Liu Z, Hu X, Ibrahim S, Cooper SA, Cao S, Shah VH, Kostallari E. Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis. Journal of Hepatology. 2020; doi:10.1016/j.jhep.2020.04.044.
• Ibrahim SH, Hirsova P, Malhi H, Gores GJ. Nonalcoholic steatohepatitis promoting kinases. Seminars in Liver Disease. 2020; doi:10.1055/s-0040-1713115.
• Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H. IRE1A stimulates hepatocyte-derived extracellular vesicles that promote inflammation in mice with steatohepatitis. Gastroenterology. 2020; doi:10.1053/j.gastro.2020.06.031.
• Guo Q, Furuta K, Lucien F, Gutierrez Sanchez LH, Hirsova P, Krishnan A, Kabashima A, Pavelko KD, Madden B, Alhuwaish H, Gao Y, Revzin A, Ibrahim SH. Integrin beta(1)-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. Journal of Hepatology. 2019; doi:10.1016/j.jhep.2019.07.019.

See a complete list of Dr. Ibrahim's publications on PubMed.