Clinical Trials

The purpose of this study is to evaluate if subjects who have already experienced tonic spinal cord stimulation would have a better pain relief status with burst spinal cord stimulation

The purpose of this study is to administer a survey to elicit interest in participating in a future proposed trial involving a very slow tapering of opioid medications (approximately 10% dose reduction every month) for up to 12 months.

The purpose of this research is to investigate whether or not a slow and gradual reduction in the amount of opioid medications will affect patients who take a stable dose of these medications for chronic pain.  Opioids are powerful painkillers, and include medications such as hydrocodone (eg Vicodin or Norco), oxycodone, hydromorphone (Dilaudid), Fentanyl, tramadol (Ultram), and morphine.  Although these medications are important in treating pain related to an injury or after surgery, long-term use of these medications can result in potentially dangerous outcomes.  There is some research to suggest that long-term use of these medications for chronic ...

The purpose of this study is to create a biorepository for samples of chronic pain patients.

The purpose of this study is to evaluate the hormonal profile related to opioid-induced hypogonadism (OIH) in chronic pain patients before and after completing 3 weeks Interdisciplinary Pain Rehabilitation Program (IPRP) at Pain Rehabilitation Center (PRC) at Mayo Clinic/Florida.

The purpose of this study is to evaluate the Neurolyser XR as a non-invasive treatment of axial chronic low back pain; to investigate the effectiveness of HIFU, using the Neurolyser XR, in a rigorous randomized double-blind sham-controlled fashion. This study will allow the evaluation of a portable, non-invasive and simple to use HIFU method guided by a routine fluoroscopy. 

The purpose of this study is to develop MRE-based imaging biomarkers to measur the mechanical properties of the myofascial interface and determine if there are changes in these parameters in MPS patients and if these parameters can be used to monitor treatment responses and predict patient outcomes.

The purposes of this study are to compare the functional connectivity in adolescent patients with Postural Orthostatic Tachycardia Syndrome (POTS) both with and without chronic pain, to those with chronic pain alone, to that of healthy controls; to evaluate whether there is a change in functional connectivity following participation in an intensive rehabilitation-oriented program previously demonstrated to have excellent outcomes with regard to functional recovery and symptom control; and to correlate outcomes using standardized symptom and function rating scales to imaging findings.

The purpose of this study is to determine the safety and feasibility of allogeneic, culture-expanded BM-MSCs in subjects with painful facet joint arthropathy.

The purpose of this study is to assess the safety of the Angel® Concentrated Platelet Rich Plasma System and Angel® CPRP Processing Set to process Platelet Rich Plasma for intra-articular injection into four lumbar facet joints (2 levels) causing chronic low back pain.