Clinical Trials

This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research questions, including: * How the study drug changes heart rate and blood pressure in participants with POTS * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead ...

The purpose of this research study is to better understand what causes POTS. We believe that a number of different causes of POTS exist and that detailed testing can demonstrate the different causes. Knowing what causes POTS in a particular patient will be helpful in choosing the right treatment strategy for that particular patient in the future.

The purpose of this study is to test the feasibility of using a novel wearable biosensor and mobile health monitoring platform to capture patients’ physiology, functional capacity and assessment of symptoms, thereby building a profile of Positional Orthostatic Tachycardia Syndrome (POTS) while excluding more serious cardiac, neurological and endocrine causes for their symptomatology. We hypothesize that as a non-fatal condition, a complete physiological profile of the POTS patients can be built entirely remotely therefore avoiding the need for these patients to visit the hospital and clinic.

This study is designed to investigate whether the treatment of non-anemic iron deficiency with intervenous iron sucrose will result in decreased symptom reporting and improved cardiovascular indices in adolescents (age 12-18) with Postural Orthostatic Tachycardia Syndrome (POTS).

The study aims to evaluate if a hybrid semi-supervised remote monitoring three month strength and aerobic exercise training program can be as efficacious as in-person exercise training has previously demonstrated. 

The purpose of this study is to evaluate if the patient/participant will self-enter clinical survey information into an iPad or choose to enter the same information by paper and pen for use in clinical research.

The purpose of this study is to assess the hydration status via body impedance of patients suffering from postural orthostatic tachycardia syndrome.

The goal of this study is to gain a better understanding of the sleep and fatigue complaints of adolescent POTS patients by objectively measuring sleep with actigraphy prior to and after attending the Pain Rehabilitation Center (PRC) 3 week program. A questionnaire will be administered to assess subjective sleep complaints and correlate them with objective findings.

This is a 3-day study comparing pyridostigmine versus placebo in the treatment of postural tachycardia syndrome (POTS). The researchers expect pyridostigmine to improve tachycardia and stabilize blood pressure.

This study aims to investigate whether the treatment of non-anemic iron deficiency with intravenous iron sucrose will result in decreased symptom reporting and improved cardiovascular indices in patients with Postural Orthostatic Tachycardia syndrome (POTS).

The purpose of this study is to gather information about symptoms of autonomic dysfunction, depressive and anxiety symptoms, health behaviors, social support, and ability to do everyday tasks.

The purposes of this study are to compare the functional connectivity in adolescent patients with Postural Orthostatic Tachycardia Syndrome (POTS) both with and without chronic pain, to those with chronic pain alone, to that of healthy controls; to evaluate whether there is a change in functional connectivity following participation in an intensive rehabilitation-oriented program previously demonstrated to have excellent outcomes with regard to functional recovery and symptom control; and to correlate outcomes using standardized symptom and function rating scales to imaging findings.

The purpose of this study is to gain a better understanding of the sleep quality and fatigue complaints of adolescent orthostatic intolerance (OI) and postural orthostatic tachycardia syndrome (POTS) patients by objectively measuring sleep duration and timing with actigraphy. Sleep questionnaire will be administered to assess subjective sleep complaints and correlate them with objective findings.

If the efficacy of 3,4-diaminopyridine (3,4-DAP) can be demonstrated in this study, the use of 3,4-DAP alone and in combination with other agents such as pyridostigmine and L-DOPS would be further evaluated in a double-blind randomized placebo-controlled cross-over study