Faculty

Sean M. Caples, D.O., M.S.

Clinical Studies

Sleep Wake Disturbances Profiles in Mayo Clinic ICU Provider Staff Physicians Rochester, Minn.
The purpose of this study is to identify the degree of sleep disturbance which occurs with night shift work and the persists of disturbances into the recovery period following the night shift series.

Sleep Apnea Cardiovascular Endpoints Study - An Investigator-Initiated and Conducted, Collaborative, Phase III, Multi-Centre Open Label, Randomized, Controlled Trial of Continuous Positive Airway Pressure for the Treatment of Obstructive Sleep Apnea to Prevent Cardiovascular Disease (SAVE) Rochester, Minn.
Obstructive Sleep Apnea (OSA) is a condition in which a person stops breathing for several seconds at a time due to relaxation of the throat muscles. This can occur many times during sleep and is known to cause sleepiness and poor concentration during the day. Research indicates that OSA may be a modifiable risk factor for cardiovascular disease due to its association with hypertension, stroke, heart attack and sudden death. The standard therapy for symptomatic OSA is continuous positive airway pressure (CPAP). CPAP has been shown to effectively reduce snoring, obstructive episodes and daytime sleepiness and to modestly reduce blood pressure and other risk factors for cardiovascular disease. The overall aim of SAVE is to determine if CPAP can reduce the risk of heart attack, stroke or heart failure for people with OSA.