David F. Kallmes, M.D.

Closed for Enrollment

• Assessing the Accuracy of Dual Energy CT as a Method for Identifying Renal Damage following Contrast-Enhanced CT or Contrast-Enhanced Arterial Interventional Procedures Rochester, Minn.

  The purpose of this study is to see how the contrast affects your kidney function. Your kidney function will be measured by testing several blood and urine samples that you provide before and after the CT scan or arterial interventional procedure. A CT scan of your kidneys will also be performed after the CT scan or arterial interventional procedure.

• Connective Tissue and Wound Healing Characteristics in Patients with Multiple Brain Aneurysms Rochester, Minn.

  The purpose of this study is to develop an increased understanding of the role of connective tissue structural abnormalities and impaired function (i.e. wound healing) in the development of intracranial aneurysms.

• Evaluating DNA Damage in Peripheral Blood Mononuclear Cells after Commonly Used Radiological Modalities Rochester, Minn.

  The purpose of this study is to analyze the effects of different types and amounts/durations of commonly-used radiological imaging and treatment modalities on cellular DNA by evaluating markers of DNA damage.

• Evaluation of Changes in Renal Biomarkers after Exposure to Intravenous Iodinated Contrast Associated with CT scan Rochester, Minn.

  The purpose of this study is to see how the contrast affects kidney function. Kidney function will be measured by testing several blood and urine samples that you provide before and after the CT scan.

• How to Ask Pain Questions for Vertebroplasty Patients along with Monitoring Physical Activity Rochester, Minn.

  This is a study of the vertebroplasty population in which we ask them a variety of pain questions. There is highly fragmented material published concerning pain questionnaires in vertebroplasty literature.

  This study is unique in that it consists of two parts, the first portion consists of a pain questionnaire and the second portion consists of the pain questionnaire along with monitoring the physical activity of patients before and after their vertebroplasty procedure.

• Ischemic Preconditioning Prior to Cerebrovascular Interventional Procedures Rochester, Minn.

  The purpose of this study is to determine if patients receiving Remote ischemic conditioning (RIC) prior to elective endovascular treatment of intracranial aneurysms will have a reduction in rates of cerebral ischemia as detected onimaging when compared to a group of historical controls.  Our secondary aim is to determine if patients who receive ischemic preconditioning have any elevation in serum markers for cerebral ischemia.

• Pivotal Study of the MicroVention Flow Re-Direction Endoluminal Device (FRED) Stent System in the Treatment of Intracranial Aneurysms (FRED) Rochester, Minn.

  The purpose of this study is to evaluate the safety and effectiveness of the MicroVention Flow Redirection Intraluminal Device (FRED) system when used in the treatment of wide-necked intracranial aneurysms.

• Premier Prospective Study on Embolization of Intracranial Aneurysms with Pipeline™ Embolization Device (PREMIER) Rochester, Minn.

  The purpose of this study is to assess the safety and effectiveness of the Pipeline™ device in the treatment of unruptured, wide-neck intracranial aneurysms.

• Prospective Simulation of Endovascular Repair of Cerebral Aneurysms Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn.

  This study will look at how a new investigational software program, called the Endovantage Interventional Suite (EVIS), can help your doctor better plan surgeries like yours through computer simulation. The software allows your doctor to see how the chosen medical device(s) will perform when it is placed in the blood vessel in your brain. We hope to determine if the computer simulation is realistic and indeed accurately shows your doctor exactly what happened at the time of surgery. If the computer simulation is an accurate reflection of the actual surgery, then the software could help your doctor take better care of future patients with brain aneurysms through improved planning before surgery is performed.

• Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke (STRATIS) Registry (STRATIS) Rochester, Minn.

  The purpose of this registry is to assess outcomes associated with the use of devices intended to restore blood flow in patients experiencing acute ischemic stroke.

• The WEB ® Intrasaccular Therapy Study (WEB-IT) (WEB-IT) Rochester, Minn.

  The purpose of this study is to determine the safety and effectiveness of the WEB Aneurysm Embolization System for the treatment of WNBAs located in the anterior (middle cerebral artery (MCA) bifurcation, internal carotid artery terminus (ICAt) or anterior communicating artery complex (ACom) and posterior (basilar apex) circulations.