Afsaneh Alavi, M.D.

The purpose of this study is to focus on the interaction between stress hormones and mast cells (MCs in lesional skin of Hidradenitis Suppurativa (HS) patients. In clinical practice, psychological stress can trigger the symptoms in HS patients. Furthermore, there is increasing evidence to suggest that there is a link between chronic inflammatory skin disorders and psychiatric comorbidities even though it isdifficult to decipher the impact of underlying cutaneous inflammatory disease compared to the psychosocial impact of living with chronic illness.

The purpose of this study is to evaluate the effectiveness of PCS499 at 6 Months in treating ulcerations in patients who have necrobiosis lipoidica.

The purpose of this study is to provide the first specific globally comparable prevalence data on Hidradenitis Suppurativa (HS).

The purpose of this study is to comprehensively characterize Hidradenitis Suppurativa (HS) from clinical and biological perspectives. Study subjects will be individuals with HS. Consented subjects will complete electronic surveys and undergo comprehensive dermatologic evaluations at designated time points. Study subjects will be asked to donate skin swabs, saliva samples, stool samples, blood samples, hair samples and/or skin specimens.

Collected biospecimens will be stored in a local tissue bank for future study. Subjective measures will be collected to characterize the effect of disease on quality of life.

The purpose of this study is to identify the incidence and prevalence of inflammatory arthritis in patients with Hidradenitis Suppurativa (HS) and compare them with those in patients with psoriasis through implementing a routine screening. Identifying the incidence and prevalence of this comorbidity has the potential to increase awareness across the specialties of rheumatology and comorbid diseases.

The aims of this study are to determine the frequency, severity, and duration of symptoms of arthritis in patients with HS and compare them with those in patients with psoriasis, to determine the association between inflammatory arthritis and disease flare-ups/severity in HS, to investigate impact of inflammatory arthritis on the quality of life and mental health of HS patients, and to determine the association of inflammatory arthritis in the context of other systemic inflammatory diseases (inflammatory bowel disease (IBD), rheumatoid arthritis (RA), etc.) in these two-patient population of psoriasis and HS.

The purpose of this study is to evaluate the effectiveness of PCS499 at 6 Months in treating ulcerations in patients who have necrobiosis lipoidica.

The primary objective of this trial is to assess the long-term safety of spesolimab in patients with HS who have completed the 1368-0052 PoCC trial and are qualified for entry into this trial. The secondary objectives are to evaluate effectiveness at a lower dose than tested in PoCC trial.

The purpose of this study is to assess the effectivess and safety of Spesolimab in Hidradenitis Suppurativa (HS) patients.