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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 241-250 of 3416 for cancer

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  1. The BEACON Study (Breast Cancer Outcomes With NKTR-102)

  2. Combination Chemotherapy in Treating Women With Stage II or Stage IIIA Breast Cancer That Has Spread to the Lymph Nodes

    La Crosse, WI

  3. Etigilimab and Nivolumab in Subjects With Locally Advanced or Metastatic Tumors

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  4. Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer

    Rochester, MN

  5. Anastrozole and Letrozole After Surgery for the Treatment of Stage I-III Breast Cancer

    Scottsdale/Phoenix, AZ, Rochester, MN

  6. A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  7. Safety and Efficacy of Combination Listeria/GVAX Pancreas Vaccine in the Pancreatic Cancer Setting

    Rochester, MN

  8. Monitoring Symptoms to Help Young Women Take Hormone Therapy for Stage I-III Breast Cancer, ASPEN Study

    La Crosse, WI, Albert Lea, MN, Eau Claire, WI

  9. A Study of Selpercatinib to Treat Participants with RET-Mutant Medullary Thyroid Cancer

    Scottsdale/Phoenix, AZ

  10. Study of Cabozantinib Combined With Atezolizumab Vs. Second Novel Hormonal Therapy in Subjects with Metastatic Castration-Resistant Prostate Cancer

    Rochester, MN

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