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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 61-70 of 82 for joint replacement

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  1. A Study to Evaluate Preventative Saphenous Nerve Neurectomy in Primary Total Knee Arthroplasty

    Jacksonville, FL

  2. A Study Evaluating Time to Return of Lower Extremity Motor Function Following Spinal Anesthetic with Mepivacaine Versus Low-Dose Bupivacaine for Primary Total Hip and Knee Arthroplasty

    Rochester, MN

  3. A Study to Evaluate Cardiotoxicity in Total Hip and Knee Arthroplasty

    Rochester, MN

  4. Does the Critical Shoulder Angle Influence the Rotator Cuff Failure After Anatomic Shoulder Arthroplasty?

    Rochester, MN

  5. CT Assessment of Differences in Arm Position in Glenohumeral Subluxation

    Jacksonville, FL, Scottsdale/Phoenix, AZ

  6. Non-invasive Hemoglobin Monitoring in Patients Undergoing Outpatient TJA

    Rochester, MN

  7. A Study to Collect Clinical Outcomes in Patients after Knee Arthroplasty

    Rochester, MN

  8. A Study to Evaluate A Patient's Perception of Indwelling Foley Catheters Following Total Hip or Total Knee Arthroplasty

    Jacksonville, FL

  9. A Study of Outcomes from the Use of Tranexamic Acid in Revision Total Joint Arthroplasty

    Rochester, MN

  10. A Study to Evaluate Outcomes of Shoulder Arthroplasty

    Rochester, MN

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