Clinical Trials

The purposes of this study are to determine:  the risk of cardiomyopathy and heart failure, and cardiac structure and function in patients with THA and TKA. This study will also determine the association between serum and/or synovial fluid metal ion levels with cardiac structure and function in 100 prospectively-recruited THA and TJA patients.

The purpose of this study is to evaluate the outcomes of patients who received an Allograft-Prosthesis Composite for Revision of Catastrophic Failure of Ulnar Component of Total Elbow Arthroplasty.

The purpose of this study is to:

• Evaluate the influence of the critical shoulder angle (CSA) on outcomes after total anatomic shoulder arthroplasty; and
• Evaluate the influence of the critical shoulder angle (CSA) on rotator cuff failure after total anatomic shoulder arthroplasty.

This project is focused on understanding the risk of cognitive impairment and dementia in total hip and total knee arthroplasty patients. It involves 4 aims:

AIM 1. To determine the risk of dementia in patients with TJA. Using the REP, we will identify a population-based cohort of 9,000 TJA patients and a matched cohort of 9,000 non-TJA patients. The overall risk of dementia and subtypes will be compared between the two cohorts.

AIM 2. To determine cognitive function and neuroimaging measures in patients with TJA. Within the existing data from the MCSA cohort (IRB: 14-004401), we will identify the sub-cohort of 1,200 patients with TJA and compare their cross-sectional and longitudinal cognition and neuroimaging measures with a matched cohort of non-TJA subjects.

AIM 3. To determine the association between serum and synovial fluid metal ion levels with cognitive function and neuroimaging findings. We will prospectively recruit 100 TJA patients presenting for revision TJA and with at least 10 years of exposure to TJA implants. Serum metal ion levels will be measured and TJA patients will undergo cognitive assessments and neuroimaging, similar to the MCSA cohort.

AIM 4. To determine neuropathological features and metal ion levels in postmortem brain autopsy tissue of patients with TJA. We will use stored brain autopsy tissues of 100 patients with TJA and 100 non-TJA subjects.

This research study is being done to find out if there is any correlation between metal ion levels (cobalt and chromium) in the fluid around your hip, and those that are found in your blood. One factor that may cause failure of a total hip arthroplasty is an elevated level of these ions around the hip.